Did you mean: acidovorax temperance
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Oncogenesis Apr 2024Change within the intratumoral microbiome is a common feature in lung and other cancers and may influence inflammation and immunity in the tumor microenvironment,...
Change within the intratumoral microbiome is a common feature in lung and other cancers and may influence inflammation and immunity in the tumor microenvironment, affecting growth and metastases. We previously characterized the lung cancer microbiome in patients and identified Acidovorax temperans as enriched in tumors. Here, we instilled A. temperans in an animal model driven by mutant K-ras and Tp53. This revealed A. temperans accelerates tumor development and burden through infiltration of proinflammatory cells. Neutrophils exposed to A. temperans displayed a mature, pro-tumorigenic phenotype with increased cytokine signaling, with a global shift away from IL-1β signaling. Neutrophil to monocyte and macrophage signaling upregulated MHC II to activate CD4 T cells, polarizing them to an IL-17A phenotype detectable in CD4 and γδ populations (T17). These T17 cells shared a common gene expression program predictive of poor survival in human LUAD. These data indicate bacterial exposure promotes tumor growth by modulating inflammation.
PubMed: 38570533
DOI: 10.1038/s41389-024-00513-6 -
PloS One 2024The productivity of agricultural ecosystems is heavily influenced by soil-dwelling organisms. To optimize agricultural practices and management, it is critical to know...
The productivity of agricultural ecosystems is heavily influenced by soil-dwelling organisms. To optimize agricultural practices and management, it is critical to know the composition, abundance, and interactions of soil microorganisms. Our study focused on Acrobeles complexus nematodes collected from tomato fields in South Africa and analyzed their associated bacterial communities utilizing metabarcoding analysis. Our findings revealed that A. complexus forms associations with a wide range of bacterial species. Among the most abundant species identified, we found Dechloromonas sp., a bacterial species commonly found in aquatic sediments, Acidovorax temperans, a bacterial species commonly found in activated sludge, and Lactobacillus ruminis, a commensal motile lactic acid bacterium that inhabits the intestinal tracts of humans and animals. Through principal component analysis (PCA), we found that the abundance of A. complexus in the soil is negatively correlated with clay content (r = -0.990) and soil phosphate levels (r = -0.969) and positively correlated with soil sand content (r = 0.763). This study sheds light on the bacterial species associated to free-living nematodes in tomato crops in South Africa and highlights the occurrence of various potentially damaging and beneficial nematode-associated bacteria, which can in turn, impact soil health and tomato production.
Topics: Animals; Solanum lycopersicum; South Africa; Soil Microbiology; Crops, Agricultural; Nematoda; Bacteria; Soil; RNA, Ribosomal, 16S; Principal Component Analysis
PubMed: 38843239
DOI: 10.1371/journal.pone.0304663 -
Microbiology Resource Announcements Apr 2024A heavy metal and xenobiotic-tolerant strain of strain LMJ was isolated from a contaminated Tris-Acetate-Phosphate medium plate of a green micro-alga, . Here, we report...
A heavy metal and xenobiotic-tolerant strain of strain LMJ was isolated from a contaminated Tris-Acetate-Phosphate medium plate of a green micro-alga, . Here, we report the complete genome sequence of this strain to provide insights into its survival strategies and nearest taxonomic neighbor.
PubMed: 38488374
DOI: 10.1128/mra.01293-23