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Journal of Sports Science & Medicine Sep 2023No previous study has analyzed the impact of caffeine intake on prooxidant-antioxidant balance and muscle damage following resistance exercise. The aim of this study was... (Randomized Controlled Trial)
Randomized Controlled Trial
The Effect of Acute Caffeine Intake on Resistance Training Volume, Prooxidant-Antioxidant Balance and Muscle Damage Markers Following a Session of Full-Body Resistance Exercise in Resistance-Trained Men Habituated to Caffeine.
No previous study has analyzed the impact of caffeine intake on prooxidant-antioxidant balance and muscle damage following resistance exercise. The aim of this study was to determine the effect of 3 mg/kg of caffeine on the number of repetitions and the prooxidant-antioxidant balance and muscle damage after a session of full-body resistance exercise. Ten resistance-trained men habituated to caffeine participated in a randomized, crossover and double-blind experiment. Each participant performed two identical resistance training sessions after the intake of 3 mg/kg of caffeine or a placebo. Blood was collected before and 60 min after substance intake, just after exercise, 60 minutes after exercise, and 24 hours after testing to evaluate the activity of antioxidant enzymes (superoxide dismutase, glutathione peroxidase, catalase), non-enzymatic antioxidants (reduced glutathione, uric acid) levels of oxidative stress markers (plasma malondialdehyde) and muscle damage markers (creatine kinase, lactate dehydrogenase). There were no significant differences between placebo and caffeine conditions in the total number of repetitions (180 ± 15 vs 185 ± 14 repetitions, respectively; p = 0.276; Effect size [ES] = 0.34), the total time under tension (757 ± 71 vs 766 ± 56 s, respectively; p = 0.709; ES = 0.14) or the rating of perceived exertion (13.8 ± 2.7 vs 14.7 ± 2.7 a.u., respectively; p = 0.212; ES = 0.32). Reduced glutathione concentration obtained 1 hour after exercise was higher with caffeine than with placebo (p = 0.047), without significant difference between conditions for any other prooxidant-oxidant or muscle damage marker at any time point (p > 0.050 for all). The oral intake of 3 mg/kg of caffeine by resistance-trained men habituated to caffeine did not enhance the number of repetitions during a medium load full-body resistance training session to failure and had a minimal impact on the prooxidant-antioxidant balance and muscle damage. The study was registered prospectively at ClinicalTrials.gov with the following ID: NCT05230303.
Topics: Male; Humans; Antioxidants; Caffeine; Reactive Oxygen Species; Resistance Training; Glutathione; Muscles
PubMed: 37711718
DOI: 10.52082/jssm.2023.436 -
Irish Journal of Medical Science Aug 2023Resistance training (RT) has become an important topic for the treatment of fibromyalgia (FM); however, there are still controversies regarding its ability to... (Meta-Analysis)
Meta-Analysis
Effects of resistance training on the physical symptoms and functional capacity of patients with fibromyalgia: a systematic review and meta-analysis of randomized clinical trials.
BACKGROUND
Resistance training (RT) has become an important topic for the treatment of fibromyalgia (FM); however, there are still controversies regarding its ability to significantly improve physical symptoms and a lack of adequate recommendations for evidence-based practice.
AIM
The aim of this study is to analyze the effects of RT on the physical symptoms of patients with FM through a systematic review with meta-analysis.
METHODS
We conducted a systematic review of randomized controlled trials in June 2022, according to PRISMA recommendations. The searches were carried out on the databases PubMed, Embase, Science Direct, Web of Science, PEDro, CINAHL, SciELO, and Google Scholar for gray literature, and the protocol was recorded in PROSPERO. Studies that evaluated patients with FM undergoing an RT program lasting more than 2 weeks and that analyzed physical health were selected. To carry out the meta-analysis, the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions were followed.
RESULTS
In total, 13 studies were included for qualitative analysis and nine for meta-analysis. Regarding meta-analysis, a favorable improvement was found for pain ([MD = - 10.22 (95% CI: - 18.86 to - 1.58; I: 64%; P for heterogeneity: 0.003)]; very low quality of evidence {QoE}), fatigue ([SMD = - 0.39 (95% CI: - 0.61 to - 0.17; I: 0%; P = 0.91)]; moderate QoE), and muscle strength ([SMD = 0.94 (95% CI: 0.02 to 1.85; I: 93%; for heterogeneity: < 0.0001)]; very low QoE) and improvement in functional capacity ([MD = 18.75 (95% CI: 4.27 to 33.22; I: 39%; P = 0.19)]; low QoE), in the general comparison.
CONCLUSION
RT was effective in reducing pain and fatigue and increasing strength and functional capacity; however, due to the quality of the evidence, more studies are needed.
Topics: Humans; Fibromyalgia; Resistance Training; Randomized Controlled Trials as Topic; Fatigue; Pain
PubMed: 36326999
DOI: 10.1007/s11845-022-03205-5 -
Journal of Strength and Conditioning... Jun 2024Lang, HM, Duffourc, MM, Bazyler, CD, Ramsey, MW, and Gentles, JA. The relationship between cell-free DNA and resistance training volume load. J Strength Cond Res 38(6):...
Lang, HM, Duffourc, MM, Bazyler, CD, Ramsey, MW, and Gentles, JA. The relationship between cell-free DNA and resistance training volume load. J Strength Cond Res 38(6): 1008-1012, 2024-The primary purpose of this study was to assess the sensitivity of cell-free DNA (cf-DNA) to different resistance training volume loads. The secondary purpose was to examine the relationship between change in cf-DNA and relative strength. Researchers hypothesized that (a) cf-DNA concentrations would increase with increasing volume load and (b) increases in relative strength would result in predicted decreases to %Δ of cf-DNA. Thirty subjects were recruited for this study, 15 men and 15 women. Blood was collected through venous draws into 4-ml vacutainers at 3 time points: immediately before (T1), after 3 sets (T2), and after 6 sets (T3) of the back squat exercise. A critical alpha of 0.05 was set for inferential statistics. A repeated-measures ANOVA showed that cf-DNA increased significantly from T1 (407.72 ± 320.83) to T2 (1,244.6 ± 875.83) ( p < 0.01) and T1 (407.72 ± 320.83) to T3 (1,331.15 ± 1,141.66) ( p < 0.01), whereas no difference was found from T2 to T3 ( p = 1.00). The linear regression model used to examine the predictive capabilities relative strength had on cf-DNA %Δ from T1 to T3 was found to be significant ( p = 0.04; R2 = 0.15). The results of this study demonstrate the short response of cf-DNA in relation to variations in resistance training volume load. Results also demonstrated the positive relationship between relative strength and cf-DNA %Δ. The current study builds on the body of research that cf-DNA provides insight regarding the level of immune response after exercise training.
Topics: Humans; Resistance Training; Male; Female; Adult; Cell-Free Nucleic Acids; Young Adult; Muscle Strength
PubMed: 38373069
DOI: 10.1519/JSC.0000000000004751 -
BMC Women's Health Oct 2023Resistance training (RT) is effective in counteracting the age- and menopause-related loss of muscle mass (MM) and strength in middle-aged women (40-60 years). Research... (Randomized Controlled Trial)
Randomized Controlled Trial
BACKGROUND
Resistance training (RT) is effective in counteracting the age- and menopause-related loss of muscle mass (MM) and strength in middle-aged women (40-60 years). Research on RT with free weights is limited in pre- and post-menopausal women. Based on this, a 20-week training intervention was conducted with this population to investigate the effects of systematic RT with free weights on strength capacity and body composition.
METHOD
Forty-one healthy women (52.0 ± 3.6 years) participated in this study. After 10-week control phase (no RT, T0-T1) followed by a 10-week intervention phase (T1-T2) with RT twice a week and 6-8 sets of each muscle per week. Subjects were randomly assigned to a low-intensity (50% 1-RM) or moderate-intensity (75% 1-RM) RT group and divided into pre-menopausal and post-menopausal according to their hormone profile. Fat-free mass (FFM), MM, fat mass (FM), muscle thickness (Vastus lateralis (VL), Rectus femoris (RF), Triceps brachii (TB)), grip strength, 1-RM squat and bench press were assessed before and after each phase. Statistical analysis was performed using a linear mixed model to account for fixed (time and group) and random (individual) effects.
RESULTS
A total of 31 women successfully completed the study. No injuries occurred during the intervention. Significant increases in 1-RM squat and bench press were observed in all groups. No interaction effect was observed for the strength parameters. In pre-menopausal women, FFM, MM and RF muscle thickness increased significantly, while VL showed a trend. These effects were not present in post-menopausal women regardless of RT intensity.
CONCLUSION
RT with free weight is safe and effective for middle-aged women to increase 1-RM. Hypertrophy effects were found exclusively in pre-menopausal women. To achieve hypertrophy and/or body composition changes in post-menopausal women, larger training volumes (> 6-8 sets/muscle per week) are likely required.
Topics: Middle Aged; Humans; Female; Muscle Strength; Resistance Training; Muscle, Skeletal; Body Composition; Menopause; Hypertrophy
PubMed: 37803287
DOI: 10.1186/s12905-023-02671-y -
The Journal of Sports Medicine and... Jan 2024Hypoxia is an environmental condition that occurs in sports performed at high altitude. Adaptation to hypoxia is accompanied by changes in body composition and cardiac...
BACKGROUND
Hypoxia is an environmental condition that occurs in sports performed at high altitude. Adaptation to hypoxia is accompanied by changes in body composition and cardiac function that could impair sport performance in altitude. These changes concern mainly to a reduction in muscle mass and an increased heart rate. In this context, a resistance training protocol in a normobaric hypoxia chamber has been implemented. Therefore, the aim of this study was to study the changes in body composition and cardiovascular variables after a training period in intermittent hypoxia.
METHODS
A single-blind experimental study was carried out for 3 weeks. Thirty-two participants were distributed in a control group resistance training in normoxia (N) at sea level and an experimental group resistance training in intermittent hypoxia (IH) between a simulated 5100-5800m during 15 sessions with a controlled diet. Anthropometry according to ISAK was used to determine body composition. Systolic and diastolic blood pressures and other cardiovascular parameters were monitored.
RESULTS
IH showed a reduction in body fat (from 8.9±1.9% to 8.2±1.7%) compared to N (from 8.4±1.5% to 8.1±1.4%) (P<0.001). In addition, significant changes in blood pressure were observed at the end compared to the beginning of the intervention in the IH (from 124.7±10.2 to 116.9±8.3 mmHg and 68.3±8.8 to 62.4±5.7 mmHg in systolic a diastolic blood pressure respectively). In addition, resting heart rate was significantly reduced in IH. However, partial oxygen saturation displayed no changes in both groups.
CONCLUSIONS
Altogether, the training protocol in intermittent hypoxia performed in the present report allowed to adjust body weight through fat mass reduction but maintaining muscle mass. In addition, a decrease in blood pressure and basal heart rate was observed.
Topics: Humans; Blood Pressure; Endurance Training; Single-Blind Method; Hypoxia; Adipose Tissue; Resistance Training
PubMed: 37902805
DOI: 10.23736/S0022-4707.23.15323-0 -
Time to consider the potential role of alternative resistance training methods in cancer management?Journal of Sport and Health Science Nov 2023Exercise has emerged as fundamental therapeutic medicine in the management of cancer. Exercise improves health-related outcomes, including quality of life, neuromuscular... (Review)
Review
Exercise has emerged as fundamental therapeutic medicine in the management of cancer. Exercise improves health-related outcomes, including quality of life, neuromuscular strength, physical function, and body composition, and it is associated with a lower risk of disease recurrence and increased survival. Moreover, exercise during or post cancer treatments is safe, can ameliorate treatment-related side effects, and may enhance the effectiveness of chemotherapy and radiation therapy. To date, traditional resistance training (RT) is the most used RT modality in exercise oncology. However, alternative training modes, such as eccentric, cluster set, and blood flow restriction are gaining increased attention. These training modalities have been extensively investigated in both athletic and clinical populations (e.g., age-related frailty, cardiovascular disease, type 2 diabetes), showing considerable benefits in terms of neuromuscular strength, hypertrophy, body composition, and physical function. However, these training modes have only been partially or not at all investigated in cancer populations. Thus, this study outlines the benefits of these alternative RT methods in patients with cancer. Where evidence in cancer populations is sparse, we provide a robust rationale for the possible implementation of certain RT methods that have shown positive results in other clinical populations. Finally, we provide clinical insights for research that may guide future RT investigations in patients with cancer and suggest clear practical applications for targeted cancer populations and related benefits.
Topics: Humans; Resistance Training; Diabetes Mellitus, Type 2; Quality of Life; Muscle Strength; Exercise; Neoplasms
PubMed: 37399886
DOI: 10.1016/j.jshs.2023.06.007 -
Archives of Gerontology and Geriatrics Nov 2023To examine the effect of high-velocity resistance training (HVRT) on the executive function of middle-aged and older adults with and without mobility limitations.
OBJECTIVES
To examine the effect of high-velocity resistance training (HVRT) on the executive function of middle-aged and older adults with and without mobility limitations.
METHODS
Participants (n = 41, female: 48.9%) completed a supervised 12-week HVRT intervention (2 sessions/week; at 40-60% of one-repetition maximum). The sample included 17 middle-aged adults (40-55 years); 16 older adults (>60 years) and 8 mobility-limited older adults (LIM). Executive function was assessed before and after the intervention period and was reported as z-scores. Maximal dynamic strength, peak power, quadriceps muscle thickness, maximal isometric voluntary contraction (MVIC), and functional performance were also measured pre and post intervention. Training-related adaptations in cognitive measures were calculated using a Generalized Estimating Equation model.
RESULTS
HVRT improved executive function in LIM (adjusted marginal mean differences [AMMD]: 0.21; 95%CI: 0.04, 0.38; p = 0.040) although no effect on middle-aged (AMMD: 0.04; 95%CI: -0.09; 0.17; p = 0.533) and older (AMMD: -0.11; 95%CI: -0.25; 0.02; p = 0.107) participants was observed. Improvements in maximal dynamic strength, peak power, MVIC, quadriceps muscle thickness, and functional performance were all associated with changes in executive function, and changes in the first four also seem to mediate the association between changes in functional performance and executive function.
CONCLUSIONS
HVRT-induced improvement in executive function of mobility-limited older adults were mediated by changes in lower-body muscle strength, power, and muscle thickness. Our findings reinforce the relevance of muscle-strengthening exercises to preserve cognition and mobility in older adults.
Topics: Humans; Female; Middle Aged; Aged; Resistance Training; Executive Function; Muscle Strength; Quadriceps Muscle; Exercise Therapy
PubMed: 37269697
DOI: 10.1016/j.archger.2023.105081 -
Gut and Liver Jul 2023
Topics: Humans; Non-alcoholic Fatty Liver Disease; Resistance Training; Insulin Resistance; Exercise; Liver
PubMed: 37449429
DOI: 10.5009/gnl230232 -
Resistance training effects on healthy postmenopausal women: a systematic review with meta-analysis.Climacteric : the Journal of the... Jun 2024The aim of this systematic review with meta-analysis was to evaluate the effects of resistance training on physical fitness, physiological variables and body composition... (Meta-Analysis)
Meta-Analysis
The aim of this systematic review with meta-analysis was to evaluate the effects of resistance training on physical fitness, physiological variables and body composition of postmenopausal women. The present systematic review was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statement and was registered in PROSPERO. A total of 12 studies were included. The literature search was performed in PubMed, Web of Science and EBSCO. Randomized control trials were included. Two blinded investigators performed the search, study selection and data collection, and assessed the quality and risk of bias. A random-effects model was used for all analyses. Compared to the control group, resistance training produced a significant improvement in maximal oxygen volume (standardized mean difference [SMD] = 2.32, < 0.001), lower extremity strength (SMD = 4.70, < 0.001) and upper extremity strength (SMD = 7.42, < 0.001). The results obtained in the systematic review and meta-analysis confirm the benefits of resistance training on physical fitness in postmenopausal women, although there is more debate regarding its influence on bone mineral density, and anthropometric and derived variables. This work provides a solid starting point for promoting resistance training at a frequency of 3 days per week, in 60-min sessions, with the aim of improving parameters directly related to quality of life, functionality and disease prevention of postmenopausal women.
Topics: Humans; Female; Resistance Training; Postmenopause; Muscle Strength; Physical Fitness; Body Composition; Bone Density; Middle Aged; Randomized Controlled Trials as Topic
PubMed: 38353251
DOI: 10.1080/13697137.2024.2310521 -
PloS One 2023Stroke impacts nearly 14 million people annually. Muscle strength and physical function are often affected by stroke and important determinants of stroke recovery....
BACKGROUND
Stroke impacts nearly 14 million people annually. Muscle strength and physical function are often affected by stroke and important determinants of stroke recovery. Resistance exercise training (RT) has been shown to improve muscle strength, but RT prescriptions may be suboptimal for other aspects of stroke recovery. Parameters such as frequency, intensity, type, and duration may influence the effectiveness of RT interventions but have not been systematically evaluated.
OBJECTIVES
1) To determine the effects of RT on stroke recovery, and 2) to examine the influence of RT parameters on intervention effects.
ELIGIBILITY CRITERIA
Randomized controlled trials examining the effects of RT will be eligible for this systematic review if they: 1) included only adults with stroke or transient ischemic attack, 2) compared RT to no exercise or usual care, and 3) did not apply a co-intervention.
STUDY SELECTION
Eight databases (MEDLINE, EMBASE, EMCARE, AMED, PsychINFO, CINAHL, SPORTDiscus, and Web of Science) and 2 clinical trials registries (ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform) will be searched from inception. Two independent pairs of authors will compare titles, abstracts, and full-text reports against the eligibility criteria. Conflicts will be resolved by consensus or third author.
MAIN OUTCOME MEASURES
The construct of interest is stroke recovery. An advisory group of clinicians, researchers, and partners with lived experience of stroke will be consulted to determine specific outcome measures of interest, and to rank their relative importance. We expect to include measures of physical function, strength, cognition, and quality of life. Random-effects meta-analyses will be used to pool results for each outcome across studies, and RT parameters (frequency, intensity, type, and duration) will be used as covariates in meta-regression analyses.
CONCLUSION
The results of this review will inform the optimal RT prescription parameters for promoting stroke recovery.
Topics: Adult; Humans; Resistance Training; Quality of Life; Systematic Reviews as Topic; Exercise; Stroke; Review Literature as Topic
PubMed: 38060604
DOI: 10.1371/journal.pone.0295680