-
Pediatrics International : Official... 2024
Topics: Humans; Animals; Paragonimiasis; B-Lymphocyte Subsets; Immunoglobulin G; Enzyme-Linked Immunosorbent Assay; Paragonimus
PubMed: 38409883
DOI: 10.1111/ped.15727 -
Clinical Nuclear Medicine Aug 2023A 32-year-old man underwent 18 F-FDG PET/CT to evaluate suspicious hepatic metastases, which were revealed by ultrasonography and MRI. The FDG PET/CT images demonstrated...
A 32-year-old man underwent 18 F-FDG PET/CT to evaluate suspicious hepatic metastases, which were revealed by ultrasonography and MRI. The FDG PET/CT images demonstrated only one focus of subtly increased activity in the liver without abnormality elsewhere. The pathological result from hepatic biopsy was consistent with Paragonimus westermani infection.
Topics: Humans; Male; Adult; Paragonimiasis; Liver; Positron Emission Tomography Computed Tomography; Magnetic Resonance Imaging; Ultrasonography
PubMed: 37290448
DOI: 10.1097/RLU.0000000000004736 -
Zhongguo Xue Xi Chong Bing Fang Zhi Za... Mar 2024To investigate the population distribution of intermediate host snails and crabs of along the Jiulongjiang River, Zhangjiang River, and Dongxi River basins in...
[Investigation of the population diversity of intermediate host snails and crabs of along Jiulong River, Zhangjiang River and Dongxi River basins in southern Fujian Province].
OBJECTIVE
To investigate the population distribution of intermediate host snails and crabs of along the Jiulongjiang River, Zhangjiang River, and Dongxi River basins in Bopingling Mountain, southern Fujian Province, so as to provide baseline data for researches on parasitic disease prevention and control and enlargement of samples in the parasitic resource bank.
METHODS
A total of 23 villages in 8 counties (districts) along the Jiulong River, Zhangjiang River, and Dongxi River basins in Zhangzhou City, Fujian Province were selected as survey sites during the period from November 2020 through March 2023, and snail and freshwater crabs were sampled from 1 to 3 streams and ditches neighboring residential areas in each village. Morphological identification of snails was performed according to the external morphological characteristics of collected snail shells, and the unidentified snail species sampled from the natural foci of paragonimiasis in Yunxiao County were subjected to se-quence analysis of the mitochondrial cytochrome oxidase 1 () gene. The crab species was identified by observing the morphological characteristics of the terminal segment of the first pleopod of male crabs, and cercariae and metacercariae were detected in collected snails.
RESULTS
The shells of the unidentified snails sampled from the natural foci of paragonimiasis in Yunxiao County were approximately 50 mm in height and 18 mm in width, thick and solid, long tower cone-shaped, and had 8 to 10 whorls. gene sequence analysis identified the snail species as . A total of 6 freshwater snail species belonging to 5 genera within 3 families, identified 23 survey sites, including , and that belonged to the Family Pleurceridae, and that belonged to the subfamily Triculinae, Family Pomatiopsidae, and (Family Thiaridae), and 11 species of freshwater crabs belonging to 5 genera within 2 families were identified, including genus of , , and , genus of and , genus of and , and genus of and that belonged to the Family Potamidae, and genus of and (Family Parathelphusidae). In addition, the prevalence of cercariae infections was 0.08% (2/2 317) in from Danyan Village in Changtai District and 0.09% (1/1 039) in from Jinkeng Village in Yunxiao County, and the prevalence of metacercariae infections was 25.81% (8/31) in from Danyan Village in Changtai District, and 26.31% (5/19) in from Jinkeng Village in Yunxiao County, respectively.
CONCLUSIONS
There is a population diversity in the intermediate host snails and crabs along the Jiulongjiang River, Zhangjiang River, and Dongxi River basins in Bopingling Mountain, southern Fujian Province, and and are, for the first time, confirmed as the first intermediate hosts of .
Topics: Humans; Animals; Male; Paragonimus; Brachyura; Paragonimiasis; Rivers; Fresh Water; Gastropoda
PubMed: 38604684
DOI: 10.16250/j.32.1374.2023144 -
Journal of Infection in Developing... Mar 2024Paragonimiasis is a common zoonotic parasitic disease. The retinoic acid-inducible gene I (RIG-I) signaling is very important for the host to recognize invading...
Paragonimiasis is a common zoonotic parasitic disease. The retinoic acid-inducible gene I (RIG-I) signaling is very important for the host to recognize invading pathogens (especially viruses and bacteria). However, the role of RIG-I signaling in the early stages of P. proliferus infection remains unclear. Therefore, in this study, Sprague-Dawley (SD) rat models with lung damage caused by P. proliferus were established. Experimental methods including Enzyme-linked Immuno Sorbent Assay (ELISA), real-time fluorescent quantitative polymerase chain reaction (PCR), western blotting, and hematoxylin and eosin (HE) staining were used to explore the mechanisms of lung injury caused by P. proliferus. As a result, the expression of the mRNA and proteins of RIG-I signal-related key target molecules, including RIG-I, tumor necrosis factor (TNF) receptor associated factor 6 (TRAF6), interferon regulatory Factor 7 (IRF7), IPS-1, and downstream C-X-C chemokine ligand 10 (CXCL10), were significantly up-regulated immediately after infection, peaked at 3 or 7 days, and showed a downward trend on after 14 days. The levels of pro-inflammatory cytokines interleukin-1 (IL-1), interferon (IFN)-α, -β, and -γ, which represent type 1 immune response, gradually increased and reached a peak by 14 days, which was consistent with the changes in the degree of inflammatory damage observed under HE staining of lung tissues. In conclusion, RIG-I signaling is activated in the early stage (before 14 days) of P. proliferus infection, it is inferred that the lung injury of the host may be related to the activation of RIG-I like signaling to induce type I immune response.
Topics: Animals; Rats; DEAD Box Protein 58; Paragonimiasis; Lung Injury; Rats, Sprague-Dawley; Interferon-alpha; Immunity; Paragonimus; RNA Helicases
PubMed: 38635624
DOI: 10.3855/jidc.18863