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Alternative Therapies in Health and... Nov 2023Leukemia is the most prevalent cancer among children and adolescents. This study investigated the potential association between exposure to magnetic fields and the risk... (Meta-Analysis)
Meta-Analysis
OBJECTIVE
Leukemia is the most prevalent cancer among children and adolescents. This study investigated the potential association between exposure to magnetic fields and the risk of pediatric leukemia.
METHODS
We conducted a comprehensive search of electronic databases, including Scopus, EMBASE, Cochrane, Web of Science, and Medline, up to December 15, 2022, to identify relevant studies examining the link between childhood leukemia and magnetic field exposure.
RESULTS
The first meta-analysis revealed a statistically significant inverse association between pediatric leukemia and magnetic field strengths ranging from 0.4 μT to 0.2 μT, suggesting a reduced risk associated with this range. The second meta-analysis focused on wiring configuration codes and observed a potential link between residential magnetic field exposure and childhood leukemia. Pooled relative risk estimates were 1.52 (95% CI = 1.05-2.04, P = .021) and 1.58 (95% CI = 1.15-2.23, P = .006) for exposure to 24-hour magnetic field measurements, suggesting a possible causal relationship. In the third meta-analysis, the odds ratios for the exposure groups of 0.1 to 0.2 μT, 0.2 to 0.3 μT, 0.3 to 0.4 μT, and 0.4 μT above 0.2 μT were 1.09 (95% confidence interval = 0.82 to 1.43 μT), 1.14 (95% confidence interval = 0.68 to 1.92 μT), and 1.45 (95% confidence interval = 0.87 to 2.37 μT), respectively. In contrast to the findings of the three meta-analyses, there was no evidence of a statistically significant connection between exposure to 0.2 μT and the risk of juvenile leukemia. A further result showed no discernible difference between the two groups of children who lived less than 100 meters from the source of magnetic fields and those who lived closer (OR = 1.33; 95% CI = 0.98-1.73 μT).
CONCLUSIONS
The collective results of three meta-analyses, encompassing magnetic field strengths ranging from 0.1 μT to 2.38 μT, underscore a statistically significant association between the intensity of magnetic fields and the occurrence of childhood leukemia. However, one specific analysis concluded that no apparent relationship exists between exposure to 0.1 μT and an elevated risk of leukemia development in children.
Topics: Adolescent; Child; Humans; Electromagnetic Fields; Leukemia; Magnetic Fields; Neoplasms; Electromagnetic Radiation; Environmental Exposure; Case-Control Studies
PubMed: 37678874
DOI: No ID Found -
Chemistry (Weinheim An Der Bergstrasse,... Sep 2023Optical imaging has a wide range of applications in the biomedical field, allowing the visualization of physiological processes and helping in the diagnosis and... (Review)
Review
Optical imaging has a wide range of applications in the biomedical field, allowing the visualization of physiological processes and helping in the diagnosis and treatment of diseases. Unexcited light source imaging technologies, such as chemiluminescence imaging, bioluminescence imaging and afterglow imaging have attracted great attention in recent years because of the absence of excitation light interference in their application and the advantages of high sensitivity and high signal-to-noise ratio. In this review, the latest advances in unexcited light source imaging technology for biomedical applications are highlighted. The design strategies of unexcited light source luminescent probes in improving luminescence brightness, penetration depth, quantum yield and targeting, and their applications in inflammation imaging, tumor imaging, liver and kidney injury imaging and bacterial infection imaging are introduced in detail. The research progress and future prospects of unexcited light source imaging for medical applications are further discussed.
Topics: Humans; Luminescence; Optical Imaging; Liver Neoplasms
PubMed: 37401914
DOI: 10.1002/chem.202301689 -
Current Opinion in Chemical Biology Aug 2023The field of organic chemistry began with 19th century scientists identifying and then expanding upon synthetic dye molecules for textiles. In the 20th century, dye... (Review)
Review
The field of organic chemistry began with 19th century scientists identifying and then expanding upon synthetic dye molecules for textiles. In the 20th century, dye chemistry continued with the aim of developing photographic sensitizers and laser dyes. Now, in the 21st century, the rapid evolution of biological imaging techniques provides a new driving force for dye chemistry. Of the extant collection of synthetic fluorescent dyes for biological imaging, two classes reign supreme: rhodamines and cyanines. Here, we provide an overview of recent examples where modern chemistry is used to build these old-but-venerable classes of optically responsive molecules. These new synthetic methods access new fluorophores, which then enable sophisticated imaging experiments leading to new biological insights.
Topics: Fluorescent Dyes; Rhodamines; Light
PubMed: 37269674
DOI: 10.1016/j.cbpa.2023.102335 -
Luminescence : the Journal of... Jan 2024In past decades, organic crystals have presented considerable potential in the field of optoelectronics due to their rich tunable physical and chemical properties and... (Review)
Review
In past decades, organic crystals have presented considerable potential in the field of optoelectronics due to their rich tunable physical and chemical properties and excellent optoelectronic characteristics. White-light emission, as a special application, has received widespread attention and has been applied in various fields, generating significant interest in the scientific community. By preparing white light-emitting organic crystals, a series of applications for future white-light sources can be realized. This article reviews the research progress on the molecular design and synthesis, preparation, and application of white light-emitting organic crystals in recent years. We hope that this review will help to understand and facilitate the development of white light-emitting organic crystals.
Topics: Light
PubMed: 37635303
DOI: 10.1002/bio.4585 -
Advanced Materials (Deerfield Beach,... Dec 2023Recently, 2D transition metal carbide, nitride, and carbonitrides (MXenes) materials stand out in the field of tumor therapy, particularly in the construction of... (Review)
Review
Recently, 2D transition metal carbide, nitride, and carbonitrides (MXenes) materials stand out in the field of tumor therapy, particularly in the construction of functional platforms for optimal antitumor therapy due to their high specific surface area, tunable performance, strong absorption of near-infrared light as well as preferable surface plasmon resonance effect. In this review, the progress of MXene-mediated antitumor therapy is summarized after appropriate modifications or integration procedures. The enhanced antitumor treatments directly performed by MXenes, the significant improving effect of MXenes on different antitumor therapies, as well as the MXene-mediated imaging-guided antitumor strategies are discussed in detail. Moreover, the existing challenges and future development directions of MXenes in tumor therapy are presented.
Topics: Humans; Infrared Rays; Nitrites; Surface Plasmon Resonance; Neoplasms
PubMed: 37142810
DOI: 10.1002/adma.202302559 -
Applied Optics Sep 2023Eye movement research is an established methodology and widely used in fundamental research fields such as psychology or neuroscience. Most research is performed in...
Eye movement research is an established methodology and widely used in fundamental research fields such as psychology or neuroscience. Most research is performed in controlled environments with screen-based eye trackers, but demand for a wearable requirement is on the rise. Yet, a state of the art wearable eye tracking system thus far has not been feasible for subjects with refractive errors; therefore, a trial frame is proposed for researching the eye movement of people with or without refractive errors. Two iris cameras and several infrared radiation LEDs were fixed behind the frame for recording eye images. The images were sent to a host computer using 2.4G wireless, which was also fixed on the frame. The entire electronic system in the trial frame was driven using a battery. Eye position in the images was recognized and segmented by a model that was trained through machine learning. Then the pupil and blinks were detected from the segmented eye area using ellipse fitting and the eye aspect ratio. Experiments showed that the correct rate of pupil and blink detections were 97.24% and 96.14%, respectively.
Topics: Humans; Eye Movements; Electric Power Supplies; Infrared Rays; Iris; Refractive Errors
PubMed: 37706808
DOI: 10.1364/AO.498375 -
Journal of Synchrotron Radiation Jul 2023An in-house designed transmission X-ray microscopy (TXM) instrument has been developed and commissioned at beamline BL18B of the Shanghai Synchrotron Radiation Facility...
An in-house designed transmission X-ray microscopy (TXM) instrument has been developed and commissioned at beamline BL18B of the Shanghai Synchrotron Radiation Facility (SSRF). BL18B is a hard (5-14 keV) X-ray bending-magnet beamline recently built with sub-20 nm spatial resolution in TXM. There are two kinds of resolution mode: one based on using a high-resolution-based scintillator-lens-coupled camera, and the other on using a medium-resolution-based X-ray sCMOS camera. Here, a demonstration of full-field hard X-ray nano-tomography for high-Z material samples (e.g. Au particles, battery particles) and low-Z material samples (e.g. SiO powders) is presented for both resolution modes. Sub-50 nm to 100 nm resolution in three dimensions (3D) has been achieved. These results represent the ability of 3D non-destructive characterization with nano-scale spatial resolution for scientific applications in many research fields.
Topics: Synchrotrons; X-Rays; Silicon Dioxide; China; Tomography, X-Ray
PubMed: 37145138
DOI: 10.1107/S1600577523003168 -
International Microbiology : the... Nov 2023The study of the effects of the magnetic field (MF) on living matter continues to be a dilemma. Until now, the interaction mechanisms of MF with living matter that...
The study of the effects of the magnetic field (MF) on living matter continues to be a dilemma. Until now, the interaction mechanisms of MF with living matter that explain the observed phenomena are unknown. Despite the existing literature and the multiple effects described to date, there are few published articles that study the combined effect of MF with other physical agents during the cellular aging process. In this sense, the aim of this work is to study whether low frequency and intensity pulsed and sinusoidal MF exposure produce alterations in the cell killing effect of ultraviolet C (UVC) radiation and thermal shock during the chronological aging of S. cerevisiae. Yeast cells were exposed to 2.45 mT (50 Hz) sinusoidal MF and 1.5 mT (25 Hz) pulsed MF, during 40 days of aging, in combination with UVC radiation (50 J/m) and/or thermal shock (52°C). Cell survival was evaluated by clonogenic assay. The exposure of yeast to pulsed MF produces an acceleration of aging, which is not observed in cells exposed to sinusoidal MF. The pulsed MF modifies the cellular response to damaging agents only in aged S. cerevisiae cells. In this sense, the pulsed MF applied increases the damage induced by UVC radiation and by thermal shock. In contrast, the sinusoidal MF used has no effect.
Topics: Saccharomyces cerevisiae; Magnetic Fields; Ultraviolet Rays; Cell Survival
PubMed: 36997813
DOI: 10.1007/s10123-023-00352-2 -
Annals of Agricultural and... Dec 2023Mobile phones and Wi-Fi are the most commonly used forms of telecommunications. Initiated with the first generation, the mobile telephony is currently in its fifth...
INTRODUCTION AND OBJECTIVE
Mobile phones and Wi-Fi are the most commonly used forms of telecommunications. Initiated with the first generation, the mobile telephony is currently in its fifth generation without being screened extensively for any biological effects that it may have on humans or on animals. Some studies indicate that high frequency electromagnetic radiation emitted by mobile phone and Wi-Fi connection can have a negative effect upon human health, and can cause cancer, including brain tumour.
OBJECTIVE
The aim of the study was to investigate the influence of 2.4 GHz radiofrequency electromagnetic field (RF-EMF) on the proliferation and morphology of normal (human embryonic kidney cell line Hek-293) and cancer cells (glioblastoma cell line U-118 MG).
MATERIAL AND METHODS
The cell cultures were incubated in RF-EMF at the frequency of 2.4 GHz, with or without dielectric screen, for 24, 48 and 72h. In order to analyse the influence of the electromagnetic field on cell lines, Cytotoxicity test Cell Counting Kit-8 was performed. To protect cells against emission of the electromagnetic field, a dielectric screen was used.
RESULTS
It was found that 2.4 GHz RF electromagnetic field exposure caused a significant decrease in viability of U-118 MG and Hek-293 cells. The impact of the electromagnetic field was strongest in the case of cancer cells, and the decrease in their survival was much greater compared to the healthy (normal) cells of the Hek-293 line.
CONCLUSIONS
Results of the study indicate that using a radio frequency electromagnetic field (2.4 GHz) has a clearly negative effect on the metabolic activity of glioblastoma cells. RF-EMF has much less impact on reducing the viability of normal cells (Hek -293) than cancer cells.
Topics: Animals; Humans; Electromagnetic Fields; Glioblastoma; Environmental Exposure; HEK293 Cells; Radio Waves
PubMed: 38153083
DOI: 10.26444/aaem/176405 -
Sensors (Basel, Switzerland) Nov 2023The field of flexible electronics is undergoing an exponential evolution due to the demand of the industry for wearable devices, wireless communication devices and... (Review)
Review
The field of flexible electronics is undergoing an exponential evolution due to the demand of the industry for wearable devices, wireless communication devices and networks, healthcare sensing devices and the technology around the Internet of Things (IoT) framework. E-tex tiles are attracting attention from within the healthcare areas, amongst others, for providing the possibility of developing continuous patient monitoring solutions and customized devices to accommodate each patient's specific needs. This review paper summarizes multiple approaches investigated in the literature for wearable/flexible resonators working as antenna-based systems, sensors and filters with special attention paid to the integration to flexible materials, especially textiles. This review manuscript provides a general overview of the flexible resonators' advantages and drawbacks, materials, fabrication techniques and processes and applications. Finally, the main challenges and future prospects of wearable resonators are discussed.
Topics: Humans; Microwaves; Wearable Electronic Devices; Electronics; Monitoring, Physiologic; Textiles
PubMed: 38005491
DOI: 10.3390/s23229103