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Advanced Healthcare Materials Feb 2024Osteoarthritis (OA) is a prevalent, chronic degenerative disease that affects people worldwide. It is characterized by the destruction of cartilage and inflammatory...
Osteoarthritis (OA) is a prevalent, chronic degenerative disease that affects people worldwide. It is characterized by the destruction of cartilage and inflammatory reactions. High levels of reactive oxygen species (ROS) cause oxidative stress, which damages lipids, proteins, and DNA, leading to cell damage and death. Furthermore, ROS also induces the production of inflammatory cytokines and cell chemotaxis, further worsening the inflammatory response and damaging cartilage resulted in limited movement. Herein, this work reports a dual-functional injectable hydrogel, which can help inhibit inflammation by scavenging ROS and provide lubrication to reduce wear and tear on the joints. To create the hydrogel, 3-aminophenylboronic acid modified hyaluronic acid is synthesized, then which is crosslinked with hydroxyl-containing polyvinyl alcohol (PVA) to construct a dual dynamic covalent crosslinked hydrogel oHA-PBA-PVA gel, Gel (HPP). The hydrogel mentioned here possesses a unique bond structure that allows it to be injected, self-heal, and provide lubrication. This innovative approach offers a new possibility for treating osteoarthritis by combining anti-inflammatory and lubrication effects.
Topics: Humans; Hydrogels; Reactive Oxygen Species; Cartilage, Articular; Osteoarthritis; Hyaluronic Acid; Inflammation; Polyvinyl Alcohol
PubMed: 37988224
DOI: 10.1002/adhm.202302551 -
Survey of Ophthalmology 2024Polyvinyl pyrrolidone or povidone-iodine (PVP-I) is a water-soluble complex formed by the combination of iodine and a water-soluble polymer, polyvinyl pyrrolidone. This... (Review)
Review
Polyvinyl pyrrolidone or povidone-iodine (PVP-I) is a water-soluble complex formed by the combination of iodine and a water-soluble polymer, polyvinyl pyrrolidone. This complex exerts bactericidal, fungicidal, and virucidal action by gradually releasing free iodine at the site of application to react with pathogens. In ophthalmology, PVP-I is used as a disinfectant and antiseptic agent for preoperative preparation of the skin and mucous membranes and for treating contaminated wounds. PVP-I has been shown to reduce effectively the risk of endophthalmitis in various ocular procedures, including cataract surgery and intravitreal injections; however, it has also been used in the treatment of conjunctivitis, keratitis, and endophthalmitis, with promising results especially in low-resource situations. PVP-I has been associated with complications such as postoperative eye pain, persistent corneal epithelial defects, ocular inflammation, and an attendant risk of keratitis. In cases of poor PVP-I tolerance, applying PVP-I at lower concentrations or using alternative antiseptics such as chlorhexidine should be considered. We provide an update on the efficacy of PVP-I in the prophylaxis and treatment of conjunctivitis, keratitis, and endophthalmitis and a comprehensive analysis of the current literature regarding the use of PVP-I in the management of these ocular conditions. Also, PVP-I-related adverse effects and toxicities and its alternatives are discussed. The goal is to present a thorough evaluation of the available evidence and to offer practical recommendations for clinicians regarding the therapeutic usage of PVP-I in ophthalmology.
Topics: Humans; Povidone-Iodine; Ophthalmology; Polyvinyls; Anti-Infective Agents, Local; Iodine; Cataract Extraction; Endophthalmitis; Povidone; Conjunctivitis; Keratitis; Water
PubMed: 37944600
DOI: 10.1016/j.survophthal.2023.11.002 -
International Journal of Biological... Jul 2023Hydrogels is a hydrophilic, cross-linked polymer of three-dimensional network structures. The application of hydrogels prepared from a single polymer in the biomedical... (Review)
Review
Hydrogels is a hydrophilic, cross-linked polymer of three-dimensional network structures. The application of hydrogels prepared from a single polymer in the biomedical field has many drawbacks. The functional blend of polyvinyl alcohol and chitosan allows hydrogels to have better and more desirable properties than those produced from a single polymer, which is a good biomaterial for development and design. In this paper, we have reviewed the progress in the application of polyvinyl alcohol/chitosan composite hydrogels in various medical fields, the different cross-linking agents and cross-linking methods, and the research progress in the optimization of composite hydrogels for their subsequent wide range of biomedical applications.
Topics: Chitosan; Polyvinyl Alcohol; Biocompatible Materials; Hydrogels
PubMed: 37276897
DOI: 10.1016/j.ijbiomac.2023.125192 -
Waste Management (New York, N.Y.) Jul 2023The extensive production and consumption of plastics has resulted in significant plastic waste and plastic pollution. Polyvinyl chloride (PVC) waste has a high chlorine... (Review)
Review
The extensive production and consumption of plastics has resulted in significant plastic waste and plastic pollution. Polyvinyl chloride (PVC) waste has a high chlorine content and is the primary source of chlorine in the plastic waste stream, potentially generating hazardous chlorinated organic pollutants if treated improperly. This review discusses PVC synthesis, applications, and the current types and challenges of PVC waste management. Dechlorination is vital for the chemical recycling of PVC waste and PVC-containing plastic waste. We review dehydrochlorination and dechlorination mechanisms of PVC using thermal degradation and wet treatments, and summarize the recent progress in chemical treatments and dechlorination principles. This review provides readers with a comprehensive analysis of chemical recycling technologies for PVC waste and PVC-containing plastic waste to transform them into chemicals, fuels, feedstock, and value-added polymers.
Topics: Plastics; Chlorine; Polymers; Waste Management; Recycling; Polyvinyl Chloride
PubMed: 37196390
DOI: 10.1016/j.wasman.2023.05.012 -
Environmental Pollution (Barking, Essex... Oct 2023In light of the current COVID-19 pandemic caused by the virus SARS-CoV-2, there is an urgent need to identify and investigate the various pathways of transmission. In... (Review)
Review
In light of the current COVID-19 pandemic caused by the virus SARS-CoV-2, there is an urgent need to identify and investigate the various pathways of transmission. In addition to contact and aerosol transmission of the virus, this review investigated the possibility of its transmission via microplastics found in sewage. Wastewater-based epidemiological studies on the virus have confirmed its presence and persistence in both influent sewage as well as treated ones. The hypothesis behind the study is that the huge amount of microplastics, especially Polyvinyl Chloride and Polyethylene particles released into the open waters from sewage can become a good substrate and vector for microbes, especially Polyvinyl Chloride and Polyethylene particles, imparting stability to microbes and aiding the "plastisphere" formation. A bibliometric analysis highlights the negligence of research toward plastispheres and their presence in sewage. The ubiquity of microplastics and their release along with the virus into the open waters increases the risk of viral plastispheres. These plastispheres may be ingested by aquatic organisms facilitating reverse zoonosis and the commercial organisms already reported with accumulating microplastics through the food chain poses a risk to human populations as well. Reliance of high population density areas on open waters served by untreated sewage in economically less developed countries might bring back viral transmission.
Topics: Humans; SARS-CoV-2; Sewage; COVID-19; Microplastics; Wastewater; Plastics; Pandemics; Polyvinyl Chloride; Polyethylene
PubMed: 37437759
DOI: 10.1016/j.envpol.2023.122171 -
Molecules (Basel, Switzerland) May 2024In this work, we present the modification of a medical-grade silicone catheter with the -vinylimidazole monomer using the grafting-from method at room temperature and...
In this work, we present the modification of a medical-grade silicone catheter with the -vinylimidazole monomer using the grafting-from method at room temperature and induced by gamma rays. The catheters were modified by varying the monomer concentration (20-100 vol%) and the irradiation dose (20-100 kGy). Unlike the pristine material, the grafted poly(-vinylimidazole) chains provided the catheter with hydrophilicity and pH response. This change allowed for the functionalization of the catheters to endow it with antimicrobial features. Thus, the quaternization of amines with iodomethane and bromoethane was performed, as well as the immobilization of silver and ampicillin. The inhibitory capacity of these materials, functionalized with antimicrobial agents, was challenged against and strains, showing variable results, where loaded ampicillin was amply better at eliminating bacteria.
Topics: Escherichia coli; Staphylococcus aureus; Silicones; Imidazoles; Catheters; Microbial Sensitivity Tests; Polyvinyls; Anti-Infective Agents; Anti-Bacterial Agents; Ampicillin; Gamma Rays
PubMed: 38792087
DOI: 10.3390/molecules29102225 -
Materials Horizons May 2024Soft materials are widely used in tissue engineering, soft robots, wearable electronics, However, it remains a challenge to fabricate soft materials, such as hydrogels,...
Soft materials are widely used in tissue engineering, soft robots, wearable electronics, However, it remains a challenge to fabricate soft materials, such as hydrogels, with both high strength and toughness that are comparable to biological tissues. Inspired by the anisotropic structure of biological tissues, a novel solvent-exchange-assisted wet-stretching strategy is proposed to prepare anisotropic polyvinyl alcohol (PVA) hydrogels by tuning the macromolecular chain movement and optimizing the polymer network. The reinforcing and toughening mechanisms are found to be "macromolecule crystallization and nanofibril formation". These hydrogels exhibit excellent mechanical properties, such as extremely high fracture stress (12.8 ± 0.7 MPa) and fracture strain (1719 ± 77%), excellent modulus (4.51 ± 0.76 MPa), high work of fracture (134.47 ± 9.29 MJ m), and fracture toughness (305.04 kJ m) compared with other strong hydrogels and even natural tendons. In addition, excellent conductivity, strain sensing capability, water retention, freezing resistance, swelling resistance, and biocompatibility can also be achieved. This work provides a new and effective method to fabricate multifunctional anisotropic hydrogels with high tunable strength and toughness with potential applications in the fields of regenerative medicine, flexible sensors, and soft robotics.
Topics: Hydrogels; Polyvinyl Alcohol; Anisotropy; Tissue Engineering; Biocompatible Materials; Materials Testing; Humans; Animals; Biomimetic Materials; Stress, Mechanical
PubMed: 38376175
DOI: 10.1039/d3mh02032k -
Contact Lens & Anterior Eye : the... Oct 2023To evaluate if topical povidone iodine (alone (PI) or combined with dexamethasone (PI-DXM)) is superior to placebo for treating adenoviral conjunctivitis (AC). (Meta-Analysis)
Meta-Analysis Review
PURPOSE
To evaluate if topical povidone iodine (alone (PI) or combined with dexamethasone (PI-DXM)) is superior to placebo for treating adenoviral conjunctivitis (AC).
METHODS
A systematic review was performed according to Preferred Reporting Items for the Systematic Review and Meta-Analyses (PRISMA) Statement. An electronic search was made on PubMed, Embase and Cochrane Library. Randomized control studies that compared PI or PI-DXM with placebo were included. At least three researchers were involved in all phases. Primary outcomes were AC duration and the number of clinical resolutions during the first week. Secondary outcomes were conjunctival redness and serous discharge one week after starting treatment and the rate of AC complications.
RESULTS
Only five studies met the inclusion criteria. PI-DXM reduced the duration of the disease by 2.4 days (IC95% 4.09-0.71), however this result was based only in one study. PI and PI-DXM did not modify the probability of clinical resolution during the first week; relative risk (RR) = 1.77 (IC95% 0.63-4.96) and 1.70 (IC95% 0.67-4.36). The impact of PI on the probability of pseudomembranes could not be estimated. PI-DXM did not influence the risk of developing subepithelial infiltrates RR = 0.73 (IC95% 0.02-33.38).
CONCLUSIONS
At this time there is great uncertainty about the usefulness of PI on the course of adenoviral conjunctivitis. PI-DXM may have a small effect on AC duration. To make future reviews possible, it is important to standardize the way in which these results are reported. Futures studies should include etiological confirmation, unit of study (eyes vs patients) and report on those aspects that are more relevant for patient quality of life (duration of the disease, development of complications: pseudomembranes and subepithelial infiltrates).
Topics: Humans; Povidone-Iodine; Povidone; Quality of Life; Conjunctivitis
PubMed: 37380515
DOI: 10.1016/j.clae.2023.101873 -
Microstructural and micromechanical modeling of gum-gelatin-based soft tissue engineering scaffolds.International Journal of Biological... Jun 2023Oral and dental diseases, including periodontal disease, are among the most common conditions in the field of dentistry. The best treatment for this complication is the...
Oral and dental diseases, including periodontal disease, are among the most common conditions in the field of dentistry. The best treatment for this complication is the use of different polymers and multi-component biological tissue prepared through the freeze-drying technique. In this study, biocompatible and biodegradable polymers, namely polyvinyl alcohol (PVA) and gelatin (GN), were used for this purpose, along with Arabian gum-hydroxyapatite (HA) for its antibacterial properties. Arabian gum, with weight percentages of 0, 2, 4, and 6 wt%, was added to the polyvinyl alcohol-gelatin composition at -55 °C for 28 h in the freezer and 48 h at -45 °C under a pressure of 0.01 mbar. The resulting porous biological tissue, with four different ratios, was tested for mechanical and biological analysis in a physiological solution. Then, the samples were analyzed using a scanning electron microscope (SEM) and X-ray diffraction (XRD) technique to study the morphology and structure of the compounds before and after placement in biological solutions. Additionally, a wettability and antibacterial test were performed on the nanocomposite specimen. The SEM observations reveal that this method can create a porous structure with a porosity of about 30-50 μm with a spherical and circular architecture, which was further improved by the addition of gum, reducing the percentage of porosity and improving the tissue's tensile strength and elastic modulus. The porosity changes showed a decrease from 72 % to 60 %, and the tensile strength increased from 53.5 kPa to 76 kPa, resulting in an elastic modulus of 510 kPa to 800 kPa. The addition of gum also reduced the rate of destruction of the biological tissue, making it more suitable for soft tissue applications. The obtained results of the pH test showed that the concentration changes were neutral. The contact angle of water droplets was measured to determine hydrophilicity, indicating an improvement in hydrophilicity after the addition of gum. The results showed that the use of PVA and gelatin, due to their ductility and suitable mechanical properties, along with Arabian gum-HA, could accelerate the healing process of dental periodontal problems.
Topics: Tissue Engineering; Biocompatible Materials; Gelatin; Polyvinyl Alcohol; Tissue Scaffolds; Durapatite; Polymers; Anti-Bacterial Agents; Porosity
PubMed: 37086767
DOI: 10.1016/j.ijbiomac.2023.124544 -
The Journal of Contemporary Dental... Dec 2023The aim of the current study was to evaluate the dimensional accuracy of three various interocclusal recording materials.
AIM
The aim of the current study was to evaluate the dimensional accuracy of three various interocclusal recording materials.
MATERIALS AND METHODS
A total of 90 disc-shaped samples were prepared using polyether paste, wax, and polyvinyl siloxane material with the support of stainless steel die. For the purposes of this investigation, three frequently utilized interocclusal recording materials were chosen, and 30 samples from each material were prepared. Group I: Bite registration using polyether paste; Group II: Bite registration using wax; Group III: Bite registration using polyvinyl siloxane material. No samples were exposed to direct sunlight during storage and were kept at room temperature. Using a 10x universal measuring microscope, each sample disc was examined for the presence of horizontal and vertical lines inscripted in the die. For each of the samples, readings were taken at different time periods of 24, 48, and 72 hours.
RESULTS
After 24 hours, the less dimensional changes were found in polyether paste group (0.11 ± 0.07) followed by polyvinyl siloxane material group (0.19 ± 0.04) and wax group (0.25 ± 0.12). After 48 hours, the less dimensional changes were found in polyether paste group (0.34 ± 0.02) followed by polyvinyl siloxane material group (0.42 ± 0.01) and wax group (0.94 ± 0.12). After 72 hours, the least dimensional changes were found in polyether paste group (0.46 ± 0.14) followed by polyvinyl siloxane material group (0.92 ± 0.03) and wax group (1.14 ± 0.09).
CONCLUSION
The present study concluded that both the material and time factors had an impact on dimensional stability. The most dimensionally stable group was the polyether paste group, which was followed by the polyvinyl siloxane and wax material groups.
CLINICAL SIGNIFICANCE
Interocclusal recording material records the occlusal connection between real or artificial teeth for occlusal rehabilitation planning and for creating removable and fixed dentures. The creation of a clinically acceptable prosthesis is dependent upon the accuracy of the patient's diagnostic or working casts and the interocclusal record. How to cite this article: Sonkesriya S, Subramanian D, Saha P, . Assessment of Dimensional Accuracy of Three Different Types of Interocclusal Recording Materials. J Contemp Dent Pract 2023;24(12):936-939.
Topics: Humans; Dental Impression Materials; Jaw Relation Record; Siloxanes; Polyvinyls
PubMed: 38317389
DOI: 10.5005/jp-journals-10024-3574