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Acta Psychologica May 2024This study explored demographic, ideological, self-rating and personality traits correlates of the Dark Tetrad (DT4) which measures Narcissism (Special),...
This study explored demographic, ideological, self-rating and personality traits correlates of the Dark Tetrad (DT4) which measures Narcissism (Special), Machiavellianism (Crafty), Psychopathy (Wild), and Sadism (Mean) traits. In total, 447 adults completed three tests: a bright-side, work-related, personality test (HPTI: High Performance Type Indicator), a dark-side test (Short Dark Tetrad) and a number of self-ratings. Correlations and regressions showed that all four dark traits were associated with low Adjustment (Neuroticism), but also with high Risk-Taking and Competitiveness (low Agreeableness). The various measures accounted for a third of the variance in explaining the Mean (Sadistic) score, and 40 % for Special (Narcissism). Trait Competitiveness was most closely associated with all four dark traits.
Topics: Adult; Humans; Machiavellianism; Antisocial Personality Disorder; Sadism; Cognition; Neuroticism; Personality
PubMed: 38502994
DOI: 10.1016/j.actpsy.2024.104222 -
Acta Psychiatrica Scandinavica Sep 2023Childhood trauma (CT) is associated with severe sequelae, including stress-related mental health disorders that can perpetuate long into adulthood. A key mechanism in...
BACKGROUND
Childhood trauma (CT) is associated with severe sequelae, including stress-related mental health disorders that can perpetuate long into adulthood. A key mechanism in this relationship seems to be emotion regulation. We aimed to investigate (1) whether childhood trauma is associated with anger in adulthood, and, if so, (2) to explore which types of childhood trauma predominate in the prediction of anger in a cohort that included participants with and without current affective disorders.
METHODS
In the Netherlands Study of Depression and Anxiety (NESDA), childhood trauma was assessed with a semi-structured Childhood Trauma Interview (CTI) at baseline, and analyzed in relation to anger as measured at a 4-year follow-up with the Spielberger Trait Anger Subscale (STAS), the Anger Attacks Questionnaire, and cluster B personality traits (i.e., borderline, antisocial) of the Personality Disorder Questionnaire 4 (PDQ-4), using analysis of covariance (ANCOVA) and multivariable logistic regression analyses. Post hoc analyses comprised cross-sectional regression analyses, using the Childhood Trauma Questionnaire-Short Form (CTQ-SF) also obtained at a 4-year follow-up.
RESULTS
Participants (n = 2271) were on average 42.1 years (SD = 13.1), and 66.2% were female. Childhood trauma showed a dose-response association with all anger constructs. All types of childhood trauma were significantly associated with borderline personality traits, independently of depression and anxiety. Additionally, all types of childhood trauma except for sexual abuse were associated with higher levels of trait anger, and a higher prevalence of anger attacks and antisocial personality traits in adulthood. Cross-sectionally, the effect sizes were larger compared with the analyses with the childhood trauma measured 4 years prior to the anger measures.
CONCLUSIONS
Childhood trauma is linked with anger in adulthood, which could be of particular interest in the context of psychopathology. Focus on childhood traumatic experiences and adulthood anger may help to enhance the effectiveness of treatment for patients with depressive and anxiety disorders. Trauma-focused interventions should be implemented when appropriate.
Topics: Humans; Adult; Female; Male; Cross-Sectional Studies; Adverse Childhood Experiences; Anxiety Disorders; Anxiety; Anger; Surveys and Questionnaires
PubMed: 37430486
DOI: 10.1111/acps.13589 -
Medicina (Kaunas, Lithuania) Jul 2023: Higher level of aggression and antisocial behavior have been found in the period following head trauma. These changes are attributable to specific brain alterations... (Review)
Review
: Higher level of aggression and antisocial behavior have been found in the period following head trauma. These changes are attributable to specific brain alterations that generally involved frontal lobe, insula and limbic system. A descriptive review was conducted on the specificity of aggressive behavior in relation to traumatic brain injury by evaluating numerous variables, focusing on age at the time of trauma and neuroimaging studies. : We searched on PubMed and the Web of Science databases to screen references of included studies and review articles for additional citations. From an initial 738 publications, only 27 met the search criteria of describing the relationship between aggression, brain alterations and traumatic brain injury. : These findings showed that traumatic brain injury (TBI) is related to changes in behavior, personality and mood. : The development of aggressive and criminal behavior is associated with multiple factors, including the etiology of injury, environmental, psychosocial and personality factors and age at the time of trauma.
Topics: Humans; Brain Injuries, Traumatic; Aggression; Brain; Craniocerebral Trauma; Personality
PubMed: 37629667
DOI: 10.3390/medicina59081377 -
CNS Spectrums Dec 2023Problems with cognitive flexibility have been associated with multiple psychiatric disorders, but there has been little understanding of how cognitive flexibility...
OBJECTIVE
Problems with cognitive flexibility have been associated with multiple psychiatric disorders, but there has been little understanding of how cognitive flexibility compares across these disorders. This study examined problems of cognitive flexibility in young adults across a range of psychiatric disorders using a validated computerized -diagnostic flexibility paradigm. We hypothesized that obsessive-compulsive spectrum disorders (eg, obsessive-compulsive disorder, trichotillomania, and skin-picking disorder) would be associated with pronounced flexibility problems as they are most often associated with irrational or purposeless repetitive behaviors.
METHODS
A total of 576 nontreatment seeking participants (aged 18-29 years) were enrolled from general community settings, provided demographic information, and underwent structured clinical assessments. Each participant undertook the intra-extra-dimensional task, a validated computerized test measuring set-shifting ability. The specific measures of interest were total errors on the task and performance on the extra-dimensional (ED) shift, which reflects the ability to inhibit and shift attention away from one stimulus dimension to another.
RESULTS
Participants with depression and PTSD had elevated total errors on the task with moderate effect sizes; and those with the following had deficits of small effect size: generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD), antisocial personality disorder, and binge-eating disorder. For ED errors, participants with PTSD, GAD, and binge-eating disorder exhibited deficits with medium effect sizes; those with the following had small effect size deficits: depression, social anxiety disorder, OCD, substance dependence, antisocial personality disorder, and gambling disorder.
CONCLUSIONS
These data indicate cognitive flexibility deficits occur across a range of mental disorders. Future work should explore whether these deficits can be ameliorated with novel treatment interventions.
Topics: Young Adult; Humans; Obsessive-Compulsive Disorder; Trichotillomania; Anxiety Disorders; Cognition; Attention
PubMed: 37114560
DOI: 10.1017/S1092852923002237 -
The Primary Care Companion For CNS... Oct 2023To examine the relationship between khat use disorder and antisocial personality disorder in newly admitted inmates in a correctional facility in Ethiopia. A...
To examine the relationship between khat use disorder and antisocial personality disorder in newly admitted inmates in a correctional facility in Ethiopia. A cross-sectional study using successive sampling was conducted among 411 new inmates from April 20 to July 19, 2019. The Alcohol, Smoking, and Substance Involvement Screening Test was utilized to measure khat use. diagnostic criteria were used to identify antisocial personality disorder. Environmental, criminal, and clinical backgrounds of the inmates were also evaluated. The prevalence of current khat use and khat use disorder was 49.4% and 37%, respectively. The prevalence of khat use disorder among inmates with antisocial personality disorder was 76%. Inmates with antisocial personality disorder were twice as likely as those without antisocial personality disorder to have khat use disorder (adjusted odds ratio [AOR] = 2; 95% CI, 1.2-3.4). Punishment for misconduct in prior imprisonment (AOR = 3; 95% CI, 1.6-5.3), family history of alcohol use (AOR = 2; 95% CI, 1.3-3.5), and chronic physical illness (AOR = 5.3; 95% CI, 2.4-11.8) were significantly associated with khat use disorder. The prevalence of khat use disorder was higher among inmates with antisocial personality disorder, and antisocial personality disorder is linked to khat use disorder. The findings of this study suggest the need for the establishment of a mental health system in all prison institutions in Ethiopia to enhance early screening for underlying medical conditions, history of substance use, and antisocial personality disorder. Those inmates with identified substance use need detoxification therapy and motivational interviews after prison admission. .
Topics: Humans; Antisocial Personality Disorder; Catha; Cross-Sectional Studies; Ethiopia; Substance-Related Disorders; Prevalence
PubMed: 37857303
DOI: 10.4088/PCC.22m03470 -
Schizophrenia Bulletin Nov 2023Neuroimaging-based machine learning (ML) algorithms have the potential to aid the clinical diagnosis of schizophrenia. However, literature on the effect of prevalent...
BACKGROUND AND HYPOTHESIS
Neuroimaging-based machine learning (ML) algorithms have the potential to aid the clinical diagnosis of schizophrenia. However, literature on the effect of prevalent comorbidities such as substance use disorder (SUD) and antisocial personality (ASPD) on these models' performance has remained unexplored. We investigated whether the presence of SUD or ASPD affects the performance of neuroimaging-based ML models trained to discern patients with schizophrenia (SCH) from controls.
STUDY DESIGN
We trained an ML model on structural MRI data from public datasets to distinguish between SCH and controls (SCH = 347, controls = 341). We then investigated the model's performance in two independent samples of individuals undergoing forensic psychiatric examination: sample 1 was used for sensitivity analysis to discern ASPD (N = 52) from SCH (N = 66), and sample 2 was used for specificity analysis to discern ASPD (N = 26) from controls (N = 25). Both samples included individuals with SUD.
STUDY RESULTS
In sample 1, 94.4% of SCH with comorbid ASPD and SUD were classified as SCH, followed by patients with SCH + SUD (78.8% classified as SCH) and patients with SCH (60.0% classified as SCH). The model failed to discern SCH without comorbidities from ASPD + SUD (AUC = 0.562, 95%CI = 0.400-0.723). In sample 2, the model's specificity to predict controls was 84.0%. In both samples, about half of the ASPD + SUD were misclassified as SCH. Data-driven functional characterization revealed associations between the classification as SCH and cognition-related brain regions.
CONCLUSION
Altogether, ASPD and SUD appear to have effects on ML prediction performance, which potentially results from converging cognition-related brain abnormalities between SCH, ASPD, and SUD.
Topics: Humans; Antisocial Personality Disorder; Schizophrenia; Substance-Related Disorders; Neuroimaging
PubMed: 37449305
DOI: 10.1093/schbul/sbad103 -
Trends in Cognitive Sciences Feb 2024Antisocial behaviour (ASB) incurs substantial costs to the individual and society. Cognitive neuroscience has the potential to shed light on developmental risk for ASB,... (Review)
Review
Antisocial behaviour (ASB) incurs substantial costs to the individual and society. Cognitive neuroscience has the potential to shed light on developmental risk for ASB, but it cannot achieve this potential in an 'essentialist' framework that focuses on the brain and cognition isolated from the environment. Here, we present the case for studying the social transactional and iterative unfolding of brain and cognitive development in a relational context. This approach, which we call the study of the 'embedded brain', is needed to fully understand how risk for ASB arises during development. Concentrated efforts are required to develop and unify methods to achieve this approach and reap the benefits for improved prevention and intervention of ASB.
Topics: Humans; Antisocial Personality Disorder; Conduct Disorder; Brain; Behavior Therapy; Emotions
PubMed: 37718176
DOI: 10.1016/j.tics.2023.08.013 -
International Journal of Environmental... Jan 2024The relationship between antisocial personality traits and the expression of somatic symptoms has been the subject of several theoretical and empirical investigations....
The relationship between antisocial personality traits and the expression of somatic symptoms has been the subject of several theoretical and empirical investigations. The present study sought to advance the understanding of the relationship between these variables by testing two moderation models. It was hypothesized that the relationship between antisocial traits and somatization would be moderated by alcohol use, such that the presence of alcohol dependence would strengthen the relationship between antisocial traits and somatization. It was also hypothesized that gender would play a moderating role in the relationship between ASPD and somatization, such that the relationship would be stronger among women than among men. These models were tested in a sample of 787 criminal offenders. Gender did not emerge as a significant moderator in the relationship between antisocial traits and somatization. Although substance use did significantly moderate the relationship between antisocial traits and somatization, the direction of the effect ran counter to expectations: among participants reporting a history of alcohol dependency, the relationship between antisocial features and somatization was diminished. The implications of these findings are discussed.
Topics: Male; Humans; Female; Antisocial Personality Disorder; Alcoholism; Substance-Related Disorders; Alcohol Drinking; Criminals
PubMed: 38248526
DOI: 10.3390/ijerph21010061 -
Neuropsychobiology 2024Dual diagnosis in individuals with cocaine use disorders (CUDs) presents a mental health challenge marked by an increased susceptibility to disabling morbidities and...
Dysregulation of Plasma Growth Factors and Chemokines in Cocaine Use Disorder: Implications for Dual Diagnosis with Schizophrenia and Antisocial Personality Disorder in an Exploratory Study.
INTRODUCTION
Dual diagnosis in individuals with cocaine use disorders (CUDs) presents a mental health challenge marked by an increased susceptibility to disabling morbidities and premature mortality. Despite extensive research on depression and anxiety, other prevalent comorbidities, such as psychotic and personality disorders, have received less attention. This study explores inflammation-related mediators as potential biomarkers for CUD and dual diagnosis with schizophrenia (SCZ) or antisocial personality disorder (APD).
METHODS
This exploratory study included 95 participants, comprising 40 healthy subjects and 55 abstinent patients with CUD. Lifetime CUD was diagnosed either as single diagnosis (CUD group, N = 25) or as a dual diagnosis (DD group. N = 30) with SCZ (CUD+SCZ subgroup) or APD (CUD+APD subgroup). Participants were clinically assessed, and the plasma concentrations of growth factors (i.e., G-CSF, BDNF, and VEGF-A) and chemokines (i.e., CCL11/eotaxin-1, CCL2/MCP-1, and CXCL12/SDF-1) were determined and log(10)-transformed for analysis.
RESULTS
Growth factors and chemokines were dysregulated by CUD and psychiatric diagnoses. Specifically, patients in the CUD group exhibited significantly lower concentrations of G-CSF and CCL11/eotaxin-1 than the control group. In contrast, the DD group showed significantly higher concentrations of all analytes than both the CUD and control groups. Additionally, no differences in these analytes were observed between the CUD+SCZ and CUD+APD subgroups within the DD group. Regarding cocaine-related variables, significant associations were identified in the CUD group: an inverse correlation between the age at first cocaine use and the concentrations of BDNF and CCL2/MCP-1; and a positive correlation between the duration of the cocaine abstinence and the concentrations of BDNF and CCL11/eotaxin-1. Lastly, a logistic regression model incorporating all these analytes demonstrated high discriminatory power in distinguishing patients with CUD alone from those with dual diagnosis.
CONCLUSIONS
Individuals with dual diagnosis of CUD exhibit elevated concentrations of growth factors and chemokines, distinguishing them from those with CUD alone. It is unclear whether the differences in these inflammatory mediators are specific to the presence of SCZ and APD. The study highlights potential biomarkers and associations, providing valuable insights into the intricate interplay of CUD and psychiatric disorders to enhance clinical diagnosis and therapeutics.
Topics: Humans; Male; Cocaine-Related Disorders; Adult; Schizophrenia; Female; Antisocial Personality Disorder; Chemokines; Diagnosis, Dual (Psychiatry); Brain-Derived Neurotrophic Factor; Biomarkers; Middle Aged; Intercellular Signaling Peptides and Proteins; Vascular Endothelial Growth Factor A; Chemokine CCL2
PubMed: 38768577
DOI: 10.1159/000536265 -
Frontiers in Psychology 2024Antisocial personality disorder (ASPD) is associated with therapeutic pessimism among health professionals. Several variables are associated with obstacles in... (Review)
Review
Antisocial personality disorder and therapeutic pessimism - how can mentalization-based treatment contribute to an increased therapeutic optimism among health professionals?
Antisocial personality disorder (ASPD) is associated with therapeutic pessimism among health professionals. Several variables are associated with obstacles in therapist's willingness to treat ASPD. Variables that are relevant are (i) confusion associated with the term ASPD, (ii) characteristics of the disorder, (iii) attitudes, experiences, and knowledge clinicians possess, and (iv) insufficient management of countertransference. We assume that therapeutic pessimism is related to the lack of evidence-based, effective treatment for individuals with ASPD. This is problematic because ASPD is associated with large socio-economic costs and considerable suffering for the individual and the society. Mentalization-based treatment (MBT) was developed in treating borderline personality disorder (BPD) and is now considered an effective treatment for this group. Mentalization is defined as the process by which individuals make sense of themselves and others in terms of subjective states and mental processes. This ability affects an individual's psychological functioning, mental health, self-organization, and interpersonal relationships. The overall goal of MBT is to strengthen the individual's mentalizing abilities and facilitate more adaptive handling of problematic, internal states. Recently, a version of MBT tailored for individuals with ASPD (MBT-ASPD) has been developed. The purpose of this review is to investigate how MBT-ASPD relates to the major obstacles that contribute to the therapeutic pessimism toward this group. Despite a limited evidence base, preliminary studies indicate promising results for MBT-ASPD. More research is still required, this review suggests MBT-ASPD can contribute to increased therapeutic optimism and demonstrate specific characteristics of MBT-ASPD that contribute to management of therapeutic pessimism.
PubMed: 38449745
DOI: 10.3389/fpsyg.2024.1320405