-
Colloids and Surfaces. B, Biointerfaces Sep 2023Tissue engineering has gained prominence during the past decade since it offers a key solution to defects associated with the tissue regeneration. The limited healing...
Tissue engineering has gained prominence during the past decade since it offers a key solution to defects associated with the tissue regeneration. The limited healing potential of the cartilage tissue damage has significant clinical implications. Herein, dysprosium (Dy) impregnated polyvinyl alcohol (PVA) hydrogels have been developed to enhance the therapeutic efficacy, enabling simultaneous diagnostic imaging and antibacterial drug delivery for potential applications in articular cartilage. Based on the favorable imaging features, Dy impregnated PVA hydrogels with enhanced stability were formed through successive steps of repeated cycles of freezing at - 30 °C for 21 h, thawing at 25 °C for 4 h and lyophilization. The tensile and compression tests of the hydrogels respectively determined a maximum of 3.88 and 1.58 MPa, which reflected better compatibility towards cartilage. The hydrogels fetched a sustained drug release for a period of 12 h with an associated swelling ratio of 80%. The potential of the resultant hydrogels in image diagnosis has been deliberated through their blue and yellow emissions in the visible region. Further, the computed tomography (CT) and magnetic resonance imaging characteristics of the hydrogels respectively accomplished a maximum of 343 Hounsfiled units (HU) and relaxivity of 7.25 mMs. The cytocompatibility of the hydrogels is also determined through in vitro tests performed in Murine pro B cell line (BA/F3) and human Megakaryocyte cell line (Mo7e) cell lines.
Topics: Mice; Humans; Animals; Polyvinyl Alcohol; Dysprosium; Cartilage, Articular; Hydrogels
PubMed: 37499545
DOI: 10.1016/j.colsurfb.2023.113470 -
International Journal of Biological... Jul 2023Macromolecules with antioxidant properties such as polysaccharides from Agaricus blazei Murill mushroom (PAbs) are an excellent option for manufacturing wound dressings....
Macromolecules with antioxidant properties such as polysaccharides from Agaricus blazei Murill mushroom (PAbs) are an excellent option for manufacturing wound dressings. Based on this, this study aimed to analyze preparation, physicochemical characterization, and assessment of the potential wound-healing activity of films based on sodium alginate and polyvinyl alcohol loaded with PAbs. PAbs did not significantly alter the cell viability of human neutrophils in a concentration range of 1-100 μg mL. The Infrared Spectroscopy (FTIR) indicates that the components present in the films (PAbs/Sodium Alginate (SA)/Polyvinyl Alcohol (PVA)) present an increase in hydrogen bonds due to the increase of hydroxyls present in the components. Thermogravimetry (TGA), Differential Scanning Calorimetry (DSC) and X-ray Diffraction (XRD) characterizations indicate a good miscibility between the components where PAbs increasing the amorphous characteristics of the films and that the addition of SA increased the mobility of the chains PVA polymers. The addition of PAbs to films significantly improves properties such as mechanical, thickness, and water vapor permeation. The morphological study evidenced good miscibility between the polymers. The wound healing evaluation indicated that F100 film presented better results from the fourth day onward compared to the other groups. It favored the formation of a thicker dermis (476.8 ± 18.99 μm), with greater collagen deposition and a significant reduction in malondialdehyde and nitrite/nitrate, markers of oxidative stress. These results indicate that PAbs is a candidate for wound dressing.
Topics: Humans; Polyvinyl Alcohol; Alginates; Polysaccharides; Wound Healing; Bandages; Polymers
PubMed: 37301351
DOI: 10.1016/j.ijbiomac.2023.125278 -
ACS Applied Materials & Interfaces Feb 2024To inhibit viral infection, it is necessary for the surface of polypropylene (PP), a polymer of significant industrial relevance, to possess biocidal properties....
To inhibit viral infection, it is necessary for the surface of polypropylene (PP), a polymer of significant industrial relevance, to possess biocidal properties. However, due to its low surface energy, PP weakly interacts with other organic molecules. The biocidal effects of quaternary ammonium compounds (QACs) have inspired the development of nonwoven PP fibers with surface-bound quaternary ammonium (QA). Despite this advancement, there is limited knowledge regarding the durability of these coatings against scratching and abrasion. It is hypothesized that the durability could be improved if the thickness of the coating layer were controlled and increased. We herein functionalized PP with three-dimensionally surface-grafted poly(-benzyl-4-vinylpyridinium bromide) (PBVP) by a simple and rapid method involving graft polymerization and benzylation and examined the influence of different factors on the antiviral effect of the resulting plastic by using a plaque assay. The thickness of the PBVP coating, surface roughness, and amount of QACs, which jointly determine biocidal activity, could be controlled by adjusting the duration and intensity of the ultraviolet irradiation used for grafting. The best-performing sample reduced the viral infection titer of an enveloped model virus (bacteriophage ϕ6) by approximately 5 orders of magnitude after 60 min of contact and retained its antiviral activity after surface polishing-simulated scratching and abrasion, which indicated the localization of QACs across the coating interior. Our method may expand the scope of application to resin plates as well as fibers of PP. Given that the developed approach is not limited to PP and may be applied to other low-surface-energy olefinic polymers such as polyethylene and polybutene, our work paves the way for the fabrication of a wide range of biocidal surfaces for use in diverse environments, helping to prevent viral infection.
Topics: Humans; Polypropylenes; Quaternary Ammonium Compounds; Polymers; Virus Diseases; Antiviral Agents; Polyvinyls; Pyridinium Compounds; Vinyl Compounds
PubMed: 38343039
DOI: 10.1021/acsami.3c15125 -
Chemosphere Oct 2023Dechlorination is essential for the chemical recycling of waste polyvinyl chloride (PVC) plastics. This study investigated the use of non-thermal plasma (NTP) for...
Dechlorination is essential for the chemical recycling of waste polyvinyl chloride (PVC) plastics. This study investigated the use of non-thermal plasma (NTP) for chlorine removal, with a focus on the effects of treatment time and discharge power on dechlorination efficiency. The results showed that longer treatment times and higher discharge powers led to better dechlorination performance. The maximum efficiency (98.25%) and HCl recovery yield (55.72%) were achieved at 180 W power after 40 min of treatment where 96.44% of Cl existed in the form of HCl gas, 1.44% in the liquid product, and 2.12% in the solid residue product. NTP at a discharge power of 150 W showed better dechlorination performance compared to traditional thermal pyrolysis treatment in temperatures ranging from 200 to 400 °C. The activation energy analysis of the chlorine removal showed that compared to pyrolysis-based dechlorination (137.09 kJ/mol), NTP-based dechlorination (23.62 kJ/mol) was more easily achievable. This work presents a practical method for the dechlorination of waste PVC plastic using a novel technology without requiring additional thermal and pressure input.
Topics: Polyvinyl Chloride; Chlorine; Temperature; Chlorides; Recycling; Plastics
PubMed: 37467857
DOI: 10.1016/j.chemosphere.2023.139535 -
Journal of Environmental Management Nov 2023Poor cementation between soil particles is a fundamental cause of soil erosion and desertification. In recent decades, many polymers have been used to cement soil...
Poor cementation between soil particles is a fundamental cause of soil erosion and desertification. In recent decades, many polymers have been used to cement soil particles and improve the physical and chemical properties of soils. The contributions of polymers with different structures and functional groups to soil improvement vary considerably. In this study, a mixture comprising polyacrylamide (PAM), sodium polyacrylate (PAAS), hydroxypropyl methylcellulose (HPMC), and polyvinyl alcohol (PVA) was investigated to meet the requirements of soil water retention, erosion resistance, and plant growth. The results showed that the time required for the modified soil to reach drought conditions was extended by 4-7 days. The PAM/HPMC, PAM/PVA and PAM/PAAS experimental groups reduced the erosion rate by 99.57%, 98.3% and 96.38%, respectively, compared to that of the control group. The belowground plant biomass was significantly increased by PAM/HPMC, PAM/PAAS, and PAM/PVA, with increases of 115.92%, 145.23%, and 205.67%, respectively. HPMC contributed more to the soil erosion resistance and water-holding capacity, PAAS improved the soil porosity substantially, and PVA significantly increased the plant biomass. The rigid structures of the polymer chains enhanced the structural stability of the soil, and the hydrophilic functional groups increased the hydrophilicity of the amended soil. This study indicates different polymers that may be used to improve soil properties.
Topics: Soil; Sand; Polymers; Polyvinyl Alcohol; Soil Erosion
PubMed: 37673010
DOI: 10.1016/j.jenvman.2023.118847 -
Food Chemistry Dec 2023To develop food packaging with good antibacterial activity and mechanical performance, four amino carboxymethyl chitosan (ACC)//dialdehyde starch (DAS) /polyvinyl...
To develop food packaging with good antibacterial activity and mechanical performance, four amino carboxymethyl chitosan (ACC)//dialdehyde starch (DAS) /polyvinyl alcohol (PVA) films were prepared by Schiff base and hydrogen bond interactions for efficient loading and release of ε-polylysine (ε-PL). The effects of the Schiff base reaction on the physicochemical properties of the films were explored based on the different aldehyde group contents in DAS. The ACC//DAS/PVA film exhibited a tensile strength of 62.5 MPa, and the water vapor and oxygen permeability was 8.77 × 10·g·mm/m·d·kPa and 0.15 × 10·cm·mm/m·d, respectively. By leveraging the Schiff base reaction, the film swelling properties were improved by adjusting the cross-link density, mesh size, and molecular mass between the cross-links. The ACC//DAS/PVA film could efficiently load ε-PL with a value of 98.44% and long-term release in a food simulant of 10% ethanol at 25 °C for 120 min. Moreover, the ACC-ε-PL//DAS/PVA film was successfully used for salmon preservation.
Topics: Chitosan; Polyvinyls; Polyvinyl Alcohol; Polylysine; Schiff Bases; Anti-Bacterial Agents; Food Packaging
PubMed: 37423111
DOI: 10.1016/j.foodchem.2023.136775 -
PloS One 2023Nitric oxide synthase 3 (NOS3) eluting polyvinyl alcohol-based hydrogels have a large potential in medical applications and device coatings. NOS3 promotes nitric oxide...
Nitric oxide synthase 3 (NOS3) eluting polyvinyl alcohol-based hydrogels have a large potential in medical applications and device coatings. NOS3 promotes nitric oxide and nitrate production and can effectively be delivered using insect cell viruses, termed baculoviruses. Nitric oxide is known for regulating cell proliferation, promoting blood vessel vasodilation, and inhibiting bacterial growth. The polyvinyl alcohol (PVA)-based hydrogels investigated here sustained baculovirus elution from five to 25 days, depending on the hydrogel composition. The quantity of viable baculovirus loaded significantly declined with each freeze-thaw from one to four (15.3 ± 2.9% vs. 0.9 ± 0.5%, respectively). The addition of gelatin to the hydrogels protected baculovirus viability during the freeze-thaw cycles, resulting in a loading capacity of 94.6 ± 1.2% with sustained elution over 23 days. Adding chitosan, PEG-8000, and gelatin to the hydrogels altered the properties of the hydrogel, including swelling, blood coagulation, and antimicrobial effects, beneficial for different therapeutic applications. Passive absorption of the baculovirus into PVA hydrogels exhibited the highest baculovirus loading (96.4 ± 0.6%) with elution over 25 days. The baculovirus-eluting hydrogels were hemocompatible and non-cytotoxic, with no cell proliferation or viability reduction after incubation. This PVA delivery system provides a method for high loading and sustained release of baculoviruses, sustaining nitric oxide gene delivery. This proof of concept has clinical applications as a medical device or stent coating by delivering therapeutic genes, improving blood compatibility, preventing thrombosis, and preventing infection.
Topics: Baculoviridae; Gelatin; Nitric Oxide; Polyvinyl Alcohol; Insect Viruses; Hydrogels
PubMed: 37733661
DOI: 10.1371/journal.pone.0290902 -
Scientific Reports Oct 2023Microplastics (MPs), as carriers of organic pollutants in the environment, have become a growing public concern in recent years. Tetracycline (TTC) is an antibiotic that...
Microplastics (MPs), as carriers of organic pollutants in the environment, have become a growing public concern in recent years. Tetracycline (TTC) is an antibiotic that can be absorbed by MPs and have a harmful effect on human health. Therefore, this study was conducted with the aim of investigating the adsorption rate of TTC onto polyvinyl chloride (PVC) MPs. In addition, the adsorption mechanism of this process was studied using isothermal, kinetic, and thermodynamic models. For this purpose, experimental runs using the Box-Behnken model were designed to investigate the main research parameters, including PVC dose (0.5-2 g/L), reaction time (5-55 min), initial antibiotic concentration (5-15 mg/L), and pH (4-10). Based on the research findings, the highest TTC adsorption rate (93.23%) was obtained at a pH of 10, a contact time of 55 min, an adsorbent dose of 1.25 g/L, and an antibiotic concentration of 10 mg/L. The study found that the adsorption rate of TTC followed the pseudo-second-order and Langmuir models. Thermodynamic data indicated that the process was spontaneous, exothermic, and physical. Increasing ion concentration decreased TTC adsorption, and distilled water had the highest adsorption, while municipal wastewater had the lowest adsorption. These findings provide valuable insights into the behavior of MPs and organic pollutants, underscoring the importance of conducting additional research and implementing measures to mitigate their detrimental effects on human health and the environment.
Topics: Humans; Microplastics; Plastics; Polyvinyl Chloride; Adsorption; Anti-Bacterial Agents; Tetracycline; Water; Environmental Pollutants; Water Pollutants, Chemical; Kinetics
PubMed: 37864009
DOI: 10.1038/s41598-023-44288-z -
Biomedical Materials (Bristol, England) Sep 2023Diabetic wounds are one of the most challenging clinical conditions in diabetes, necessitating the development of new treatments to foster healing and prevent microbial...
Diabetic wounds are one of the most challenging clinical conditions in diabetes, necessitating the development of new treatments to foster healing and prevent microbial contamination. In this study, polyvinyl alcohol was used as a matrix polymer, and amoxicillin (AMX) and salicylic acid (SA) were selected as bioactive compounds with antimicrobial (with AMX) and anti-inflammatory action (with SA) to obtain innovative drug-loaded electrospun nanofiber patches for the management of diabetic wounds. Scanning electron microscope images revealed the uniform and beadless structure of the nanofiber patches. Mechanical tests indicated that AMX minimally increased the tensile strength, while SA significantly reduced it. The patches demonstrated effective antibacterial activity against both gram-positive () and gram-negative () strains. The potential of these patches in the development of novel wound dressings is highlighted by the excellent biocompatibility with fibroblast cells maintained for up to 7 d.
Topics: Humans; Salicylic Acid; Amoxicillin; Polyvinyl Alcohol; Nanofibers; Wound Infection; Escherichia coli
PubMed: 37604153
DOI: 10.1088/1748-605X/acf25c -
International Journal of Biological... Aug 2023Bioactive films of chitosan (CS)/polyvinyl alcohol (PVA)/trans-cinnamaldehyde (CIN) were prepared by co-blending, and the impact of varying concentrations (0.5, 1.0 and...
Bioactive films of chitosan (CS)/polyvinyl alcohol (PVA)/trans-cinnamaldehyde (CIN) were prepared by co-blending, and the impact of varying concentrations (0.5, 1.0 and 1.5 %) of CIN on the physicochemical properties of the ternary films was investigated. The ATR/FT-IR analysis revealed that the bioactive film is modulated by Schiff base (C=N) and hydrogen-bond interactions of CS, PVA, and CIN. Inclusion of CIN into the film improved mechanical properties with tensile strength increased from 0.5 % (68.52 MPa) to 1.5 % (76.95 MPa). The presence of CIN within the CS/PVA film also remarkably affected oxygen permeability and improved light transmittance. Additionally, the water barrier and contact angle properties were improved with increasing CIN content. The morphology of the CIN-containing films appeared non-stratified and dense when observed by SEM and AFM. Moreover, spore germination and in vitro assays confirmed strong antifungal activity of the CIN-containing film against P. italicum (~90 %) and B. cinerea (~85 %). The ternary films also exhibited excellent antioxidant activity, as evidenced by DPPH radical scavenging activity (31.43 %) and ferric reducing power (OD700 nm = 0.172) at the highest CIN concentration tested. Thus, this bioactive CIN films are proposed as a versatile packaging material for the food industry.
Topics: Chitosan; Polyvinyl Alcohol; Spectroscopy, Fourier Transform Infrared; Food Packaging; Tensile Strength
PubMed: 37406895
DOI: 10.1016/j.ijbiomac.2023.125680