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Chemical Science Dec 2023The coordination and organometallic chemistry of the f-elements, that is group 3, lanthanide, and actinide ions, supported by nitrogen ligands, amides, imides, and... (Review)
Review
The coordination and organometallic chemistry of the f-elements, that is group 3, lanthanide, and actinide ions, supported by nitrogen ligands, amides, imides, and nitrides, has become well developed over many decades. In contrast, the corresponding f-element chemisty with the heavier pnictogen analogues phosphorus, arsenic, antimony, and bismuth has remained significantly underdeveloped, due largely to a lack of suitable synthetic methodologies and also the inherent hard(f-element)-soft(heavier pnictogen) acid-base mismatch, but has begun to flourish in recent years. Here, we review complexes containing chemical bonds between the f-elements and heavy pnictogens from phosphorus to bismuth that spans five decades of endeavour. We focus on complexes whose identity has been unambiguously established by structural authentication by single-crystal X-ray diffraction with respect to their synthesis, characterisation, bonding, and reactivity, in order to provide a representative overview of this burgeoning area. By highlighting that much has been achieved but that there is still much to do this review aims to inspire, focus and guide future efforts in this area.
PubMed: 38131077
DOI: 10.1039/d3sc05056d -
Materials (Basel, Switzerland) Sep 2023Lead-based halide perovskite nanocrystals (PeNCs) have demonstrated remarkable potential for use in light-emitting diodes (LEDs). This is because of their high... (Review)
Review
Lead-based halide perovskite nanocrystals (PeNCs) have demonstrated remarkable potential for use in light-emitting diodes (LEDs). This is because of their high photoluminescence quantum yield, defect tolerance, tunable emission wavelength, color purity, and high device efficiency. However, the environmental toxicity of Pb has impeded their commercial viability owing to the restriction of hazardous substances directive. Therefore, Pb-free PeNCs have emerged as a promising solution for the development of eco-friendly LEDs. This review article presents a detailed analysis of the various compositions of Pb-free PeNCs, including tin-, bismuth-, antimony-, and copper-based perovskites and double perovskites, focusing on their stability, optoelectronic properties, and device performance in LEDs. Furthermore, we address the challenges encountered in using Pb-free PeNC-LEDs and discuss the prospects and potential of these Pb-free PeNCs as sustainable alternatives to lead-based PeLEDs. In this review, we aim to shed light on the current state of Pb-free PeNC LEDs and highlight their significance in driving the development of eco-friendly LED technologies.
PubMed: 37763594
DOI: 10.3390/ma16186317 -
BMC Cancer Jul 2023To investigate the relationship among 18 heavy metals, microsatellite instability (MSI) status, ERCC1, XRCC1 (rs25487), BRAF V600E and 5 tumor markers and their role in...
OBJECTIVE
To investigate the relationship among 18 heavy metals, microsatellite instability (MSI) status, ERCC1, XRCC1 (rs25487), BRAF V600E and 5 tumor markers and their role in the development of colorectal cancer (CRC).
METHODS
A total of 101 CRC patients and 60 healthy controls were recruited in the present study. The levels of 18 heavy metals were measured by ICP-MS. MSI status and the genetic polymorphism were determined by PCR (FP205-02, Tiangen Biochemical Technology Co., Ltd., Beijing, China) and Sanger sequencing. Spearman's rank correlation was used to analyze the relationship among various factors.
RESULTS
The level of selenium (Se) was lower in the CRC group compared with the control group (p < 0.01), while vanadium (V), arsenic (As), tin (Sn), barium (Ba) and lead (Pb) were higher (p < 0.05), chromium (Cr) and copper (Cu) were significantly higher (p < 0.0001) in the CRC group than those in the control group. Multivariate logistic regression analysis indicated that Cr, Cu, As and Ba were the risk factors for CRC. In addition, CRC was positively correlated with V, Cr, Cu, As, Sn, Ba and Pb, but negatively correlated with Se. MSI was positively correlated with BRAF V600E, but negatively correlated with ERCC1. BRAF V600E was positively correlated with antimony (Sb), thallium (Tl), CA19-9, NSE, AFP and CK19. XRCC1 (rs25487) was found to be positively correlated with Se but negatively correlated with Co. The levels of Sb and Tl were significantly higher in the BRAF V600E positive group compared to the negative group. The mRNA expression level of ERCC1 was significantly higher (P = 0.035) in MSS compared to MSI. And there was a significant correlation between XRCC1 (rs25487) polymorphism and MSI status (P<0.05).
CONCLUSION
The results showed that low level of Se and high levels of V, As, Sn, Ba, Pb, Cr, and Cu increased the risk of CRC. Sb and Tl may cause BRAF V600E mutations, leading to MSI. XRCC1 (rs25487) was positively correlated with Se but negatively correlated with Co. The expression of ERCC1 may be related to MSS, while the XRCC1 (rs25487) polymorphism is related to MSI.
Topics: Colorectal Neoplasms; Metals, Heavy; DNA-Binding Proteins; Endonucleases; X-ray Repair Cross Complementing Protein 1; Proto-Oncogene Proteins B-raf; Polymorphism, Genetic; Risk Factors; Humans; Male; Female; Adult; Middle Aged; Microsatellite Instability; Incidence
PubMed: 37400750
DOI: 10.1186/s12885-023-11120-w -
Cellular and Molecular Life Sciences :... Oct 2023Arsenic and antimony are metalloids with profound effects on biological systems and human health. Both elements are toxic to cells and organisms, and exposure is... (Review)
Review
Arsenic and antimony are metalloids with profound effects on biological systems and human health. Both elements are toxic to cells and organisms, and exposure is associated with several pathological conditions including cancer and neurodegenerative disorders. At the same time, arsenic- and antimony-containing compounds are used in the treatment of multiple diseases. Although these metalloids can both cause and cure disease, their modes of molecular action are incompletely understood. The past decades have seen major advances in our understanding of arsenic and antimony toxicity, emphasizing genotoxicity and proteotoxicity as key contributors to pathogenesis. In this review, we highlight mechanisms by which arsenic and antimony cause toxicity, focusing on their genotoxic and proteotoxic effects. The mechanisms used by cells to maintain proteostasis during metalloid exposure are also described. Furthermore, we address how metalloid-induced proteotoxicity may promote neurodegenerative disease and how genotoxicity and proteotoxicity may be interrelated and together contribute to proteinopathies. A deeper understanding of cellular toxicity and response mechanisms and their links to pathogenesis may promote the development of strategies for both disease prevention and treatment.
Topics: Humans; Arsenic; Antimony; Metalloids; Neurodegenerative Diseases; DNA Damage
PubMed: 37904059
DOI: 10.1007/s00018-023-04992-5 -
ArXiv Sep 2023We describe a web-based tool, MakeSBML (https://sys-bio.github.io/makesbml/), that provides an installation-free application for creating, editing, and searching the...
We describe a web-based tool, MakeSBML (https://sys-bio.github.io/makesbml/), that provides an installation-free application for creating, editing, and searching the Biomodels repository for SBML-based models. MakeSBML is a client-based web application that translates models expressed in human-readable Antimony to the System Biology Markup Language (SBML) and vice-versa. Since MakeSBML is a web-based application it requires no installation on the user's part. Currently, MakeSBML is hosted on a GitHub page where the client-based design makes it trivial to move to other hosts. This model for software deployment also reduces maintenance costs since an active server is not required. The SBML modeling language is often used in systems biology research to describe complex biochemical networks and makes reproducing models much easier. However, SBML is designed to be computer-readable, not human-readable. We therefore employ the human-readable Antimony language to make it easy to create and edit SBML models.
PubMed: 37731653
DOI: No ID Found -
Biophysical Reviews Aug 2023The pentavalent meglumine antimoniate (MA) is still a first-line drug in the treatment of leishmaniasis in several countries. As an attempt to elucidate its mechanism of... (Review)
Review
The pentavalent meglumine antimoniate (MA) is still a first-line drug in the treatment of leishmaniasis in several countries. As an attempt to elucidate its mechanism of action and develop new antimonial drugs with improved therapeutic profile, Sb(V) complexes with different ligands, including β-cyclodextrin (β-CD), nucleosides and non-ionic surfactants, have been studied. Interestingly, Sb(V) oxide, MA, its complex with β-CD, Sb(V)-guanosine complex and amphiphilic Sb(V) complexes with N-alkyl-N-methylglucamide, have shown marked tendency to self-assemble in aqueous solutions, forming nanoaggregates, hydrogel or micelle-like nanoparticles. Surprisingly, the resulting assemblies presented in most cases slow dissociation kinetics upon dilution and a strong influence of pH, which impacted on their pharmacokinetic and therapeutic properties against leishmaniasis. To explain this unique property, we raised the hypothesis that multiple pnictogen bonds could contribute to the formation of these assemblies and their kinetic of dissociation. The present article reviews our current knowledge on the structural organization and physicochemical characteristics of Sb-based supramolecular assemblies, as well as their pharmacological properties and potential for treatment of leishmaniasis. This review supports the feasibility of the rational design of new Sb(V) complexes with supramolecular assemblies for the safe and effective treatment of leishmaniasis.
PubMed: 37681109
DOI: 10.1007/s12551-023-01073-6 -
Bioinformatics (Oxford, England) Dec 2023Developing biochemical models in systems biology is a complex, knowledge-intensive activity. Some modelers (especially novices) benefit from model development tools with...
MOTIVATION
Developing biochemical models in systems biology is a complex, knowledge-intensive activity. Some modelers (especially novices) benefit from model development tools with a graphical user interface. However, as with the development of complex software, text-based representations of models provide many benefits for advanced model development. At present, the tools for text-based model development are limited, typically just a textual editor that provides features such as copy, paste, find, and replace. Since these tools are not "model aware," they do not provide features for: (i) model building such as autocompletion of species names; (ii) model analysis such as hover messages that provide information about chemical species; and (iii) model translation to convert between model representations. We refer to these as BAT features.
RESULTS
We present VSCode-Antimony, a tool for building, analyzing, and translating models written in the Antimony modeling language, a human readable representation of Systems Biology Markup Language (SBML) models. VSCode-Antimony is a source editor, a tool with language-aware features. For example, there is autocompletion of variable names to assist with model building, hover messages that aid in model analysis, and translation between XML and Antimony representations of SBML models. These features result from making VSCode-Antimony model-aware by incorporating several sophisticated capabilities: analysis of the Antimony grammar (e.g. to identify model symbols and their types); a query system for accessing knowledge sources for chemical species and reactions; and automatic conversion between different model representations (e.g. between Antimony and SBML).
AVAILABILITY AND IMPLEMENTATION
VSCode-Antimony is available as an open source extension in the VSCode Marketplace https://marketplace.visualstudio.com/items?itemName=stevem.vscode-antimony. Source code can be found at https://github.com/sys-bio/vscode-antimony.
Topics: Humans; Antimony; Software; Systems Biology; Language; Models, Biological; Programming Languages
PubMed: 38096590
DOI: 10.1093/bioinformatics/btad753 -
Environment International Nov 2023Limited evidence suggests that antimony induces vascular inflammation and oxidative stress and may play a role in cardiovascular disease (CVD) risk. However, few studies...
BACKGROUND
Limited evidence suggests that antimony induces vascular inflammation and oxidative stress and may play a role in cardiovascular disease (CVD) risk. However, few studies have examined whether environmental antimony from sources other than tobacco smoking is related with CVD risk. The general population may be exposed through air, drinking water, and food that contains antimony from natural and anthropogenic sources, such as mining, coal combustion, and manufacturing.
OBJECTIVES
To examine the association of urine antimony with incident acute myocardial infarction (AMI), heart failure, and stroke among people who never smoked tobacco.
METHODS
Between 1993 and 1997, the Danish Diet, Cancer and Health (DCH) cohort enrolled participants (ages 50-64 years), including n = 19,394 participants who reported never smoking at baseline. Among these never smokers, we identified incident cases of AMI (N = 809), heart failure (N = 958), and stroke (N = 534) using the Danish National Patient Registry. We also randomly selected a subcohort of 600 men and 600 women. We quantified urine antimony concentrations in samples provided at enrollment. We used modified Cox proportional hazards models to estimate adjusted hazard ratios (HR) for each incident CVD outcome in relation to urine antimony, statistically adjusted for creatinine. We used a separate prospective cohort, the San Luis Valley Diabetes Study (SLVDS), to replicate these results.
RESULTS
In the DCH cohort, urine antimony concentrations were positively associated with rates of AMI and heart failure (HR = 1.52; 95%CI = 1.12, 2.08 and HR = 1.58; 95% CI = 1.15, 2.18, respectively, comparing participants in the highest (>0.09 µg/L) with the lowest quartile (<0.02 µg/L) of antimony). In the SLVDS cohort, urinary antimony was positively associated with AMI, but not heart failure.
DISCUSSION
Among this sample of Danish people who never smoked, we found that low levels of urine antimony are associated with incident CVD. These results were partially confirmed in a smaller US cohort.
Topics: Female; Humans; Male; Antimony; Cardiovascular Diseases; Cohort Studies; Denmark; Heart Failure; Myocardial Infarction; Non-Smokers; Risk Factors; Stroke; Prospective Studies
PubMed: 37866238
DOI: 10.1016/j.envint.2023.108269 -
Scientific Reports Dec 2023Thin-film antimony chalcogenide binary compounds are potential candidates for efficient and low-cost photovoltaic absorbers. This study investigates the performance of...
Thin-film antimony chalcogenide binary compounds are potential candidates for efficient and low-cost photovoltaic absorbers. This study investigates the performance of SbS and SbSe as photovoltaic absorbers, aiming to optimize their efficiency. The standalone SbS and SbSe sub-cells are analyzed using SCAPS-1D simulations, and then a tandem structure with SbS as the top-cell absorber and SbSe as the bottom-cell absorber is designed, using the filtered spectrum and the current matching technique. The optimal configuration for maximum efficiency is achieved by adjusting the thickness of the absorber layer. The results show that antimony chalcogenide binary compounds have great potential as photovoltaic absorbers, enabling the development of efficient and low-cost solar cells. A remarkable conversion efficiency of 22.2% is achieved for the optimized tandem cell structure, with absorber thicknesses of 420 nm and 1020 nm for the top and bottom sub-cells respectively. This study presents a promising approach towards high-performance tandem solar cells.
PubMed: 38114523
DOI: 10.1038/s41598-023-49269-w -
Journal of Hazardous Materials May 2024Antimony (Sb) is an poorly understood, increasingly common pollutant, especially in soils susceptible to waterlogging. We investigated the impact of waterlogging on Sb...
Antimony (Sb) is an poorly understood, increasingly common pollutant, especially in soils susceptible to waterlogging. We investigated the impact of waterlogging on Sb release, methylation, and volatilization from an organic-rich wetland soil and an iron (Fe)-rich floodplain soil in a 27-day microcosm experiment. The release of Sb into the porewaters of the organic-rich soil was environmentally relevant and immediate with waterlogging (3.2 to 3.5 mg L), and likely associated with a complex interplay of sulfide precipitation, sorption with organic matter and manganese (Mn) (oxyhydr)oxides in the soil. The release of Sb from the Fe-rich soil was likely associated with Fe-(oxyhydr)oxide reduction and immobilized due to co-precipitation with Fe-sulfides or as Sb-sulfides. Volatile Sb was produced from the soils after waterlogging. The organic-rich soil produced more volatile Sb (409 to 835 ng kg), but the Fe-rich soil volatilized Sb more efficiently. The negligible association of Sb volatilization with soil parameters indicates a more complex underlying, potentially microbial, mechanism and that antimony volatilization could be ubiquitous and not dependent on specific soil properties. Future works should investigate the microbial and physiochemical drivers of Sb volatilization in soils as it may be an environmentally relevant part of the biogeochemical cycle.
PubMed: 38608583
DOI: 10.1016/j.jhazmat.2024.134230