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Chemosphere Feb 2024The present study investigated the potential of a composite prepared from kaolinite clay and moringa seedcake in removing methylene blue (MB) and acid orange-7 (AO-7)...
The present study investigated the potential of a composite prepared from kaolinite clay and moringa seedcake in removing methylene blue (MB) and acid orange-7 (AO-7) dyes from aqueous solutions using batch and column tests. The composite was modified using different chemicals during the synthesis process, and the composites were characterised using different techniques such as FTIR, SEM-EDS and XRD. Characterisation showed the presence of actively charged functional groups and porous structure on the composites prepared. Batch tests were performed to assess the effect of operating conditions such as adsorbent dosage, pH, initial dye concentration and contact time. NaOH-modified and HSO/NaOH-modified composites demonstrated the highest adsorption capacities for AO-7 and MB, respectively, and were selected for subsequent studies. The adsorption process of dye was best fitted by the Freundlich isotherm and pseudo-second-order kinetic models suggesting that the sorption of MB and AO-7 onto the composites is a heterogeneous, multilayer chemical adsorption process. Long-term fixed-column tests were conducted with the composites to assess the impact of flow rate, bed depth and initial dye concentration on the dye removal efficiency. Optimum removals of 86 and 94%, respectively at pH 2 and pH 10 were obtained for AO-7 and MB in batch tests, along with adsorption capacities of 205.65 and 230.49 mg/g for AO-7 and MB. Results from the column tests were best explained by the Clark model and the Bed Depth-Service Time model. Competing ions impacted the removal of AO-7, while no significant effect was found for MB. The composites could be reused up to four cycles without significantly affecting the adsorption capacity. The present study thus shows the potential of the composite for removal of both the dyes.
Topics: Clay; Coloring Agents; Sodium Hydroxide; Kinetics; Adsorption; Methylene Blue; Hydrogen-Ion Concentration; Water Pollutants, Chemical; Azo Compounds; Benzenesulfonates
PubMed: 38160948
DOI: 10.1016/j.chemosphere.2023.141083 -
Environmental Monitoring and Assessment Jul 2023Water bodies with the dye methylene blue pose serious environmental and health risks to humans. Therefore, the creation and investigation of affordable, potential... (Review)
Review
Water bodies with the dye methylene blue pose serious environmental and health risks to humans. Therefore, the creation and investigation of affordable, potential adsorbents to remove methylene blue dye from water resources as a long-term fix is one focus of the scientific community. Food plants and other carbon-source serve as a hotspot for a wider range of application on different pollutants that impact the environment and living organisms. Here, we reviewed the use of treated and untreated biosorbents made from plant waste leaves for removing the dye methylene blue from aqueous media. After being modified, activated carbon made from various plant leaves improves adsorption performance. The range of activating chemicals, activation methods, and bio-sorbent material characterisation using FTIR analysis, Barunauer-Emmett-Teller (BET) surface area, scanning electron microscope (SEM-EDX), and SEM-EDX have all been covered in this review. It has been thoroughly described how the pH solution of the methylene blue dye compares to the pH of the adsorbent surface. The presentation also includes a thorough analysis of the application of the isotherm model, kinetic model, and thermodynamic parameters. The selectivity of the adsorbent is the main focus of the adsorption kinetics and isotherm models. It has been studied how adsorption occurs, how surface area and pH affect it, and how biomass waste compares to other adsorbents. The use of biomass waste as adsorbents is both environmentally and economically advantageous, and it has been discovered to have exceptional color removal capabilities.
Topics: Humans; Methylene Blue; Adsorption; Kinetics; Environmental Monitoring; Thermodynamics; Plant Leaves; Water Pollutants, Chemical; Hydrogen-Ion Concentration; Spectroscopy, Fourier Transform Infrared
PubMed: 37436672
DOI: 10.1007/s10661-023-11432-1 -
International Journal of Biological... Jul 2023Industrial dye wastewater poses a threat to human health due to its harmful effects, and the treatment of related wastewater is receiving increasing attention. In this...
Industrial dye wastewater poses a threat to human health due to its harmful effects, and the treatment of related wastewater is receiving increasing attention. In this paper, the melamine sponge with high porosity and convenient separation was selected as matrix material, and alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS) was prepared through crosslinking strategy. Not only does the composite cleverly combined the merits of alginate and carboxymethyl cellulose, it also enhanced the adsorption performance for methylene blue (MB). The adsorption data manifested that the adsorption process of SA/CMC-MeS agreed with the Langmuir model and pseudo-second-order kinetic model, and theoretical maximum adsorption capacity was 230 mg/g (pH 8). The characterization results demonstrated that the adsorption mechanism was attributed to the electrostatic attraction between the carboxyl anions on the composite and the dye cations in solution. Importantly, SA/CMC-MeS could selectively separate MB from binary dye system and had positive anti-interference ability in the face of coexisting cations. After 5 times of cycles, the adsorption efficiency remained above 75 %. Based on these outstanding practical properties, this material has a potential to solve dye contamination.
Topics: Humans; Carboxymethylcellulose Sodium; Methylene Blue; Wastewater; Alginates; Water Pollutants, Chemical; Adsorption; Kinetics; Cations; Hydrogen-Ion Concentration
PubMed: 37301350
DOI: 10.1016/j.ijbiomac.2023.125280 -
Chemosphere Dec 2023The presence of dye pollutants in industrial wastewater poses significant environmental and health risks, necessitating effective treatment methods. The optimal...
Integrating artificial neural networks and response surface methodology for predictive modeling and mechanistic insights into the detoxification of hazardous MB and CV dyes using Saccharum officinarum L. biomass.
The presence of dye pollutants in industrial wastewater poses significant environmental and health risks, necessitating effective treatment methods. The optimal adsorption treatment of methylene blue (MB) and crystal violet (CV) dye-simulated wastewater utilising Saccharum officinarum L presents a key challenge in the selection of appropriate modelling approaches. While RSM and ANN models are frequently used, there is a noticeable knowledge gap when it comes to evaluating their relative strengths and weaknesses in this context. The study compared the predictive abilities of response surface methodology (RSM) and artificial neural network (ANN) for the adsorption treatment of MB and CV dye-simulated wastewater using Saccharum officinarum L. The process experimental variables were modelled and predicted using a three-layer artificial neural network trained using the Levenberg-Marquard backpropagation algorithm and 30 central composite designs (CCD). The adsorption study used a specific mechanism, which led to noteworthy maximum removals of 98.3% and 98.2% for dyes (MB and CV), respectively. The RSM model achieved an impressive R of 0.9417, while the ANN model achieved 0.9236 in MB. Adsorption is commonly used to remove colour from many different materials. Saccharum officinarum L., a byproduct of sugarcane processing, has shown potential as an efficient and ecological adsorbent in this environment. The purpose of this study is to evaluate sugarcane bagasse's potential as an adsorbent for the removal of dyes MB and CV from industrial wastewater, providing a long-term strategy for reducing dye pollution. Due to its beneficial economic and environmental characteristics, the Saccharum officinarum L. adsorbent has prompted research into sustainable resources with low pollutant indices.
Topics: Gentian Violet; Wastewater; Methylene Blue; Saccharum; Coloring Agents; Biomass; Cellulose; Water Pollutants, Chemical; Kinetics; Neural Networks, Computer; Adsorption; Environmental Pollutants; Hydrogen-Ion Concentration
PubMed: 37793550
DOI: 10.1016/j.chemosphere.2023.140262 -
Photodiagnosis and Photodynamic Therapy Apr 2024The aim was to systematically review clinical studies that investigated the efficacy of antimicrobial photodynamic therapy (aPDT) in reducing oral yeasts growth (OYG) in... (Review)
Review
OBJECTIVE
The aim was to systematically review clinical studies that investigated the efficacy of antimicrobial photodynamic therapy (aPDT) in reducing oral yeasts growth (OYG) in individuals wearing implant overdentures (IO).
METHODS
The focused question was "Is aPDT effective in reducing OYG in patients wearing IO?" Literature search was performed in accordance with PRISMA guidelines. Indexed databases were searched without time and language restrictions up to and including January 2024. Clinical studies were included; and letters to the Editor, case-reports/case-series, perspectives/commentaries, in-vitro/ex-vivo studies, studies on animal models and expert opinions were excluded. The risk of bias was also assessed.
RESULTS
Two clinical studies were included and processed for data extraction. The study population comprised of 100 (mean age: 58.5 years) and 53 (mean age: 58.5 years) individuals. The numbers of males and females included in these studies ranged between 33 and 35 males and 18-67 females, respectively. In both studies, follow-up evaluations were performed after 60 days. In both studies, aPDT was performed using a 660 nm diode laser at a power of 100 mW and using methylene-blue as photosensitizer. Results from both studies showed that aPDT is effective in significantly reducing oral yeasts CFU/ml and improvement of OHRQoL of individuals using IO.
CONCLUSION
The aPDT is useful in reducing OYG on IO; however, further well-designed and power-adjusted studies are needed in this area of research.
Topics: Photochemotherapy; Humans; Photosensitizing Agents; Denture, Overlay; Methylene Blue; Lasers, Semiconductor; Yeasts; Clinical Trials as Topic
PubMed: 38548040
DOI: 10.1016/j.pdpdt.2024.104050 -
PeerJ 2024To study the efficacy of PAD Plus-based photoactivated disinfection (PAD) for treating denture stomatitis (DS) in diabetic rats by establishing a diabetic rat DS model.
OBJECTIVE
To study the efficacy of PAD Plus-based photoactivated disinfection (PAD) for treating denture stomatitis (DS) in diabetic rats by establishing a diabetic rat DS model.
METHODS
The diabetic rat DS model was developed by randomly selecting 2-month-old male Sprague-Dawley rats and dividing them into four groups. The palate and denture surfaces of rats in the PAD groups were incubated with 1 mg/mL toluidine blue O for 1 min each, followed by a 1-min exposure to 750-mW light-emitting diode light. The PAD-1 group received one radiation treatment, and the PAD-2 group received three radiation treatments over 5 days with a 1-day interval. The nystatin (NYS) group received treatment for 5 days with a suspension of NYS of 100,000 IU. The infection group did not receive any treatment. In each group, assessments included an inflammation score of the palate, tests for fungal load, histological evaluation, and immunohistochemical detection of interleukin-17 (IL-17) and tumor necrosis factor (TNF-α) conducted 1 and 7 days following the conclusion of treatment.
RESULTS
One day after treatment, the fungal load on the palate and dentures, as well as the mean optical density values of IL-17 and TNF-α, were found to be greater in the infection group than in the other three treatment groups ( < 0.05). On the 7th day after treatment, these values were significantly higher in the infection group than in the PAD-2 and NYS groups ( < 0.05). Importantly, there were no differences between the infection and PAD-1 groups nor between the PAD-2 and NYS groups ( 0.05).
CONCLUSIONS
PAD effectively reduced the fungal load and the expressions of IL-17 and TNF-α in the palate and denture of diabetic DS rats. The efficacy of multiple-light treatments was superior to that of single-light treatments and similar to that of NYS.
Topics: Animals; Male; Rats, Sprague-Dawley; Rats; Stomatitis, Denture; Disinfection; Diabetes Mellitus, Experimental; Tolonium Chloride; Tumor Necrosis Factor-alpha; Interleukin-17; Disease Models, Animal
PubMed: 38708351
DOI: 10.7717/peerj.17268 -
Journal of Analytical Toxicology Sep 2023Rilmazafone is a pro-drug that can be prescribed in Japan to treat insomnia. Rilmazafone metabolizes into active compounds by a ring closure resulting in a triazolo...
Rilmazafone is a pro-drug that can be prescribed in Japan to treat insomnia. Rilmazafone metabolizes into active compounds by a ring closure resulting in a triazolo benzodiazepine structure similar to alprazolam. In mid-2022, the National Board of Forensic Medicine in Sweden were requested to investigate two separate deaths with the suspected use of pagoclone. Packages labeled "Pagoclone" were found at each scene that was suspected to contain rilmazafone based on website information. During screening by high resolution mass spectrometry, rilmazafone metabolites were presumptively identified. Due to the lack of reference material for the active metabolites, the metabolites were synthesized in house and quantification of the compounds identified in the two autopsy cases was prompted. In Case 1, femoral blood concentrations of 7.9, 65 and 170 ng/g of the metabolites rilmazolam, N-desmethyl rilmazolam and di-desmethyl rilmazolam, respectively, were detected. Additional toxicological findings included the medications haloperidol, alimemazine, fluoxetine, olanzapine and acetaminophen. In Case 2, femoral blood concentrations of 1.7, 1.4 and 70 ng/g of rimazolam, N-desmethyl rilmazolam and di-desmethyl rilmazolam, respectively, were detected. Additional toxicological findings included loperamide, alimemazine and pregabalin. The intake of rilmazafone was determined as the cause of death in Case 1 and contributed in the Case 2.
Topics: Benzodiazepines; Prodrugs; Trimeprazine; Triazoles
PubMed: 37348041
DOI: 10.1093/jat/bkad041 -
West African Journal of Medicine Dec 2023Promethazine is a phenothiazine derivative that possesses antihistamine, anti-dopaminergic and anticholinergic properties. It is commonly used to treat motion sickness,...
INTRODUCTION
Promethazine is a phenothiazine derivative that possesses antihistamine, anti-dopaminergic and anticholinergic properties. It is commonly used to treat motion sickness, allergic conditions, nausea and vomiting, in addition to its use as a sedative. Promethazine has vesicant properties and is highly caustic to the intima of blood vessels and surrounding tissues. Intravenous administration may result in thrombophlebitis, unintentional intra-arterial administration, perivascular extravasation and tissue necrosis. To the best of our knowledge there is no previous published report of promethazine-induced thrombophlebitis from sub- Saharan Africa.
CASE REPORT
A 29-year-old Nigerian male was admitted at our hospital on account of malaria with acute gastroenteritis. Due to persistent vomiting, he was administered 25 mg of promethazine injection via a size 22G intravenous cannula which was inserted the previous day on the anteromedial aspect of his right forearm and maintained with continuous intravenous crystalloid infusion. Upon administration of promethazine, he experienced intense burning and erythema. The cannula was removed immediately, another cannula was inserted on the contralateral arm, and promethazine was replaced with ondansetron. Subsequently, he developed a tender, subcutaneous cord-like swelling extending from the middle-third of the anteromedial aspect of his right forearm, corresponding with the site of previous venous cannulation. Ultrasonography revealed a hypoechoic, non-compressible basilic vein, with no flow on colour Doppler interrogation, in keeping with superficial thrombophlebitis. He was treated with a topical anti-inflammatory agent, and the pain and redness subsided after four weeks.
CONCLUSION
The preferred parenteral route of administration of promethazine is deep intramuscular injection. Recommendations to prevent promethazine-induced thrombophlebitis include: use of large and patent veins, use of lower doses, drug dilution and slow administration, use of alternative therapies, and patient education. Promethazine-induced tissue injury is under-reported in this part of the world. Creating awareness through this case report would help reduce the morbidity following promethazine administration.
Topics: Humans; Male; Adult; Promethazine; Ondansetron; Vomiting; Nausea; Thrombophlebitis
PubMed: 38070188
DOI: No ID Found -
Environmental Research Aug 2023In this study, the deployment of post Reverse Osmosis (RO)-carbon as a adsorbent for dye removal from water has been investigated. The post RO-carbon was thermally...
In this study, the deployment of post Reverse Osmosis (RO)-carbon as a adsorbent for dye removal from water has been investigated. The post RO-carbon was thermally activated (RO900), and the material thus obtained exhibited high surface area viz. 753 m/g. In the batch system, the efficient Methylene Blue (MB) and Methyl Orange (MO) removal was obtained by using 0.08 g and 0.13 g/50 mL adsorbent dosage respectively. Moreover, 420 min was the optimized equilibration time for both the dyes. The maximum adsorption capacities of RO900 for MB and MO dyes were 223.29 and 158.14 mg/g, respectively. The comparatively higher MB adsorption was attributed to the electrostatic attraction between adsorbent and MB. The thermodynamic findings revealed the process as spontaneous, endothermic, and accompanied by entropy increment. Additionally, simulated effluent was treated, and >99% dye removal efficiency was achieved. To mimic an industrial perspective, MB adsorption onto RO900 was also carried out in continuous mode. The initial dye concentration and effluent flow rate were among the process parameters that were optimized using the continuous mode of operation. Further, the experimental data of continuous mode was fitted with Clark, Yan, and Yoon-Nelson models. Py-GC/MS investigation revealed that dye-loaded adsorbents could be pyrolyzed to produce valuable chemicals. The cost and low toxicity associated benefits of discarded RO-carbon over other adsorbents reveal the significance of the present study.
Topics: Wastewater; Carbon; Coloring Agents; Adsorption; Water Pollutants, Chemical; Kinetics; Thermodynamics; Methylene Blue; Osmosis; Hydrogen-Ion Concentration
PubMed: 37196691
DOI: 10.1016/j.envres.2023.116165 -
New Zealand Veterinary Journal Sep 2023To evaluate the effect of IM administration of three sedative drugs, acepromazine, alfaxalone and dexmedetomidine, in combination with morphine, on the size of the...
AIMS
To evaluate the effect of IM administration of three sedative drugs, acepromazine, alfaxalone and dexmedetomidine, in combination with morphine, on the size of the feline spleen using ultrasonography.
METHODS
Twenty-four client-owned cats undergoing elective de-sexing or minor procedures were recruited for a focused ultrasonographic examination of the spleen prior to and at 10, 20 and 30 minutes following administration of one of three randomly assigned IM sedation protocols: 0.05 mg/kg acepromazine (ACE group), 3 mg/kg alfaxalone (ALF group), or 10 μg/kg dexmedetomidine (DEX group), in combination with 0.5 mg/kg morphine. B-mode images of the spleen were collected and measured following a standardised protocol. Cardiorespiratory parameters and sedation score were also recorded. Mean thickness of the head, body and tail of the spleen for each group at 10, 20 and 30 minutes after drug administration was compared to baseline.
RESULTS
Mean splenic thickness increased over time in the ACE group (thickness of body at T0 = 8.9 (SE 2.1) mm and at T30 = 10.5 (SE 2.0) mm; p = 0.001) and the ALF group (thickness of body at T0 = 8.8 (SE 1.0) mm and at T30 = 10.3 (SE 1.7) mm; p = 0.022) but not in the DEX group (thickness of body at T0 = 8.6 mm (1.2) and at T30 = 8.9 mm (0.6); p = 0.67). Mean arterial blood pressure in the DEX group was significantly higher than in the other groups (p = 0.002). Sedation scores in the DEX group were consistently high for the entire period. However, the sedation score in the ACE group increased over 30 minutes (p = 0.007). Sedation score in the ALF group was highest at 10 minutes but gradually decreased over the following 20 minutes (p = 0.003).
CONCLUSIONS
Sedation with IM dexmedetomidine and morphine did not change splenic size, whereas acepromazine or alfaxalone and morphine increased it regardless of the degree of sedation.
CLINICAL RELEVANCE
Where splenomegaly is identified in a cat sedated with acepromazine or alfaxalone, the effects of the sedation protocol could be considered as a possible cause.
Topics: Cats; Animals; Dexmedetomidine; Acepromazine; Spleen; Hypnotics and Sedatives; Morphine; Ultrasonography
PubMed: 37345417
DOI: 10.1080/00480169.2023.2223177