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The Science of the Total Environment Feb 2024Maternal exposure to organophosphate esters (OPEs) has been linked to an increased risk of adverse birth outcomes. However, the impact of OPEs on childhood growth...
Maternal exposure to organophosphate esters (OPEs) has been linked to an increased risk of adverse birth outcomes. However, the impact of OPEs on childhood growth remains uncertain. This study assessed the associations between prenatal concentrations of OPE metabolites and the growth trajectory in early childhood. 212 singleton pregnant women were included in this study, and they were recruited between August 2014 and August 2016 in Wuhan, China. We measured the urinary concentrations of OPE metabolites during the 1st, 2nd, and 3rd trimesters. Standard deviation scores for weight and length were calculated for children at birth, 1, 6, 12, and 24 months. Trajectories of weight-for-age z-score (WAZ) and weight-for-length z-score (WLZ) were classified into four groups using group-based trajectory modeling. Trajectories of length-for-age z-score (LAZ) were classified into three groups with the same model. Then, we calculated odds ratios (ORs) and 95 % confidence interval (95%CI) using multinomial logistic regression to estimate increases in odds of different growth trajectories per doubling in OPE concentrations compared with moderate-stable trajectory. For average concentrations of OPE metabolites and growth trajectory, our results indicated that higher bis(2-butoxyethyl) phosphate, total aromatic OPE metabolites, and total OPE metabolites during pregnancy were associated with a higher likelihood of children falling into the low-stable and low-rising WAZ trajectory. Furthermore, compared to the moderate-stable LAZ trajectory, increased concentrations of 1-hydroxy-2-propyl bis(1-chloro-2-propyl) phosphate were linked to an elevated risk of a low-stable LAZ trajectory. Additionally, the 1st and 2nd trimesters may represent critical windows of heightened vulnerability to the effects of OPE metabolites on childhood growth. In conclusion, our study proves that prenatal exposure to OPE metabolites is inversely related to childhood growth. It is essential to conduct further research involving larger populations and to consider other compounds with known developmental toxicity to obtain more reliable and comprehensive results.
Topics: Female; Humans; Infant, Newborn; Pregnancy; Esters; Flame Retardants; Organophosphates; Phosphates; Pregnancy Trimester, Second; Prenatal Exposure Delayed Effects
PubMed: 38052391
DOI: 10.1016/j.scitotenv.2023.169080 -
Journal of Exposure Science &... Mar 2024Organophosphate esters (OPEs) are ubiquitously detected in environments and their exposure may affect respiratory health. However, epidemiological evidence, particularly...
BACKGROUND
Organophosphate esters (OPEs) are ubiquitously detected in environments and their exposure may affect respiratory health. However, epidemiological evidence, particularly among adolescents, is very limited.
OBJECTIVE
We aimed to investigate the associations of urinary OPEs metabolites with asthma and lung function among adolescents and to identify potential effect modifiers.
METHODS
Included were 715 adolescents aged 12-19 years old participating in the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Multivariable binary logistic regression and linear regression were used to assess associations with asthma and lung function, respectively. Stratified analyses were conducted to assess the effect modifications of serum sex hormones, vitamin D levels, and body mass index (BMI).
RESULTS
After multivariable adjustment, we found that bis(2-chloroethyl) phosphate (BCEP) (3rd tertile [T3] vs 1st tertile [T1], OR = 1.87, 95% CI: 1.08, 3.25; P-trend=0.029) and diphenyl phosphate (DPHP) (T3 vs T1, OR = 2.52, 95%CI: 1.25, 5.04; P-trend=0.013) were associated with elevated odds of asthma in all adolescents. Sex-stratified analyses revealed that associations of these two OPEs metabolites tended to be stronger in males. Meanwhile, BCEP and the molecular sum of OPEs metabolites (∑OPEs) were significantly associated with declined lung function, either in all adolescents or by sex. Furthermore, stratified analyses revealed that positive associations of OPEs metabolites with asthma tended to be stronger among adolescents with insufficient levels of Vitamin D (VD < 50 nmol/L), relatively high levels of total testosterone (≥356 ng/dL and ≥22.5 ng/dL for males and females, respectively), or low levels of estradiol (<19.1 pg/mL and <47.3 pg/mL for males and females, respectively).
SIGNIFICANCE
Certain urinary OPEs metabolites, especially DPHP and BCEP, were associated with elevated odds of asthma and declined lung function in adolescents. Such associations might be partly modified by levels of VD and sex steroid hormones.
IMPACT STATEMENT
The observed associations of urinary OPEs metabolites with increased risk of asthma and declined lung function highlight the potential hazard of OPEs exposure to respiratory health among adolescents.
Topics: Humans; Adolescent; Asthma; Male; Female; Organophosphates; Child; Young Adult; Nutrition Surveys; Esters; Environmental Exposure; Lung; Respiratory Function Tests; Cross-Sectional Studies; Body Mass Index; Environmental Pollutants
PubMed: 37019982
DOI: 10.1038/s41370-023-00540-2 -
Environmental Science and Pollution... Aug 2023The limited evidence linking exposure to organophosphate insecticides (OPIs) and asthma in the general population prompted us to investigate this association. Our study...
The limited evidence linking exposure to organophosphate insecticides (OPIs) and asthma in the general population prompted us to investigate this association. Our study focused on US adults and utilized representative samples from the National Health and Nutrition Examination Survey (NHANES). From the 7 NHANES waves (1999-2018), we detected OPIs exposure using the urinary concentrations of six metabolites of dialkyl phosphates (DAPs). To evaluate the relationship between these OPIs and asthma, we employed three statistical methods: survey-multivariable logistic regression (SMLR), generalized weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR). Stratified analyses were done based on the relevant variable subgroups, and sensitivity analyses were carried out to evaluate the robustness of findings. A total of 6009 adults aged from 20 to 85 years old, representing the 313.5 million adults in the non-institutionalized US population, were included in our analyses. Among them, 842 participants were determined as asthma patients with an age-adjusted prevalence of 14.2%. Our results showed that dimethyl phosphate (DMP) (adjusted odd ratio (AOR) = 1.471, 95% CI: 1.086, 1.993), diethyl phosphate (DEP) (AOR = 1.453, 95% CI: 1.118, 1.888), dimethyl thiophosphate (DMTP) (AOR = 1.454, 95% CI: 1.071, 1.973), and dimethyl dithiophosphate (DMDTP) (AOR = 1.478, 95% CI: 1.119, 1.953) had a positive correlation with asthma in adults. This association was stronger in females, non-Hispanic White populations and those with a small amount of physical activity. Our study findings indicated that exposure to OPIs may elevate the risk of asthma in US general adults. Specifically, females, individuals from non-Hispanic White backgrounds, and those with lower levels of physical activity are more susceptible to developing asthma when exposed to OPIs.
Topics: Female; Humans; Adult; Young Adult; Middle Aged; Aged; Aged, 80 and over; Insecticides; Nutrition Surveys; Bayes Theorem; Organophosphates; Biomarkers; Environmental Exposure
PubMed: 37482592
DOI: 10.1007/s11356-023-28740-1 -
Environmental Research Jan 2024Organophosphate ester flame retardants and plasticizers (OPEs) are common exposures in modern built environments. Toxicological models report that some OPEs reduce...
Organophosphate ester flame retardants and plasticizers (OPEs) are common exposures in modern built environments. Toxicological models report that some OPEs reduce dopamine and serotonin in the brain. Deficiencies in these neurotransmitters are associated with anxiety and depression. We hypothesized that exposure to higher concentrations of OPEs in house dust would be associated with a greater risk of depression and stress in mothers across the prenatal and postpartum periods. We conducted a nested prospective cohort study using data collected on mothers (n = 718) in the CHILD Cohort Study, a longitudinal multi-city Canadian birth cohort (2008-2012). OPEs were measured in house dust sampled at 3-4 months postpartum. Maternal depression and stress were measured at 18 and 36 weeks gestation and 6 months and 1 year postpartum using the Centre for Epidemiologic Studies for Depression Scale (CES-D) and Perceived Stress Scale (PSS). We used linear mixed models to examine the association between a summed Z-Score OPE index and continuous depression and stress scores. In adjusted models, one standard deviation increase in the OPE Z-score index was associated with a 0.07-point (95% CI: 0.01, 0.13) increase in PSS score. OPEs were not associated with log-transformed CES-D (β: 0.63%, 95% CI: -0.18%, 1.46%). The effect of OPEs on PSS score was strongest at 36 weeks gestation and weakest at 1 year postpartum. We observed small increases in maternal perceived stress levels, but not depression, with increasing OPEs measured in house dust during the prenatal and early postpartum period in this cohort of Canadian women. Given the prevalence of prenatal and postpartum anxiety and the ubiquity of OPE exposures, additional research is warranted to understand if these chemicals affect maternal mental health.
Topics: Pregnancy; Humans; Female; Flame Retardants; Plasticizers; Cohort Studies; Prospective Studies; Dust; Canada; Esters; Organophosphates; Outcome Assessment, Health Care
PubMed: 37871788
DOI: 10.1016/j.envres.2023.117451 -
The Science of the Total Environment Nov 2023Micro(nano)plastics (MNPs) and organophosphate esters (OPEs) are becoming ubiquitous as emerging pollutants. To data, the effects of MNPs on the uptake, accumulation and...
Uptake, accumulation and translocation of traditional and novel organophosphate esters by rice seedlings in the presence of micro(nano)-polystyrene plastics: Effects of concentration and size of particles.
Micro(nano)plastics (MNPs) and organophosphate esters (OPEs) are becoming ubiquitous as emerging pollutants. To data, the effects of MNPs on the uptake, accumulation and translocation of OPEs by rice plant are still unclear, especially for novel OPE species. In this study, the impacts of polystyrene MNPs of different sizes and concentrations on the uptake of eight OPEs (six traditional organophosphate triesters and two novel discovered aryl organophosphate triesters) by rice seedlings were investigated in hydroponic exposure experiments. The results showed that OPEs accumulated in a concentration-dependent manner in both the roots and shoots of rice seedlings. The impacts of MNPs on uptake by rice seedlings were concentration- and size-dependent by influencing the transpiration rate or activities of antioxidant enzymes. Especially, significant effects were usually found in exposure group of medium-size and high-concentration MNPs. MNPs had more obvious effects on OPE species with lower logK in roots, whereas, more obvious effects on OPE species with higher logK in shoots were observed. There was a significantly positive linear relationship between logTF and logK (p < 0.001), and a significantly negative linear relationship between logRCF and logK (p < 0.001), indicating that OPEs with higher hydrophobicity seemed to be more liable to be absorbed from solutions to roots, but difficult to further translocate to shoots. Without novel OPEs (bis-(2-ethylhexyl)-phenyl phosphate and tris(2,4-di-tert-butylphenyl)phosphate), better fits for a linear model for logK and logRCF (or logTF) were exhibited, indicating differences between novel and traditional OPEs. This work highlights that the presence of MNPs could altered the characteristics of uptake, translocation and accumulation of OPEs in rice seedlings, and provides an important evidence for comprehensive control strategy of new pollutants.
Topics: Plastics; Polystyrenes; Oryza; Seedlings; Flame Retardants; Esters; Environmental Pollutants; Organophosphates; Phosphates; China; Environmental Monitoring
PubMed: 37454839
DOI: 10.1016/j.scitotenv.2023.165534 -
Environmental Research Jan 2024The association of prenatal exposure to organophosphate esters (OPEs) and replacement brominated flame retardants (RBFRs) with respiratory outcomes has not been...
BACKGROUND
The association of prenatal exposure to organophosphate esters (OPEs) and replacement brominated flame retardants (RBFRs) with respiratory outcomes has not been previously investigated in humans, despite reports that these chemicals can cross the placenta and alter lung development as well as immune functions.
METHODS
In a cohort of 342 pregnant women recruited between 2003 and 2006 in the greater Cincinnati, Ohio Metropolitan area, we measured indoor dust OPEs and RBFRs at 20 weeks of gestation and urinary OPEs at 16 and 26 weeks of gestation and at delivery. We performed generalized estimating equations and linear mixed models adjusting for covariates to determine the associations of prenatal OPEs and RBFRs exposures with adverse respiratory outcomes in childhood, reported every six months until age 5 years and with lung function at age 5 years. We used multiple informant modeling to examine time-specific associations between maternal urinary OPEs and the outcomes.
RESULTS
Dust concentrations of triphenyl phosphate (TPHP) (RR: 1.40, 95% CI: 1.18-1.66), 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (RR: 1.51, 95% CI: 1.23-1.85), and bis(2-ethylhexyl) tetrabromophthalate (RR: 1.57, 95% CI: 1.28-1.94) were associated with higher risk of wheezing during childhood. Dust TPHP concentrations were associated with higher risk of respiratory infections (RR: 1.43, 95% CI: 1.08-1.94), and dust tris-(2-chloroethyl) phosphate concentrations were associated with hay fever/allergies (RR: 1.11, 95% CI: 1.01-1.21). We also found that dust tris-(2-chloroethyl) phosphate loadings were associated with lower lung function. Urinary OPEs mainly at week 16 of gestation tended to be associated with adverse respiratory outcome, while bis(1-chloro-2-propyl) phosphate and diphenyl phosphate at delivery were associated with lower risk of hay fever/allergies.
CONCLUSIONS
In-utero exposure to OPEs and RBFRs may be a risk factor for adverse respiratory outcomes in childhood, depending on the timing of exposure.
Topics: Pregnancy; Humans; Female; Child, Preschool; Flame Retardants; Rhinitis, Allergic, Seasonal; Prenatal Exposure Delayed Effects; Phosphates; Hypersensitivity; Dust; Organophosphates
PubMed: 37925128
DOI: 10.1016/j.envres.2023.117523 -
The Science of the Total Environment Oct 2023This study analysed settled dust samples in Sweden to assess children's combined exposure to 39 organohalogenated flame retardants (HFRs) and 11 organophosphate esters...
This study analysed settled dust samples in Sweden to assess children's combined exposure to 39 organohalogenated flame retardants (HFRs) and 11 organophosphate esters (OPEs) from homes and preschools. >94 % of the targeted compounds were present in dust, indicating widespread use of HFRs and OPEs in Swedish homes and preschools. Dust ingestion was the primary exposure pathway for most analytes, except BDE-209 and DBDPE, where dermal contact was predominant. Children's estimated intakes of ∑ HFRs and ∑ HFRs from homes were 1-4 times higher than from preschools, highlighting higher exposure risk for HFRs in homes compared to preschools. In a worst-case scenario, intakes of tris(2-butoxyethyl) phosphate (TBOEP) were 6 and 94 times lower than the reference dose for children in Sweden, indicating a potential concern if exposure from other routes like inhalation and diet is as high. The study also found significant positive correlations between dust concentrations of some PBDEs and emerging HFRs and the total number of foam mattresses and beds/m, the number of foam-containing sofas/m, and the number of TVs/m in the microenvironment, indicating these products as the main source of those compounds. Additionally, younger preschool building ages were found to be linked to higher ΣOPE concentrations in preschool dust, suggesting higher ΣOPE exposure. The comparison with earlier Swedish studies indicates decreasing dust concentrations for some banned and restricted legacy HFRs and OPEs but increasing trends for several emerging HFRs and several unrestricted OPEs. Therefore, the study concludes that emerging HFRs and OPEs are replacing legacy HFRs in products and building materials in homes and preschools, possibly leading to increased exposure of children.
Topics: Child; Child, Preschool; Humans; Environmental Exposure; Environmental Monitoring; Flame Retardants; Sweden; Dust; Air Pollution, Indoor; Organophosphates; Esters
PubMed: 37391153
DOI: 10.1016/j.scitotenv.2023.165198 -
IEEE Journal of Biomedical and Health... Feb 2024In this article, we survey the current research trends of enhancement and denoising of depth-based motion capture data (D-Mocap) and also discuss possible future... (Review)
Review
In this article, we survey the current research trends of enhancement and denoising of depth-based motion capture data (D-Mocap) and also discuss possible future research issues. We first present the commonly used problem formulation for human motion enhancement. We then review related work and cover a broad set of methodologies including filtering based, learning based, and evolutionary based approaches. In addition, we present some important experiments-related issues, such as data creation or collection, reference data generation, and the metrics used for performance evaluation. It is our intent to provide a comprehensive tutorial and survey on the recent efforts on D-Mocap improvement, both methodologically and experimentally. By comparing the state-of-the-art methods, we also propose future research needs that could make D-Mocap more useful and relevant for real-world clinical applications.
Topics: Humans; Algorithms; Motion; Organothiophosphates
PubMed: 37030727
DOI: 10.1109/JBHI.2023.3257662 -
Environmental Science and Pollution... Feb 2024Organophosphates are the most extensively used class of pesticides to deal with increasing pest diversity and produce more on limited terrestrial areas to feed the... (Review)
Review
Organophosphates are the most extensively used class of pesticides to deal with increasing pest diversity and produce more on limited terrestrial areas to feed the ever-expanding global population. Profenofos, an organophosphate group of non-systematic insecticides and acaricides, is used to combat aphids, cotton bollworms, tobacco budworms, beet armyworms, spider mites, and lygus bugs. Profenofos was inducted into the system as a replacement for chlorpyrifos due to its lower toxicity and half-life. It has become a significant environmental concern due to its widespread presence. It accumulates in various environmental components, contaminating food, water, and air. As a neurotoxic poison, it inhibits acetylcholinesterase receptor activity, leading to dizziness, paralysis, and pest death. It also affects other eukaryotes, such as pollinators, birds, mammals, and invertebrates, affecting ecosystem functioning. Microbes directly expose themselves to profenofos and adapt to these toxic compounds over time. Microbes use these toxic compounds as carbon and energy sources and it is a sustainable and economical method to eliminate profenofos from the environment. This article explores the studies and developments in the bioremediation of profenofos, its impact on plants, pollinators, and humans, and the policies and laws related to pesticide regulation. The goal is to raise awareness about the global threat of profenofos and the role of policymakers in managing pesticide mismanagement.
Topics: Animals; Humans; Acetylcholinesterase; Ecosystem; Organothiophosphates; Insecticides; Pesticides; Chlorpyrifos; Mammals
PubMed: 38291208
DOI: 10.1007/s11356-024-32159-7 -
Ecotoxicology and Environmental Safety Sep 2023Cantaloupe is a popular agricultural product in the hot season of Iran. On the other hand, the frequent use of pesticides in cantaloupe fields is the most important...
Pesticides residues determination and probabilistic health risk assessment in the soil and cantaloupe by Monte Carlo simulation: A case study in Kashan and Aran-Bidgol, Iran.
Cantaloupe is a popular agricultural product in the hot season of Iran. On the other hand, the frequent use of pesticides in cantaloupe fields is the most important threat to the health of farmers and consumers. Therefore, the present study aims to measure the concentration of diazinon (DZN), chlorpyrifos (CPF), and malathion (MLT) in cantaloupe cultivated in Kashan and Aran-Bidgol (Iran) and to estimate the possible oral and dermal risk of these pesticides by Monte Carlo simulation (MCS). 36 cantaloupe samples, 18 samples before, and 18 samples after the latent period were collected from different places of cantaloupe cultivation from April to May 2021. After measuring the pesticides using the QuEChERS approach, oral and dermal risk assessments were calculated.The mean and standard deviation of the concentrations of chlorpyrifos, malathion, and diazinon in 18 cantaloupe samples, after the latent period, were (30.39 ± 13.85), (18.361 ± 1.8), and (21.97 ± 0.86) μg kg-, respectively. Concentration of Malathion, diazinon, and Chlorpyrifos in the soil were 0.22, 0.25, and 0.3 mg kg-, respectively, and pesticide cumulative risk assessment in soil was obtained 0.011 for Malathion, 0.05 for diazinon and 0.03 for Chlorpyrifos. Target Hazard Quotient (THQ) according to the cantaloupe consumption and dermal exposure in children and adults, was safe range. Although non-cancerous dermal and oral risk of cantaloupe is low, constant exposure can be harmful. Therefore, the findings of this study play an important role in increasing the understanding of the negative health consequences of pesticide contamination in cantaloupe for consumers, especially local residents, and can help by adopting remedial strategies to reduce environmental concerns.
Topics: Adult; Child; Humans; Pesticide Residues; Chlorpyrifos; Diazinon; Malathion; Cucumis melo; Soil; Iran; Monte Carlo Method; Pesticides; Risk Assessment
PubMed: 37441953
DOI: 10.1016/j.ecoenv.2023.115229