-
Joint Bone Spine May 2024
Topics: Humans; Osteitis Deformans
PubMed: 38246574
DOI: 10.1016/j.jbspin.2024.105691 -
JSES Reviews, Reports, and Techniques Feb 2024
PubMed: 38323213
DOI: 10.1016/j.xrrt.2023.10.002 -
Skeletal Radiology Jan 2024Paget disease of bone is a metabolic disorder with a strong genetic component, characterised by pronounced disorganised bone remodelling. Complications of this disease...
Paget disease of bone is a metabolic disorder with a strong genetic component, characterised by pronounced disorganised bone remodelling. Complications of this disease include an increased risk of developing bone neoplasms. Here, we describe the case of a 60-year-old Italian patient with Paget disease of bone, presenting with an osteoclast-rich tumour. Our analysis of this entity, based on the clinical, morphological and genetic data (whole exome sequencing), suggests that osteoclast-rich lesions in Paget disease of bone are genetically distinct from classical giant cell tumour of bone. We discuss the importance of differentiating these osteoclast-rich lesions.
Topics: Humans; Middle Aged; Osteoclasts; Osteitis Deformans; Giant Cell Tumors; Bone Neoplasms; Bone and Bones; Giant Cells
PubMed: 37310481
DOI: 10.1007/s00256-023-04369-6