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ACS Nano Sep 2023An essential challenge in diabetic periodontal regeneration is achieving the transition from a hyperglycemic inflammatory microenvironment to a regenerative one. Here,...
An essential challenge in diabetic periodontal regeneration is achieving the transition from a hyperglycemic inflammatory microenvironment to a regenerative one. Here, we describe a polydopamine (PDA)-mediated ultralong silk microfiber (PDA-mSF) and metformin (Met)-loaded zeolitic imidazolate framework (ZIF) incorporated into a silk fibroin/gelatin (SG) patch to promote periodontal soft and hard tissue regeneration by regulating the immunomodulatory microenvironment. The PDA-mSF endows the patch with a reactive oxygen species (ROS)-scavenging ability and anti-inflammatory activity, reducing the inflammatory response by suppressing M1 macrophage polarization. Moreover, PDA improves periodontal ligament reconstruction via its cell affinity. Sustained release of Met from the Met-ZIF system confers the patch with antiaging and immunomodulatory abilities by activating M2 macrophage polarization to secrete osteogenesis-related cytokines, while release of Zn also promotes bone regeneration. Consequently, the Met-ZIF system creates a favorable microenvironment for periodontal tissue regeneration. These features synergistically accelerate diabetic periodontal bone and ligament regeneration. Thus, our findings offer a potential therapeutic strategy for hard and soft tissue regeneration in diabetic periodontitis.
Topics: Zeolites; Metformin; Cell Differentiation; Periodontium; Osteogenesis; Diabetes Mellitus
PubMed: 37578444
DOI: 10.1021/acsnano.3c02407 -
International Journal of Biological... Nov 2023One of the most attractive approaches in biomedicine and pharmacy is the application of multifunctional materials. The mesoporous structure of clinoptilolite (CZ)...
One of the most attractive approaches in biomedicine and pharmacy is the application of multifunctional materials. The mesoporous structure of clinoptilolite (CZ) absorbs various types of substances and can be used as a model for studying the carriers for targeted drug delivery with controlled release. CZ-dye composites are fabricated by incorporation into clinoptilolite pores commonly used dyes, aluminum phthalocyanine, zinc porphine, and hypericin. We examined and compared the effect of pure dyes and CZ-dye composites on insulin amyloidogenesis. The formation of insulin amyloid fibrils and the disassembly of preformed fibrils is significantly affected by any of the three compounds, however, the strongest effect is observed for aluminum phthalocyanine indicating a structurally-dependent anti-amyloidogenic activity of the dyes. The incorporation of dyes into CZ particles resulted in enhanced anti-amyloidogenic activity in comparison to pure CZ particles. The cell metabolic activity, biocompatibility and fluorescence biodistribution of the dyes entrapped in the composites were tested in vitro (U87 MG cells) and in vivo in the quail chorioallantoic membrane model. Considering the photoactive properties of the dyes used, we assume their applicability in photodiagnostics and photodynamic therapy. It can also be expected that their anti-amyloidogenic potential can be enhanced by photodynamic effect.
Topics: Zeolites; Humans; Animals; Biocompatible Materials; Coloring Agents; Amyloid; Insulin; Indoles; Cell Line, Tumor
PubMed: 37579899
DOI: 10.1016/j.ijbiomac.2023.126331 -
Journal of Environmental Management Nov 2023Aluminum is an important lightweight and high-value metal that is widely used in the transportation, construction, and military industries. China is the largest producer... (Review)
Review
Aluminum is an important lightweight and high-value metal that is widely used in the transportation, construction, and military industries. China is the largest producer of Al in the world, and vast quantities of Al dross (ash) are generated and stored every year. Aluminum dross contains fluoride and heavy metals, and easily reacts with water and acid to produce stimulating, toxic, and explosive gases. Owing to a lack of developed technologies, most of this dross cannot be safely treated, resulting in a waste of resources and serious environmental and ecological risks. This review briefly describes the distribution and proportions of bauxite deposits in China, the Al extraction process, and the hazardous solid waste that is generated. It also discusses the comprehensive treatments for Al dross, including the hydrometallurgy and pyrometallurgy recovery processes, and reuse of Al, AlO, SiO, and chloride salts as a summarized comparison of their advantages and disadvantages. In particular, this review focuses on the efforts to analyze the relationship between existing processes and the attempts to establish a comprehensive technology to treat Al dross. Additionally, areas for future research are suggested, which may provide new ideas for the closed-loop treatment of Al dross.
Topics: Aluminum; Silicon Dioxide; Metals; Aluminum Oxide; China
PubMed: 37451029
DOI: 10.1016/j.jenvman.2023.118575 -
Biosensors Jul 2023Interferometry-based, reflectometric, label-free biosensors have made significant progress in the analysis of molecular interactions after years of development. The... (Review)
Review
Interferometry-based, reflectometric, label-free biosensors have made significant progress in the analysis of molecular interactions after years of development. The design of interference substrates is a key research topic for these biosensors, and many studies have focused on porous films prepared by top-down methods such as porous silicon and anodic aluminum oxide. Lately, more research has been conducted on ordered porous layer interferometry (OPLI), which uses ordered porous colloidal crystal films as interference substrates. These films are made using self-assembly techniques, which is the bottom-up approach. They also offer several advantages for biosensing applications, such as budget cost, adjustable porosity, and high structural consistency. This review will briefly explain the fundamental components of self-assembled materials and thoroughly discuss various self-assembly techniques in depth. We will also summarize the latest studies that used the OPLI technique for label-free biosensing applications and divide them into several aspects for further discussion. Then, we will comprehensively evaluate the strengths and weaknesses of self-assembly techniques and discuss possible future research directions. Finally, we will outlook the upcoming challenges and opportunities for label-free biosensing using the OPLI technique.
Topics: Porosity; Interferometry; Biosensing Techniques; Silicon; Aluminum Oxide
PubMed: 37504128
DOI: 10.3390/bios13070730 -
Journal of Controlled Release :... Jul 2023Zeolitic imidazolate frameworks (ZIFs), as a very well-known subset of metal-organic frameworks (MOFs), have attracted considerable attention in biomedicine due to their... (Review)
Review
Zeolitic imidazolate frameworks (ZIFs), as a very well-known subset of metal-organic frameworks (MOFs), have attracted considerable attention in biomedicine due to their unique structural features such as tunable pore size, high surface area, high thermal stability, biodegradability, and biocompatibility. Moreover, it is possible to load a wide variety of therapeutic agents, drugs, and biomolecules into ZIF structures during the fabrication process owing to the ZIFs' porous structure and concise synthesis methods under mild conditions. This review focuses on the most recent advances in the bioinspiration of ZIFs and ZIF-integrated nanocomposites in boosting antibacterial efficiencies and regenerative medicine capabilities. The first part summarizes the various synthesis routes and physicochemical properties of ZIFs, including size, morphology, surface, and pore size. The recent advancements in the antibacterial aspects of using ZIFs and ZIF-integrated nanocomposites as carriers for antibacterial agents and drug cargo are elaborated. Moreover, the antibacterial mechanisms based on the factors affecting the antibacterial properties of ZIFs such as oxidative stress, internal and external triggers, the effect of metal ions, and their associated combined therapies, are discussed. The recent trends of ZIFs and their composites in tissue regeneration, especially bone regeneration and wound healing, are also reviewed with in-depth perspectives. Finally, the biological safety aspects of ZIFs, the latest reports about their toxicity, and the future prospects of these materials in regenerative medicine have been discussed.
Topics: Imidazoles; Zeolites; Metal-Organic Frameworks; Wound Healing
PubMed: 37290724
DOI: 10.1016/j.jconrel.2023.06.002 -
The Journal of Prosthetic Dentistry Jul 2023Polyetherketoneketone (PEKK) is a high-performance polymer gaining popularity in dentistry for the fabrication of crowns, fixed partial dentures, removable partial...
STATEMENT OF PROBLEM
Polyetherketoneketone (PEKK) is a high-performance polymer gaining popularity in dentistry for the fabrication of crowns, fixed partial dentures, removable partial denture frameworks, and frameworks for implant-supported fixed complete dentures. Despite a lack of performance data, lithium disilicate crowns have been bonded to retentive elements in PEKK frameworks.
PURPOSE
The purpose of this in vitro study was to compare the bond strengths and flexibility of lithium disilicate to PEKK or zirconia.
MATERIAL AND METHODS
Forty-five PEKK, 15 zirconia, and 60 lithium disilicate beam-shaped specimens (12.5×2×2 mm) were fabricated. The ends of the PEKK beams were subjected to 3 different surface treatments before the application and light polymerization of a primer: 50-μm aluminum oxide airborne-particle abrasion, nonthermal air plasma, and argon-oxygen plasma. The zirconia specimen bonding surfaces were prepared with 50-μm aluminum oxide airborne-particle abrasion and the application of primer. Lithium disilicate specimens were etched with 4.5% hydrofluoric acid, and primer was applied. The lithium disilicate specimens were luted with an adhesive resin cement to the PEKK and zirconia specimens by using light-activated and chemically activated polymerization. Fifteen monolithic specimens of PEKK, lithium disilicate, and zirconia (25×2×2 mm) were also fabricated. All specimens were incubated overnight in 100% humidity before testing. Bonded and monolithic specimens were loaded in a universal testing machine, and 4-point bend tests were conducted until failure (n=15). The flexural modulus and strength were calculated and statistically analyzed with 1-way analysis of variance and Student-Newman-Keuls post hoc tests (α=.05).
RESULTS
All bonded specimens failed at the adhesive interface. The zirconia-lithium disilicate bond strength was approximately twice that of the strongest group of PEKK (airborne-particle abrasion group) bonded to lithium disilicate (42 ±12 MPa and 24 ±13 MPa, respectively) and was approximately 9 times more rigid (71 ±19 GPa and 8 ±2 GPa, respectively). Monolithic PEKK fractured at 238 ±22 MPa, monolithic zirconia at 771 ±128 MPa, and monolithic lithium disilicate at 173 ±26 MPa. Monolithic PEKK was approximately 30 times more flexible than monolithic zirconia (6 ±1 GPa and 178 ±16 GPa, respectively). All values were statistically significantly different (P<.05), except for the bond strength between lithium disilicate and PEKK treated with airborne-particle abrasion and nonthermal air plasma and the flexural moduli of PEKK to lithium disilicate.
CONCLUSIONS
Bond strength between PEKK and lithium disilicate was significantly weaker than that between zirconia and lithium disilicate. Monolithic PEKK was significantly more flexible than monolithic zirconia.
Topics: Humans; Ceramics; Materials Testing; Dental Porcelain; Zirconium; Resin Cements; Aluminum Oxide; Surface Properties; Dental Stress Analysis; Dental Bonding
PubMed: 34863577
DOI: 10.1016/j.prosdent.2021.10.008 -
Environmental Research Sep 2023Various catalysts are being used in fuel production from biomass and polymeric waste for the obtention of an alternative energy source with both environmental... (Review)
Review
Various catalysts are being used in fuel production from biomass and polymeric waste for the obtention of an alternative energy source with both environmental friendliness and economic viability. Biochar, red mud bentonite, and calcium oxide have been shown to play a pertinent role as catalysts in waste-to-fuel conversion processes, such as transesterification and pyrolysis. In this line of thought, this paper has provided a compendium of the fabrication and modification technologies of bentonite, red mud calcium oxide, and biochar, together with their various performances in their application in the waste-to-fuel processes. Additionally, an overview of the structural and chemical attributes of these components is discussed regarding their efficiency. Ultimately, research trends and future points of focus are evaluated, and it is observed that techno-economic optimization of catalyst synthetic routes and investigation of new catalytic formulations, such as biochar and red mud-based nanocatalysts, are potential prospects. This report also offers future research directions that are anticipated to contribute to the development of sustainable green fuel generation systems.
Topics: Bentonite; Oxides; Charcoal
PubMed: 37270078
DOI: 10.1016/j.envres.2023.116284 -
Journal of Esthetic and Restorative... May 2024This scoping review aims to assess the influence of air abrasion with aluminum oxide and bioactive glass on dentin bond strength. (Review)
Review
OBJECTIVE
This scoping review aims to assess the influence of air abrasion with aluminum oxide and bioactive glass on dentin bond strength.
MATERIALS AND METHODS
An electronic search was conducted in three databases (PubMed, Cochrane Library, and Embase), on March 3rd, 2023, with previously identified MeSH Terms. A total of 1023 records were screened. Exclusion criteria include primary teeth, air abrasion of a substrate other than sound dentin, use of particles apart from aluminum oxide or bioactive glass, and studies in which bond strength was not assessed.
RESULTS
Out of the 1023 records, title and abstract screening resulted in the exclusion of 895 and 67 studies, respectively, while full-text analysis excluded another 25 articles. In addition, 5 records were not included, as full texts could not be obtained after requesting the authors. Two cross-references were added. Thus, 33 studies were included in this review. It is important to emphasize the absence of standardization of air abrasion parameters. According to 63.6% of the studies, air abrasion does not influence dentin bond strength. Moreover, 30.3% suggest improving bonding performance, and 6.1% advocate a decrease.
CONCLUSIONS
Air abrasion with aluminum oxide does not enhance or impair dentin bond strength. The available data on bioactive glass are limited, which hinders conclusive insights.
CLINICAL SIGNIFICANCE
Dentin air abrasion is a widely applied technique nowadays, with numerous clinical applications. Despite the widespread adoption of this procedure, its potential impact on bonding performance requires a thorough analysis of the existing literature.
Topics: Composite Resins; Dental Bonding; Air Abrasion, Dental; Materials Testing; Surface Properties; Aluminum Oxide; Dentin; Resin Cements
PubMed: 38130045
DOI: 10.1111/jerd.13183 -
Small (Weinheim An Der Bergstrasse,... Aug 2023Cancer is one of the deadliest diseases, and current treatment regimens suffer from limited efficacy, nonspecific toxicity, and chemoresistance. With the advantages of... (Review)
Review
Cancer is one of the deadliest diseases, and current treatment regimens suffer from limited efficacy, nonspecific toxicity, and chemoresistance. With the advantages of good biocompatibility, large specific surface area, excellent cation exchange capacity, and easy availability, clay minerals have been receiving ever-increasing interests in cancer treatment. They can act as carriers to reduce the toxic side effects of chemotherapeutic drugs, and some of their own properties can kill cancer cells, etc. Compared with other morphologies clays, layered clay minerals (LCM) have attracted more and more attention due to adjustable interlayer spacing, easier ion exchange, and stronger adsorption capacity. In this review, the structure, classification, physicochemical properties, and functionalization methods of LCM are summarized. The state-of-the-art progress of LCM in antitumor therapy is systematically described, with emphasis on the application of montmorillonite, kaolinite, and vermiculite. Furthermore, the property-function relationships of LCM are comprehensively illustrated to reveal the design principles of clay-based antitumor systems. Finally, foreseeable challenges and outlook in this field are discussed.
Topics: Clay; Aluminum Silicates; Minerals; Kaolin; Bentonite; Adsorption; Neoplasms
PubMed: 37093210
DOI: 10.1002/smll.202300842 -
Lasers in Medical Science Aug 2023Conventional surface roughening treatments used for silica-based ceramics in order to improve subsequent adhesion become unreliable for zirconia ceramics. Laser...
In vitro comparative study between adhesion forces obtained on zirconia ceramic micromechanically treated with femtosecond laser (1027 nm), carbon dioxide laser (10,600 nm), and aluminum-oxide particles.
Conventional surface roughening treatments used for silica-based ceramics in order to improve subsequent adhesion become unreliable for zirconia ceramics. Laser conditioning can be a good alternative. The purpose of this in vitro study was to compare conventional (macro) shear bond strength (SBS) values obtained between resin composite and zirconium oxide ceramic samples grouped according to different micromechanical treatments received, and examine differences in surface roughness. One-hundred and fifty disks of sintered zirconia were randomly divided into 5 groups and roughened as follows: (1) Group NOT, no surface treatment; (2) Group APA, abraded with 50-μm aluminum-oxide (AlO) particles; (3) Group TBS, abraded with 30-μm aluminum-oxide particles covered with silica; (4) Group CO2, irradiated with a CO laser which emitted in continuous wave mode at 3 W of power; and (5) Group FEM, irradiated with a pulsed femtosecond laser, with an incident energy of 10 μJ, a frequency of 1000 Hz, and a fluence of 1.3 kJ/cm. All surfaces were treated with a MDP-containing adhesive/silane coupling agent mixture upon which were prepared and light polymerized composite resin cylinders. Shear bond strength was measured and samples were observed by scanning electron microscopy (SEM). Statistically significant differences (p < 0.05) were found among all groups, except between CO and FEM, which showed the highest adhesion values (15.12 ± 2.35 MPa and 16.03 ± 2.73 MPa). SEM revealed differences in surface patterns. CO laser irradiation can be an alternative to sandblasting, although it could also weaken the ceramic. Suitable surface patterns on zirconia ceramics can be obtained with ultrashort pulsed radiation emitted by a pulsed femtosecond laser.
Topics: Lasers, Gas; Aluminum; Carbon Dioxide; Aluminum Oxide; Ceramics; Composite Resins
PubMed: 37626207
DOI: 10.1007/s10103-023-03859-2