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Memory & Cognition Oct 2023Word learning is one of the first steps into language, and vocabulary knowledge predicts reading, speaking, and writing ability. There are several pathways to word... (Randomized Controlled Trial)
Randomized Controlled Trial
Word learning is one of the first steps into language, and vocabulary knowledge predicts reading, speaking, and writing ability. There are several pathways to word learning and little is known about how they differ. Previous research has investigated paired-associate (PAL) and cross-situational word learning (CSWL) separately, limiting the understanding of how the learning process compares across the two. In PAL, the roles of word familiarity and working memory have been thoroughly examined, but these same factors have received very little attention in CSWL. We randomly assigned 126 monolingual adults to PAL or CSWL. In each task, names of 12 novel objects were learned (six familiar words, six unfamiliar words). Logistic mixed-effects models examined whether word-learning paradigm, word type and working memory (measured with a backward digit-span task) predicted learning. Results suggest better learning performance in PAL and on familiar words. Working memory predicted word learning across paradigms, but no interactions were found between any of the predictors. This suggests that PAL is easier than CSWL, likely because of reduced ambiguity between the word and the referent, but that learning across both paradigms is equally enhanced by word familiarity, and similarly supported by working memory.
Topics: Adult; Humans; Language; Learning; Memory, Short-Term; Paired-Associate Learning; Verbal Learning; Vocabulary
PubMed: 37012500
DOI: 10.3758/s13421-023-01421-7 -
Psychological Medicine Aug 2023The cognitive profile in 22q11.2 deletion syndrome (22q11.2DS) is often characterized by a discrepancy between nonverbal verbal reasoning skills, in favor of the latter...
BACKGROUND
The cognitive profile in 22q11.2 deletion syndrome (22q11.2DS) is often characterized by a discrepancy between nonverbal verbal reasoning skills, in favor of the latter skills. This dissociation has also been observed in memory, with verbal learning skills described as a relative strength. Yet the development of these skills is still to be investigated. We thus aimed to explore verbal learning longitudinally. Furthermore, we explored verbal learning and its respective associations with hippocampal alterations and psychosis, which remain largely unknown despite their high prevalence in 22q11.2DS.
METHODS
In total, 332 individuals (173 with 22q11.2DS) aged 5-30 years completed a verbal-paired associates task. Mixed-models regression analyses were conducted to explore developmental trajectories with threefold objectives. First, verbal learning and retention trajectories were compared between 22q11.2DS HC. Second, we examined hippocampal volume development in 22q11.2DS participants with lower higher verbal learning performance. Third, we explored verbal learning trajectories in 22q11.2DS participants with without positive psychotic symptoms and with without a psychotic spectrum disorder (PSD).
RESULTS
Our findings first reveal lower verbal learning performance in 22q11.2DS, with a developmental plateau emerging from adolescence. Second, participants with lower verbal learning scores displayed a reduced left hippocampal tail volume. Third, participants with PSD showed a deterioration of verbal learning performance, independently of verbal reasoning skills.
CONCLUSION
Our study challenges the current view of preserved verbal learning skills in 22q11.2DS and highlights associations with specific hippocampal alterations. We further identify verbal learning as a novel cognitive marker for psychosis in 22q11.2DS.
Topics: Adolescent; Humans; DiGeorge Syndrome; Psychotic Disorders; Learning; Verbal Learning; Hippocampus
PubMed: 35775360
DOI: 10.1017/S0033291722001842 -
Behavior Research Methods Mar 2024Iconic words and signs are characterized by a perceived resemblance between aspects of their form and aspects of their meaning. For example, in English, iconic words...
Iconic words and signs are characterized by a perceived resemblance between aspects of their form and aspects of their meaning. For example, in English, iconic words include peep and crash, which mimic the sounds they denote, and wiggle and zigzag, which mimic motion. As a semiotic property of words and signs, iconicity has been demonstrated to play a role in word learning, language processing, and language evolution. This paper presents the results of a large-scale norming study for more than 14,000 English words conducted with over 1400 American English speakers. We demonstrate the utility of these ratings by replicating a number of existing findings showing that iconicity ratings are related to age of acquisition, sensory modality, semantic neighborhood density, structural markedness, and playfulness. We discuss possible use cases and limitations of the rating dataset, which is made publicly available.
Topics: Humans; Language; Semantics; Language Development; Verbal Learning; Sound
PubMed: 37081237
DOI: 10.3758/s13428-023-02112-6 -
Alzheimer's Research & Therapy Aug 2023Subjective cognitive decline (SCD) is a risk factor for Alzheimer's disease (AD); however, the rates of cognitive decline are variable according to underlying... (Observational Study)
Observational Study
BACKGROUND
Subjective cognitive decline (SCD) is a risk factor for Alzheimer's disease (AD); however, the rates of cognitive decline are variable according to underlying pathologies and biomarker status. We conducted an observational study and aimed to investigate baseline characteristics and biomarkers related with cognitive declines in SCD. Our study also assessed whether SCD participants showed different cognitive and biomarker trajectories according to baseline amyloid deposition.
METHODS
This study is a part of a longitudinal cohort study conducted in multi-centers in South Korea between 2018 and 2021. Individuals (≥ 60 years old) with persistent cognitive complaint despite of normal cognitive functions were eligible for the study. All participants underwent neuropsychological tests, florbetaben PET scans, plasma amyloid markers, and brain MRI scans. Annual follow-up evaluations included neuropsychological tests and assessments for clinical progressions. Regional brain volumetry and amyloid burden represented by PET-based standardized uptake value ratio (SUVR) were measured. We compared cognitive and brain atrophic changes over 24 months between amyloid positive-SCD (Aβ + SCD) and amyloid negative-SCD (Aβ-SCD) groups. Baseline factors associated with cognitive outcomes were investigated.
RESULTS
A total of 120 participants with SCD were enrolled and 107 completed follow-up evaluations. Aβ + SCD participants (n = 20, 18.5%) were older and more frequently APOE4 carriers compared with Aβ-SCD participants (n = 87). Baseline cognitive scores were not different between the two groups, except the Seoul Verbal Learning Test (SVLT) scores showing lower scores in the Aβ + SCD group. After 24 months, plasma amyloid markers were higher, and regional volumes (entorhinal, hippocampal, and pallidum) were smaller in the Aβ + SCD participants compared with Aβ-SCD participants adjusted by age, sex, and baseline volumes. SVLT delayed recall and controlled oral word association test (COWAT) scores indicated more declines in Aβ + SCD participants. Baseline left entorhinal volumes were related to verbal memory decline, while baseline frontal volumes and global SUVR values were related to frontal functional decline.
CONCLUSION
Aβ + SCD participants showed more cognitive decline and medial temporal atrophic changes during 24 months. Baseline neurodegeneration and amyloid burden were related with future cognitive trajectories in SCD.
TRIAL REGISTRATION
This study was registered at CRIS (KCT0003397).
Topics: Humans; Middle Aged; Amyloid beta-Peptides; Longitudinal Studies; Prospective Studies; Alzheimer Disease; Cognitive Dysfunction; Positron-Emission Tomography; Cognition; Cohort Studies; Biomarkers
PubMed: 37550761
DOI: 10.1186/s13195-023-01273-y -
AIDS (London, England) Nov 2023To evaluate the peripheral hearing sensitivity and central auditory processing in persons with HIV (PWH) and persons without HIV (PWoH); and the association between... (Observational Study)
Observational Study
OBJECTIVES
To evaluate the peripheral hearing sensitivity and central auditory processing in persons with HIV (PWH) and persons without HIV (PWoH); and the association between cognitive function and central auditory processing in PWH and PWoH.
DESIGN
Cross-sectional, observational study.
METHODS
Participants included 67 PWH {70.2% men; mean age = 66.6 years [standard deviation (SD) = 4.7 years]} and 35 PWoH [51.4% men; mean age = 72.9 years (SD = 7.0 years)]. Participants completed a hearing assessment and a central auditory processing assessment that included dichotic digits testing (DDT). Pure-tone air-conduction thresholds were obtained at octave frequencies from 0.25 through 8 kHz. A pure-tone average (PTA) was calculated from 0.5, 1, 2, and 4 kHz thresholds for each ear. Participants also completed a neuropsychological battery assessing cognition in seven domains.
RESULTS
PWH had slightly lower (i.e. better) PTAs compared with PWoH, but this was not statistically significant. Conversely, PWH and PWoH had similar DDT results for both ears. Poorer verbal fluency, learning, and working memory performance was significantly related to lower DDT scores, and those defined as having verbal fluency, learning, and working memory impairment had significantly poorer DDT scores (8-18% lower) in both ears.
CONCLUSION
Hearing and DDT results were similar in PWH and PWoH. The relationship between verbal fluency, learning, and working memory impairment and poorer DDT results did not differ by HIV serostatus. Clinicians, particularly audiologists, should be mindful of cognitive functioning abilities when evaluating central auditory processing.
Topics: Male; Humans; Aged; Female; Cross-Sectional Studies; HIV Infections; Cognition; Cognition Disorders; Learning
PubMed: 37289579
DOI: 10.1097/QAD.0000000000003618 -
Adicciones Mar 2024Brain damage related to alcohol consumption is associated with impairments in cognitive functions, among which memory and verbal learning stand out. The main objective...
Brain damage related to alcohol consumption is associated with impairments in cognitive functions, among which memory and verbal learning stand out. The main objective is to evaluate memory and verbal learning in a sample of 111 patients with alcohol use disorder (AUD) versus 78 with major depressive disorder (MDD) and 100 healthy controls. The evaluation included sociodemographic and clinical variables, the Hamilton Depression Scale (HDRS) and the California Verbal Learning Test (CVLT). One-way ANOVA was used for comparisons between the 3 groups and two-way ANCOVAS including different covariates. The one-way ANOVA shows that patients with AUD and MDD had scores similar to each other and lower than those of the control group (p < 0.001), with the exception of the Cued CVLT (worse scores in MDD vs AUD, p < 0.001). After including age, sex and years of completed studies as covariates, the differences between the AUD and MDD groups persisted compared to the control group (p ≤ 0.003) in all indices except for the Immediate Free CVLT and the Cued CVLT (worse performance in MDD vs AUD, p = 0.022 and p = 0.035, respectively). In the second ANCOVA, after controlling for depression severity, differences were only detected between AUD patients and healthy controls (p ≤ 0.007). Patients with AUD present a significant impairment in learning and verbal memory when compared with patients with MDD and with healthy people.
Topics: Humans; Depressive Disorder, Major; Alcoholism; Alcohol Drinking; Verbal Learning
PubMed: 34882245
DOI: 10.20882/adicciones.1696 -
Cognition Nov 2023When people use rule-based integration of abstracted cues to make multiple-cue judgments they tend to default to linear additive integration of the cues, which may...
When people use rule-based integration of abstracted cues to make multiple-cue judgments they tend to default to linear additive integration of the cues, which may interfere with efficient learning in non-additive tasks. We hypothesize that this effect becomes especially pronounced when cues are presented numerically rather than verbally, because numbers elicit expectations about a task with a simple numerical solution that can be appropriately addressed by linear and additive integration. This predicts that, relative to a verbal format, a numerical format should be advantageous for learning in additive tasks, but detrimental for learning in non-additive tasks. In two experiments, we find support for the hypothesis that a verbal format can improve learning in non-additive tasks. The division-of-labor between cognitive processes observed in previous research (Juslin et al., 2008), with cue abstraction in additive tasks and exemplar memory in non-additive tasks, was only present in conditions with numeric information and may therefore in part be driven by the use of numeric formats. This illustrates how surface characteristic of stimuli can elicit different priors about the nature of the variables and the generative model that produced the cues and the criterion. We fitted cue-abstraction and exemplar algorithms by PNP-modeling (Sundh et al., 2021). At the end of training both cue abstraction and exemplar memory processes primarily involved exact analytic processes marred by occasional error, rather than the noisy and approximate intuitive processes typically assumed in previous studies - specifically, cue abstraction was primarily implemented by number crunching and exemplar memory by rote memorization.
Topics: Humans; Cues; Learning; Memory; Concept Formation; Algorithms
PubMed: 37657396
DOI: 10.1016/j.cognition.2023.105584 -
Cancers Sep 2023About one-in-three breast cancer survivors have lingering cognitive complaints and objective cognitive impairment. Chronic inflammation and intestinal permeability...
About one-in-three breast cancer survivors have lingering cognitive complaints and objective cognitive impairment. Chronic inflammation and intestinal permeability (i.e., leaky gut), two risk factors for cognitive decline, can also fuel depression-another vulnerability for cognitive decline. The current study tested whether depression accompanied by high levels of inflammation or intestinal permeability predicted lower subjective and objective cognitive function in breast cancer survivors. We combined data from four breast cancer survivor studies ( = 613); some had repeated measurements for a total of 1015 study visits. All participants had a blood draw to obtain baseline measures of lipopolysaccharide binding protein-a measure of intestinal permeability, as well as three inflammatory markers that were incorporated into an inflammatory index: C-reactive protein, interleukin-6, and tumor necrosis factor-α. They reported depressive symptoms on the Center for Epidemiological Studies depression scale (CES-D), and a binary variable indicated clinically significant depressive symptoms (CES-D ≥ 16). The Kohli (749 observations) and the Breast Cancer Prevention Trial (591 observations) scales assessed subjective cognitive function. Objective cognitive function tests included the trail-making test, Hopkins verbal learning test, Conners continuous performance test, n-back test, FAS test, and animal-naming test (239-246 observations). Adjusting for education, age, BMI, cancer treatment type, time since treatment, study visit, and fatigue, women who had clinically elevated depressive symptoms accompanied by heightened inflammation or intestinal permeability reported poorer focus and marginally poorer memory. However, poorer performance across objective cognitive measures was not specific to inflammation-associated depression. Rather, there was some evidence of lower verbal fluency; poorer attention, verbal learning and memory, and working memory; and difficulties with visuospatial search among depressed survivors, regardless of inflammation. By themselves, inflammation and intestinal permeability less consistently predicted subjective or objective cognitive function. Breast cancer survivors with clinically significant depressive symptoms accompanied by either elevated inflammation or intestinal permeability may perceive greater cognitive difficulty, even though depression-related objective cognitive deficits may not be specific to inflammation- or leaky-gut-associated depression.
PubMed: 37686689
DOI: 10.3390/cancers15174414 -
Experimental Brain Research Apr 2024Psychomotor slowing has consistently been observed in schizophrenia, however research on motor learning in schizophrenia is limited. Additionally, motor learning in...
Psychomotor slowing has consistently been observed in schizophrenia, however research on motor learning in schizophrenia is limited. Additionally, motor learning in schizophrenia has never been compared with the waning of motor learning abilities in the elderly. Therefore, in an extensive study, 30 individuals with schizophrenia, 30 healthy age-matched controls and 30 elderly participants were compared on sensorimotor learning tasks including sequence learning and adaptation (both explicit and implicit), as well as tracking and aiming. This paper presents new findings on an explicit motor sequence learning task, an explicit verbal learning task and a simple aiming task and summarizes all previously published findings of this large investigation. Individuals with schizophrenia and elderly had slower Movement Time (MT)s compared with controls in all tasks, however both groups improved over time. Elderly participants learned slower on tracking and explicit sequence learning while individuals with schizophrenia adapted slower and to a lesser extent to movement perturbations in adaptation tasks and performed less well on cognitive tests including the verbal learning task. Results suggest that motor slowing is present in schizophrenia and the elderly, however both groups show significant but different motor skill learning. Cognitive deficits seem to interfere with motor learning and performance in schizophrenia while task complexity and decreased movement precision interferes with motor learning in the elderly, reflecting different underlying patterns of decline in these conditions. In addition, evidence for motor slowing together with impaired implicit adaptation supports the influence of cerebellum and the cerebello-thalamo-cortical-cerebellar (CTCC) circuits in schizophrenia, important for further understanding the pathophysiology of the disorder.
Topics: Humans; Aged; Psychomotor Performance; Schizophrenia; Learning; Aging; Verbal Learning
PubMed: 38459999
DOI: 10.1007/s00221-024-06797-9 -
Clinical Neurophysiology : Official... Dec 2023To clarify whether preoperative language magnetoencephalography (MEG) predicts postoperative verbal memory (VM) changes in left mesial temporal lobe epilepsy (LMTLE). (Review)
Review
OBJECTIVE
To clarify whether preoperative language magnetoencephalography (MEG) predicts postoperative verbal memory (VM) changes in left mesial temporal lobe epilepsy (LMTLE).
METHODS
We reviewed 18 right-handed patients with LMTLE who underwent anterior temporal lobectomy or selective amygdala hippocampectomy, 12 with (HS+) and 6 without hippocampal sclerosis (HS-). Patients underwent neuropsychological assessment before and after surgery. MEG was measured with an auditory verbal learning task in patients preoperatively and in 15 right-handed controls. Dynamic statistical parametric mapping (dSPM) was used for source imaging of task-related activity. Language laterality index (LI) was calculated by z-score of dSPM in language-related regions. LI in the region of HS+ and HS- was compared to controls. The correlation between LI and postoperative VM change was assessed in HS+ and HS-.
RESULTS
Preoperative LI in supramarginal gyrus showed greater right-shifted lateralization in both HS+ and HS- than in controls. Right-shifted LI in supramarginal gyrus was correlated with postoperative VM increase in HS+ (p = 0.019), but not in HS-.
CONCLUSIONS
Right-shifted language lateralization in dSPM of MEG signals may predict favorable VM outcome in HS+ of LMTLE.
SIGNIFICANCE
Findings warrant further investigation of the relation between regional language laterality index and postoperative verbal memory changes.
Topics: Humans; Epilepsy, Temporal Lobe; Magnetoencephalography; Memory; Temporal Lobe; Language; Epilepsy; Neuropsychological Tests; Functional Laterality; Magnetic Resonance Imaging; Hippocampus
PubMed: 37890232
DOI: 10.1016/j.clinph.2023.09.010