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European Heart Journal. Cardiovascular... May 2024
Topics: Humans; Aspirin; Drug Hypersensitivity
PubMed: 38268418
DOI: 10.1093/ehjcvp/pvae008 -
Intensive Care Medicine Dec 2023
Topics: Humans; Analgesics, Opioid; Acetaminophen; Administration, Intravenous; Pain, Postoperative
PubMed: 37922011
DOI: 10.1007/s00134-023-07254-x -
American Journal of Translational... 2023Plant-based natural antioxidants have a wide variety of biological activities with significant therapeutic value. has been used traditionally to treat a variety of...
OBJECTIVE
Plant-based natural antioxidants have a wide variety of biological activities with significant therapeutic value. has been used traditionally to treat a variety of ailments in animals and human, but little is defined about its biological or pharmacological effects. Therefore, the objective of the present study was to evaluate phytochemical, antioxidant, antipyretic and anti-inflammatory activities of aqueous-methanolic leaf extract of .
METHODS
To investigate the possible impact of aqueous-methanolic leaf extract of on oxidative stress, inflammation, and pyrexia, we used a combined in vitro and in vivo series of experiments on laboratory animals.
RESULTS
Results revealed significant antioxidant potential in 2,2-diphenylpicrylhydrazyl (DPPH) and nitric oxide (NO) scavenging assay, while significant but dose dependent antipyretic potential was documented in typhoid-paratyphoid A and B (TAB) vaccine and prostaglandin E (PGE) induced pyrexia models. Significant anti-inflammatory effects were observed in both acute and chronic inflammatory models of arachidonic acid and formalin. Phytochemical screening and high-performance liquid chromatography (HPLC) analysis of confirmed the presence of mangiferin, quercetin, and isoquercetin. These phytoconstituents likely play a role in the observed biological activities. Our results show that has antioxidant, anti-inflammatory, and antipyretic effects, lending credence to its traditional use and advocating for its utilization as a viable contender in treating oxidative stress-associated ailments.
CONCLUSION
It is concluded that has various properties in the treatment of various diseases.
PubMed: 37560231
DOI: No ID Found -
Inflammopharmacology Feb 2024Non-medicinal therapies with water, salts, exercise, massage, supportive devices, and electricity have been used for centuries and continue to be of benefit for some... (Review)
Review
Non-medicinal therapies with water, salts, exercise, massage, supportive devices, and electricity have been used for centuries and continue to be of benefit for some people with musculoskeletal disorders. Historical texts refer to the two electuaries mithridatium and theriaca as early therapeutic attempts of man to provide relief of musculoskeletal symptoms and attempt disease cures. For over 200 years, morphine-derived products have been used for musculoskeletal pain. The development of acetyl salicylic acid was a major breakthrough in joint pain management. This was followed by the introduction of nonsteroidal anti-inflammatory agents, paracetamol, and the use of corticosteroids. The gold-based compounds were the initial disease-modifying drugs and have been followed by the highly successful biologics agents. The basic objectives of musculoskeletal pain management include: reduction or elimination of joint pain; improvement or restoration of joint function and mobility; improvement of muscle strength to protect cartilage, ligaments, and joint capsule; prevention and reduction of damage to joint cartilage and supporting structures.
Topics: Male; Humans; Musculoskeletal Pain; Rheumatic Diseases; Pain Management; Arthralgia; Acetaminophen; Morphine
PubMed: 37632655
DOI: 10.1007/s10787-023-01312-y -
BMJ Case Reports Jan 2024Vertebral artery dissections are a rare pathology that carries a high risk of stroke in a younger population. They may be caused by minor mechanisms and the index of...
Vertebral artery dissections are a rare pathology that carries a high risk of stroke in a younger population. They may be caused by minor mechanisms and the index of suspicion should be high. Treatment with anticoagulation or antiplatelets should follow if no surgical management is indicated.We describe a case of a female in her 30s who fell backward off a swing and rolled over her head and complained of continued posterior neck pain. The patient was found to have a vertebral artery dissection on MRI. The patient was then anticoagulated with high-dose apixaban and low-dose aspirin.The emergency medicine provider should be aware of possible low-impact mechanisms that can cause vertebral artery dissection and should have a high index of suspicion. If surgical management is not indicated, anticoagulation should be initiated.
Topics: Female; Humans; Affect; Anticoagulants; Aspirin; Awareness; Vertebral Artery Dissection; Adult
PubMed: 38195187
DOI: 10.1136/bcr-2023-255923 -
The New England Journal of Medicine Mar 2024
Topics: Female; Humans; Pregnancy; Aspirin; Platelet Aggregation Inhibitors; Pre-Eclampsia; Racism; Risk Factors; Black or African American; United States; Systemic Racism
PubMed: 38466616
DOI: 10.1056/NEJMp2311019 -
Obstetrics and Gynecology Mar 2024
Topics: Pregnancy; Female; Humans; Aspirin; Pre-Eclampsia
PubMed: 38359436
DOI: 10.1097/AOG.0000000000005517 -
Archives of Disease in Childhood Jun 2024
Topics: Humans; Acetaminophen; Drug Overdose; Child; Analgesics, Non-Narcotic; Child, Preschool; Female; Male; Infant; Adolescent; Administration, Intravenous
PubMed: 38589200
DOI: 10.1136/archdischild-2024-326872 -
The Journal of Allergy and Clinical... Jan 2024There has been a paradigm shift in the management of aspirin-exacerbated respiratory disease (AERD). It started in 2015 when the first biologic was Food and Drug... (Review)
Review
There has been a paradigm shift in the management of aspirin-exacerbated respiratory disease (AERD). It started in 2015 when the first biologic was Food and Drug Administration (FDA) approved for severe eosinophilic asthma. Thus, there emerged a new era in the treatment of patients with type 2-mediated airway diseases. This has led to an increasing number of options for patients, undoubtably a great thing, but has left clinicians without a clear answer for how to balance the therapies that exist for AERD, what to recommend for treatment, and how to best assess the benefits and risks of each therapy. This paper aims to explore these benefits and risks, and to provide a roadmap for future studies.
Topics: Humans; Aspirin; Asthma, Aspirin-Induced; Respiration Disorders; Desensitization, Immunologic; Sinusitis; Asthma; Biological Products; Nasal Polyps; Chronic Disease; Rhinitis
PubMed: 37778627
DOI: 10.1016/j.jaip.2023.09.019 -
The Orthopedic Clinics of North America Oct 2023Total Knee Arthroplasty is associated with significant postoperative pain that can limit functional outcomes and patient satisfaction. In recent years, the standard of... (Review)
Review
Total Knee Arthroplasty is associated with significant postoperative pain that can limit functional outcomes and patient satisfaction. In recent years, the standard of care for postoperative pain management has reduced reliance on opioids in favor of multimodal analgesia. These regimens consist of systemic medications such as COX-2 inhibitors, acetaminophen, corticosteroids, and gabapentinoids, as well as regional and local approaches such as peripheral nerve blocks and local infiltrative analgesics. Newer therapies, such as cryoneurolysis, are still being studied but have shown promising results. Additional studies are needed to determine the ideal pain regimen that will optimize pain control and eliminate the need for postoperative opioids.
Topics: Humans; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Pain Management; Pain, Postoperative; Acetaminophen
PubMed: 37718075
DOI: 10.1016/j.ocl.2023.05.002