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Food Chemistry Jun 2024Researchers are addressing environmental concerns related to petroleum-based plastic packaging by exploring biopolymers from natural sources, chemical synthesis, and... (Review)
Review
Researchers are addressing environmental concerns related to petroleum-based plastic packaging by exploring biopolymers from natural sources, chemical synthesis, and microbial fermentation. Despite the potential of individual biopolymers, they often exhibit limitations like low water resistance and poor mechanical properties. Blending polymers emerges as a promising strategy to overcome these challenges, creating films with enhanced performance. This review focuses on recent advancements in chitosan/polyvinyl alcohol (PVA) blend food packaging films. It covers molecular structure, properties, strategies for performance improvement, and applications in food preservation. The blend's excellent compatibility and intermolecular interactions make it a promising candidate for biodegradable films. Future research should explore large-scale thermoplastic technologies and investigate the incorporation of additives like natural extracts and nanoparticles to enhance film properties. Chitosan/PVA blend films offer a sustainable alternative to petroleum-based plastic packaging, with potential applications in practical food preservation.
Topics: Polyvinyl Alcohol; Chitosan; Food Packaging; Biopolymers; Petroleum
PubMed: 38306905
DOI: 10.1016/j.foodchem.2024.138506 -
International Journal of Biological... Dec 2023This study focuses on the formulation of polyvinyl alcohol (PVA)-based films with pH-sensitive properties and ultraviolet (UV) resistance by incorporating sodium...
This study focuses on the formulation of polyvinyl alcohol (PVA)-based films with pH-sensitive properties and ultraviolet (UV) resistance by incorporating sodium lignosulfonate (LS) and varying concentrations of black rice anthocyanin extract (BRE) into PVA matrix. The films were characterized through Fourier transform-infrared spectroscopy (FT-IR), X-ray diffraction (XRD), tensile test, water vapor permeability (WVP), and ultraviolet-visible (UV-vis) spectroscopy. The results indicated that BRE and LS effectively formed strong hydrogen bonds with PVA, leading to reduced film crystallinity, improved mechanical properties, and lowered WVP as the BRE content increased. The addition of LS and BRE improved the UV resistance of the films, and BRE imparted films with excellent pH-sensitive properties. Among the film variants, the PVA/LS/BRE film containing 1 wt% BRE exhibited excellent mechanical performance, boasting an elongation at a break of 360.66 % and a strength of 35.68 MPa. Additionally, soil pH visualization holds significant potential within agriculture. In this study, the PVA/LS/BRE film containing 2 wt% BRE exhibited minimum UV transparency (0.9 %) and displayed the most distinct color response across varying pH environments. Therefore, the PVA/LS/BRE film containing 2 wt% BRE excelled in both UV resistance and pH sensitivity, positioning it as the most suitable material for the development of agricultural films integrated with soil pH monitoring capabilities.
Topics: Polyvinyl Alcohol; Oryza; Anthocyanins; Soil; Spectroscopy, Fourier Transform Infrared; Hydrogen-Ion Concentration; Agriculture
PubMed: 37717865
DOI: 10.1016/j.ijbiomac.2023.126800 -
International Journal of Biological... Dec 2023Chronic tympanic membrane (TM) perforation is a consequence of trauma or chronic otitis media, and these chronic TM perforations often lead to conduction hearing loss....
Chronic tympanic membrane (TM) perforation is a consequence of trauma or chronic otitis media, and these chronic TM perforations often lead to conduction hearing loss. This study focuses on the development of a patch using a combination of chitosan (CS) and polyvinyl alcohol (PVA) as graft material for repairing chronic tympanic membrane (TM) perforations. Aligned nanofibers were created using a specially designed collector (SDC) through the electrospinning method. The scanning electron microscopy (SEM) analysis revealed that the CS/PVA ratio of (15:85) resulted in uniform and bead-free nanofibers. The aligned nanofibers had a diameter of 131.11 ± 28 nm, indicating that the influence of the electrostatic field introduced by the SDC affected not only the nanofiber alignment but also the nanofiber diameter. The nanofiber angles demonstrated effective alignment. This patch is infused with thyme essential oil (TEO) for antibacterial properties. The results showed that its antibacterial property for Pseudomonas aeruginosa bacteria was enhanced in such a way that the diameter of the antibacterial halo increased from zero to 25 mm. Cell viability assays showed >80 % viability. A preclinical case study on six patients demonstrated the biocompatibility and promising potential of the fabricated patch for eardrum repair.
Topics: Humans; Chitosan; Tympanic Membrane Perforation; Nanofibers; Polyvinyl Alcohol; Anti-Bacterial Agents
PubMed: 37660854
DOI: 10.1016/j.ijbiomac.2023.126597 -
International Journal of Biological... Dec 2023Diabetes-related ulcers are still a therapeutic problem because of their susceptibility to infection, ongoing inflammation, and diminished vascularization. The design...
Diabetes-related ulcers are still a therapeutic problem because of their susceptibility to infection, ongoing inflammation, and diminished vascularization. The design and development of novel dressings are clinically urgent for the treatment of chronic wounds due to diabetic ulcers. In this study, we made taxifolin (TAX) loaded sodium alginate (SA)/poly(vinyl alcohol) (PVA) nanofibers for the treatment of chronic wounds. The SA/PVA/TAX nanofibers that have been created are smooth and bead-free, with good thermal stability, hydrophilicity, and mechanical properties. The release profile indicated a sustained drug release, with a cumulative release rate of 64.6 ± 3.7 % at 24 h. In vitro experiments have shown that SA/PVA/TAX has good antibacterial activity, antioxidant activity, and biocompatibility. In vivo experiments have shown that SA/PVA/TAX exhibits desirable biochemical properties and is involved in the diabetic wound healing process by promoting cell proliferation (Ki67), angiogenesis (CD31, VEGFA), and alleviating inflammation (CD68). Western blotting experiments suggest that SA/PVA/TAX may promote diabetic wound healing by inhibiting the TLR4/NF-κB/NLRP3 signaling pathway and upregulating the expression of VEGFA and PDGFA. The 16S rRNA sequencing results showed that SA/PVA/TAX increased the wound surface flora's diversity and reversed the skin microbiota's structural imbalance. Therefore, SA/PVA/TAX can promote diabetic wound healing by modulating the inflammatory response, angiogenesis, and skin flora and has the potential to be an excellent wound dressing.
Topics: Humans; Polyvinyl Alcohol; Nanofibers; Alginates; RNA, Ribosomal, 16S; Ulcer; Wound Healing; Anti-Bacterial Agents; Diabetes Mellitus; Inflammation
PubMed: 37634780
DOI: 10.1016/j.ijbiomac.2023.126530 -
Biomaterials Advances Sep 2023Electrospinning is an increasingly popular technique for obtaining scaffolds for skin regeneration. However, electrospun scaffolds may also have some disadvantages, as...
Electrospinning is an increasingly popular technique for obtaining scaffolds for skin regeneration. However, electrospun scaffolds may also have some disadvantages, as the densely packed fibers in the scaffold structure can limit the penetration of skin cells into the inner part of the material. Such a dense arrangement of fibers can cause the cells to treat the 3D material as 2D one, and thus cause them to accumulate only on the upper surface. In this study, bi-polymer scaffolds made of polylactide (PLA) and polyvinyl alcohol (PVA) electrospun in a sequential or a concurrent system were investigated in a different PLA:PVA ratio (2:1 and 1:1). The properties of six types of model materials were investigated and compared i.e.; the initial materials electrospun by the sequential (PLA/PVA, 2PLA/PVA) and the concurrent system (PLA||PVA) and the same materials with removed PVA fibers (PLA/rPVA, 2PLA/rPVA, PLA||rPVA). The fiber models were intended to increase the porosity and coherent structure parameters of the scaffolds. The applied treatment involving the removal of PVA nanofibers increased the size of interfibrous pores formed between the PLA fibers. Ultimately, the porosity of the PLA/PVA scaffolds increased from 78 % to 99 %, and the time of water absorption decreased from 516 to 2 s. The change in wettability was induced by a synergistic effect of decrease in roughness after washing out and the presence of residual PVA fibers. The chemical analysis carried out confirmed the presence of PVA residues on the PLA fibers (FTIR-ATR study). In vitro studies were performed on human keratinocytes (HaKaT) and macrophages (RAW264.7), for which penetration into the inner part of the PLAIIPVA scaffold was observed. The new proposed approach, which allows the removal of PVA fibers from the bicomponent material, allows to obtain a scaffold with increased porosity, and thus better permeability for cells and nutrients.
Topics: Humans; Polyvinyl Alcohol; Porosity; Polyesters; Regeneration
PubMed: 37364396
DOI: 10.1016/j.bioadv.2023.213506 -
International Journal of Biological... Dec 2023The discharge of dye wastewater resulting from rapid industrial development has become a serious environmental concern. Therefore, there is a pressing need to develop...
The discharge of dye wastewater resulting from rapid industrial development has become a serious environmental concern. Therefore, there is a pressing need to develop efficient methods and technologies for the removal of dye pollutants. This study introduced a double network hydrogel, with varying carboxymethyl chitosan (CMCS) contents and polyvinyl alcohol (PVA), employing a combination of freeze- thawing and calcium chloride cross-linking. The investigation focused on the rheological properties of the hydrogels and their removal ability of acidic blue 93 (AB). The results showed that the strength and viscoelastic modulus of composite hydrogels were positively correlated with the CMCS content, and all composite hydrogels exhibited the typical weak strain overshoot behavior. The pore size of the gel initially decreased and then increased, with the densest pores observed at 4 wt% CMCS, showing the optimal removal ability for AB. The adsorption process followed pseudo second-order kinetic model, dominated by external diffusion, and exhibited inhomogeneous multilayer adsorption. This study unveils the potential of CMCS/PVA gels as adsorbents, offering inspirations for the design and development of polyvinyl alcohol-based gels for applications in the food industry.
Topics: Chitosan; Calcium Chloride; Polyvinyl Alcohol; Adsorption; Hydrogels
PubMed: 37709214
DOI: 10.1016/j.ijbiomac.2023.126897 -
Journal of the Mechanical Behavior of... Dec 2023In this study, a three-component biofilm for rapid wound dressing consisting of polyvinyl alcohol (PVA)/tannic acid (TA)/with CuO/SiO with different percentages (0, 5,...
In this study, a three-component biofilm for rapid wound dressing consisting of polyvinyl alcohol (PVA)/tannic acid (TA)/with CuO/SiO with different percentages (0, 5, 10, and 15 wt% NPs) is evaluated. In addition to controlling bleeding and absorption of blood and wound secretions, it protects the damaged tissue from the attack of microbes. It protects against viruses and thus reduces the treatment time. Analysis of biofilms morphology is performed by Field emission scanning electron microscopy (FE-SEM), phases in biofilms were analyzed by X-ray diffraction (XRD) analysis, chemical bonds, and functional groups are analyzed by Fourier transform infrared (FTIR) spectroscopy, and mechanical tests are performed to evaluate the strength of the samples. The thermogravimetric analysis (TGA) is applied to estimate the thermal stability of the biopolymer films with various percentages of CuO/SiO nanoparticles. Also, antibacterial test, bioactivity of the biofilms, the percentage of swelling ratio, and porosity of the samples were examined by immersing the samples in simulated body fluid (SBF) and Phosphate-buffered saline (PBS) for 14 days in vitro. The composite makeup of the TA/PVA sample, comprising 15 wt % CuO/SiO and containing 15 wt% of nanoparticles, exhibited superior heat resistance compared to other samples by an increase of 50 °C. This improvement can be attributed to the nanoparticles reaching their saturation point. The swelling ratio was assessed in both SBF and PBS, and in both instances, the sample increased by up to 10 wt% before decreasing, indicating the saturation of the nanoparticles.
Topics: Biocompatible Materials; Polyvinyl Alcohol; Silicon Dioxide; Polymers; Anti-Bacterial Agents; Spectroscopy, Fourier Transform Infrared
PubMed: 37951146
DOI: 10.1016/j.jmbbm.2023.106219 -
ACS Applied Materials & Interfaces Sep 2023Implantable neural microelectrodes are recognized as a bridge for information exchange between inner organisms and outer devices. Combined with novel modulation...
Implantable neural microelectrodes are recognized as a bridge for information exchange between inner organisms and outer devices. Combined with novel modulation technologies such as optogenetics, it offers a highly precise methodology for the dissection of brain functions. However, achieving chronically effective and stable microelectrodes to explore the electrophysiological characteristics of specific neurons in free-behaving animals continually poses great challenges. To resolve this, poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate)/poly(vinyl alcohol) (PEDOT/PSS/PVA) interpenetrating conducting polymer networks (ICPN) are fabricated via a hydrogel scaffold precoating and electrochemical polymerization process to improve the performance of neural microelectrodes. The ICPN films exhibit robust interfacial adhesion, a significantly lower electrochemical impedance, superior mechanical properties, and improved electrochemical stability compared to the pure poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate)(PEDOT/PSS) films, which may be attributed to the three-dimensional (3D) porous microstructure of the ICPN. Hippocampal neurons and rat pheochromocytoma cells (PC12 cells) adhesion on ICPN and neurite outgrowth are observed, indicating enhanced biocompatibility. Furthermore, alleviated tissue response at the electrode-neural tissue interface and improved recording signal quality are confirmed by histological and electrophysiological studies, respectively. Owing to these merits, optogenetic modulations and electrophysiological recordings are performed , and an anxiolytic effect of hippocampal glutamatergic neurons on behavior is shown. This study demonstrates the effectiveness and advantages of ICPN-modified neural implants for applications.
Topics: Animals; Rats; Polymers; Hydrogels; Polystyrenes; Microelectrodes; Polyvinyl Alcohol
PubMed: 37590473
DOI: 10.1021/acsami.3c07189 -
Chemosphere Dec 2023The extensive use and improper handling of plastics have caused extensive microplastic (MP) pollution in terrestrial environments. Di(2-ethylhexyl) phthalate (DEHP), the...
The extensive use and improper handling of plastics have caused extensive microplastic (MP) pollution in terrestrial environments. Di(2-ethylhexyl) phthalate (DEHP), the main additive used in plastics, is toxic to organisms and may pose risks to human and animal reproductive functions. However, research on the release behavior of DEHP from MPs is scarce. In this study, the effects of particle size and environmental conditions (temperature, pH, ionic strength, and cation type) on DEHP release from polylactide (PLA), polystyrene (PS), and polyvinyl chloride (PVC) MPs were determined by performing leaching experiments. The results showed that when particle size decreased, the content of DEHP in the MPs and the amount of released DEHP increased though increasing specific surface area. An increase in temperature also promoted DEHP release; when the temperature increased from 15 °C to 45 °C, the amount of DEHP released from PLA, PS, and PVC increased by 38.4%, 71.0%, and 109%, respectively. The lower the crystallinity, the greater the increase in the amount of DEHP released. Ionic strength inhibited the release of DEHP from MPs. When Na concentration increased from 0 to 200 mM, the amount of DEHP released from PLA, PS, and PVC decreased by 27.4%, 41.6%, and 35.3%, respectively. The effect of Ca on DEHP release from MPs was greater than that of Na. In addition, the process of DEHP release from MPs fit well with a pseudo-first-order kinetic model. The results of this study provide a theoretical basis for managing and controlling the risks associated with plastic wastes.
Topics: Animals; Humans; Diethylhexyl Phthalate; Plastics; Microplastics; Particle Size; Polyvinyl Chloride; Polyesters; Polystyrenes
PubMed: 37865205
DOI: 10.1016/j.chemosphere.2023.140474 -
Journal of the Mechanical Behavior of... Dec 2023The polymeric nanofiber may interact and control certain regeneration processes at the molecular level to repair damaged tissues. This research focuses on the...
The polymeric nanofiber may interact and control certain regeneration processes at the molecular level to repair damaged tissues. This research focuses on the development of characterization and antibacterial capabilities of polyvinyl alcohol (PVA)/chitosan (CS) nanofibres containing fucoidan (FUC) for tissue engineering as a skin tissue substitute. A control group consisting of 13% PVA/(0.1)% CS nanofiber was prepared. To confer antibacterial properties to the nanofiber, 10, 20, and 30 mg of FUC were incorporated into this control group. The scanning electron microscope (SEM) proved the homogeneous and beadless structures of the nanofibers. The antibacterial activity of the 13% PVA/(0.1)% CS/(10, 20, 30) FUC was tested against the S.aureus and E.coli and the results showed that with FUC addition, the antibacterial activities of the nanofibers increased. The biocompatibility test was performed with a fibroblast cell line for 1, 3, and 7 days of incubation and the results demonstrated that FUC addition enhanced the bioactivity of the 13% PVA/(0.1)% CS nanofibers. In addition, the biocompatibility results showed that 13% PVA/(0.1)% CS/10 FUC had the highest viability value for all incubation periods compared to the others. In addition, the tensile test results showed that; the maximum tensile strength value was observed for 13% PVA/(0.1)% CS/10 FUC nanofibers.
Topics: Chitosan; Polyvinyl Alcohol; Nanofibers; Polyvinyls; Tissue Engineering; Anti-Bacterial Agents; Staphylococcus aureus; Escherichia coli
PubMed: 37832172
DOI: 10.1016/j.jmbbm.2023.106163