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BMC Gastroenterology Nov 2023Identifying risk factors for metachronous colorectal cancer (CRC) and metachronous advanced neoplasia could be useful for guiding surveillance. We conducted a systematic... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Identifying risk factors for metachronous colorectal cancer (CRC) and metachronous advanced neoplasia could be useful for guiding surveillance. We conducted a systematic review and meta-analysis to investigate risk factors for metachronous CRC and advanced neoplasia.
METHODS
Searches were conducted in MEDLINE, Embase, Web of Science and Cochrane Central Registry of Controlled Trials for articles (searching period: 1945 to Feburary, 2021) that reported the results of an association between any factor and metachronous advanced neoplasia or metachronous CRC. There were no restrictions on the publication date or language. Random effects models were fitted to estimate the combined association between the risk factors and metachronous CRC or advanced neoplasia. The Risk of Bias In Non-Randomised Studies of Interventions tool (ROBINS-I) was used to assess the risk of bias of included studies.
RESULTS
In total, 22 observational studies with 625,208 participants were included in the systematic review and meta-analysis. Of these, 13 studies investigated risk factors for metachronous CRC and 9 for advanced neoplasia. The risks of metachronous CRC or advanced neoplasia were higher if the first CRC was diagnosed in the presence of a synchronous advanced lesion (pooled risk ratio (RR) from 3 studies: 3.61, 95% confidence interval (CI): 1.44-9.05; and pooled RR from 8 studies: 2.77, 95% CI: 2.23-3.43, respectively). The risk of metachronous CRC was lower, but the risk of metachronous advanced neoplasia was higher if the first CRC was distal (compared with proximal) (pooled RR from 3 studies: 0.48, 95% CI: 0.23-0.98; and pooled RR from 2 studies: 2.99, 95% CI: 1.60-5.58 respectively). The risk of metachronous advanced neoplasia increased with age (pooled RR from 3 studies: 1.07 per year of age, 95% CI: 1.03-1.11). There was no evidence that any lifestyle risk factors studied were associated with the risk of metachronous CRC or advanced neoplasia.
CONCLUSIONS
The identified risk factors for metachronous CRC and advanced neoplasia might be useful to tailor the existing surveillance guidelines after the first CRC. There were potential limitations due to possible misclassification of the outcome, confounding and risk of bias, and the findings cannot be generalised to high-risk genetic syndrome cases.
Topics: Humans; Colorectal Neoplasms; Risk Factors; Neoplasms, Second Primary
PubMed: 38036994
DOI: 10.1186/s12876-023-03053-2 -
Cureus Dec 2023When restoring proximal surfaces in posterior teeth, dentists frequently encounter the difficulty of reproducing the proximal contact that is naturally present in... (Review)
Review
When restoring proximal surfaces in posterior teeth, dentists frequently encounter the difficulty of reproducing the proximal contact that is naturally present in unrestored teeth. In order to guarantee the durability of restorations made from class II composite resin, it is imperative that both functional and aesthetic requirements are met. This entails the choice of the matrix system that replicates the optimal proximal contact subsequent to the insertion of restorations made of class II composite resin. The objective of this systematic review is to assemble current research conducted on the various matrix systems utilized in class II composite restorations and assess their impact on the pre-existing composite proximal contact. Three examiners conducted an independent electronic search utilizing the subsequent databases: Web of Science, Cochrane Library, Scopus, PubMed, and Embase. Publications on proximal contact in class II composite restorations were compiled from the time of their inception until August 2022, in accordance with predetermined inclusion and exclusion criteria. The methodological quality assessment was conducted utilizing the Effective Public Health Practice Project (EPHPP) instrument. Among the six studies that were included, it was observed that the sectional matrix system generated greater proximal contact tightness than the circumferential matrix system (Tofflemire). However, no significant distinction was found between the metal and polyester matrix systems. In contrast to alternative circumferential matrix systems, the utilization of a sectional matrix system yields a statistically significant improvement in the optimum proximal contact of class II composite restorations, according to the studies.
PubMed: 38259361
DOI: 10.7759/cureus.50835 -
Journal of Clinical Medicine Jun 2024: The treatment of complex proximal humerus fractures in elderly patients is not yet fully elucidated. Of all treatment options, reverse shoulder arthroplasty (RSA) and... (Review)
Review
Reverse Shoulder Arthroplasty versus Non-Operative Treatment of Three-Part and Four-Part Proximal Humerus Fractures in the Elderly Patient: A Pooled Analysis and Systematic Review.
: The treatment of complex proximal humerus fractures in elderly patients is not yet fully elucidated. Of all treatment options, reverse shoulder arthroplasty (RSA) and non-operative treatment (NOT) appear to provide the best results. Evidence to guide the choice between the two is sparse. Therefore, this review provides an overview of the available evidence on RSA versus NOT. : Studies comparing complex proximal humerus fractures in patients aged >65 years treated either with RSA or NOT were included for systematic review and direct comparison via pooled analysis of patient-rated outcome and range of motion. Indirect comparison of case series and non-comparative studies on either treatment was performed separately. : Three comparative studies including 77 patients treated with RSA and 81 treated non-operatively were analysed. The RSA group scored better for both the Constant-Murley score (mean difference 6 points) and DASH score (mean difference 8 points). No differences were detected in ASES, PENN score, pain scores, or range of motion between treatment groups. The most common complications for RSA were infection (3%), nerve injury (2%), and dislocation (2%). Reoperation was required in 5%. In the NOT group, common complications included malunion (42%), osteonecrosis (25%), and non-union (3%); no reoperation was required. Patient satisfaction was equal in both groups. : The functional outcomes and range of motion after RSA seemed satisfactory and potentially superior to NOT in elderly patients. Patient satisfaction was comparable despite a high malunion and osteonecrosis rate in the non-operative treatment group, which did not require re-interventions.
PubMed: 38893055
DOI: 10.3390/jcm13113344 -
Annals of Anatomy = Anatomischer... Aug 2023The infrapyloric artery (IPA) supplies the pylorus and the large curvature of the antrum. Its common origin points include the gastroduodenal artery (GDA) and right... (Meta-Analysis)
Meta-Analysis
BACKGROUND
The infrapyloric artery (IPA) supplies the pylorus and the large curvature of the antrum. Its common origin points include the gastroduodenal artery (GDA) and right gastroepiploic artery (RGEA). The prevalence of variations in IPA origins can be of interest to gastric cancer surgeons who wish to increase their understanding of this vessel. The primary aim of this study was to perform a systematic review and meta-analysis on the origin of the IPA. The secondary aims were to assess imaging identification accuracy, to identify IPA morphological features, and to explore the relationship of IPA origin and clinicopathological characteristics.
METHODS
Electronic databases, currently registered studies, conference proceedings and the reference lists of included studies were searched through March 2023. There were no constraints based on language, publication status, or patient demographics. Database search, data extraction and risk of bias assessment were performed independently by two reviewers. The point of origin of the IPA was the primary outcome. Secondary outcomes were imaging identification accuracy, relationship between IPA origin and clinicopathological characteristics, and IPA morphological features. A random-effects meta-analysis of the prevalence of different IPA origins was conducted. Secondary outcomes were narratively synthesized given the heterogeneity of studies reporting on these.
RESULTS
A total of 7279 records were screened in the initial search. Seven studies were included in the meta-analysis, assessing 998 patients. The IPA arose most frequently from the anterior superior pancreaticoduodenal artery (ASPDA), with a pooled prevalence of 40.4% (95% CI 17.1-55.8%), followed by the RGEA with a pooled prevalence of 27.6% (95% CI 8.7-43.7%), and the GDA with a pooled prevalence of 23.7% (95% CI 6.4-39.7%). Cases of multiple IPAs had a pooled prevalence of 4.9% (95% CI 0-14.3%). The IPA was absent in 2.6% (95% CI 0-10.3%) of cases and arose from the posterior superior pancreaticoduodenal artery (PSPDA) in the remaining 0.8% (95% CI 0 - 6.1%). Distance between the pylorus and the proximal branch of the IPA and distance from the pylorus to the first gastric branch of the RGEA when the IPA originated from the ASPDA and RGEA were longer than when the IPA originated from the GDA. The IPA is a small vessel (<1 mm), and its origin is not related to clinicopathological characteristics including patient sex, age, and tumor stage and location.
CONCLUSIONS
Surgeons must be aware of the most common origin points of the IPA. Recommendations for future study include the stratification of IPA origin according to demographic characteristics, and further investigation into IPA morphological parameters such as tortuosity, course and relation to adjacent lymph nodes, aiding the creation of a standardized classification system pertaining to the anatomy of this vessel.
Topics: Humans; Pylorus; Stomach Neoplasms; Lymph Nodes; Hepatic Artery
PubMed: 37207852
DOI: 10.1016/j.aanat.2023.152109 -
Pathogens (Basel, Switzerland) Mar 2024Beau's lines are transverse grooves in the nail plate that result from transient interruption of the growth of the proximal nail matrix after severe disease. The aim of... (Review)
Review
BACKGROUND
Beau's lines are transverse grooves in the nail plate that result from transient interruption of the growth of the proximal nail matrix after severe disease. The aim of this study is to systematically report all evidence on the association of Beau's lines with COVID-19 infection or vaccination against COVID-19.
METHODS
PubMed and Scopus databases were searched up to January 2024 for articles reporting Beau's lines associated with COVID-19 infection or vaccination for COVID-19.
PROSPERO ID
CRD42024496830.
RESULTS
PubMed search identified 299 records while Scopus search identified 18 records. After screening the bibliography, nine studies including 35 cases were included in our systematic review. The studies were reported from different areas around the world. Included studies documented Beau's lines following COVID-19 vaccination (two studies) or after COVID-19 infection (seven studies). High variability was recorded in onset and resolution times among included cases, averaging 3 months and 6 months after COVID-19 infection, respectively. In the two studies reporting Beau's lines after vaccination, onset was at 7 days and 6 weeks and resolution occurred after 8 and 17 weeks, respectively.
CONCLUSIONS
To the best of our knowledge, this is the first systematic review reporting the association of Beau's lines with COVID-19 infection and vaccination. Severe immune response can result in the formation of these nail disorders. Of importance, Beau's lines represent a potential indicator of prior severe COVID-19 infection or vaccination for COVID-19, as well as a sign of long COVID-19 syndrome.
PubMed: 38535608
DOI: 10.3390/pathogens13030265 -
Journal of Medical Internet Research Feb 2024Accelerated by technological advancements and the recent global pandemic, there is burgeoning interest in digital mental health literacy (DMHL) interventions that can... (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
Accelerated by technological advancements and the recent global pandemic, there is burgeoning interest in digital mental health literacy (DMHL) interventions that can positively affect mental health. However, existing work remains inconclusive regarding the effectiveness of DMHL interventions.
OBJECTIVE
This systematic review and meta-analysis investigated the components and modes of DMHL interventions, their moderating factors, and their long-term impacts on mental health literacy and mental health.
METHODS
We used a random-effects model to conduct meta-analyses and meta-regressions on moderating effects of DMHL interventions on mental health.
RESULTS
Using 144 interventions with 206 effect sizes, we found a moderate effect of DMHL interventions in enhancing distal mental health outcomes (standardized mean difference=0.42, 95% CI -0.10 to 0.73; P<.001) and a large effect in increasing proximal mental health literacy outcomes (standardized mean difference=0.65, 95% CI 0.59-0.74; P<.001). Uptake of DMHL interventions was comparable with that of control conditions, and uptake of DMHL interventions did not moderate the effects on both proximal mental health literacy outcomes and distal mental health outcomes. DMHL interventions were as effective as face-to-face interventions and did not differ by platform type or dosage. DMHL plus interventions (DMHL psychoeducation coupled with other active treatment) produced large effects in bolstering mental health, were more effective than DMHL only interventions (self-help DMHL psychoeducation), and were comparable with non-DMHL interventions (treatment as usual). DMHL interventions demonstrated positive effects on mental health that were sustained over follow-up assessments and were most effective in enhancing the mental health of emerging and older adults.
CONCLUSIONS
For theory building, our review and meta-analysis found that DMHL interventions are as effective as face-to-face interventions. DMHL interventions confer optimal effects on mental health when DMHL psychoeducation is combined with informal, nonprofessional active treatment components such as skills training and peer support, which demonstrate comparable effectiveness with that of treatment as usual (client-professional interactions and therapies). These effects, which did not differ by platform type or dosage, were sustained over time. Additionally, most DMHL interventions are found in Western cultural contexts, especially in high-income countries (Global North) such as Australia, the United States, and the United Kingdom, and limited research is conducted in low-income countries in Asia and in South American and African countries. Most of the DMHL studies did not report information on the racial or ethnic makeup of the samples. Future work on DMHL interventions that target racial or ethnic minority groups, particularly the design, adoption, and evaluation of the effects of culturally adaptive DMHL interventions on uptake and mental health functioning, is needed. Such evidence can drive the adoption and implementation of DMHL interventions at scale, which represents a key foundation for practice-changing impact in the provision of mental health resources for individuals and the community.
TRIAL REGISTRATION
PROSPERO International Prospective Register of Systematic Reviews CRD42023363995; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023363995.
Topics: Humans; Aged; Health Literacy; Mental Health; Ethnicity; Minority Groups; Africa
PubMed: 38421687
DOI: 10.2196/51268 -
Global Spine Journal Apr 2024Systematic Review. (Review)
Review
The Effect of Osteoporosis on Complications and Reoperation Rates After Surgical Management of Adult Thoracolumbar Spinal Deformity: A Systematic Review and Meta Analysis.
STUDY DESIGN
Systematic Review.
OBJECTIVES
While substantial research has explored the impact of osteoporosis on patients undergoing adult spinal deformity (ASD) correction, the literature remains inconclusive. As such, the purpose of this study is to synthesize and analyze existing studies pertaining to osteoporosis as a predictor of postoperative outcomes in ASD surgery.
METHODS
We performed a systematic review and meta-analysis to determine the effect that a diagnosis of osteoporosis, based on ICD-10 coding, dual-energy X-ray absorptiometry (DEXA) or computed tomography, has on the incidence of adverse outcomes following surgical correction of ASD. Statistical analysis was performed using Comprehensive Meta-Analysis (Version 2) using a random effects model to account for heterogeneity between studies.
RESULTS
After application of inclusion and exclusion criteria, 36 and 28 articles were included in the systematic review and meta-analysis, respectively. The meta-analysis identified greater rates of screw loosening amongst osteoporotic patients (70.5% vs 31.9%, = .009), and decreased bone mineral density in patients who developed proximal junctional kyphosis (PJK) (.69 vs .79 g/cm, = .001). The systematic review demonstrated significantly increased risk of any complication, reoperation, and proximal junctional failure (PJF) associated with reduced bone density. No statistical difference was observed between groups regarding fusion rates, readmission rates, and patient-reported and/or functional outcome scores.
CONCLUSION
This study demonstrates a higher incidence of screw loosening, PJK, and revision surgery amongst osteoporotic ASD patients. Future investigations should explore outcomes at various follow-up intervals in order to better characterize how risk changes with time and to tailor preoperative planning based on patient-specific characteristics.
PubMed: 38666610
DOI: 10.1177/21925682241250031 -
Orthopaedic Surgery May 2024To compare the analgesic efficacy and adverse events of proximal versus distal ACB for adults undergoing knee arthroplasty, we searched PubMed, Cochrane, Web of Science,... (Meta-Analysis)
Meta-Analysis Review
Does Proximal Adductor Canal Block Provide Better Analgesic Efficacy than Distal Adductor Canal Block in Patients Undergoing Knee Arthroplasty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
To compare the analgesic efficacy and adverse events of proximal versus distal ACB for adults undergoing knee arthroplasty, we searched PubMed, Cochrane, Web of Science, and Embase to identify all eligible randomized controlled trials (RCTs). The study quality of the RCTs was evaluated using the Cochrane risk of bias assessment tool. Heterogeneity among studies was examined by Cochrane Q test. Our primary outcomes were pain intensity at rest/during movement and morphine consumption. Statistical analyses were conducted by RevMan Software. Seven eligible studies involving 400 subjects were included in this meta-analysis with 202 participants in the proximal ACB group and 198 participants in the distal ACB group. The results demonstrated that proximal ACB provided significantly better pain relief at rest at 2 h (SMD -0.27, 95% CI -0.54 to -0.01, four trials, 222 participants, I = 0, p = 0.04) and 24 h (SMD -0.28, 95% CI -0.48 to -0.08, seven trials, 400 participants, I = 0, p = 0.006) following the surgery. We found no evidence of a difference in postoperative pain intensity at other timepoints. Furthermore, we noted no evidence of a difference in cumulative morphine consumption and occurrence of adverse events. Proximal ACB provides better pain relief and comparable adverse effects profile compared with distal ACB. The analgesic benefit offered by proximal ACB, however, did not appear to extend beyond the first 24 h. The overall evidence level was mostly low or very low, which requires more well-organized multicenter randomized trials in the future.
Topics: Humans; Arthroplasty, Replacement, Knee; Randomized Controlled Trials as Topic; Nerve Block; Pain, Postoperative; Pain Measurement
PubMed: 38506184
DOI: 10.1111/os.14027 -
Knee Surgery, Sports Traumatology,... Oct 2023After four weeks from injury, tears of the Achilles tendon are considered chronic. Their management is challenging, and the use of a graft is suggested when the gap... (Review)
Review
PURPOSE
After four weeks from injury, tears of the Achilles tendon are considered chronic. Their management is challenging, and the use of a graft is suggested when the gap between proximal and distal stumps is greater than 6 cm. The present study systematically reviews the outcome of free tendon grafts in chronic ruptures of the Achilles tendon, evaluating clinical outcomes, complications and return to sport.
METHODS
The present study was conducted according to the PRISMA 2020 guidelines. PubMed, Google Scholar, Embase, and Web of Science databases were accessed in February 2023. All the published clinical studies reporting clinical outcome, return to sport and complications of free tendon grafts used the treatment of chronic rupture of the midportion of the Achilles Tendon were accessed. The mean CMS (Coleman Methodology Score) of 65.7 suggested an overall good quality of the available published articles, attesting to the low risk of bias.
RESULTS
Data from 22 articles (368 patients with a mean age of 47 years) were retrieved. The average time from rupture to surgery was 25.1 week. At last follow-up, the AOFAS (American Orthopaedic Foot and Ankle Surgery) and ATRS (Achilles Tendon Total Rupture Score) scores improved of 33.8 (P = 0.0004), and 45.1 points (P = 0.0001) respectively. Return to activity was reported in 105 patients, and 82 (78.1%) had no activity limitations, while 19 (18.1%) had limited recreational but not daily activity limitations, and 4 (3.8%) reported limitations in daily activities. Return to sport data was reported in six studies, and 45 of 93 (48.4%) patients returned to sport at an average of 22.6 weeks.
CONCLUSION
In chronic tears of the Achilles tendon, with a gap of at least 6 cm, free tendon grafts allow predictable return to sport and acceptable recovery function.
LEVEL OF EVIDENCE
Level IV.
Topics: Humans; Middle Aged; Achilles Tendon; Treatment Outcome; Tendon Injuries; Plastic Surgery Procedures; Sports; Rupture; Retrospective Studies
PubMed: 37193823
DOI: 10.1007/s00167-023-07446-4 -
Arthroscopy, Sports Medicine, and... Oct 2023The purpose of this study was to describe the incidence of soft tissue injuries associated with pediatric proximal tibial fractures (PPTF) and the frequency that... (Review)
Review
PURPOSE
The purpose of this study was to describe the incidence of soft tissue injuries associated with pediatric proximal tibial fractures (PPTF) and the frequency that magnetic resonance imaging (MRI) was used before surgery in this patient population.
METHODS
A systematic review of English literature, using EMBASE and PubMed, was completed. Articles reporting on soft tissue injury in PPTFs between 1980 and 2021 were identified. Associated pathology (meniscal tear, meniscal entrapment, cruciate ligament injury, extensor mechanism injury, and chondral injury) and use of MRI at time of diagnosis, were assessed in these studies. Twenty-three articles were included.
RESULTS
Extraction of data revealed 1046 patients and 1057 fractures, with a mean age of 12.3 ± 1.7 at the time of injury. Most patients were male (n = 757 [72.3%]). Most fractures were tibial eminence fractures (TEF) (n = 747 [70.7%]), followed by tibial tubercle (n = 218 [20.6%]) and then tibial plateau fractures (n = 92 [8.7%]). Associated soft tissue injuries were found in 58.8% (n = 621) of fractures overall. Meniscal entrapment was the most common, occurring in 22.1% (n = 234) of cases. Meniscal tears occurred in 18.6% of cases (n = 197), followed by ligament injury in 9.4% (n = 99), chondral injury in 6.5% (n = 69), and extensor mechanism injury in 2.1% (n = 22) of cases. All cases of tendinous extensor mechanism injury were seen in tibial tubercle fractures, with 22 injuries occurring in 10.1% of tibial tubercle fractures. At time of injury just 24.3% (n = 257) of fractures had an MRI performed before surgery.
CONCLUSIONS
PPTFs are associated with a high incidence of associated injury (58.8%), particularly in TEFs (63.5%) and TPFs (100%).
LEVEL OF EVIDENCE
Systematic Review of Level III-IV studies.
PubMed: 37576909
DOI: 10.1016/j.asmr.2023.100771