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American Journal of Preventive... Sep 2023The prevalence of heart failure (HF) in the United States (U.S.) is estimated at over 6 million adults, with the incidence continuing to increase. A large proportion of... (Review)
Review
The prevalence of heart failure (HF) in the United States (U.S.) is estimated at over 6 million adults, with the incidence continuing to increase. A large proportion of the U.S. population is also at risk of HF due to the high prevalence of established HF risk factors, such as hypertension, diabetes, and obesity. Many individuals have multiple risk factors, placing them at even higher risk. In addition, these risk factors disproportionately impact various racial and ethnic groups. Recognizing the rising health and economic burden of HF in the U.S., the 2022 American Heart Association / American College of Cardiology / Heart Failure Society of America (AHA/ACC/HFSA) Heart Failure Guideline placed a strong emphasis on prevention of HF. The purpose of this review is to highlight the role of both primary and secondary prevention in HF, as outlined by the recent guideline, and address the role of the preventive cardiology community in reducing the prevalence of HF in at-risk individuals.
PubMed: 37637197
DOI: 10.1016/j.ajpc.2023.100527 -
Frontiers in Allergy 2023The incidence of IgE-mediated food allergy (FA) has continued to increase over the years which places substantial burden on patient health and quality of life. With no... (Review)
Review
The incidence of IgE-mediated food allergy (FA) has continued to increase over the years which places substantial burden on patient health and quality of life. With no cure for this disease, the mainstay of management has been allergen avoidance. However, there have been advancements in FA treatment in recent years with multiple clinical trials utilizing novel and innovative therapeutic strategies. A landmark event came in 2020 with the first drug approval for food allergy with the approval of a product for peanut oral immunotherapy. In addition to oral immunotherapy, different delivery systems of immunotherapy (SLIT, EPIT) are being studied in addition to probiotics, biologic agents - used as monotherapy and as an adjunct, and modified allergens has taken place with the hope to further enhance existing therapeutic options. The hope through these continued developments is for therapies to emerge that will provide a more comprehensive benefit to this patient population.
PubMed: 37520143
DOI: 10.3389/falgy.2023.1154541 -
Global Change Biology Jul 2023Both urban and rural environments around the globe have become dominated by alien plant species to the extent that plantscapes from one region or country have become...
Both urban and rural environments around the globe have become dominated by alien plant species to the extent that plantscapes from one region or country have become difficult to distinguish from many others. This process of plant community homogenisation comes at a cost to cultural identity and undermines people's sense of place. Although invasive alien plant species have received considerable attention in recent decades, issues with non-invasive alien plant species have largely been ignored, and yet they contribute significantly to biotic homogeneity and impose an ever accumulating invasion debt: a debt that increases in proportion with their population sizes. By contrast, an abundance of native species in the places where people live is important for strengthening commitment to biodiversity conservation. Is there therefore sufficient evidence of harm from increasing numbers of non-invasive alien plants to justify local and central governments introducing measures to substantially reduce the proportion of non-invasive aliens in both urban and rural environments?
Topics: Humans; Introduced Species; Biodiversity; Ecosystem
PubMed: 37272874
DOI: 10.1111/gcb.16704 -
Journal of the American Academy of... Apr 2024Have you ever built a spaceship using Magna-Tiles with a 4-year-old child? If not, place this on the top of your to-do list, as there are many lessons hidden within...
Have you ever built a spaceship using Magna-Tiles with a 4-year-old child? If not, place this on the top of your to-do list, as there are many lessons hidden within these colorful pieces of plastic. In addition to teaching patience and cooperation, the process of building with a preschooler with big emotions and an underdeveloped prefrontal cortex offers endless opportunities to serve as both a safe haven and a secure base. As each tile is carefully (or not so carefully) placed, you are building more than just a misshapen spaceship; you are reinforcing a foundation of trust and mutual respect. In helping my own 4-year-old daughter build a unicorn-themed spaceship that resembled a tug boat, I cringed when she placed the final tile that would collapse our creative masterpiece. Much to my surprise, instead of disappointment and tears, she erupted into laughter and began the process of building all over again. She reminded me that joy can come from an experience rather than an outcome, that creativity and imagination should be sprinkled daily into the work we do, and that not every spaceship is destined to be out of this world!
PubMed: 38697346
DOI: 10.1016/j.jaac.2024.04.006 -
Cortex; a Journal Devoted To the Study... Oct 2023Reduplicative paramnesia refers to the delusional belief that there are identical places in different locations. In this case-control study we investigated the clinical,...
Reduplicative paramnesia refers to the delusional belief that there are identical places in different locations. In this case-control study we investigated the clinical, phenomenological, neuropsychological and neuroanatomical data of eleven patients with reduplicative paramnesia and compared them against a control group of eleven patients with severe spatial disorientation without signs of reduplicative paramnesia. We show that most patients with reduplicative paramnesia report that a current place is reduplicated and/or relocated to an other familiar place. Patients with reduplicative paramnesia show a higher prevalence of deficits in the executive functions compared to the control patients, while mnestic and visuo-spatial deficits were both frequent in patients with reduplicative paramnesia and the control group. Patients with reduplicative paramnesia mostly suffer from right hemispheric lesions with a maximal overlap in the dorsolateral prefrontal cortex. Using lesion network mapping we show that lesions causing reduplicative paramnesia are connected to bilateral anterior insula and the right cingulate cortex. We argue that patients with reduplicative paramnesia fail to integrate the actual context with visuo-spatial memories and personal relevant emotional information due to a disruption of the neural network within the anterior temporal lobe, the cingulate cortex and the anterior insula. Also patients with reduplicative paramnesia are not able to resolve this conflict due to the lesion of the dorsolateral prefrontal cortex and executive dysfunction.
Topics: Humans; Neuroanatomy; Delusions; Neuropsychology; Case-Control Studies; Memory Disorders
PubMed: 37515831
DOI: 10.1016/j.cortex.2023.06.006 -
Chemistry (Weinheim An Der Bergstrasse,... Sep 20231,n-dicarbonyls are one of the most fascinating chemical feedstocks finding abundant usage in the field of pharmaceuticals. Besides, they are utilized in a plethora of... (Review)
Review
1,n-dicarbonyls are one of the most fascinating chemical feedstocks finding abundant usage in the field of pharmaceuticals. Besides, they are utilized in a plethora of synthesis in general synthetic organic chemistry. A number of 'conventional' methods are available for their synthesis, such as the Stetter reaction, Baker-Venkatraman rearrangement, oxidation of vicinal diols, and oxidation of deoxybenzoins, synonymous with unfriendly reagents and conditions. In the last 15 years or so, photocatalysis has taken the world of synthetic organic chemistry by a remarkable renaissance. It is fair to say now that everybody loves the light and photoredox chemistry has opened a new gateway to organic chemists towards milder, more simpler alternatives to the previously available methods, allowing access to many sensitive reactions and products. In this review, we present the readers with the photochemical synthesis of a variety of 1,n-dicarbonyls. Diverse photocatalytic pathways to these fascinating molecules have been discussed, placing special emphasis on the mechanisms, giving the reader an opportunity to find all these significant developments in one place.
PubMed: 37335758
DOI: 10.1002/chem.202301147 -
Leveraging the metacoupling framework for sustainability science and global sustainable development.National Science Review Jul 2023Sustainability science seeks to understand human-nature interactions behind sustainability challenges, but has largely been place-based. Traditional sustainability... (Review)
Review
Sustainability science seeks to understand human-nature interactions behind sustainability challenges, but has largely been place-based. Traditional sustainability efforts often solved problems in one place at the cost of other places, compromising global sustainability. The metacoupling framework offers a conceptual foundation and a holistic approach to integrating human-nature interactions within a place, as well as between adjacent places and between distant places worldwide. Its applications show broad utilities for advancing sustainability science with profound implications for global sustainable development. They have revealed effects of metacoupling on the performance, synergies, and trade-offs of United Nations Sustainable Development Goals (SDGs) across borders and across local to global scales; untangled complex interactions; identified new network attributes; unveiled spatio-temporal dynamics and effects of metacoupling; uncovered invisible feedbacks across metacoupled systems; expanded the nexus approach; detected and integrated hidden phenomena and overlooked issues; re-examined theories such as Tobler's First Law of Geography; and unfolded transformations among noncoupling, coupling, decoupling, and recoupling. Results from the applications are also helpful to achieve SDGs across space, amplify benefits of ecosystem restoration across boundaries and across scales, augment transboundary management, broaden spatial planning, boost supply chains, empower small agents in the large world, and shift from place-based to flow-based governance. Key topics for future research include cascading effects of an event in one place on other places both nearby and far away. Operationalizing the framework can benefit from further tracing flows across scales and space, uplifting the rigor of causal attribution, enlarging toolboxes, and elevating financial and human resources. Unleashing the full potential of the framework will generate more important scientific discoveries and more effective solutions for global justice and sustainable development.
PubMed: 37305165
DOI: 10.1093/nsr/nwad090 -
Frontiers in Psychology 2023In the mobile era, place attachment among rural migrants and returnees has become dynamic and diversified. However, research on place attachment to native place among...
In the mobile era, place attachment among rural migrants and returnees has become dynamic and diversified. However, research on place attachment to native place among rural migrants and returnees is limited. The focus of previous research has primarily been on the destination place attachment of rural migrants, which makes it difficult to gain a comprehensive understanding of the place attachment among both rural migrants and returnees. This study aims to investigate the state of place attachment to both native and destination places among rural migrants and returnees originating from the same birthplace. It explores their place attachment after migrating from rural areas to cities. A quantitative research approach was adopted, garnering questionnaire responses from 274 rural migrants and returnees, all born in Shuangfeng County, Hunan Province. The questionnaire encompassed a Likert scale for measuring place attachment, as well as sociodemographic statistical information. Exploratory factor analysis and confirmatory factor analysis were conducted to ascertain the reliability and validity of the questionnaire. Based on the factor scores of place attachment to both places from migrants and returnees, a two-step cluster analysis identified three types of migrants and two types of returnees. Chi-square tests revealed significant differences among migrants in terms of property ownership, educational level, marital status, presence of children, age at departure, and time away from hometown. The study discovered that, regardless of being a migrant or returnee, the overall attachment to hometown was stronger than that to the current or previously inhabited city. In the context of existing literature primarily concerned with the integration of rural migrants into urban areas, this paper offers a fresh research perspective, highlighting the significance of emotional ties to one's hometown for rural migrants. The findings of this paper provide direction and a theoretical basis for rural areas to attract return migration and for urban regions to facilitate the integration of migrants.
PubMed: 38090189
DOI: 10.3389/fpsyg.2023.1279679 -
Journal of Pain and Symptom Management May 2024The place where people are cared towards the end of their life and die is a complex phenomenon, requiring a deeper understanding. Honoring preferences is critical for... (Meta-Analysis)
Meta-Analysis Review
CONTEXT
The place where people are cared towards the end of their life and die is a complex phenomenon, requiring a deeper understanding. Honoring preferences is critical for the delivery of high-quality care.
OBJECTIVES
In this umbrella review we examine and synthesize the evidence regarding preferences about place of end-of-life care and death of patients with life-threatening illnesses and their families.
METHODS
Following the Joanna Briggs Institute methodology, we conducted a comprehensive search for systematic reviews in PsycINFO, MEDLINE, EMBASE, CINAHL, Epistemonikos, and PROSPERO without language restrictions.
RESULTS
The search identified 15 reviews (10 high-quality, three with meta-analysis), covering 229 nonoverlapping primary studies. Home is the most preferred place of end-of-life care for both patients (11%-89%) and family members (23%-84%). It is also the most preferred place of death (patient estimates from two meta-analyses: 51%-55%). Hospitals and hospice/palliative care facilities are preferred by substantial minorities. Reasons and factors affecting preferences include illness-related, individual, and environmental. Differences between preferred places of care and death are underexplored and the evidence remains inconclusive about changes over time. Congruence between preferred and actual place of death ranges 21%-100%, is higher in studies since 2004 and a meta-analysis shows noncancer patients are at higher risk of incongruence than cancer patients (OR 1.23, 95% CI: 1.01-1.49, I2 = 62%).
CONCLUSION
These findings are a crucial starting point to address gaps and enhance strategies to align care with patient and family preferences. To accurately identify patient and family preferences is an important opportunity to change their lives positively.
Topics: Humans; Palliative Care; Systematic Reviews as Topic; Terminal Care; Hospice Care; Family; Patient Preference; Attitude to Death
PubMed: 38237790
DOI: 10.1016/j.jpainsymman.2024.01.014 -
Journal of Comparative Physiology. A,... Jul 2023Panoramic views offer information on heading direction and on location to visually navigating animals. This review covers the properties of panoramic views and the... (Review)
Review
Panoramic views offer information on heading direction and on location to visually navigating animals. This review covers the properties of panoramic views and the information they provide to navigating animals, irrespective of image representation. Heading direction can be retrieved by alignment matching between memorized and currently experienced views, and a gradient descent in image differences can lead back to the location at which a view was memorized (positional image matching). Central place foraging insects, such as ants, bees and wasps, conduct distinctly choreographed learning walks and learning flights upon first leaving their nest that are likely to be designed to systematically collect scene memories tagged with information provided by path integration on the direction of and the distance to the nest. Equally, traveling along routes, ants have been shown to engage in scanning movements, in particular when routes are unfamiliar, again suggesting a systematic process of acquiring and comparing views. The review discusses what we know and do not know about how view memories are represented in the brain of insects, how they are acquired and how they are subsequently used for traveling along routes and for pinpointing places.
Topics: Bees; Animals; Homing Behavior; Learning; Insecta; Ants; Wasps
PubMed: 36515743
DOI: 10.1007/s00359-022-01599-2