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The Journal of Dermatological Treatment Dec 2023We aimed to systematically evaluate the efficacy and safety of adalimumab biosimilar agents in the treatment of moderate-to-severe plaque psoriasis, in order to provide... (Meta-Analysis)
Meta-Analysis Review
PURPOSE
We aimed to systematically evaluate the efficacy and safety of adalimumab biosimilar agents in the treatment of moderate-to-severe plaque psoriasis, in order to provide evidence-based reference data for clinical medicine.
MATERIALS AND METHODS
Five databases were searched by electronic retrieval: PubMed, Embase, Cochrane Library, WanFang and CNKI (China National Knowledge Internet). The retrieval period was from the establishment of each database up to April 2022. Randomized controlled trials (RCTs) on adalimumab biosimilar agents compared with their reference agents in the treatment of moderate-to-serve plague psoriasis were included. A meta-analysis using RevMan software was applied to 8 RCTs involving 2589 patients.
RESULTS
After 16 weeks of medication, there was no significant difference in the response rates of adalimumab biosimilar agents and their reference agents defined as a decrease in the Psoriasis Area and Severity Index (PASI) of ≥75% (PASI 75) ( > 0.05), or in the PASI 50, PASI 90 and PASI 100 measures ( > 0.05). After 16 weeks and 24 weeks of medication, there was no significant difference in the incidence rate of serious adverse events (SAEs) between adalimumab biosimilar agents and their reference agents ( > 0.05). After 16 weeks, 24 weeks and 51 weeks of medication, there was no significant difference in withdrawal rate due to SAEs, treatment-emergent adverse events and adverse events of special interest between adalimumab biosimilar agents and their reference agents ( > 0.05).
CONCLUSION
These findings suggest that biosimilar agents of adalimumab have an overall efficacy and safety profile for psoriasis comparable to those of their reference agents.
Topics: Humans; Adalimumab; Biosimilar Pharmaceuticals; China; Databases, Factual; Psoriasis
PubMed: 37608703
DOI: 10.1080/09546634.2023.2249145 -
Advanced Materials (Deerfield Beach,... Dec 2023Bacterial pneumonia is the leading cause of death worldwide among all infectious diseases. However, currently available vaccines against fatal bacterial lung infections,...
Bacterial pneumonia is the leading cause of death worldwide among all infectious diseases. However, currently available vaccines against fatal bacterial lung infections, e.g., pneumonic plague, are accompanied by limitations, including insufficient antigen-adjuvant co-delivery and inadequate immune stimulation. Therefore, there is an urgent requirement to develop next-generation vaccines to improve the interaction between antigen and adjuvant, as well as enhance the effects of immune stimulation. This study develops a novel amino-decorated mesoporous manganese silicate nanoparticle (AMMSN) loaded with rF1-V10 (rF1-V10@AMMSN) to prevent pneumonic plague. These results suggest that subcutaneous immunization with rF1-V10@AMMSN in a prime-boost strategy induces robust production of rF1-V10-specific IgG antibodies with a geometric mean titer of 315,844 at day 42 post-primary immunization, which confers complete protection to mice against 50 × LD of Yersinia pestis (Y. pestis) challenge via the aerosolized intratracheal route. Mechanistically, rF1-V10@AMMSN can be taken up by dendritic cells (DCs) and promote DCs maturation through activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway and production of type I interferon. This process results in enhanced antigen presentation and promotes rF1-V10-mediated protection against Y. pestis infection. This manganese-based nanoparticle vaccine represents a valuable strategy for combating fatal bacterial pneumonia.
Topics: Mice; Animals; Plague; Plague Vaccine; Nanovaccines; Manganese; Antigens, Bacterial; Vaccines; Pneumonia, Bacterial; Adjuvants, Immunologic; Bacterial Proteins
PubMed: 37784226
DOI: 10.1002/adma.202304514 -
Scientific Reports Nov 2023Leptospirosis, a formidable zoonotic threat spawned by Leptospira, plagues tropical and subtropical realms. This study delves deep into tropical Indian states, namely,...
Leptospirosis, a formidable zoonotic threat spawned by Leptospira, plagues tropical and subtropical realms. This study delves deep into tropical Indian states, namely, Kerala, Gujarat, Karnataka, Maharashtra, and Tamil Nadu, unraveling the dynamics of leptospirosis through a comprehensive mathematical model that embraces temperature-driven growth rates of Leptospira. Sensitivity analysis and parameter estimation techniques fortified the model's accuracy, unraveling the factors shaping leptospirosis transmission. Notably, the numerical results highlight the significant impact of rainfall, fishing, climate, mining, agriculture, and cattle farming on leptospirosis prevalence in the endemic states of India. Finally, our study urges resolute preventive action to control and combat leptospirosis in India. Strengthening surveillance, impactful awareness campaigns, targeted interventions, and improved hygiene practices among high-risk individuals are vital. Embracing these proactive strategies will alleviate the burden of leptospirosis and enhance public health in India and beyond.
Topics: Humans; Animals; Cattle; India; Leptospirosis; Leptospira; Public Health; Climate
PubMed: 37957218
DOI: 10.1038/s41598-023-46326-2 -
Food Chemistry Aug 2023Pesticides are a suitable tool for controlling plagues and disease vectors. However, their inappropriate use allows for contamination of the environment, soil, water,... (Review)
Review
Pesticides are a suitable tool for controlling plagues and disease vectors. However, their inappropriate use allows for contamination of the environment, soil, water, and foods. Carbamates and dithiocarbamates pesticides present accumulative effects in the human body resulting in hormonal, neurological and reproductive disorders, and some are still suspected or proven to give carcinogenic or mutagenic effects. This review provides a current electroanalytical approach in the carbamates and dithiocarbamates determination, showing the use of voltammetric techniques such as amperometry, cyclic and linear scan, differential pulse, and square wave voltammetry, indicating their advantages, disadvantages, and perspectives in electroanalytical detection of carbamates and dithiocarbamates in natural water and foods. Also are reported the different materials used in the preparation of working electrodes since their choice has an important impact on the success of the analytical applications, resulting in suitable sensitivity, selectivity, stability, and robustness.
Topics: Humans; Carbamates; Pesticides; Water; Electrodes
PubMed: 36944296
DOI: 10.1016/j.foodchem.2023.135900 -
Frontiers in Immunology 2024Despite major global efforts to eliminate tuberculosis, which is caused by (Mtb), this disease remains as a major plague of humanity. Several factors associated with... (Review)
Review
Despite major global efforts to eliminate tuberculosis, which is caused by (Mtb), this disease remains as a major plague of humanity. Several factors associated with the host and Mtb interaction favor the infection establishment and/or determine disease progression. The Early Secreted Antigenic Target 6 kDa (ESAT-6) is one of the most important and well-studied mycobacterial virulence factors. This molecule has been described to play an important role in the development of tuberculosis-associated pathology by subverting crucial components of the host immune responses. This review highlights the main effector mechanisms by which ESAT-6 modulates the immune system, directly impacting cell fate and disease progression.
Topics: Humans; Antigens, Bacterial; Bacterial Proteins; Tuberculosis; Mycobacterium tuberculosis; Disease Progression
PubMed: 38633252
DOI: 10.3389/fimmu.2024.1383098 -
Indian Journal of Ophthalmology Mar 2024Selective laser trabeculoplasty (SLT) has experienced a resurgence in interest, primarily driven by promising findings from the Laser in Glaucoma and Ocular Hypertension... (Review)
Review
Selective laser trabeculoplasty (SLT) has experienced a resurgence in interest, primarily driven by promising findings from the Laser in Glaucoma and Ocular Hypertension Trial. By offering SLT as an initial drug-free treatment option, we may be able to thwart issues such as adherence and persistence that plague our current medical management protocols. In this comprehensive narrative review, we delve into the current body of literature that explores the utility of SLT across a wide spectrum of scenarios and glaucoma subtypes. We present evidence that provides valuable insight into the efficacy and benefits of SLT, positioning it as a viable option in the management of glaucoma. Careful consideration of the associated risks and challenges is also necessary for successful adoption into clinical practice. Despite the ample evidence supporting SLT's efficacy, some questions remain regarding its long-term effects and the potential need for retreatment. This review aims to shed light on these aspects to guide clinicians in making informed decisions and tailoring treatment plans to individual patient needs. This review also provides the readers with a bird's eye view of the potential impact of SLT and adds clarity to the various therapeutic protocols that one can follow to ensure optimal clinical outcomes for our patients.
Topics: Humans; Trabeculectomy; Laser Therapy; Glaucoma; Decision Making; Lactic Acid
PubMed: 38421290
DOI: 10.4103/IJO.IJO_2104_23 -
Human Vaccines & Immunotherapeutics Aug 2023is a gram-negative bacterium that causes plague in animals and humans. Depending on the route of disease transmission, the bacterium can cause an acute, often fatal...
is a gram-negative bacterium that causes plague in animals and humans. Depending on the route of disease transmission, the bacterium can cause an acute, often fatal disease that has a narrow window for treatment with antibiotics. Additionally, antibiotic resistant strains have been identified, emphasizing the need for novel treatments. Antibody therapy is an appealing option that can direct the immune system to clear bacterial infections. Advances in biotechnology have made both engineering and producing antibodies easier and more affordable. In this study, two screening assays were optimized to evaluate the ability of antibodies to promote phagocytosis of by macrophages and to induce a cytokine signature in vitro that may be predictive of protection in vivo. We evaluated a panel of 21 mouse monoclonal antibodies targeting either the anti-phagocytic capsule F1 protein or the LcrV antigen, which is part of the type 3 secretion system that facilitates translocation of virulence factors into the host cell, using two functional assays. Anti-F1 and anti-LcrV monoclonal antibodies both increased bacterial uptake by macrophages, with greater uptake observed in the presence of antibodies that were protective in the mouse pneumonic plague model. In addition, the protective anti-F1 and anti-LcrV antibodies produced unique cytokine signatures that were also associated with in vivo protection. These antibody-dependent characteristics from in vitro functional assays will be useful in down-selecting efficacious novel antibodies that can be used for treatment of plague.
Topics: Mice; Humans; Animals; Yersinia pestis; Plague; Antibodies, Monoclonal; Antigens, Bacterial; Antibodies, Bacterial; Cytokines; Plague Vaccine; Pore Forming Cytotoxic Proteins
PubMed: 37289480
DOI: 10.1080/21645515.2023.2216085 -
Biochimica Et Biophysica Acta.... Oct 2023Autophagy maintains cellular homeostasis and plays a crucial role in managing pathological conditions including ischemic myocardial injury leading to heart failure (HF).... (Review)
Review
Autophagy maintains cellular homeostasis and plays a crucial role in managing pathological conditions including ischemic myocardial injury leading to heart failure (HF). Despite treatments, no intervention can replace lost cardiomyocytes. Stem cell therapy offers potential for post-myocardial infarction repair but struggles with poor cell retention due to immune rejection. In the search for effective therapies, stem cell-derived extracellular vesicles (EVs), especially exosomes, have emerged as promising tools. These tiny bioactive molecule carriers play vital roles in intercellular communication and tissue engineering. They offer numerous therapeutic benefits including modulating immune responses, promoting tissue repair, and boosting angiogenesis. Additionally, biomaterials provide a conducive 3D microenvironment for cell, exosome, and biomolecule delivery, and enhance heart muscle strength, making it a comprehensive cardiac repair strategy. In this regard, the current review delves into the intricate application of extracellular vesicles (EVs) and biomaterials for managing autophagy in the heart muscle during cardiac injury. Central to our investigation is the exploration of how these elements interact within the context of cardiac repair and regeneration. Additionally, this review also casts light on the formidable challenges that plague this field, such as the issues of safety, efficacy, controlled delivery, and acceptance of these therapeutic strategies for effective clinical translation. Addressing these challenges is crucial for unlocking the full therapeutic potential of EV and biomaterial-based therapies and ensuring their successful translation from bench to bedside.
Topics: Humans; Exosomes; Biocompatible Materials; Myocytes, Cardiac; Stem Cells; Heart Injuries; Autophagy
PubMed: 37437748
DOI: 10.1016/j.bbadis.2023.166806 -
Trends in Pharmacological Sciences Oct 2023Since May 2022, mpox virus (MPXV) has attracted considerable attention due to a multi-country outbreak. Marked differences in epidemiology, transmission, and pathology... (Review)
Review
Since May 2022, mpox virus (MPXV) has attracted considerable attention due to a multi-country outbreak. Marked differences in epidemiology, transmission, and pathology between the 2022 global mpox outbreak (clade IIb) and classical mpox disease, endemic in Africa (clades I and IIa) have been highlighted. MPXV genome analysis has identified the genomic changes characterizing clade IIb and the drivers of MPXV rapid evolution. Although mpox cases have largely declined, MPXV cryptic transmission and microevolution continues, which may lead to an MPXV of unpredictable pathogenicity. Vaccines and antivirals developed against variola virus, the agent that caused the extinguished plague smallpox, have been used to contain the 2022 mpox outbreak. In this review article, recent findings on MPXV origin and evolution and relevant models able to recapitulate differences in MPXV pathogenicity, which are important for drug and vaccine development, are discussed.
Topics: Humans; Virulence; Monkeypox virus; Mpox (monkeypox); Drug Discovery; Vaccine Development
PubMed: 37673695
DOI: 10.1016/j.tips.2023.08.003