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Nutrients Jul 2023There is a worldwide epidemic of obesity and its associated metabolic dysfunction [...].
There is a worldwide epidemic of obesity and its associated metabolic dysfunction [...].
Topics: Adolescent; Young Adult; Humans; Fructose; Obesity; Carbohydrate Metabolism; Biochemical Phenomena; Metabolic Syndrome
PubMed: 37513580
DOI: 10.3390/nu15143162 -
Nutrients Jul 2023The study aimed to assess the associations of dietary patterns and circadian syndrome (CircS). Data from National Health and Nutrition Examination Survey (NHANES)...
The study aimed to assess the associations of dietary patterns and circadian syndrome (CircS). Data from National Health and Nutrition Examination Survey (NHANES) 2005-2016 were analyzed ( = 10,486). Factor analysis was used to construct dietary patterns based on two 24 h food recalls. CircS was defined based on components of the metabolic syndrome, with the addition of short sleep and depression symptoms. Multivariable logistic regression was used to analyze the associations. Two major dietary patterns were identified. The Western dietary pattern had high loadings of refined grains, solid fats, added sugars, and red and cured meats, while the prudent pattern was characterized by a high intake of vegetables, whole grains, oils, nuts, and seeds. The prevalence of CircS was 41.3%. Comparing extreme quartiles of intake, the odds ratios (OR) for having CircS were 1.96 (95%CI 1.53-2.53) and 0.71 (95%CI 0.58-0.86) for the Western pattern and prudent pattern, respectively. The association between the Western dietary pattern and CircS was stronger among men (OR = 2.05; 95%CI 1.48-2.85) and those with low income (OR = 1.94; 95%CI 1.27-2.96) and high education (OR = 3.38; 95%CI 1.90-6.04). The Western dietary pattern was associated with a higher likelihood of having CircS, while the prudent pattern was inversely associated with CircS.
Topics: Male; Adult; Humans; Nutrition Surveys; Diet; Vegetables; Nuts; Diet, Western; Metabolic Syndrome; Risk Factors
PubMed: 37571333
DOI: 10.3390/nu15153396 -
The Journal of Clinical Endocrinology... Dec 2023Mitochondrial DNA (mtDNA) plays a key role in diabetes mellitus and metabolic syndrome (MetS). An increasing number of studies have reported the association between... (Meta-Analysis)
Meta-Analysis
CONTEXT
Mitochondrial DNA (mtDNA) plays a key role in diabetes mellitus and metabolic syndrome (MetS). An increasing number of studies have reported the association between mtDNA copy number (mtDNA-CN) and the risk of diabetes mellitus and MetS; however, the associations remain conflicted and a systematic review and meta-analysis on the association between mtDNA-CN and diabetes mellitus and MetS is lacking.
OBJECTIVE
We aimed to investigate the association of mtDNA-CN and diabetes mellitus and MetS using a systematic review and meta-analysis of observational studies.
METHODS
PubMed, EMBASE, and Web of Science were searched up to December 15, 2022. Random-effect models were used to summarize the relative risks (RRs) and 95% CIs.
RESULTS
A total of 19 articles were included in the systematic review and 6 articles (12 studies) in the meta-analysis involving 21 714 patients with diabetes (318 870 participants) and 5031 MetS (15 040 participants). Compared to the highest mtDNA-CN, the summary RR (95% CIs) for the lowest mtDNA-CN were 1.06 (95% CI, 1.01-1.12; I2 = 79.4%; n = 8) for diabetes (prospective study: 1.11 (1.02-1.21); I2 = 22.6%; n = 4; case-control: 1.27 (0.66-2.43); I2 = 81.8%; n = 2; cross-sectional: 1.01 (0.99-1.03); I2 = 74.7%; n = 2), and 1.03 (0.99-1.07; I2 = 70.6%; n = 4) for MetS (prospective: 2.87 (1.51-5.48); I2 = 0; n = 2; cross-sectional: 1.02 (1.01-1.04); I2 = 0; n = 2).
CONCLUSION
Decreased mtDNA-CN was associated with increased risk of diabetes mellitus and MetS when limited to prospective studies. More longitudinal studies are warranted.
Topics: Humans; Metabolic Syndrome; Prospective Studies; DNA, Mitochondrial; DNA Copy Number Variations; Cross-Sectional Studies; Diabetes Mellitus; Risk Factors
PubMed: 37431585
DOI: 10.1210/clinem/dgad403 -
Journal of Cachexia, Sarcopenia and... Jun 2024The risk of subsequent cardiovascular disease (CVD) is high in cancer survivors. Although metabolic syndrome is an established risk factor for CVD, its association with...
BACKGROUND
The risk of subsequent cardiovascular disease (CVD) is high in cancer survivors. Although metabolic syndrome is an established risk factor for CVD, its association with cancer survivors has not yet been established. This study aimed to clarify whether metabolic syndrome is associated with subsequent CVD risk in patients with cancer using a nationwide epidemiological dataset.
METHODS
We retrospectively analysed 53 510 patients with a history of breast, colorectal, or stomach cancer, which is reportedly a major site for developing cancer in Japan. Study participants were categorized into two groups based on the presence of metabolic syndrome, defined using the Japanese criteria (high waist circumference and ≥2 metabolic parameters including elevated blood pressure, elevated triglycerides, reduced high-density lipoprotein cholesterol, or elevated fasting plasma glucose). The clinical outcomes were collected between 2005 and 2021. The primary endpoint was defined as the composite CVD outcome, including myocardial infarction, angina pectoris, stroke, and heart failure.
RESULTS
The median patient age was 54 years, and 37.5% of the patients were men. Metabolic syndrome was observed in 5558 (10.4%) patients. Over a mean follow-up period of 973 ± 791 days, 3085 composite CVD outcomes were recorded. Multivariable Cox regression analyses showed that metabolic syndrome was associated with a greater risk of developing CVD events (HR = 1.29, 95% CI = 1.15-1.45). Metabolic syndrome was also associated with an increased risk of CVD in patients with a follow-up period ≥1 year (HR = 1.33, 95% CI = 1.15-1.53). This relationship was also observed when metabolic syndrome was defined according to the International Diabetes Federation criteria (HR = 1.34, 95% CI = 1.21-1.49) and the National Cholesterol Education Program Adult Treatment Panel III criteria (HR = 1.32, 95% CI = 1.19-1.46). Subgroup analyses showed that the relationship between metabolic syndrome and incident CVD was more pronounced in the non-obese participants than in the obese participants.
CONCLUSIONS
Metabolic syndrome is associated with a greater risk of developing CVD, even among cancer survivors.
Topics: Humans; Metabolic Syndrome; Male; Female; Middle Aged; Cardiovascular Diseases; Cancer Survivors; Risk Factors; Neoplasms; Retrospective Studies; Aged; Adult; Japan
PubMed: 38515400
DOI: 10.1002/jcsm.13443 -
Inflammation Aug 2023The pathogeneses of psoriasis and metabolic syndrome are closely related; however, the underlying biological mechanisms are yet to be clarified. A psoriasis training set...
The pathogeneses of psoriasis and metabolic syndrome are closely related; however, the underlying biological mechanisms are yet to be clarified. A psoriasis training set was downloaded from the Gene Expression Omnibus database and analyzed to identify the differentially expressed genes (|logFC|> 1 and adjust P < 0.05). Differentially expressed genes for metabolic syndrome were obtained from the GeneCards, Online Mendelian Inheritance in Man, and DisGeNET databases, and crosstalk genes were obtained for multiple enrichment analysis after identifying the disease intersection. Characteristic crosstalk genes were screened using the least absolute shrinkage and selection operator regression model and random forest tree model, and the genes with area under the receiver operating characteristic curve > 0.7 were selected for validation by the two validation sets. Differential analyses of immune cell infiltration were performed on psoriasis lesion and control samples using the CIBERSORT and ImmuCellAI methods, and correlation analyses were performed between the screened signature crosstalk genes and immune cell infiltration. Significant crosstalk genes were analyzed based on the psoriasis area and severity index and on the responses to biological agents. We found five signature genes (NLRX1, KYNU, ABCC1, BTC, and SERPINB4) were screened based on two machine learning algorithms, and NLRX1 was validated. The infiltration of multiple immune cells in psoriatic lesions and non-lesions was associated with NLRX1 expression. NLRX1 was found to be associated with psoriasis severity and response rate after the use of biologics. NLRX1 could be a significant crosstalk gene for psoriasis and metabolic syndrome.
Topics: Humans; Metabolic Syndrome; Computational Biology; Databases, Genetic; Mitochondrial Proteins
PubMed: 37222907
DOI: 10.1007/s10753-023-01815-4 -
Journal of Cerebral Blood Flow and... Nov 2023The role of metabolic syndrome (MetS) on stroke has been explored only in many observational studies. We conducted Mendelian randomization (MR) to clarify whether or not...
The role of metabolic syndrome (MetS) on stroke has been explored only in many observational studies. We conducted Mendelian randomization (MR) to clarify whether or not the genetically predicted MetS and its components are causally associated with stroke and its subtypes. Genetic instruments of MetS and its components and outcome data sets for stroke and its subtypes came from the gene-wide association study in the UK Biobank and MEGASTROKE consortium, respectively. Inverse variance weighting was utilized as the main method. Genetically predicted MetS, waist circumference (WC), and hypertension increase the risk of stroke. WC and hypertension are related to increased risk of ischemic stroke. MetS, WC, hypertension, and triglycerides (TG) are causally associated with the increasing of large artery stroke. Hypertension increased the risk of cardioembolic stroke. Hypertension and TG lead to 77.43- and 1.19-fold increases, respectively, in small vessel stroke (SVS) risk. The protective role of high-density lipoprotein cholesterol on SVS is identified. Results of the reverse MR analyses show that stroke is related to hypertension risk. From the genetical variants perspective, our study provides novel evidence that early management of MetS and its components are effective strategies to decrease the risk of stroke and its subtypes.
Topics: Humans; Metabolic Syndrome; Mendelian Randomization Analysis; Polymorphism, Single Nucleotide; Stroke; Triglycerides; Genome-Wide Association Study; Hypertension
PubMed: 37198928
DOI: 10.1177/0271678X231169838 -
BMC Geriatrics Jul 2023It was reported that metabolic syndrome increases the risk for cognitive impairment and circadian rhythm may influence cognition behavior. Identifying the potential risk...
BACKGROUND
It was reported that metabolic syndrome increases the risk for cognitive impairment and circadian rhythm may influence cognition behavior. Identifying the potential risk factors is essential to screen individuals with neuronal dysfunction, neuronal loss, and cognitive decline and prevent cognitive impairment and dementia development.
METHODS
We clarified participants by the presence of metabolic syndrome (MetS) and circadian syndrome (CircS) and employed three multivariable Generalized Estimating Equation (GEE) models to control the potential confounding factors and estimate the β values for cognitive function using as referents those had neither MetS nor CircS at baseline. The cognitive function consists of episodic memory and executive function was estimated via the modified Telephone Interview for Cognitive Status (TICS) every two years until 2015.
RESULTS
The mean age of the participants was 58.80 (8.93) years and 49.92% (male). The prevalence of MetS and CircS was 42.98% and 36.43%, respectively. 1,075 (11.00%) and 435 (4.45%) participants had either MetS or CircS alone and 3,124 (31.98%) had both CircS and MetS. Participants with both MetS and CircS compared with normal had a significantly decreased cognitive function score during the 4-years cohort (β = -0.32, 95% CI: -0.63, -0.01) with the complete model, as well as among participants who suffered from CircS alone (β = -0.82, 95% CI: -1.47, -0.16), while not among participants with MetS alone (β = 0.13, 95% CI: -0.27, 0.53). Specifically, compared with the normal population a significantly lower score was discovered in the episodic memory (β = -0.51, 95% CI: -0.95, -0.07), while slightly lower in executive function (β = -0.33, 95% CI: -0.68, -0.01) among individuals with CircS alone.
CONCLUSIONS
Individuals with CircS alone or both MetS and CircS have a high risk of cognitive impairment. The association was even stronger in participants with CircS alone than those with both MetS and CircS, suggesting CircS probably have a stronger association with cognitive functioning than MetS and could be a better predictor for cognitive impairment.
Topics: Humans; Male; Metabolic Syndrome; Cognitive Dysfunction; Risk Factors; Cognition; Executive Function
PubMed: 37403015
DOI: 10.1186/s12877-023-03996-x -
Annals of Medicine Dec 2023The study aims to determine whether body mass index (BMI), metabolic syndrome (MS) or its individual components (primary hypertension, type 2 diabetes mellitus and...
Association between body mass index, metabolic syndrome and common urologic conditions: a cross-sectional study using a large multi-institutional database from the United States.
INTRODUCTION
The study aims to determine whether body mass index (BMI), metabolic syndrome (MS) or its individual components (primary hypertension, type 2 diabetes mellitus and dyslipidemias) are risk factors for common urological diseases.
MATERIALS AND METHODS
Cross-sectional study with data collected on February 28, 2022 from the TriNetX Research Network. Patients were divided in cohorts according to their BMI, presence of MS (BMI > 30 kg/m, type 2 diabetes mellitus, primary hypertension and disorders of lipoprotein metabolism) and its individual components and its association with common urological conditions was determined. For each analysis, odds ratio (OR) with 95% confidence intervals were calculated. Statistical significance was assessed at < .05.
RESULTS
BMI > 30 kg/m was associated with increased risk of lithiasis, kidney cancer, overactive bladder, male hypogonadism, benign prostatic hyperplasia, and erectile dysfunction ( < .05). On the contrary, BMI was inversely associated with ureteral, bladder and prostate cancer ( < .05). In all urological diseases, MS was the strongest risk factor, with prostate cancer (OR = 2.53) showing the weakest and male hypogonadism the strongest (OR = 13.00) associations.
CONCLUSIONS
MS and its individual components were significant risk factors for common urological conditions. Hence holistic approaches with lifestyle modification might prevent common urological disease.Key messagesOverall, metabolic syndrome is the strongest risk factor for all the analysed urological diseases.Abnormally high body mass index can be a risk or protective factor depending on the threshold and urological disease that are being evaluated.Metabolic syndrome and increased BMI should be considered important factors associated to the prevalence of common urological diseases.
Topics: Humans; Male; United States; Metabolic Syndrome; Body Mass Index; Diabetes Mellitus, Type 2; Cross-Sectional Studies; Risk Factors; Prostatic Neoplasms; Urologic Diseases; Essential Hypertension; Hypogonadism
PubMed: 37036830
DOI: 10.1080/07853890.2023.2197293 -
Metabolic Syndrome and Related Disorders Dec 2023Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors that includes central obesity, hyperglycemia, hypertension, and dyslipidemias and whose... (Review)
Review
Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors that includes central obesity, hyperglycemia, hypertension, and dyslipidemias and whose inter-related occurrence may increase the odds of developing type 2 diabetes and cardiovascular diseases. MetS has become one of the most studied conditions, nevertheless, due to its complex etiology, this has not been fully elucidated. Recent evidence describes that both genetic and environmental factors play an important role on its development. With the advent of genomic-wide association studies, single nucleotide polymorphisms (SNPs) have gained special importance. In this review, we present an update of the genetics surrounding MetS as a single entity as well as its corresponding risk factors, considering SNPs and gene-diet interactions related to cardiometabolic markers. In this study, we focus on the conceptual aspects, diagnostic criteria, as well as the role of genetics, particularly on SNPs and polygenic risk scores (PRS) for interindividual analysis. In addition, this review highlights future perspectives of personalized nutrition with regard to the approach of MetS and how individualized multiomics approaches could improve the current outlook.
Topics: Humans; Metabolic Syndrome; Diabetes Mellitus, Type 2; Obesity; Diet; Risk Factors; Polymorphism, Single Nucleotide
PubMed: 37816229
DOI: 10.1089/met.2023.0125 -
Critical Care Medicine Mar 2024
Topics: Humans; Metabolic Syndrome; Respiratory Distress Syndrome
PubMed: 38381011
DOI: 10.1097/CCM.0000000000006168