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IEEE Transactions on Haptics 2024New interactions are often developed by mimicking the real world. Therefore, many researchers in haptics have focused on creating a realistic experience of contact...
New interactions are often developed by mimicking the real world. Therefore, many researchers in haptics have focused on creating a realistic experience of contact between users and objects. However, dispensing with mimicry may allow us to develop novel haptic interactions. We present Haptic Magnetism, an interaction modality that delivers sensations of distant objects through tactile stimulation and enables interactions through pseudo-magnetic attraction and repulsion. To show the feasibility of Haptic Magnetism, we designed 12 pseudo-magnetic stimuli and assessed them in two studies. In the first study, we show that participants gain a sense of distant objects. In the second study, we evaluate a subset of stimuli to show that participants can interact with the objects based on experiences of pseudo-magnetic attraction and repulsion. Finally, we discuss how Haptic Magnetism supports guiding movements, nudging users, and revealing affordances.
Topics: Humans; Touch Perception; Male; Female; Adult; Young Adult; Touch; Physical Stimulation; User-Computer Interface
PubMed: 37498752
DOI: 10.1109/TOH.2023.3299528 -
Cell Aug 2023Injury induces systemic responses, but their functions remain elusive. Mechanisms that can rapidly synchronize wound responses through long distances are also mostly...
Injury induces systemic responses, but their functions remain elusive. Mechanisms that can rapidly synchronize wound responses through long distances are also mostly unknown. Using planarian flatworms capable of whole-body regeneration, we report that injury induces extracellular signal-regulated kinase (Erk) activity waves to travel at a speed 10-100 times faster than those in other multicellular tissues. This ultrafast propagation requires longitudinal body-wall muscles, elongated cells forming dense parallel tracks running the length of the organism. The morphological properties of muscles allow them to act as superhighways for propagating and disseminating wound signals. Inhibiting Erk propagation prevents tissues distant to the wound from responding and blocks regeneration, which can be rescued by a second injury to distal tissues shortly after the first injury. Our findings provide a mechanism for long-range signal propagation in large, complex tissues to coordinate responses across cell types and highlight the function of feedback between spatially separated tissues during whole-body regeneration.
Topics: Animals; MAP Kinase Signaling System; Muscles; Phosphorylation; Planarians; Protein Processing, Post-Translational; Regeneration
PubMed: 37480850
DOI: 10.1016/j.cell.2023.06.019 -
Current Opinion in Immunology Oct 2023Delivery of vaccines via the mucosal route is regarded as the most effective mode of immunization to counteract infectious diseases that enter via mucosal tissues,... (Review)
Review
Delivery of vaccines via the mucosal route is regarded as the most effective mode of immunization to counteract infectious diseases that enter via mucosal tissues, including oral, nasal, pulmonary, intestinal, and urogenital surfaces. Mucosal vaccines not only induce local immune effector elements, such as secretory Immunoglobulin A (IgA) reaching the luminal site of the mucosa, but also systemic immunity. Moreover, mucosal vaccines may trigger immunity in distant mucosal tissues because of the homing of primed antigen-specific immune cells toward local and distant mucosal tissue via the common mucosal immune system. While most licensed intramuscular vaccines induce only systemic immunity, next-generation mucosal vaccines may outperform parenteral vaccination strategies by also eliciting protective mucosal immune responses that block infection and/or transmission. Especially the nasal route of vaccination, targeting the nasal-associated lymphoid tissue, is attractive for local and distant mucosal immunization. In numerous studies, bacterial outer membrane vesicles (OMVs) have proved attractive as vaccine platform for homologous bacterial strains, but also as antigen delivery platform for heterologous antigens of nonbacterial diseases, including viruses, parasites, and cancer. Their application has also been extended to mucosal delivery. Here, we will summarize the characteristics and clinical potential of (engineered) OMVs as vaccine platform for mucosal, especially intranasal delivery.
Topics: Humans; Vaccines; Administration, Intranasal; Immunization; Vaccination; Immunity, Mucosal; Mucous Membrane
PubMed: 37598549
DOI: 10.1016/j.coi.2023.102376 -
Pharmaceuticals (Basel, Switzerland) Oct 2023Cancer is a disease that can affect any organ and spread to other nearby or distant organs [...].
Cancer is a disease that can affect any organ and spread to other nearby or distant organs [...].
PubMed: 37895908
DOI: 10.3390/ph16101437 -
International Journal of Nursing Studies Mar 2024Patients who are suffering may be commonly encountered in health care. The growing use of telehealth implies that encounters with patients who are suffering may...
BACKGROUND
Patients who are suffering may be commonly encountered in health care. The growing use of telehealth implies that encounters with patients who are suffering may increasingly take place at a distance. "Distant suffering" is a concept coined within sociology to describe the suffering of far-away others. It is conceptualized as a paradox, as distance changes the relation between the witness of suffering and the suffering encountered. Impacts may include a potential detriment to the sufferer and ethical implications for the witness.
OBJECTIVE
To explore the concept of distant suffering and any relevance, implications, or important avenues for potential research within the healthcare sciences.
DESIGN
Rodgers' evolutionary concept analysis.
DATA SOURCES
Databases of Web of Science, Medline, CINAHL and PsycInfo were searched for the terms "distant suffering" or "mediated suffering".
REVIEW METHOD
Attributes, surrogate or related terms, antecedents, consequences, and uses of the concept were extracted and synthesized.
RESULTS
Thirty articles published within the past ten years were selected for review from the search results. "Distant suffering" was characterized as comprising 1) mediated far-away suffering, 2) a "recognizer" or witness, and 3) a potential role of a moderator. Antecedents include shared understandings and socially-influenced responses. Consequences include responses like empathy, compassion, pity, also indifference, cynicism and compassion fatigue.
CONCLUSIONS
Further research to explore distant suffering from healthcare sciences' perspective could uncover valuable insights for those suffering, for healthcare workers, and any who are exposed to it. An improved understanding of how distant suffering is conveyed and moderated could enable targeted reduction of exposure or improve response to distant suffering. Such knowledge could help diminish negative consequences for those suffering, for healthcare workers who are caring at a distance for those suffering, or for others who encounter distant suffering in their occupations or in daily life via media, social media, or digital communications.
TWEETABLE ABSTRACT
New analysis finds that exposure to distant suffering may have important implications for health and health care.
Topics: Humans; Empathy; Health Personnel; Compassion Fatigue; Delivery of Health Care; Telemedicine
PubMed: 38184919
DOI: 10.1016/j.ijnurstu.2023.104672