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Revista Alergia Mexico (Tecamachalco,... Dec 2023Food allergy is very common throughout the world and has become a major public health problem, with 220 million people suffering from it. Food allergy has been...
Food allergy is very common throughout the world and has become a major public health problem, with 220 million people suffering from it. Food allergy has been disproportionately observed in people from industrialized or Western countries and was previously considered to predominate in the pediatric versus adult population. However, the current exponential growth of the adult population and older adults, especially in Western countries, and environmental and lifestyle changes, have profoundly changed the epidemiology of food allergy, with a growing increase even at advanced ages. The foods that represent the greatest severity and clinical impact are peanuts, walnuts, fish, shellfish, eggs, cow's milk protein, wheat, soy and seeds. Although some types of food allergies (cow's milk and egg) may disappear, peanut and tree nut allergies may persist into adulthood. The control or cure of cow's milk protein allergy is gradual throughout childhood and adolescence. Despite the predominance of allergy to fish, shellfish, peanuts, and tree nuts in most reactions in adults, the most common form of IgE-mediated food allergy is oral allergy syndrome or pollen allergy syndrome. food.
Topics: Adolescent; Animals; Cattle; Female; Humans; Child; Aged; Food Hypersensitivity; Food; Milk Hypersensitivity; Drug Hypersensitivity Syndrome; Life Style
PubMed: 38506858
DOI: 10.29262/ram.v70i4.1328 -
Anesthesiology Sep 2023
Topics: Humans; Anaphylaxis; Drug Hypersensitivity; Perioperative Period
PubMed: 37247348
DOI: 10.1097/ALN.0000000000004595 -
Anesthesiology Sep 2023
Topics: Humans; Anaphylaxis; Drug Hypersensitivity; Perioperative Period
PubMed: 37247347
DOI: 10.1097/ALN.0000000000004597 -
Chinese Medical Journal Jul 2023
Topics: Humans; Dapsone; Drug Hypersensitivity; Hypersensitivity; Syndrome
PubMed: 37057725
DOI: 10.1097/CM9.0000000000002492 -
Anesthesiology Sep 2023
Topics: Humans; Anaphylaxis; Drug Hypersensitivity; Perioperative Period
PubMed: 37247351
DOI: 10.1097/ALN.0000000000004594 -
Anesthesiology Sep 2023
Topics: Humans; Anaphylaxis; Drug Hypersensitivity; Perioperative Period
PubMed: 37247349
DOI: 10.1097/ALN.0000000000004596 -
European Heart Journal. Cardiovascular... May 2024
Topics: Humans; Aspirin; Drug Hypersensitivity
PubMed: 38268418
DOI: 10.1093/ehjcvp/pvae008 -
Current Allergy and Asthma Reports Nov 2023As a sulfone antibacterial agent, dapsone has been widely used to treat leprosy. Moreover, dapsone is also used in many immune diseases such as herpetic dermatitis... (Review)
Review
PURPOSE OF REVIEW
As a sulfone antibacterial agent, dapsone has been widely used to treat leprosy. Moreover, dapsone is also used in many immune diseases such as herpetic dermatitis because of its anti-inflammatory and immunomodulatory effects. However, dapsone can cause several adverse effects, the most serious being dapsone hypersensitivity syndrome. Dapsone hypersensitivity syndrome is characterized by a triad of eruptions, fever, and organ involvement, which limits the application of dapsone to some extent.
RECENT FINDINGS
In this article, we review current research about the interaction model between HLA-B*13:01, dapsone, and specific TCR in dapsone-induced drug hypersensitivity. In addition to the proposed mechanisms, we also discussed clinical features, treatment progress, prevalence, and prevention of dapsone hypersensitivity syndrome. These studies reveal the pathogenesis, clinical features, and prevalence from the perspectives of genetic susceptibility and innate and adaptive immunity in dapsone hypersensitivity syndrome, thereby guiding clinicians on how to diagnose, prevent, and treat dapsone hypersensitivity syndrome.
Topics: Humans; Dapsone; Drug Hypersensitivity; Hypersensitivity; Syndrome; Leprosy
PubMed: 37804376
DOI: 10.1007/s11882-023-01109-7 -
Current Opinion in Allergy and Clinical... Aug 2024Patients with mast cell disorders frequently experience symptoms from excessive mediator release like histamine and tryptase, ranging from mild flushing to severe... (Review)
Review
PURPOSE OF REVIEW
Patients with mast cell disorders frequently experience symptoms from excessive mediator release like histamine and tryptase, ranging from mild flushing to severe anaphylactic responses. Hypersensitivity reactions (HRs) to drugs are a major cause of anaphylaxis in these patients, who often worry about triggering mast cell degranulation when taking medications. The aim of this review is to explore the complex interactions between mast cell disorders and drug HRs, focusing on the clinical challenges of managing these conditions effectively to enhance understanding and guide safer clinical practices.
RECENT FINDINGS
Among the drugs most commonly associated with hypersensitivity reactions in patients with mast cell disorders are non-steroidal anti-inflammatory drugs, antibiotics, and perioperative agents. Recent studies have highlighted the role of Mas-related G-protein coupled receptor member X2 (MRGPRX2) - a receptor involved in non-immunoglobulin E mediated mast cell degranulation - in exacerbating HRs. Investigations reveal varied drug tolerance among patients, underscoring the need for individual risk assessments.
SUMMARY
Tailored diagnostic approaches are crucial for confirming drug allergies and assessing tolerance in patients with mastocytosis, preventing unnecessary medication avoidance and ensuring safety before acute situations arise.
Topics: Humans; Mast Cells; Drug Hypersensitivity; Receptors, G-Protein-Coupled; Anaphylaxis; Receptors, Neuropeptide; Cell Degranulation; Mastocytosis; Anti-Inflammatory Agents, Non-Steroidal; Animals; Anti-Bacterial Agents; Nerve Tissue Proteins
PubMed: 38814742
DOI: 10.1097/ACI.0000000000001001 -
The Journal of Allergy and Clinical... Jan 2024Intravenous vancomycin therapy can cause liver injury as well as "drug reaction with eosinophilia and systemic symptoms" (DRESS) syndrome. This study aimed to better...
BACKGROUND
Intravenous vancomycin therapy can cause liver injury as well as "drug reaction with eosinophilia and systemic symptoms" (DRESS) syndrome. This study aimed to better define the clinical features and HLA associations of vancomycin-induced liver injury.
OBJECTIVE
To describe clinical, biochemical, and temporal characteristics of vancomycin-induced liver injury.
METHODS
Cases of liver injury with recent exposure to vancomycin who were enrolled in the US Drug-induced Liver Injury Network between 2004 and 2020 were assessed. Sequencing of HLA alleles was performed on stored blood samples.
RESULTS
Among 1697 cases of drug-induced liver injury identified between 2004 and 2021, 9 (0.5%) were attributed to intravenous vancomycin. The 9 cases included 6 men, median age 60 years (range, 23-85 days), and treatment for 26 days (range, 1-34 days). The clinical presentation was DRESS syndrome in 8 patients, of whom 6 received corticosteroids. Liver injury varied from hepatocellular to cholestatic and from mild (n = 5) to fatal (n = 1). In survivors, liver injury and DRESS syndrome ultimately resolved. HLA typing demonstrated the HLA-A∗32:01 allele in 7 vancomycin cases (78%, all with DRESS syndrome), versus 1 of 81 cases (1.2%) exposed but not attributed to vancomycin, and 113 of 1708 cases (6.6%) without vancomycin exposure. The allele frequency in vancomycin cases was 0.44 compared with less than 0.04 in US populations.
CONCLUSIONS
Vancomycin-induced liver injury is commonly associated with DRESS syndrome and linked to HLA-A∗32:01. HLA-A∗32:01 testing could be considered early to risk-stratify patients using long-term intravenous vancomycin therapy.
Topics: Humans; Male; Middle Aged; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Drug Hypersensitivity Syndrome; Eosinophilia; HLA-A Antigens; Vancomycin; Female
PubMed: 37739311
DOI: 10.1016/j.jaip.2023.09.011