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Drug Delivery and Translational Research Jun 2024Antimicrobial resistance and tolerance (AMR&T) are urgent global health concerns, with alarmingly increasing numbers of antimicrobial drugs failing and a corresponding... (Review)
Review
Antimicrobial resistance and tolerance (AMR&T) are urgent global health concerns, with alarmingly increasing numbers of antimicrobial drugs failing and a corresponding rise in related deaths. Several reasons for this situation can be cited, such as the misuse of traditional antibiotics, the massive use of sanitizing measures, and the overuse of antibiotics in agriculture, fisheries, and cattle. AMR&T management requires a multifaceted approach involving various strategies at different levels, such as increasing the patient's awareness of the situation and measures to reduce new resistances, reduction of current misuse or abuse, and improvement of selectivity of treatments. Also, the identification of new antibiotics, including small molecules and more complex approaches, is a key factor. Among these, novel DNA- or RNA-based approaches, the use of phages, or CRISPR technologies are some potent strategies under development. In this perspective article, emerging and experienced leaders in drug delivery discuss the most important biological barriers for drugs to reach infectious bacteria (bacterial bioavailability). They explore how overcoming these barriers is crucial for producing the desired effects and discuss the ways in which drug delivery systems can facilitate this process.
Topics: Humans; Anti-Bacterial Agents; Drug Delivery Systems; Animals; Drug Resistance, Microbial; Drug Resistance, Bacterial; Bacteria; Drug Tolerance
PubMed: 38341386
DOI: 10.1007/s13346-023-01513-6 -
Journal of Infection and Public Health Dec 2023
Topics: Humans; Anti-Bacterial Agents; Drug Resistance, Bacterial; One Health; World Health Organization
PubMed: 37996218
DOI: 10.1016/j.jiph.2023.11.022 -
Biomedicine & Pharmacotherapy =... Nov 2023Cancer therapy resistance (CTR) is the development of cancer resistance to multiple therapeutic strategies, which severely affects clinical response and leads to cancer... (Review)
Review
Cancer therapy resistance (CTR) is the development of cancer resistance to multiple therapeutic strategies, which severely affects clinical response and leads to cancer progression, recurrence, and metastasis. N6-methyladenosine (m6A) has been identified as the most common, abundant, and conserved internal transcriptional alterations of RNA modifications, regulating RNA splicing, translation, stabilization, degradation, and gene expression, and is involved in the development and progression of a variety of diseases, including cancer. Recent studies have shown that m6A modifications play a critical role in both cancer development and progression, especially in reversing CTR. Although m6A modifications have great potential in CTR, the specific molecular mechanisms are not fully elucidated. In this review, we summarize the potential molecular mechanisms of m6A modification in CTR. In addition, we update recent advances in natural products from Traditional Chinese Medicines (TCM) and small-molecule lead compounds targeting m6A modifications, and discuss the great potential and clinical implications of these inhibitors targeting m6A regulators and combinations with other therapies to improve clinical efficacy and overcome CTR.
Topics: Humans; Drug Resistance, Neoplasm; Neoplasms; Adenosine; Biological Products
PubMed: 37696088
DOI: 10.1016/j.biopha.2023.115477 -
Current Opinion in Microbiology Oct 2023Our ability to fight infectious diseases is being increasingly compromised due to the emergence and spread of pathogens that become resistant to one or several drugs.... (Review)
Review
Our ability to fight infectious diseases is being increasingly compromised due to the emergence and spread of pathogens that become resistant to one or several drugs. This phenomenon is ubiquitous among pathogens and has parallels in cancer treatment. Given the urgency of the problem, there is a need for a paradigm shift in drug therapy toward one in which the objective to prevent the evolution of drug resistance is considered alongside the main objective of eliminating the infection or tumor. Here, I stress the importance of considering an evolutionary perspective to achieve this goal, and review recent advances in this direction, including therapies that exploit the fitness trade-offs of resistance.
Topics: Drug Resistance; Biological Evolution
PubMed: 37348192
DOI: 10.1016/j.mib.2023.102350 -
International Journal of Molecular... Nov 2023Drug resistance remains one of the important clinical challenges, making cancer one of the leading causes of death worldwide [...].
Drug resistance remains one of the important clinical challenges, making cancer one of the leading causes of death worldwide [...].
Topics: Humans; Drug Resistance, Neoplasm; Neoplasms
PubMed: 38068907
DOI: 10.3390/ijms242316584 -
Epidemiology and Infection May 2024
Topics: Anti-Bacterial Agents; Humans; Drug Resistance, Bacterial; Bacterial Infections; Bacteria
PubMed: 38712589
DOI: 10.1017/S0950268824000530 -
The Lancet. Microbe May 2024
Topics: Humans; Anti-Bacterial Agents; Antimicrobial Stewardship; Drug Resistance, Bacterial; Brain Drain
PubMed: 38677303
DOI: 10.1016/S2666-5247(24)00102-2 -
Medicina Clinica Apr 2024
Topics: Humans; Cross Infection; Drug Resistance, Multiple, Bacterial; Anti-Bacterial Agents
PubMed: 38290873
DOI: 10.1016/j.medcli.2023.12.004 -
Molecular Oncology Feb 2024Drug resistance represents a major limitation to the long-term efficacy of anti-cancer treatments. The commonly accepted view is that the selection of inheritable...
Drug resistance represents a major limitation to the long-term efficacy of anti-cancer treatments. The commonly accepted view is that the selection of inheritable genetic mechanisms governs the development of secondary resistance. However, compelling evidence suggests an important role for adaptive cell plasticity and non-genetic mechanisms in the development of therapy resistance. The two phenomena are not mutually exclusive and the interplay between genetic and non-genetic mechanisms may affect tumor evolution during treatment. A broader characterization of the genetic and non-genetic mechanisms of drug resistance may pave the way for more precise and effective therapeutic strategies to overcome resistance.
Topics: Humans; Neoplasms; Drug Resistance; Epigenesis, Genetic; Drug Resistance, Neoplasm
PubMed: 38308461
DOI: 10.1002/1878-0261.13601 -
Journal of Chemotherapy (Florence,... Dec 2023Iron is an essential element for almost all living things. Both iron excess and iron deficiency can damage the body's health, but the body has developed complex... (Review)
Review
Iron is an essential element for almost all living things. Both iron excess and iron deficiency can damage the body's health, but the body has developed complex mechanisms to regulate iron balance. The imbalance of iron homeostasis and lipid peroxidation are important features of ferroptosis. In this review, we summarize the latest regulatory mechanisms of ferroptosis, the roles of relevant regulators that target ferroptosis for cancer therapy, and their relationship to drug resistance. In conclusion, targeting ferroptosis is an important strategy for cancer therapy.
Topics: Humans; Ferroptosis; Neoplasms; Iron; Drug Resistance; Lipid Peroxidation
PubMed: 36764828
DOI: 10.1080/1120009X.2023.2177808