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Journal of Clinical Medicine Aug 2023The association and interaction between the central nervous system (CNS) and enteric nervous system (ENS) is well established. Essentially ENS is the second brain, as we... (Review)
Review
The association and interaction between the central nervous system (CNS) and enteric nervous system (ENS) is well established. Essentially ENS is the second brain, as we call it. We tried to understand the structure and function, to throw light on the functional aspect of neurons, and address various disease manifestations. We summarized how various neurological disorders influence the gut via the enteric nervous system and/or bring anatomical or physiological changes in the enteric nervous system or the gut and vice versa. It is known that stress has an effect on Gastrointestinal (GI) motility and causes mucosal erosions. In our literature review, we found that stress can also affect sensory perception in the central nervous system. Interestingly, we found that mutations in the neurohormone, serotonin (5-HT), would result in dysfunctional organ development and further affect mood and behavior. We focused on the developmental aspects of neurons and cognition and their relation to nutritional absorption via the gastrointestinal tract, the development of neurodegenerative disorders in relation to the alteration in gut microbiota, and contrariwise associations between CNS disorders and ENS. This paper further summarizes the synergetic relation between gastrointestinal and neuropsychological manifestations and emphasizes the need to include behavioral therapies in management plans.
PubMed: 37629273
DOI: 10.3390/jcm12165231 -
Nanotechnology Nov 2023Electromagnetic fields can penetrate aqueous media in a homogeneous and instantaneous way, without physical contact, independently of its temperature, pressure,...
Electromagnetic fields can penetrate aqueous media in a homogeneous and instantaneous way, without physical contact, independently of its temperature, pressure, agitation degree and without modifying their chemical compositions nor heat and mass transfer conditions. In addition, superparamagnetic biomaterials can interact with electromagnetic fields by absorbing electromagnetic energy and transforming it in localized heat with further diffusion to surrounding media. This paper is devoted to the exploration of the potential use of hyperthermic effects resulting from the interaction between externally applied electromagnetic fields and superparamagnetic nanoparticles as a trigger for controlled drug release in soft tissue simulating materials. Gelatin based soft tissue simulating materials were prepared and doped with superparamagnetic nanoparticles. The materials were irradiated with externally applied electromagnetic fields. The effects on temperature and diffusion of a drug model in water and phosphate buffer were investigated. Significant hyperthermic effects were observed. The temperature of the soft tissue simulating material resulted increased from 35 °C to 45 °C at 2.5 °C min. Moreover, the release of an entrapped model drug reached 89%. The intensity of the hyperthermic effects was found to have a strong dependency on the concentration of superparamagnetic nanoparticles and the power and the pulse frequency of the electromagnetic field.
Topics: Drug Delivery Systems; Electromagnetic Fields; Hot Temperature; Temperature; Nanoparticles
PubMed: 37852228
DOI: 10.1088/1361-6528/ad0480 -
European Radiology Jun 2024To evaluate the efficacy and safety of microwave ablation (MWA) for the treatment of symptomatic benign thyroid nodules in children.
OBJECTIVE
To evaluate the efficacy and safety of microwave ablation (MWA) for the treatment of symptomatic benign thyroid nodules in children.
METHODS
A retrospective study of MWA for the treatment of 34 symptomatic benign thyroid nodules in 25 children was conducted. Volume reduction ratio (VRR), technique efficacy, symptom score, cosmetic score, and thyroid function were used to evaluate the efficacy of the technique. The associated complications and side effects were recorded.
RESULTS
The participants were followed for at least 6 months (median 12 months, range 6-48 months). After MWA treatment, the volumes of the targeted nodules decreased gradually (median volume 5.86 mL before MWA and 0.34 mL at the final follow-up assessment), the VRR achieved was up to 85.03% at the final follow-up assessment, and the technical efficacy at this time was 91.2%. The subjective and objective nodule-related symptoms were also ameliorated. The circulating hormone concentrations reflecting thyroid function remained within their normal ranges in all the participants after one month of follow-up. The procedure had no major complications.
CONCLUSIONS
MWA seems to be an effective and safe technique for the treatment of symptomatic benign thyroid nodules in pediatric patients.
CLINICAL RELEVANCE STATEMENT
Microwave ablation is a safe and effective method to treat symptomatic benign thyroid nodules in pediatric patients. This treatment may be selected if the patient or parents are not suitable or refuse to undergo surgery.
KEY POINTS
• Microwave ablation is effective in reducing the volume of benign thyroid nodules and ameliorating nodule-related symptoms in pediatric patients. • Microwave ablation is a safe method in children, with low complications. • Microwave ablation does not affect the circulating thyroid hormone concentrations of children.
Topics: Humans; Thyroid Nodule; Microwaves; Female; Male; Child; Retrospective Studies; Treatment Outcome; Adolescent; Ablation Techniques; Child, Preschool
PubMed: 37938388
DOI: 10.1007/s00330-023-10282-2 -
International Urology and Nephrology Sep 2023Thermal ablation, including microwave ablation (MWA) and radiofrequency ablation (RFA), has been recommended for the treatment of primary hyperparathyroidism (PHPT) and... (Meta-Analysis)
Meta-Analysis Review
OBJECTIVE
Thermal ablation, including microwave ablation (MWA) and radiofrequency ablation (RFA), has been recommended for the treatment of primary hyperparathyroidism (PHPT) and refractory secondary hyperparathyroidism (SHPT). This meta-analysis was conducted to evaluate the efficacy and safety of MWA and RFA in patients with PHPT and refractory SHPT.
METHODS
Databases including PubMed, EMbase, the Cochrane Library, CNKI (China National Knowledge Infrastructure), and Wanfang were searched from inception to December 5, 2022. Eligible studies comparing MWA and RFA for PHPT and refractory SHPT were included. Data were analyzed using Review Manager software, version 5.3.
RESULTS
Five studies were included in the meta-analysis. Two were retrospective cohort studies, and three were RCTs. Overall, 294 patients were included in the MWA group, and 194 patients were included in the RFA group. Compared with RFA for refractory SHPT, MWA had a shorter operation time for a single lesion (P < 0.01) and a higher complete ablation rate for a single lesion ≥ 15 mm (P < 0.01) but did not show a difference in the complete ablation rate for a single lesion < 15 mm (P > 0.05). There were no significant differences between MWA and RFA for refractory SHPT concerning parathyroid hormone (P > 0.05), calcium (P > 0.05), and phosphorus levels (P > 0.05) within 12 months after ablation, except that calcium (P < 0.01) and phosphorus levels (P = 0.02) in the RFA group were lower than those in the MWA group at one month after ablation. There was no significant difference between MWA and RFA concerning the cure rate of PHPT (P > 0.05). There were no significant differences between MWA and RFA for PHPT and refractory SHPT concerning the complications of hoarseness (P > 0.05) and hypocalcaemia (P > 0.05).
CONCLUSION
MWA had a shorter operation time for single lesions and a higher complete ablation rate for large lesions in patients with refractory SHPT. However, there was no significant difference in efficacy and safety between MWA and RFA in cases of both PHPT and refractory SHPT. Both MWA and RFA are effective treatment methods for PHPT and refractory SHPT.
Topics: Humans; Calcium; Ablation Techniques; Retrospective Studies; Microwaves; Radiofrequency Ablation; Hyperparathyroidism, Secondary; Treatment Outcome; Phosphorus; Catheter Ablation
PubMed: 36892812
DOI: 10.1007/s11255-023-03543-y -
ACS Nano Dec 2023Of patients bearing unresectable tumors at advanced stages, most undergo serious pain. For unresectable tumors adjacent to vital organs or nerves, eliminating local...
Of patients bearing unresectable tumors at advanced stages, most undergo serious pain. For unresectable tumors adjacent to vital organs or nerves, eliminating local cancer pain without adverse effects remains a formidable challenge. Interventional ablative therapies (IATs), such as radio frequency ablation (RFA), microwave ablation, and irreversible electroporation, have been clinically adopted to treat various carcinomas. In this study, we established another palliative interventional therapy to eliminate local cancer pain, instead of relieving nociception temporarily. Here, we developed another interventional ablative therapy (termed nanoparticle-mediated microknife ablation) to locoregionally eliminate cancer pain and tumors. The IAT system was composed of self-assembled nanodrugs, infusion catheters, puncture needles, injection pump, and an empirical tumor ablation formula. Notably, the ablation formula established in the IAT system enables us to predict the essential nanoparticle (NP) numbers used for completely destroying tumors. In a mouse model of cancer pain, tumor-targeted nanodrugs made of Paclitaxel and Hematoporphyrin, which have an extremely high drug-loading efficiency (more than 60%), were infused into tumors through injection pumps under imaging guidance. In conclusion, when compared to classic chemotherapeutic agents, IAT showed significantly higher effectiveness in cancer pain removal. It also presented no damage to the nervous, sensory, and motor capabilities of the treated mice. All of these merits resulted from NPs' long-lasting retention, targeted ablation, and confined diffusion in tumor stroma. Therefore, this safe treatment modality has great potential to eradicate local cancer pain in the clinic.
Topics: Humans; Animals; Mice; Cancer Pain; Pancreatic Neoplasms
PubMed: 38084419
DOI: 10.1021/acsnano.3c06511 -
Small (Weinheim An Der Bergstrasse,... Feb 2024Antibiotics are frequently used to clinically treat osteomyelitis caused by bacterial infections. However, extended antibiotic use may result in drug resistance, which...
Antibiotics are frequently used to clinically treat osteomyelitis caused by bacterial infections. However, extended antibiotic use may result in drug resistance, which can be life threatening. Here, a heterojunction comprising Fe O /Fe S magnetic composite is constructed to achieve short-term and efficient treat osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA). The Fe O /Fe S composite exhibits powerful microwave (MW) absorption properties, thereby effectively converting incident electromagnetic energy into thermal energy. Density functional theory calculations demonstrate that Fe O /Fe S possesses significant charge accumulation and oxygen-fixing capacity at the heterogeneous interface, which provides more active sites and oxygen sources for trapping electromagnetic hotspots. The finite element analysis indicates that Fe O /Fe S displays a larger electromagnetism field enhancement parameter than Fe O owing to a significant increase in electromagnetic hotspots. These hotspots contribute to charge differential accumulation and depletion motions at the interface, thereby augmenting the release of free electrons that subsequently combine with the oxygen adsorbed by Fe O /Fe S to generate reactive oxygen species (ROS) and heat. This research, which achieves extraordinary bacterial eradication through the synergistic effect of microwave thermal therapy (MWTT) and microwave dynamic therapy (MDT), presents a novel strategy for treating deep-tissue bacterial infections.
PubMed: 38312094
DOI: 10.1002/smll.202312280 -
Problemy Endokrinologii Feb 2024Insulinoma is the most common hormonally active neuroendocrine tumor (NET) of the pancreas. In recent years, there has been a trend towards an increase in the incidence... (Review)
Review
RELEVANCE
Insulinoma is the most common hormonally active neuroendocrine tumor (NET) of the pancreas. In recent years, there has been a trend towards an increase in the incidence of NET especially insulinoma.
AIM
Summarizing and analyzing current data on various approaches to the treatment of insulinoma. Our review includes a comprehensive assessment of the advantages and disadvantages of currently available insulinoma treatment methods in comparison with past experience, as well as a review of promising methods that are not currently widely used.
MATERIALS AND METHODS
Analysis of literature from such databases as scientific electronic library elibrary.ru, Pubmed, Google Scholar, MedLine, Scopus and Web of Science.
RESULTS
The most common treatment for insulinoma is surgery. For patients with high operative risk, alternative methods such as alcohol ablation, radiofrequency ablation, and tumor embolization may be used. Medications include the use of somatostatin analogues, diazoxide. The literature describes the potential benefit of the use of beta-blockers, phenytoin, glucagon, however, in clinical trials, these drugs have not demonstrated a significant effect. For the treatment of malignant and metastatically advanced insulinoma, targeted therapy (primarily Everolimus), chemotherapy, as well as embolization (including chemoembolization, radioembolization), radiofrequency ablation (RFA), microwave ablation and cryoablation, ultrasound ablation (HIFU), laser ablation, brachytherapy, irreversible electroporation are used.
CONCLUSION
The study of new drugs is an important task for scientists, among medications the most promising are new generations of somatostatin analogues, targeted drugs and chemotherapy drugs. The rare frequency of insulinoma makes it difficult to conduct randomized controlled trials and prospective studies. That is why physicians and scientists need to maintain close contacts with each other and take into account the experience of treating each patient with such disease, which will help develop effective treatment algorithms in the future.
Topics: Humans; Insulinoma; Prospective Studies; Neuroendocrine Tumors; Apudoma; Pancreatic Neoplasms; Somatostatin
PubMed: 38433541
DOI: 10.14341/probl13281 -
Dalton Transactions (Cambridge, England... Feb 2024Electromagnetic pollution and cancer are phenomena that essentially endanger the future of humanity. Herein, multiple approaches are being proposed to solve the...
Electromagnetic pollution and cancer are phenomena that essentially endanger the future of humanity. Herein, multiple approaches are being proposed to solve the aforementioned issues. Recent studies have demonstrated that by regulating the morphology, defect, and phase of materials, their microwave absorbing, optical, and hyperthermia properties are tunable. Calcium ferrite with proper dielectric, magnetic, and biocompatible characteristics was chosen as a substantial candidate to promote its microwave-absorbing properties by regulating its structure. Spinel CaFeO was synthesized through sol-gel and solvothermal routes and its phase, defect, and morphology were manipulated using innovative procedures. Glucose was applied as conventional defecting and templating agent; interestingly, a dendrimer was designed to bear and form nanoparticles. More importantly, a novel reductive process was designed to fabricate one-put Ca/FeO using a solvothermal method. Particularly, polypropylene (PP) was employed as a practical polymeric matrix to fabricate the eventual product. Structures were molded at a low filling ratio to evaluate their optical and microwave-absorbing performance. As expected, defects, morphology, and phase play a pivotal role in tuning the optical and microwave-absorbing properties of calcium ferrite derivates. Interestingly, the dendrimer-assisted (D-A) formation of CaFeO demonstrated a fascinating reflection loss (RL) of 70.11 dB and an efficient bandwidth (RL ≤ -20 dB) of 7.03 GHz with ultralow thickness (0.65 mm) and filling ratio (10 wt%), attaining proper shielding efficiency (SE) and hyperthermia desirable for its practical application as a material for shielding buildings and cancer therapy. The presented perspective develops new inspirations for architecting microwave absorbing/shielding materials with advanced applications in therapeutic issues.
PubMed: 38332744
DOI: 10.1039/d3dt04228f -
PloS One 2023Frankincense oil has gained increased popularity in skin care, yet its anti-aging effect remains unclear. The current study aimed to investigate the anti-photoaging...
Protective potential of frankincense essential oil and its loaded solid lipid nanoparticles against UVB-induced photodamage in rats via MAPK and PI3K/AKT signaling pathways; A promising anti-aging therapy.
Frankincense oil has gained increased popularity in skin care, yet its anti-aging effect remains unclear. The current study aimed to investigate the anti-photoaging effect of frankincense (Boswellia papyrifera (Del.) Hochst., Family Burseraceae) essential oil in an in vivo model. The oil was initially extracted by two methods: hydro-distillation (HD) and microwave-assisted hydro-distillation (MAHD). GC/MS analysis revealed the dominance of n-octyl acetate, along with other marker compounds of B. papyrifera including octanol and diterpene components (verticilla 4(20) 7, 11-triene and incensole acetate). Thereafter, preliminary investigation of the anti-collagenase and anti-elastase activities of the extracted oils revealed the superior anti-aging effect of HD-extracted oil (FO), comparable to epigallocatechin gallate. FO was subsequently formulated into solid lipid nanoparticles (FO-SLNs) via high shear homogenization to improve its solubility and skin penetration characteristics prior to in vivo testing. The optimimal formulation prepared with 0.5% FO, and 4% Tween® 80, demonstrated nanosized spherical particles with high entrapment efficiency percentage and sustained release for 8 hours. The anti-photoaging effect of FO and FO-SLNs was then evaluated in UVB-irradiated hairless rats, compared to Vitamin A palmitate as a positive standard. FO and FO-SLNs restored the antioxidant capacity (SOD and CAT) and prohibited inflammatory markers (IL6, NFκB p65) in UVB-irradiated rats via downregulation of MAPK (pERK, pJNK, and pp38) and PI3K/AKT signaling pathways, alongside upregulating TGF-β expression. Subsequently, our treatments induced Procollagen I synthesis and downregulation of MMPs (MMP1, MMP9), where FO-SLNs exhibited superior anti-photoaging effect, compared to FO and Vitamin A, highlighting the use of SLNs as a promising nanocarrier for FO. In particular, FO-SLNs revealed normal epidermal and dermal histological structures, protected against UVβ-induced epidermal thickness and dermal collagen degradation. Our results indicated the potential use of FO-SLNs as a promising topical anti-aging therapy.
Topics: Rats; Animals; Oils, Volatile; Frankincense; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Boswellia; Signal Transduction; Nanoparticles; Skin Aging; Aging; Ultraviolet Rays
PubMed: 38127865
DOI: 10.1371/journal.pone.0294067