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JAAD Case Reports Aug 2023
PubMed: 37600735
DOI: 10.1016/j.jdcr.2023.05.037 -
Nuklearmedizin. Nuclear Medicine May 2024The authors present a procedure guideline for scintigraphic detection of sentinel lymph nodes in malignant melanoma, in breast cancer, in penile and vulva tumors, in...
The authors present a procedure guideline for scintigraphic detection of sentinel lymph nodes in malignant melanoma, in breast cancer, in penile and vulva tumors, in head and neck cancer, and in prostate carcinoma. Important goals of sentinel lymph node scintigraphy comprise reduction of the extent of surgery, lower postoperative morbidity and optimization of histopathological examination focussing on relevant lymph nodes. Sentinel lymph node scintigraphy itself does not diagnose tumorous lymph node involvement and is not indicated when lymph node or distant metastases have been definitely diagnosed before sentinel lymph node scintigraphy. Procedures are compiled with the aim to reliably localise sentinel lymph nodes with a high detection rate typically in early tumour stages. New aspects in this guideline are new radiopharmaceuticals such as tilmanocept and Tc-99m-PSMA and SPECT/CT allowing an easier anatomical orientation. Initial dynamic lymphoscintigraphy in breast cancer is of little significance nowadays. Radiation exposure is low so that pregnancy is not a contraindication for sentinel lymph node scintigraphy. A one-day protocol should preferentially be used. Even with high volumes of scintigraphic sentinel lymph node procedures surgeons, theatre staff and pathologists receive a radiation exposure < 1 mSv/year so that they do not require occupational radiation surveillance. Aspects of quality control were included (scintigraphy, quality control of gamma probe, 6 h SLN course for surgeons, certified breast centers, medical surveillance center).
PubMed: 38788776
DOI: 10.1055/a-2319-8306 -
BMC Cancer Jan 2024Vulvar and vaginal melanoma (VuM & VaM) is a rare gynecologic malignancy with high mortality but low effectiveness to checkpoint immunotherapy compared to cutaneous...
BACKGROUND
Vulvar and vaginal melanoma (VuM & VaM) is a rare gynecologic malignancy with high mortality but low effectiveness to checkpoint immunotherapy compared to cutaneous melanoma. This article aims to elucidate the role of the disordered immune microenvironment in cancer progression in VuM.
METHODS
At first, this article applied single-cell RNA sequencing (scRNA-seq) to the VuM obtained from a 68-year-old female patient, and constructed a single-cell atlas of VuM consist of 12,243 single cells. Then this article explores the genomic complexity and core signal channel in VuM microenvironment.
RESULTS
This article provides new insights about the pathogenesis of VuM based on single-cell resolution data. It was found that the activation of CD8 T cell contributed to induce tumor angiogenesis and immune escape, and the activation of the antigen-presenting molecular function participated in melanoma metastasis.
CONCLUSION
This article provided new insights into underlining VuM molecular regulation and potential signaling involved in immunotherapy, which would benefit the clinical practice and administration.
Topics: Female; Humans; Aged; Melanoma; Skin Neoplasms; Vulvar Neoplasms; Single-Cell Analysis; Immunotherapy; Tumor Microenvironment
PubMed: 38233802
DOI: 10.1186/s12885-024-11839-0 -
The Australasian Journal of Dermatology Aug 2023
Topics: Humans; Warts; Treatment Outcome; Cryotherapy
PubMed: 37435948
DOI: 10.1111/ajd.14109 -
European Journal of Dermatology : EJD Apr 2024
Topics: Humans; Melanoma; Diagnosis, Differential; Bartholin's Glands; Female; Cysts; Vulvar Diseases; Vulvar Neoplasms; Middle Aged
PubMed: 38907555
DOI: 10.1684/ejd.2024.4640