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Accident; Analysis and Prevention Jun 2024Mobility and environmental benefits of Green Light Optimal Speed Advisory (GLOSA) systems have been reported by many previous research studies, however, there is... (Review)
Review
Mobility and environmental benefits of Green Light Optimal Speed Advisory (GLOSA) systems have been reported by many previous research studies, however, there is insufficient knowledge on the safety implications of such an application. For safe deployment of GLOSA system, it is most critical to identify and address potential safety issues in the design process. It can be argued that implementation of GLOSA system can improve safety by reducing traffic conflicts associated with the interrupted traffic flow at signalised intersections. However, more research findings are needed from field and simulation based studies to evaluate the impacts on safety under a variety of real-world scenarios. As part of the LEVITATE (Societal Level Impacts of Connected and Automated Vehicles) project under European Union's Horizon 2020 Programme, the main objective of this study is to examine the safety impacts of GLOSA under mixed traffic compositions with varying market penetration rates (MPR) of connected and automated vehicles (CAVs). A calibrated and validated microsimulation model (developed in Aimsun) of the greater Manchester area was used for this study where three signalised intersections in a corridor were identified for implementing GLOSA system. An improved algorithm was developed by identifying the potential issues/limitations in some of the GLOSA algorithms found in literature. Behaviours of CAVs were modelled based on the findings of a comprehensive literature review. Safety analysis was performed through processing the simulated vehicular trajectories in the surrogate safety assessment model (SSAM) by the Federal Highway Administration (FHWA). The surrogate safety assessment results showed small improvement in safety with the GLOSA implementation at multiple intersections in the test network only at low MPR (20%) scenarios of CAVs, as compared to the respective without GLOSA scenarios. No or rather slightly lower improvement in safety was observed with GLOSA implementation under mixed fleet scenarios with 40 % or higher 1st Generation or 2nd Generation CAVs, as compared to the respective scenarios without GLOSA. The implementation of GLOSA system was also found to have some impact on the traffic conflict types (although not consistent across all MPR scenarios), where rear-end conflicts were found to decrease while a slight increase was observed in lane-change conflicts.
Topics: Humans; Accidents, Traffic; Automobile Driving; Safety; Green Light; Computer Simulation
PubMed: 38552346
DOI: 10.1016/j.aap.2024.107534 -
Journal of Materials Chemistry. B Aug 2023Recently, carbon dots (CDs) as newly developed carbon-based nanomaterials due to advantages such as excellent photostability and easy surface functionalization have... (Review)
Review
Recently, carbon dots (CDs) as newly developed carbon-based nanomaterials due to advantages such as excellent photostability and easy surface functionalization have generated wide application prospects in fields such as biological imaging and chemical sensing. The multicolor emission carbon dots (M-CDs) were acquired through the selection of different carbon source precursors, change of synthesis conditions and synthesis environment. Therefore, the aim of this review is to summarize the latest research progress in polychromatic CDs from the perspectives of synthesis strategies, luminescent mechanisms, luminescent properties and applications. This review focuses on how to prepare MCDs by changing raw materials and synthesis conditions such as reaction temperature, synthesis time, synthesis pH, and synthesis solvent. This review also presents the optical properties of MCDs, concentration effects, solvent effects, pH effects, elemental doping, and surface passivation on them, as well as their creative applications in the field of sensing applications. It is anticipated that this review will serve as a guide for the development of multifunctional M-CDs and inspire future research on controllable design and preparation of M-CDs.
Topics: Quantum Dots; Carbon; Fluorescent Dyes; Luminescence; Solvents
PubMed: 37555267
DOI: 10.1039/d3tb01329d -
Nature Methods Dec 2023Brillouin microscopy is an emerging optical elastography technique capable of assessing mechanical properties of biological samples in a three-dimensional, all-optical...
Brillouin microscopy is an emerging optical elastography technique capable of assessing mechanical properties of biological samples in a three-dimensional, all-optical and noncontact fashion. The typically weak Brillouin scattering signal can be substantially enhanced via a stimulated Brillouin scattering (SBS) process; however, current implementations require high pump powers, which prohibit applications to photosensitive or live imaging of biological samples. Here we present a pulsed SBS scheme that takes advantage of the nonlinearity of the pump-probe interaction. In particular, we show that the required pump laser power can be decreased ~20-fold without affecting the signal levels or spectral precision. We demonstrate the low phototoxicity and high specificity of our pulsed SBS approach by imaging, with subcellular detail, sensitive single cells, zebrafish larvae, mouse embryos and adult Caenorhabditis elegans. Furthermore, our method permits observing the mechanics of organoids and C. elegans embryos over time, opening up further possibilities for the field of mechanobiology.
Topics: Animals; Mice; Microscopy; Caenorhabditis elegans; Zebrafish; Light; Lasers
PubMed: 37884795
DOI: 10.1038/s41592-023-02054-z -
PloS One 2023Optical microscopy is frequently used to visualize microrobotic agents (i.e., micro-agents) and physical surroundings with a relatively high spatio-temporal resolution....
Optical microscopy is frequently used to visualize microrobotic agents (i.e., micro-agents) and physical surroundings with a relatively high spatio-temporal resolution. However, the limited penetration depth of optical microscopy techniques used in microrobotics (in the order of 100 μm) reduces the capability of visualizing micro-agents below biological tissue. Two-photon microscopy is a technique that exploits the principle of two-photon absorption, permitting live tissue imaging with sub-micron resolution and optical penetration depths (over 500 μm). The two-photon absorption principle has been widely applied to fabricate sub-millimeter scale components via direct laser writing (DLW). Yet, its use as an imaging tool for microrobotics remains unexplored in the state-of-the-art. This study introduces and reports on two-photon microscopy as an alternative technique for visualizing micro-agents below biological tissue. In order to validate two-photon image acquisition for microrobotics, two-type micro-agents are fabricated and employed: (1) electrospun fibers stained with an exogenous fluorophore and (2) bio-inspired structure printed with autofluorescent resin via DLW. The experiments are devised and conducted to obtain three-dimensional reconstructions of both micro-agents, perform a qualitative study of laser-tissue interaction, and visualize micro-agents along with tissue using second-harmonic generation. We experimentally demonstrate two-photon microscopy of micro-agents below formalin-fixed tissue with a maximum penetration depth of 800 μm and continuous imaging of magnetic electrospun fibers with one frame per second acquisition rate (in a field of view of 135 × 135 μm2). Our results show that two-photon microscopy can be an alternative imaging technique for microrobotics by enabling visualization of micro-agents under in vitro and ex ovo conditions. Furthermore, bridging the gap between two-photon microscopy and the microrobotics field has the potential to facilitate in vivo visualization of micro-agents.
Topics: Microscopy, Fluorescence, Multiphoton; Imaging, Three-Dimensional; Photons; Fluorescent Dyes
PubMed: 37561749
DOI: 10.1371/journal.pone.0289725 -
Electromagnetic Biology and Medicine Oct 2023This research article presents a study that uses microwave frequencies (ISM band) for treatment of skin cancer by heating the malignant cells on skin with a Microwave...
This research article presents a study that uses microwave frequencies (ISM band) for treatment of skin cancer by heating the malignant cells on skin with a Microwave Hyperthermia (MWHT) applicator. The proposed MWHT applicator has been designed as an Archimedean Spiral Microstrip Patch Antenna (AMSPA) of dimensions 38 × 38 × 1.64 mm3 backed with a Meshed-shaped AMC (48 × 48 × 3.27mm3) reflector, placed at an optimized distance of 12 mm from AMSPA. The proposed AMSPA is designed as a single spiral resonator and fabricated on FR-4 substrate, excited using a feed network. The proposed AMSPA shows a resonance at 2.5 GHz with an impedance BW of 260 MHz (2.37-2.63 GHz) and peak gain of 3.20 dB with a bidirectional radiation pattern. An AMC is placed at its backside that can be exploited as a phase-compensation surface to attain an in-phase profile for directive emission and improve the BW upto 470 MHz, peak gain to 6.8 dB and also enhance the front-to-back ratio of the radiating antenna with radiation efficiency of 80%. The simulated environment for hyperthermia analysis is set up using penne's Bio-Heat equations to deliver microwave energy to the bio-mimic, that leads to a rise in temperature over the designed bio-mimic in CST MWS in the range of 41-45°C. The validation of MWHT radiation properties and temperature rise inside the malignancy of phantom is carried out by fabricating the bio-mimic using gelatine, vegetable oils and glycerol. This set up enhances the penetration-depth of EM waves inside the tri-layered phantom up-to 29.5 mm with Effective Field Surface of 36 × 36 mm and SAR of 8 W/Kg.
Topics: Humans; Hyperthermia, Induced; Microwaves; Skin Neoplasms; Temperature; Hot Temperature
PubMed: 38156657
DOI: 10.1080/15368378.2023.2297954 -
Scientific Reports Dec 2023The severity of chest X-ray (CXR) findings is a prognostic factor in patients with coronavirus disease 2019 (COVID-19). We investigated the clinical and genetic...
The severity of chest X-ray (CXR) findings is a prognostic factor in patients with coronavirus disease 2019 (COVID-19). We investigated the clinical and genetic characteristics and prognosis of patients with worsening CXR findings during early hospitalization. We retrospectively included 1656 consecutive Japanese patients with COVID-19 recruited through the Japan COVID-19 Task Force. Rapid deterioration of CXR findings was defined as increased pulmonary infiltrates in ≥ 50% of the lung fields within 48 h of admission. Rapid deterioration of CXR findings was an independent risk factor for death, most severe illness, tracheal intubation, and intensive care unit admission. The presence of consolidation on CXR, comorbid cardiovascular and chronic obstructive pulmonary diseases, high body temperature, and increased serum aspartate aminotransferase, potassium, and C-reactive protein levels were independent risk factors for rapid deterioration of CXR findings. Risk variant at the ABO locus (rs529565-C) was associated with rapid deterioration of CXR findings in all patients. This study revealed the clinical features, genetic features, and risk factors associated with rapid deterioration of CXR findings, a poor prognostic factor in patients with COVID-19.
Topics: Humans; COVID-19; Retrospective Studies; X-Rays; Radiography, Thoracic; Lung
PubMed: 38086863
DOI: 10.1038/s41598-023-49340-6 -
Radiation Protection Dosimetry Oct 2023Recently, the ICRU released Report 95, where new operational quantities for external radiation exposure are defined. The new quantities are defined in close relation to...
Recently, the ICRU released Report 95, where new operational quantities for external radiation exposure are defined. The new quantities are defined in close relation to the protection quantities. This change affects the practice use of dosemeters. That is why the instruments must be adapted to the measurement of new quantities before their implementing as legally binding. The discrepancies depend on radiation spectra-particle type, energy of particles and direction of incidence. To analyse the performance of currently used instruments, irradiations in photon and neutron fields of various energies were performed for personal and area dosemeters. In this work, the response of photon and neutron personal dosemeters in conditions of rotational geometry is presented. The difference between the responses with respect to the new or old operational quantity was not large, which corresponded to the similar reference values for this irradiation geometry. The mutual ratio depended on the specific radiation quality and geometry. The behaviour of different types of dosemeters varied too.
Topics: Radiation Dosage; Radiation Monitoring; Radiation Protection; Radiation Exposure; Photons; Neutrons
PubMed: 37819347
DOI: 10.1093/rpd/ncac281 -
Biosensors Sep 2023Given the advancements in modern living standards and technological development, conventional smart devices have proven inadequate in meeting the demands for a... (Review)
Review
Given the advancements in modern living standards and technological development, conventional smart devices have proven inadequate in meeting the demands for a high-quality lifestyle. Therefore, a revolution is necessary to overcome this impasse and facilitate the emergence of flexible electronics. Specifically, there is a growing focus on health detection, necessitating advanced flexible preparation technology for biosensor-based smart wearable devices. Nowadays, numerous flexible products are available on the market, such as electronic devices with flexible connections, bendable LED light arrays, and flexible radio frequency electronic tags for storing information. The manufacturing process of these devices is relatively straightforward, and their integration is uncomplicated. However, their functionality remains limited. Further research is necessary for the development of more intricate applications, such as intelligent wearables and energy storage systems. Taking smart wear as an example, it is worth noting that the current mainstream products on the market primarily consist of bracelet-type health testing equipment. They exhibit limited flexibility and can only be worn on the wrist for measurement purposes, which greatly limits their application diversity. Flexible energy storage and flexible display also face the same problem, so there is still a lot of room for development in the field of flexible electronics manufacturing. In this review, we provide a brief overview of the developmental history of flexible devices, systematically summarizing representative preparation methods and typical applications, identifying challenges, proposing solutions, and offering prospects for future development.
Topics: Electronics; Intelligence; Radio Waves; Technology; Wearable Electronic Devices
PubMed: 37754130
DOI: 10.3390/bios13090896 -
Characterization of a 0.8 mmMedscint plastic scintillator detector system for small field dosimetry.Physics in Medicine and Biology Aug 2023. Plastic scintillator detectors (PSDs) have demonstrated ability to meet requirements of small field dosimetry. Medscint developed a 1 mm long, 1 mm diameter...
. Plastic scintillator detectors (PSDs) have demonstrated ability to meet requirements of small field dosimetry. Medscint developed a 1 mm long, 1 mm diameter cylindrical PSD with effective volume of 0.8 mm. Clinically relevant, small field dosimetric properties of this detector, combined with a novel scintillation dosimetry system-HYPERSCINT RP-200, and HYPERDOSE analysis software were evaluated in this study.. This novel scintillator-based dosimetry system was characterized with 6 MV-WFF and 10 MV-FFF x-ray beams delivered by Varian TrueBeamlinear accelerator. The detector was characterized for leakage, short-term repeatability, dose response linearity, angular response, dose rate response, and field size dependence for radiation field sizes of 0.25 × 0.25 to 10 × 10 cm. Measured detector specific output ratios were compared with microDiamond output factors to determine small field output correction factors,kQclin,Qmsrfclin,fmsr.. The dosimetry system showed excellent short-term repeatability with standard deviation of only 0.04 ± 0.01%. It demonstrated good dose linearity with variations less than 1.0% for 14.4 cGy and above. The dosimetry system was found to be independent of dose rate and angle of irradiation, with deviations for both below 0.5%. Leakage was found to be comparable to background readings. For 6 MV-WFF energy beams, detector specific output ratios for field sizes down to 1 × 1 cmagreed with output factors measured with PTW TN60019 microDiamond, thus,kQclin,Qmsrfclin,fmsrequates to unity for these field sizes. For 10 MV-FFF energy beams, detector specific output ratios for field sizes down to 2 × 2 cmagreed with PTW TN60019 microDiamond output factors, thus,kQclin,Qmsrfclin,fmsrequates to unity for these field sizes.kQclin,Qmsrfclin,fmsrfor field sizes down to 0.5 × 0.5 cmwere determined to be within 6% of unity for both 6 MV-WFF and 10 MV-FFF energy beams.. The HYPERSCINT RP-200 dosimetry system coupled with a 0.8 mmPSD showed excellent dosimetric properties and was found to be clinically relevant for relative dosimetry down to field sizes of 0.5 × 0.5 cmand potentially smaller.
Topics: Monte Carlo Method; Radiometry; Particle Accelerators; Software; X-Rays; Photons
PubMed: 37494941
DOI: 10.1088/1361-6560/aceacf -
Scientific Reports Jul 2023In this paper, we propose a method to generate Vector Vortex Modes (VVM) inside a metallic cylindrical waveguide at microwave frequencies and demonstrate the...
In this paper, we propose a method to generate Vector Vortex Modes (VVM) inside a metallic cylindrical waveguide at microwave frequencies and demonstrate the experimental validation of the concept. Vector vortex modes of EM waves can carry both spin and orbital angular momentum as they propagate within a tubular medium. The existence of such waves in tubular media can be beneficial to wireless communication in such structures. These waves can carry different orbital angular momentum and spin angular momentum, and therefore, they feature the ability to carry multiple orthogonal modes at the same frequency due to spatial structure of the phase and polarization. In essence, high data rate channels can be developed using such waves. In free space, Orbital Angular Momentum carrying vortex waves have beam divergence issues and a central field-minima, which makes these waves unfavorable for free space communication. But vector vortex mode waves in guided structures do not suffer from these drawbacks. This prospect of enhancement of communication spectrum in waveguides provides the background for the study of vortex wave in circular waveguides. In this work, new feed structures and a radial array of monopoles are designed to generate the VVM carrying waves inside the waveguide. The experimental findings on the distribution of the amplitude and phase of the electromagnetic fields inside the waveguide are presented and the relationship between the waveguide fundamental modes and VVMs are discussed for the first time. The paper also presents methods for varying the cutoff frequency of the VVMs by introducing dielectric materials in the waveguide.
Topics: Communication; Electromagnetic Fields; Microwaves; Motion; Oils, Volatile
PubMed: 37422458
DOI: 10.1038/s41598-023-37890-8