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Annales de Pathologie Mar 2024A 78-year-old woman with hypertrophic cardiomyopathy underwent a septal myomectomy and valve replacement. In the immediate postoperative period she developed shock of...
A 78-year-old woman with hypertrophic cardiomyopathy underwent a septal myomectomy and valve replacement. In the immediate postoperative period she developed shock of mixed etiology and died. At autopsy, hepatomegaly and splenomegaly were identified, with PAS and Giemsa positive intracellular ceroid granular deposits. Sea-blue histiocytosis is an extremely rare, chronic and benign deposit disease. It is characterized by hepatosplenomegaly, thrombocytopenia and lymphadenopathy. The presence of ceroid substance in granules in PAS and Giemsa stains should establish the diagnosis of suspicion.
Topics: Female; Humans; Aged; Sea-Blue Histiocyte Syndrome; Ceroid; Splenomegaly; Hepatomegaly
PubMed: 37865572
DOI: 10.1016/j.annpat.2023.10.001 -
American Journal of Hematology May 2024Bone marrow smear showing histiocytes (black arrow) containing sea blue granules stained with May-Grünwald Giemsa.
Bone marrow smear showing histiocytes (black arrow) containing sea blue granules stained with May-Grünwald Giemsa.
Topics: Humans; Sea-Blue Histiocyte Syndrome; Pancytopenia; Parenteral Nutrition; Histiocytes
PubMed: 38115676
DOI: 10.1002/ajh.27185