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Medical Science Monitor : International... Dec 2023BACKGROUND Osteoporosis is a systemic chronic disease characterized by bone mineral density (BMD) reduction. This study aimed to assess the prevalence of osteoporosis...
BACKGROUND Osteoporosis is a systemic chronic disease characterized by bone mineral density (BMD) reduction. This study aimed to assess the prevalence of osteoporosis and fracture risks in northwestern China and investigate the related anthropometric risk factors. MATERIAL AND METHODS Between July 2022 and August 2022, 1429 participants (1295 females, 134 males) with measured BMD were recruited to participate in this cross-sectional study. Data on height, weight, and T score were collected. Spearman's correlation and multiple linear regression analysis were used to investigate the relationships between various demographic factors and BMD and the 10-year risk of major osteoporotic fracture (MO) and hip fracture (HP). RESULTS The overall prevalence of osteoporosis in northwest China was 42.34%, with 44.56% in females and 20.90% in males. Age negatively affects females' T scores (r=-0.304, P<0.05), and height positively influences both sexes' T scores (r=0.059 P<0.05). Age (r=0.148, P<0.05) and height were positive predictors of MO (r=0.027, P<0.05), while weight was a negative predictor (r=-0.035, P<0.05). The conclusion for HP was consistent with that of MO, except for the T score, which was a positive predictor of HP (r=0.014, P<0.05). CONCLUSIONS The prevalence of osteoporosis in northeast China is high. The association between anthropometric parameters and osteoporosis in adults in northwest China is different between sexes.
Topics: Adult; Male; Female; Humans; Cross-Sectional Studies; Prevalence; Osteoporosis; Bone Density; Osteoporotic Fractures; China; Risk Factors; Absorptiometry, Photon
PubMed: 38142297
DOI: 10.12659/MSM.942346 -
Archives of Osteoporosis Jan 2024This study aimed to illustrate the possibility of an unfavorable response to treatment with the anabolic agent romosozumab for patients with severe osteoporosis and to...
PURPOSE
This study aimed to illustrate the possibility of an unfavorable response to treatment with the anabolic agent romosozumab for patients with severe osteoporosis and to discuss explanations for treatment failure.
METHODS
Dual-energy x-ray absorptiometry (DXA) including vertebral fracture assessment (VFA) and X-rays of the thoracolumbar spine was used to assess bone mineral density (BMD) and the presence of vertebral fractures before and after treatment with romosozumab.
RESULTS
Our patient developed a decrease in the BMD of the hip, two incident new vertebral fractures, and worsening of one prevalent vertebral fracture during 1 year treatment with romosozumab. We have not detected non-adherence, there was no pretreatment with anti-resorptives, and we observed no signs of secondary osteoporosis and/or comorbidities.
CONCLUSION
As the number of patients treated with romosozumab is rising, it becomes more likely that more patients will be found with new fractures and/or an unfavorable BMD response. Probably, the unfavorable response is a (bad) chance finding, but we think it is crucial for clinicians and patients to exclude nonadherence, new comorbidities and pretreatment with anti-resorptives as explanation in these patients.
Topics: Humans; Spinal Fractures; Fractures, Bone; Osteoporosis; Bone Density; Bone Diseases, Metabolic; Absorptiometry, Photon; Antibodies, Monoclonal
PubMed: 38238593
DOI: 10.1007/s11657-024-01367-6 -
The Journal of International Medical... Mar 2024Inflammation has a crucial role in several metabolic diseases, such as obesity. The author aimed to investigate the relationship between the system inflammation response...
OBJECTIVE
Inflammation has a crucial role in several metabolic diseases, such as obesity. The author aimed to investigate the relationship between the system inflammation response index (SIRI) and android fat composition and distribution.
METHODS
Data for individuals aged 8-59 years, SIRI, android percent fat, and android-to-gynoid ratio from the 2017 to 2018 National Health and Nutrition Examination Survey were used. Weighted multiple linear regression and smooth curve fitting were used to test for linear and nonlinear associations. Additional subgroup analyses were performed. Threshold effect analysis was performed using a two-linear regression model.
RESULTS
Multiple linear regression showed a positive correlation between SIRI and android percent fat (β 0.92, 95% confidence interval [CI] 0.25-1.59) and between SIRI and the android-to-gynoid ratio (β 0.01, 95% CI 0.00-0.03) in 3783 Americans aged 8-59 years. The results showed that the effect of factors, other than smoking status, on the relationship between SIRI and android percent fat and android-to-gynoid ratio was not significant. There was a nonlinear relationship between SIRI and both android percent fat and android-to-gynoid ratio.
CONCLUSIONS
Elevated SIRI levels were associated with an increased android percent fat and android-to-gynoid ratio. Larger prospective studies are needed to validate the findings.
Topics: Humans; Cross-Sectional Studies; Nutrition Surveys; Body Fat Distribution; Cardiovascular Diseases; Risk Factors; Absorptiometry, Photon; Obesity; Heart Disease Risk Factors; Inflammation; Body Mass Index
PubMed: 38534094
DOI: 10.1177/03000605241239841 -
The Journal of Sports Medicine and... Nov 2023This study aimed to compare the relationships between bone and body composition parameters, and isometric maximal voluntary contraction (MVC) force of knee extensor (KE)...
BACKGROUND
This study aimed to compare the relationships between bone and body composition parameters, and isometric maximal voluntary contraction (MVC) force of knee extensor (KE) muscles in road cyclists and untrained controls.
METHODS
Twelve male road cyclists and 12 controls aged 20-34 years participated. The isometric MVC force of the KE muscles was assessed by a custom-made dynamometer. Bone mineral content (BMC), bone mineral density (BMD), and body composition were assessed using Dual-Energy X-ray Absorptiometry.
RESULTS
No differences were found in body mass, lean body mass, leg lean mass, MVC, whole body, and leg BMD and BMC between cyclists and controls. Controls had a significantly greater (P<0.001) body mass index (BMI), whole body (P<0.01), and leg fat (P<0.001) mass than athletes. In road cyclists, BMC correlated positively with body mass (r=0.73; P<0.01) and BMI (r=0.65; P<0.05), body (r=0.85; P<0.001) and leg lean mass (r=0.81; P<0.001); BMD correlated positively with lean body mass (r=0.60; P<0.05), leg lean mass (r=0.65 and r=0.60; P<0.05). MVC of KE muscles correlated positively with bone parameters (P<0.01) and lean mass (P<0.05) only in controls.
CONCLUSIONS
Regular cycling training was associated with lower BMI, and body and leg fat mass. There were no significant differences in bone parameters, body and leg lean mass, and isometric MVC force of KE muscle variables between road cyclists and controls. In road cyclists, bone parameters are associated with body mass, and body and leg lean mass, but not with the isometric strength of KE muscles.
Topics: Male; Humans; Body Composition; Bone and Bones; Bone Density; Absorptiometry, Photon; Lower Extremity
PubMed: 37486254
DOI: 10.23736/S0022-4707.23.15067-5 -
Clinical Nutrition (Edinburgh, Scotland) Jan 2024Athletes vary in hydration status due to ongoing training regimes, diet demands, and extreme exertion. With water being one of the largest body composition compartments,...
BACKGROUND
Athletes vary in hydration status due to ongoing training regimes, diet demands, and extreme exertion. With water being one of the largest body composition compartments, its variation can cause misinterpretation of body composition assessments meant to monitor strength and training progress. In this study, we asked what accessible body composition approach could best quantify body composition in athletes with a variety of hydration levels.
METHODS
The Da Kine Study recruited collegiate and intramural athletes to undergo a variety of body composition assessments including air-displacement plethysmography (ADP), deuterium-oxide dilution (DO), dual-energy X-ray absorptiometry (DXA), underwater-weighing (UWW), 3D-optical (3DO) imaging, and bioelectrical impedance (BIA). Each of these methods generated 2- or 3-compartment body composition estimates of fat mass (FM) and fat-free mass (FFM) and was compared to equivalent measures of the criterion 6-compartment model (6CM) that accounts for variance in hydration. Body composition by each method was used to predict abdominal and thigh strength, assessed by isokinetic/isometric dynamometry.
RESULTS
In total, 70 (35 female) athletes with a mean age of 21.8 ± 4.2 years were recruited. Percent hydration (Body Water/FFM) had substantial variation in both males (63-73 %) and females (58-78 %). ADP and DXA FM and FF M had moderate to substantial agreement with the 6C model (Lin's Concordance Coefficient [CCC] = 0.90-0.95) whereas the other measures had lesser agreement (CCC <0.90) with one exception of 3DO FFM in females (CCC = 0.91). All measures of FFM produced excellent precision with %CV < 1.0 %. However, FM measures in general had worse precision (% CV < 2.0 %). Increasing quartiles (significant p < 0.001 trend) of 6CM FFM resulted in increasing strength measures in males and females. Moreover, the stronger the agreement between the alternative methods to the 6CM, the more robust their correlation with strength, irrespective of hydration status.
CONCLUSION
The criterion 6CM showed the best association to strength regardless of the hydration status of the athletes for both males and females. Simpler methods showed high precision for both FM and FFM and those with the strongest agreement to the 6CM had the highest strength associations.
SUMMARY BOX
This study compared various body composition analysis methods in 70 athletes with varying states of hydration to the criterion 6-compartment model and assessed their relationship to muscle strength. The results showed that accurate and precise estimates of body composition can be determined in athletes, and a more accurate body composition measurement produces better strength estimates. The best laboratory-based techniques were air displacement plethysmography and dual-energy x-ray absorptiometry, while the commercial methods had moderate-poor agreement. Prioritizing accurate body composition assessment ensures better strength estimates in athletes.
Topics: Male; Humans; Female; Adolescent; Young Adult; Adult; Body Composition; Body Water; Athletes; Absorptiometry, Photon; Electric Impedance; Muscle Strength; Reproducibility of Results
PubMed: 38104490
DOI: 10.1016/j.clnu.2023.11.040 -
Food & Function Feb 2024Osteoporosis, a condition that is characterized by low bone mineral density (BMD), is a serious health concern worldwide. This study aims to explore the relationship...
Osteoporosis, a condition that is characterized by low bone mineral density (BMD), is a serious health concern worldwide. This study aims to explore the relationship between whole egg consumption and BMD levels in the US population. This study involves 19 208 participants with valid BMD and egg consumption data from the National Health and Nutrition Examination Survey (NHANES) during 2005-2006, 2007-2008, 2009-2010, 2013-2014 and 2017-2018. Linear regression analysis was conducted to evaluate the association between whole egg consumption and BMD levels. Mediation analysis was used to investigate the role of serum alkaline phosphatase (ALP) in the above relationship. After multivariate adjustment, participants consuming whole eggs over 3.53 ounce per day in their diet were found to have elevated BMD levels in the femur (0.013 g cm with 95% CI: 0.004, 0.022) and lumbar spine (0.013 g cm with 95% CI: 0.002, 0.024) ( < 0.05). The additive interaction of egg consumption and body mass index (BMI) on the BMD of both the femur and lumbar spine ( < 0.05) was also analyzed. The association between whole egg consumption and BMD of both the femur and lumbar spine were significantly mediated by ALP with 71.8% and 83.3% mediation proportion, respectively. In general, higher whole egg consumption is positively related to an increase in the BMD scores of both the femur and lumbar spine among the US population.
Topics: Humans; Bone Density; Nutrition Surveys; Absorptiometry, Photon; Cross-Sectional Studies; Femur Neck; Lumbar Vertebrae
PubMed: 38206082
DOI: 10.1039/d3fo04248k -
Journal of Bone and Mineral Research :... May 2024Romosozumab treatment in women with postmenopausal osteoporosis increases bone formation while decreasing bone resorption, resulting in large BMD gains to reduce... (Randomized Controlled Trial)
Randomized Controlled Trial
Romosozumab treatment in women with postmenopausal osteoporosis increases bone formation while decreasing bone resorption, resulting in large BMD gains to reduce fracture risk within 1 yr. DXA-based 3D modeling of the hip was used to assess estimated changes in cortical and trabecular bone parameters and map the distribution of 3D changes in bone parameters over time in patients from 2 randomized controlled clinical trials: FRAME (romosozumab vs placebo followed by denosumab) and ARCH (romosozumab vs alendronate followed by alendronate). For each study, data from a subset of ~200 women per treatment group who had TH DXA scans at baseline and months 12 and 24 and had provided consent for future research were analyzed post hoc. 3D-SHAPER software v2.11 (3D-SHAPER Medical) was used to generate patient-specific 3D models from TH DXA scans. Percentage changes from baseline to months 12 and 24 in areal BMD (aBMD), integral volumetric BMD (vBMD), cortical thickness, cortical vBMD, cortical surface BMD (sBMD), and trabecular vBMD were evaluated. Data from 377 women from FRAME (placebo, 190; romosozumab, 187) and 368 women from ARCH (alendronate, 185; romosozumab, 183) with evaluable 3D assessments at baseline and months 12 and 24 were analyzed. At month 12, treatment with romosozumab vs placebo in FRAME and romosozumab vs alendronate in ARCH resulted in greater increases in aBMD, integral vBMD, cortical thickness, cortical vBMD, cortical sBMD, and trabecular vBMD (P < .05 for all). At month 24, cumulative gains in all parameters were greater in the romosozumab-to-denosumab vs placebo-to-denosumab sequence and romosozumab-to-alendronate vs alendronate-to-alendronate sequence (P < .05 for all). 3D-SHAPER analysis provides a novel technique for estimating changes in cortical and trabecular parameters from standard hip DXA images. These data add to the accumulating evidence that romosozumab improves hip bone density and structure, thereby contributing to the antifracture efficacy of the drug.
Topics: Humans; Alendronate; Female; Denosumab; Absorptiometry, Photon; Bone Density; Aged; Antibodies, Monoclonal; Imaging, Three-Dimensional; Middle Aged; Hip
PubMed: 38477808
DOI: 10.1093/jbmr/zjae028 -
Calcified Tissue International Sep 2023Factors related to mortality after osteoporotic hip fracture (HF) have been investigated intensively, except for proximal femoral bone mineral density (BMD), which is...
Factors related to mortality after osteoporotic hip fracture (HF) have been investigated intensively, except for proximal femoral bone mineral density (BMD), which is also the primary cause of osteoporosis. In this study, we aimed to investigate the association of hip BMD with mortality risk after HF. Four hundred and eleven elderly patients with HF in Beijing, China, were included and prospectively followed up with a median time of 3 years. At baseline, quantitative CT technique (QCT) was used to measure areal BMD (aBMD) of the unaffected hip. Areal BMDs of the total hip (TH), femoral neck (FN), trochanter (TR), and intertrochanter were analyzed with postoperative mortality as the primary outcome. A total of 394 patients (78.59 ± 7.59 years, 75.4% female) were included in our final analysis, with 86 (82.23 ± 7.00 years, 81.4% female) dead. All hip bone densities demonstrated a significant association with mortality risks in the unadjusted model, but only TR aBMD remained significantly correlated after adjusting for all covariates. Compared to the lower TR aBMD group, the higher TR aBMD group yielded significantly lower death risks (HR 0.21 95% CI 0.05-0.9, P = 0.036). Higher survival probabilities were observed for higher TH and TR aBMD in survival analysis (P < 0.001). Hip BMD, especially TR BMD assessed by QCT, is an independent risk factor for postoperative mortality following HF. QCT may present a promising avenue for opportunistic analysis in immobilized patients, providing valuable information for early detection and personalized interventions to enhance patient outcomes.
Topics: Humans; Female; Aged; Male; Bone Density; Prospective Studies; Absorptiometry, Photon; Hip Fractures; Femur Neck; Osteoporotic Fractures
PubMed: 37347299
DOI: 10.1007/s00223-023-01109-9 -
Childhood Obesity (Print) Oct 2023It is essential to quantify the accuracy and precision of bioelectrical impedance (BIA)-estimated percent body fat (%BF) to better interpret community-based research...
It is essential to quantify the accuracy and precision of bioelectrical impedance (BIA)-estimated percent body fat (%BF) to better interpret community-based research findings that utilize opportunistic measures. Study 1 measured the accuracy of a new dual-frequency foot-to-foot BIA device (Tanita DC-430U) compared with dual-energy X-ray absorptiometry (DXA) among healthy elementary school-aged children ( = 50). Study 2 examined the precision of BIA %BF estimates within and between days among children and adults ( = 38). Regarding accuracy, Tanita DC-430U underestimated %BF by 8.0 percentage points compared with DXA (20.6% vs. 28.5%), but correctly ranked children in terms of %BF. Differences in %BF between BIA and DXA were driven by lower BIA-estimated fat mass (7.8 kg vs. 9.9 kg, < 0.05) and higher BIA-estimated fat-free mass (25.3 kg vs. 24.1 kg, < 0.05). The absolute agreement between BIA and DXA for estimated %BF was moderate (concordance correlation coefficients = 0.53). Regarding precision, measures taken at the same time, but on different days (root mean square standard deviation [RMSD] = 0.42-0.74) were more precise than the measures taken at different times within a single day (RMSD = 1.04-1.10). The Tanita DC-430U substantially underestimated %BF compared with DXA, highlighting the need to assess accuracy of new BIA devices when they are introduced to the market. Opportunistic measures of %BF estimates were most precise when taken at consistent times and in the morning, but may be utilized throughout the day with an understanding of within- and between-day variability.
Topics: Adult; Child; Humans; Pediatric Obesity; Body Composition; Adipose Tissue; Absorptiometry, Photon; Electric Impedance; Body Mass Index
PubMed: 36201230
DOI: 10.1089/chi.2022.0084 -
Calcified Tissue International Oct 2023In this study, we aim to evaluate the correlation between T score measured by dual X-ray absorptiometry (DXA), volumetric bone mineral density (vBMD) derived from...
In this study, we aim to evaluate the correlation between T score measured by dual X-ray absorptiometry (DXA), volumetric bone mineral density (vBMD) derived from quantitative computed tomography (QCT) and MRI-based vertebral bone quality (VBQ), explore the diagnostic performance of VBQ in osteoporosis and determine the recognition value of VBQ in osteoporotic fracture in a relatively large cohort of elderly patients scheduled to undergo spinal surgery. A total of 260 patients were enrolled in the study. DXA and QCT were used to evaluate osteoporotic status. We calculated the lumbar VBQ score, analyzed the correlation between T score, vBMD and VBQ, and explored whether VBQ was an influential factor of bone quality and fracture by binary logistic regression as well as the diagnostic performance of VBQ in osteoporosis and fracture by ROC curve. VBQ was negatively correlated with vBMD and T score. (r = - 0.487 vs. r = - 0.220). The VBQ score was a risk factor for osteoporosis under the QCT diagnostic criteria (OR = 2.245, 95% CI 1.456-3.460) and osteoporotic fractures (OR = 1.496, 95% CI 1.097-2.040). It exhibited superior discriminant performance for osteoporosis diagnosed by QCT, with a cutoff value of 3.70 and an AUC of 0.7354. Its cutoff value for osteoporotic fractures was 3.72, and its AUC was 0.6717. In a cohort of elderly patients scheduled to undergo spinal surgery, the VBQ score was more strongly associated with vBMD than the T score and could identify patients with osteoporosis and corresponding vertebral compression fracture (VCF).
Topics: Humans; Aged; Absorptiometry, Photon; Osteoporotic Fractures; Fractures, Compression; Spinal Fractures; Bone Density; Osteoporosis; Lumbar Vertebrae
PubMed: 37493798
DOI: 10.1007/s00223-023-01115-x