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Frontiers in Public Health 2023Pesticides are any mix of ingredients and substances used to eliminate or control unwanted vegetable or animal species recognized as plagues. Its use has been discussed... (Review)
Review
Pesticides are any mix of ingredients and substances used to eliminate or control unwanted vegetable or animal species recognized as plagues. Its use has been discussed in research due to the scarcity of strong scientific evidence about its health effects. International literature is still insufficient to establish a global recommendation through public policy. This study aims to explore international evidence of the presence of pesticides in urine samples from children and their effects on health through a scoping review based on the methodology described by Arksey and O'Malley. The number of articles resulting from the keyword combination was 454, and a total of 93 manuscripts were included in the results and 22 were complementary. Keywords included in the search were: urinary, pesticide, children, and childhood. Children are exposed to pesticide residues through a fruit and vegetable intake environment and household insecticide use. Behavioral effects of neural damage, diabetes, obesity, and pulmonary function are health outcomes for children that are commonly studied. Gas and liquid chromatography-tandem mass spectrometry methods are used predominantly for metabolite-pesticide detection in urine samples. Dialkylphosphates (DAP) are common in organophosphate (OP) metabolite studies. First-morning spot samples are recommended to most accurately characterize OP dose in children. International evidence in PubMed supports that organic diets in children are successful interventions that decrease the urinary levels of pesticides. Several urinary pesticide studies were found throughout the world's population. However, there is a knowledge gap that is important to address (public policy), due to farming activities that are predominant in these territories.
Topics: Animals; Pesticides; Insecticides; Agriculture; Chromatography, Liquid; Fruit
PubMed: 37711246
DOI: 10.3389/fpubh.2023.1227337 -
ACS Sensors Jul 2023Although there is a growing demand for new sensors for environmental monitoring, biofouling continues to plague current sensors and sensing networks. As soon as a sensor... (Review)
Review
Although there is a growing demand for new sensors for environmental monitoring, biofouling continues to plague current sensors and sensing networks. As soon as a sensor is placed in water, the formation of a biofilm begins. Once a biofilm is established, reliable measurements are often no longer possible. Although current biofouling mitigation strategies can slow the biofouling process, a biofilm will eventually develop on or near the sensing surface. While antibiofouling strategies are being continuously developed, the complexity of the biofilm community structure and the surrounding environment means that there is unlikely to be a single solution that will minimize biofilms on all environmental sensors. Thus, antibiofouling research often focuses on optimizing a specific biofilm mitigation approach for a given sensor, application, and environmental condition. While this is practical from the standpoint of a sensor developer, it makes the comparison of different mitigation strategies difficult. In this Perspective, we discuss the application of different biofouling mitigation strategies to sensing and then explore the need for the sensor community to adopt standard protocols to increase the comparability of the biofouling mitigation approaches and help sensor developers identify the most appropriate strategy for their system.
Topics: Biofouling; Biofilms; Water
PubMed: 37409449
DOI: 10.1021/acssensors.3c00961 -
Comparative Immunology, Microbiology... Sep 2023The relevance of the problem of the stated topic lies in the fact that the causative agent of the plague infection demonstrates high survival while maintaining high...
The relevance of the problem of the stated topic lies in the fact that the causative agent of the plague infection demonstrates high survival while maintaining high virulence in the territories, which are enzootic in terms of the plague. The study aimed to investigate the geographic distribution and genetic diversity of the plague pathogen in endemic regions through molecular genetic research. The work included the results of laboratory studies of 3058 samples, including soil - 1154, burrow substrates - 549, the contents of the feeding chamber - 349, bone remains - 18, biological objects - 988 samples of sera and suspensions from carriers and vectors of plague infection collected from 14 autonomous plague foci of Kazakhstan for the period 2021-2022. The leading method in the study was a laboratory experiment, thanks to which, using a new advanced technology on a microbiological analyser VITEK 2 COMPACT 30, it was possible to study pathogenic and non-pathogenic strains of the genus Yersinia isolated during field experiment. As a result of experimental work, it was shown that during a long inter-epizootic period, the plague pathogen can persist in the soil in symbiosis with soil microorganisms, and in this area, it chooses soil with a low-quality index of 10 points, where soils with a low total microbial number and species landscape prevail.
Topics: Animals; Plague; Yersinia pestis; Kazakhstan; Soil; Virulence
PubMed: 37523875
DOI: 10.1016/j.cimid.2023.102025 -
Heliyon May 2024No licensed vaccine exists for the lethal plague and yersiniosis. Therefore, a combination of recombinant YopE and LcrV antigens of was evaluated for its vaccine...
No licensed vaccine exists for the lethal plague and yersiniosis. Therefore, a combination of recombinant YopE and LcrV antigens of was evaluated for its vaccine potential in a mouse model. YopE and LcrV in formulation with alum imparted a robust humoral immune response, with isotyping profiles leaning towards the IgG1 and IgG2b subclasses. It was also observed that a significantly enhanced expression of IFN-γ, TNF-α, IL-6, IL-2, and IL-1β from the splenic cells of vaccinated mice, as well as YopE and LcrV-explicit IFN-γ eliciting T-cells. The cocktail of YopE + LcrV formulation conferred complete protection against 100 LD infection, while individually, LcrV and YopE provided 80 % and 60 % protection, respectively. Similarly, the YopE + LcrV vaccinated animal group had significantly lower colony forming unit (CFU) counts in the spleen and blood compared to the groups administered with YopE or LcrV alone when challenged with and . Histopathologic evidence reinforces these results, indicating the YopE + LcrV formulation provided superior protection against acute lung injury as early as day 3 post-challenge. In conclusion, the alum-adjuvanted YopE + LcrV is a promising vaccine formulation, eliciting a robust antibody response including a milieu of pro-inflammatory cytokines and T-cell effector functions that contribute to the protective immunity against infections. YopE and LcrV, conserved across all three human-pathogenic Yersinia species, provide cross-protection. Therefore, our current vaccine (YopE + LcrV) targets all three pathogens: , , and . However, the efficacy should be tested in other higher mammalian models.
PubMed: 38826713
DOI: 10.1016/j.heliyon.2024.e31446 -
Nanoscale Jan 2024The development of high-performing cathode materials for aqueous zinc-ion batteries (ZIBs) is highly important for the future large-scale energy storage. Owing to the... (Review)
Review
The development of high-performing cathode materials for aqueous zinc-ion batteries (ZIBs) is highly important for the future large-scale energy storage. Owing to the distinctive framework structure, diversity of valences, and high electrochemical activity, spinel materials have been widely investigated and used for aqueous ZIBs. However, the stubborn issues of low electrical conductivity and sluggish kinetics plague their smooth applications in aqueous ZIBs, which stimulates the development of effective strategies to address these issues. This review highlights the recent advances of spinel-based cathode materials that include the configuration of aqueous ZIBs and corresponding reaction mechanisms. Subsequently, the classifications of spinel materials and their properties are also discussed. Then, the review mainly summarizes the effective strategies for elevating their electrochemical performance, including their morphology and structure design, defect engineering, heteroatom doping, and coupling with a conductive support. In the final section, several sound prospects in this fervent field are also proposed for future research and applications.
PubMed: 38117187
DOI: 10.1039/d3nr05225g -
Microbial Biotechnology Dec 2023The United Nations heralds a world population exponential increase exceeding 9.7 billion by 2050. This poses the challenge of covering the nutritional needs of an... (Review)
Review
The United Nations heralds a world population exponential increase exceeding 9.7 billion by 2050. This poses the challenge of covering the nutritional needs of an overpopulated world by the hand of preserving the environment. Extensive agriculture practices harnessed the employment of fertilizers and pesticides to boost crop productivity and prevent economic and harvest yield losses attributed to plagues and diseases. Unfortunately, the concomitant hazardous effects stemmed from such agriculture techniques are cumbersome, that is, biodiversity loss, soils and waters contaminations, and human and animal poisoning. Hence, the so-called 'green agriculture' research revolves around designing novel biopesticides and plant growth-promoting bio-agents to the end of curbing the detrimental effects. In this field, microbe-plant interactions studies offer multiple possibilities for reshaping the plant holobiont physiology to its benefit. Along these lines, bacterial extracellular membrane vesicles emerge as an appealing molecular tool to capitalize on. These nanoparticles convey a manifold of molecules that mediate intricate bacteria-plant interactions including plant immunomodulation. Herein, we bring into the spotlight bacterial extracellular membrane vesicle engineering to encase immunomodulatory effectors into their cargo for their application as biocontrol agents. The overarching goal is achieving plant priming by deploying its innate immune responses thereby preventing upcoming infections.
Topics: Humans; Plant Development; Plants; Agriculture; Soil; Crop Production; Antigens, Bacterial
PubMed: 37530752
DOI: 10.1111/1751-7915.14323 -
PLOS Global Public Health 2023Bubonic plague, transmitted by infected flea bites, is the most common form of plague and, left untreated, can progress to the pneumonic form, which is highly...
Bubonic plague, transmitted by infected flea bites, is the most common form of plague and, left untreated, can progress to the pneumonic form, which is highly contagious. Surveillance focusing on reservoir and vector is considered to be the main approach to prevent plague. Common rodent control methods include the use of rodenticide and snap traps but, in a plague context, the dispersal of fleas from killed animals may pose a serious health threat. Therefore, there is a need for strategies which address reservoir and vector control. The aim of this study was to assess the effects of combination of reservoir and vector control through community-based surveillance. Activities were implemented by local previously trained community agents in two active plague foci in Madagascar. Kartman bait stations containing rodenticide and insecticide were placed indoors while live traps were set outdoors. Small mammals were identified and killed with their fleas. Effectiveness of control measures was evaluated by comparison of plague incidence two years before and after intervention using data on reported human cases of plague from the Central Laboratory of Plague. A total of 4,302 small mammals were captured, with the predominance of the black rat Rattus rattus. Our results found a reduction in plague incidence in the treated site for at least two years after treatment. Community-based interventions played an important role in reducing contact between humans-rodents-fleas. Our study confirms the importance of animal surveillance during the low plague transmission season. The combination of reservoir and vector control with community involvement may be effective at reducing the risks of plague spillover to humans. The strategy of using Kartman bait stations indoors with live traps outdoors can be used to refine proactive plague prevention, however, due to the potential development of resistance to pesticides in flea and rat populations, overuse should be considered.
PubMed: 38109297
DOI: 10.1371/journal.pgph.0002211 -
Current Problems in Cardiology Jan 2024This short report underlines the importance of collaboration and communication among scientists. The ideals of progress in medicine and in the care of suffering people... (Review)
Review
This short report underlines the importance of collaboration and communication among scientists. The ideals of progress in medicine and in the care of suffering people have represented continuous stimuli allowing to overcome prejudices, religious and political differences. The modern concepts of blood circulation have been established through a close collaboration and exchanges of ideas among scientists coming from different countries, different religious and political backgrounds. In those days Europe was theater of continuous wars based on political and religious contrasts. There were continuous outbreaks of Plague in several countries. Religious contrasts occurred inside the Christianity and between the Christianity and Islam; contrasts which were based on theological disputes associated with economic and expansionist ambitions, resulting in extreme and rigid religious orthodoxy. Despite these difficulties, medical scientists collaborated overcoming the close boundaries of everyday general confrontations. The ambition for advancement in science and for progress with the potential consequent common good inspired a general sense of community and drove to overcome the boundaries based on contrasts. Science, scientific thinking, dedication to research and to improve knowledge represented yesterday and continue to represent today the common ambition to break down cultural, religious and economic walls. The generosity of science is superior to the superstition of contrasts and arrogance. A message we can bring from the past back to the future and back to today.
Topics: Humans; Christianity; Cardiovascular Physiological Phenomena; Italy
PubMed: 37634672
DOI: 10.1016/j.cpcardiol.2023.102045 -
Animals : An Open Access Journal From... Aug 2023Climate warming and human activities impact the expansion and contraction of species distribution. The Himalayan marmot () is a unique mammal and an ecosystem engineer...
Climate warming and human activities impact the expansion and contraction of species distribution. The Himalayan marmot () is a unique mammal and an ecosystem engineer in the Qinghai-Tibet Plateau (QTP). This pest aggravates grassland degradation and is a carrier and transmitter of plagues. Therefore, exploring the future distribution of Himalayan marmots based on climate change and human activities is crucial for ecosystem management, biodiversity conservation, and public health safety. Here, a maximum entropy model was explored to forecast changes in the distribution and centroid migration of the Himalayan marmot in the 2050s and 2070s. The results implied that the human footprint index (72.80%) and altitude (16.40%) were the crucial environmental factors affecting the potential distribution of Himalayan marmots, with moderately covered grassland being the preferred habitat of the Himalayan marmot. Over the next 30-50 years, the area of suitable habitat for the Himalayan marmot will increase slightly and the distribution center will shift towards higher latitudes in the northeastern part of the plateau. These results demonstrate the influence of climate change on Himalayan marmots and provide a theoretical reference for ecological management and plague monitoring.
PubMed: 37684999
DOI: 10.3390/ani13172736