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Current Protein & Peptide Science 2024Membrane protein human concentrative nucleoside transporter 3 (hCNT3) can not only transport extracellular nucleosides into the cell but also transport various...
Membrane protein human concentrative nucleoside transporter 3 (hCNT3) can not only transport extracellular nucleosides into the cell but also transport various nucleoside-derived anticancer drugs to the focus of infection for therapeutic effects. Typical nucleoside anticancer drugs, including fludarabine, cladabine, decitabine, and clofarabine, are recognized by hCNT3 and then delivered to the lesion site for their therapeutic effects. hCNT3 is highly conserved during the evolution from lower to higher vertebrates, which contains scaffold and transport domains in structure and delivers substrates by coupling with Naand H ions in function. In the process of substrate delivery, the transport domain rises from the lower side of transmembrane 9 (TM9) in the inward conformation to the upper side of the outward conformation, accompanied by the collaborative motion of TM7b/ TM4b and hairpin 1b (HP1b)/ HP2b. With the report of a series of three-dimensional structures of homologous CNTs, the structural characteristics and biological functions of hCNT3 have attracted increasing attention from pharmacists and biologists. Our research group has also recently designed an anticancer lead compound with high hCNT3 transport potential based on the structure of 5-fluorouracil. In this work, the sequence evolution, conservation, molecular structure, cationic chelation, substrate recognition, elevator motion pattern and nucleoside derivative drugs of hCNT3 were reviewed, and the differences in hCNT3 transport mode and nucleoside anticancer drug modification were summarized, aiming to provide theoretical guidance for the subsequent molecular design of novel anticancer drugs targeting hCNT3.
Topics: Animals; Humans; Nucleosides; Antineoplastic Agents; Biological Transport
PubMed: 37670708
DOI: 10.2174/1389203724666230905110952 -
Journal of Environmental Management Aug 2023As climate-related impacts threaten marine biodiversity globally, it is important to adjust conservation efforts to mitigate the effects of climate change. Translating...
As climate-related impacts threaten marine biodiversity globally, it is important to adjust conservation efforts to mitigate the effects of climate change. Translating scientific knowledge into practical management, however, is often complicated due to resource, economic and policy constraints, generating a knowledge-action gap. To develop potential solutions for marine turtle conservation, we explored the perceptions of key actors across 18 countries in the Mediterranean. These actors evaluated their perceived relative importance of 19 adaptation and mitigation measures that could safeguard marine turtles from climate change. Of importance, despite differences in expertise, experience and focal country, the perceptions of researchers and management practitioners largely converged with respect to prioritizing adaptation and mitigation measures. Climate change was considered to have the greatest impacts on offspring sex ratios and suitable nesting sites. The most viable adaptation/mitigation measures were considered to be reducing other pressures that act in parallel to climate change. Ecological effectiveness represented a key determinant for implementing proposed measures, followed by practical applicability, financial cost, and societal cost. This convergence in opinions across actors likely reflects long-standing initiatives in the Mediterranean region towards supporting knowledge exchange in marine turtle conservation. Our results provide important guidance on how to prioritize measures that incorporate climate change in decision-making processes related to the current and future management and protection of marine turtles at the ocean-basin scale, and could be used to guide decisions in other regions globally. Importantly, this study demonstrates a successful example of how interactive processes can be used to fill the knowledge-action gap between research and management.
Topics: Animals; Ecosystem; Turtles; Conservation of Natural Resources; Climate Change; Biodiversity
PubMed: 37043912
DOI: 10.1016/j.jenvman.2023.117805 -
Materials (Basel, Switzerland) Jan 2024As derivatives of metal halide perovskite materials, low-dimensional metal halide materials have become important materials that have attracted much attention in recent...
As derivatives of metal halide perovskite materials, low-dimensional metal halide materials have become important materials that have attracted much attention in recent years. As one branch, zinc-based metal halides have the potential for practical applications due to their lead-free, low-toxicity and high-stability characteristics. However, pure zinc-based metal halide materials are still limited by their poor optical properties and cannot achieve large-scale practical applications. Therefore, in this work, we report an organic-inorganic hybrid zero-dimensional zinc bromide, (TDMP)ZnBr, using transition metal Mn ions as dopants and incorporating them into the (TDMP)ZnBr lattice. The original non-emissive (TDMP)ZnBr exhibits bright green emission under the excitation of external UV light after the introduction of Mn ions with a PL peak position located at 538 nm and a PLQY of up to 91.2%. Through the characterization of relevant photophysical properties and the results of theoretical calculations, we confirm that this green emission in Mn:(TDMP)ZnBr originates from the T → A optical transition process of Mn ions in the lattice structure, and the near-unity PLQY benefits from highly localized electrons generated by the unique zero-dimensional structure of the host material (TDMP)ZnBr. This work provides theoretical guidance and reference for expanding the family of zinc-based metal halide materials and improving and controlling their optical properties through ion doping.
PubMed: 38591378
DOI: 10.3390/ma17030562 -
Heliyon Apr 2024By analysing the factors influencing secondary vocational students' learning burnout in the context of social media, this study unearthed the underlying causes of...
Analysing influencing factors and correlation paths of learning burnout among secondary vocational students in the context of social media: An integrated ISM-MICMAC approach.
By analysing the factors influencing secondary vocational students' learning burnout in the context of social media, this study unearthed the underlying causes of learning burnout. It also determined the correlation paths among the factors influencing learning burnout, providing references for educational and pedagogical improvement. This contributes to preventing secondary vocational students' learning burnout and enhancing learning efficiency in secondary vocational schools. Combined with previous research results and a theoretical basis, this study identifies 10 influencing factors employing the Delphi method, and uses Interpretative Structural Modelling (ISM) and Matrice d' Impacts Croisés Multiplication Appliqués à un Classement (MICMAC) to elucidate the relationship between influencing factors of learning burnout among secondary vocational students in the context of social media. This study also constructs a corresponding mechanism model and subsequently proposes prevention and improvement strategies. The results show that the overdevelopment of social media, as driving factors, has the greatest impact on secondary vocational students' learning burnout. Simultaneously, it takes the lead in addressing cognitive bias among students, decreased self-control, and low learning efficiency, factors that contribute to learning burnout. This is particularly beneficial in alleviating the degree of learning burnout among secondary vocational students in the context of social media and improves overall learning outcomes for these students. The hierarchical structure and correlation paths identified in this study offer robust invaluable guidance for developing a scientific program to address the problem of learning burnout among this demographic. This includes implementing related educational practises, thereby reducing the unpredictability of the practical applications.
PubMed: 38586410
DOI: 10.1016/j.heliyon.2024.e28696 -
BMC Nursing Jun 2024The lack of professional identity can impede the transition from nursing students to qualified nurses and exacerbate the shortage of health care professionals....
BACKGROUND
The lack of professional identity can impede the transition from nursing students to qualified nurses and exacerbate the shortage of health care professionals. Personality is important to resilience-building and professional identity development in nursing students. However, the associations among personality, resilience, and professional identity are less explored. The study aims to identify latent subtypes of personality, to evaluate the mediating role of resilience between personality and professional identity in nursing students, and to provide practical guidance for educators' subsequent interventions with nursing students' professional identity.
METHODS
1397 nursing students were recruited from Be Resilient to Nursing Career (BRNC) between October 2020 and April 2022 by cluster sampling from 4 universities in China. NEO Five-Factor Inventory, 10-item Connor-Davidson Resilience Scale, and Professional Identity Questionnaire for Undergraduate Students were administered. Analyses of latent profiles and mediations were performed.
RESULTS
Three latent personality types were identified: Over-sensitivity (35.4%), Ordinary (53.8%), and Flexibility (10.8%). Nursing role model was found to be a significant indicator of personality (Ordinary as ref, Over-sensitivity: OR = 0.73, 95% CI: 0.57-0.93, P = 0.010; Flexibility: OR = 1.85, 95% CI: 1.29-2.65, P = 0.001). The association between personality portraits and professional identity were significantly mediated by resilience (P < 0.05).
CONCLUSIONS
There exists heterogeneity in nursing students' personality. Resilience plays a significant role in mediating the relationship between personality and professional identity.
PubMed: 38907353
DOI: 10.1186/s12912-024-02007-7 -
BMC Palliative Care May 2024WHO stated the environment is an important factor affecting the development of hospice care. The environment is the sum of factors affecting behavior besides the...
BACKGROUND
WHO stated the environment is an important factor affecting the development of hospice care. The environment is the sum of factors affecting behavior besides the individual factors. Currently, a scale to comprehensively assess the hospice environment of nurse is still lacking. This study aimed to develop an instrument to investigate the environmental factors affecting hospice care of nurses.
METHODS
Literature review and a semi-structured interview were conducted to form the items pool of the Hospice Care Environment Scale. Two rounds of Delphi expert consultation were conducted by 16 experts to revise the scale dimensions and entries to form the Hospice Care Environment Scale. A psychometric evaluation was then performed among 530 oncology nurses in a large tertiary oncology hospital in Hubei Province. The 500 valid questionnaires were randomly divided into two groups in a 1:1 ratio, sample 1 (n1 = 250) for item screening and sample 2 (n2 = 250) for quality evaluation of the resulting scale. Item analysis, reliability analysis, validity analysis and acceptability analysis were performed.
RESULT
The Hospice Care Environment Scale consists of two dimensions and 13 entries. The Cronbach's α coefficient of the Hospice Care Environment Scale was 0.970, and the Cronbach's α coefficient of the two dimensions were 0.952 and 0.969, respectively, with the Item-content validity index and average Scale- content validity index of the scale was both 1.000. The validation factor analysis showed the standardized path coefficients of each item were basically above 0.5, and the factor structure model was stable and suitable. The average completion time of the scale was about 3 min, which had good feasibility.
CONCLUSION
The Hospice Care Environment Scale to assess the environment of hospice care services, has good content and construct validity and reliability. This scale can provide guidance to evaluate the hospice care environment.
Topics: Humans; Reproducibility of Results; Psychometrics; Surveys and Questionnaires; Hospice Care; Female; Male; Delphi Technique; Adult; Middle Aged; China
PubMed: 38802846
DOI: 10.1186/s12904-024-01450-2 -
ChemPlusChem Mar 2024In this work, we explored the hydrothermal synthesize and crystallization process of SAPO-34 zeolites from two-dimensional layered silicate magadiite by using...
In this work, we explored the hydrothermal synthesize and crystallization process of SAPO-34 zeolites from two-dimensional layered silicate magadiite by using tetraethylammonium hydroxide (TEAOH) as a templating agent. Comprehensive characterization was conducted by XRD, SEM, FTIR, Raman, and BET. Time-resolved PXRD analysis revealed that SAPO-34 zeolite exhibited a steep growth curve when the crystallization time was 30 h, and the crystallinity reached 98.65 % at 48 h. Specifically, the disruption of the magadiite layer exposed charged silanol groups on the surface, fostering an affinity for AlO and PO species, thereby initiating the nucleation process. Under the guidance of TEAOH, these nucleation sites transformed into SAPO-34 nuclei, gradually advancing towards crystallization. FTIR and Raman analyses affirmed the presence of 6Rs, followed by D6R and 4Rs SBUs, along with the characteristic CHA structure. Combined with Si NMR established that disaggregated silicate minerals served as zeolite synthesis "seeds", enhancing nucleation sites and overall crystallization efficiency.
PubMed: 38459786
DOI: 10.1002/cplu.202400104 -
Scientific Reports Nov 2023The conventional star-shaped honeycomb (CSSH) structure is inherently rich in mechanical properties. Based on the CSSH structure, the Poisson's ratio and Young's modulus...
The conventional star-shaped honeycomb (CSSH) structure is inherently rich in mechanical properties. Based on the CSSH structure, the Poisson's ratio and Young's modulus can be improved by adding the tip re-entrant angle (ISSH). In this paper, a new concave four-arc honeycomb (CFAH) structure is proposed by designing the straight rod as a curved rod and retaining the tip re-entrant angle from the ISSH structure. The Young's modulus, specific stiffness and Poisson's ratio of CFAH structures are derived from Castigliano's second theorem and Moore's theorem. The theoretical results show good agreement with the numerical and experimental results. The results show that the normalized effective specific stiffness and normalized effective Young's modulus of the CFAH structure are further improved by about 12.95% and 16.86%, respectively, compared with the ISSH structure, and more significant auxiliary effects are obtained. CFAH structures show good promise in aerospace, construction and other applications due to their enhanced mechanical property. Meanwhile, the present work provides guidance for the study of concave four-arc honeycomb structures.
PubMed: 38036740
DOI: 10.1038/s41598-023-48570-y -
Scientific Reports Feb 2024The outcrop fire area in Rujigou Coal Mine in Ningxia, China has been burning continuously for over 100 years. This not only results in wastage of resources but also...
The outcrop fire area in Rujigou Coal Mine in Ningxia, China has been burning continuously for over 100 years. This not only results in wastage of resources but also poses significant damage to the ecological environment. Previous research on open fire detection has mainly focused on coalfield fire areas, using single method such as infrared remote sensing or surface temperature measurement, magnetic method, electrical method, radon measurement and mercurimetry. However, the outcrop fire area has migrated to deeper parts over the years, conventional single fire zone detection methods are not capable of accurately detecting the extent of the fire zone, inversion interpretation is faced with the problem of many solutions. In fire management, current research focuses on the development of new materials, such as fly ash gel, sodium silicate gel, etc., However, it is often difficult to quickly extinguish outcrop fire areas with a single technique. Considering this status quo, unmanned aerial vehicle (UAV) infrared thermal imaging was employed to initially detect the scope of the outcrop fire area, and then both the spontaneous potential and directional drilling methods were adopted for further scope detection in pursuit of more accurate results. In addition, an applicable fire prevention and extinguishing system was constructed, in which three-phase foam was injected for the purpose of absorbing heat and cooling. Furthermore, the composite colloid was used to plug air leakage channels, and loess was backfilled to avoid re-combustion. The comprehensive detection and control technologies proposed in this study can be applied to eliminating the outcrop fire area and protecting the environment. This study can provide guidance and reference for the treatment of other outcrop fire areas.
PubMed: 38409355
DOI: 10.1038/s41598-024-55304-1 -
Nature Sep 2023
Topics: Financing, Organized; Writing; Vocational Guidance
PubMed: 37658258
DOI: 10.1038/d41586-023-02756-6