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Scientific Reports Mar 2024Non-syndromic permanent tooth agenesis affects a significant proportion of the population, especially if third molars are considered. Although tooth agenesis has been...
Non-syndromic permanent tooth agenesis affects a significant proportion of the population, especially if third molars are considered. Although tooth agenesis has been linked to a smaller craniofacial size, reduced facial convexity and a shorter skeletal face, the occlusal characteristics of individuals with tooth agenesis remain largely unexplored. Therefore, this study investigated potential associations between tooth agenesis and metric occlusal traits in 806 individuals (491 with 4.1 missing teeth per subject, including third molars, and 315 without any tooth agenesis). Dentoskeletal morphology was defined through anatomical landmarks on pre-treatment cephalometric radiographs. Multivariate regression models, adjusted for sex and age, showed that tooth agenesis was significantly associated with a reduced overjet, an increased interincisal angle, and shorter upper and lower dental arch lengths, but not with overbite. Moreover, apart from reduced tooth length and dentoalveolar effects, as the number of missing teeth increased the upper front teeth were progressively retruded according to the craniofacial complex and to the face. Thus, tooth agenesis has a substantial influence on dental and occlusal characteristics, as well as on the sagittal position and inclination of anterior teeth. These findings emphasize the necessity for personalized, multidisciplinary approaches in individuals with multiple agenesis to successfully meet treatment goals.
Topics: Humans; Malocclusion; Tooth; Dentition, Permanent; Malocclusion, Angle Class II; Overbite; Anodontia; Cephalometry; Molar, Third
PubMed: 38462644
DOI: 10.1038/s41598-024-56449-9 -
Cureus Aug 2023Obstructive sleep apnea (OSA), caused by airway narrowing, is likely to occur if the mandibular plane to hyoid distance is greater than 15.4 mm and the posterior...
INTRODUCTION
Obstructive sleep apnea (OSA), caused by airway narrowing, is likely to occur if the mandibular plane to hyoid distance is greater than 15.4 mm and the posterior airway space (PAS) is less than 11 mm. OSA may be caused by mandibular deficit, bimaxillary retrusion, increased lower facial height, extended soft palate, a large tongue base, and a posteroinferiorly positioned hyoid bone. Snoring and drowsiness during exercise are symptoms of OSA, which is a risk factor for high blood pressure, heart disease, and stroke, and these can result in car crashes. However, orthognathic surgery can improve dental occlusion and aesthetics by adjusting facial bone position, shape, and size. When bones move, the position and tension of soft tissues change. These novel soft tissue interactions, especially when anteroposterior, change the face's appearance and PAS dimensions. This study uses barium sulfate paste to enhance lateral cephalograms before and after orthognathic surgery to assess posterior pharyngeal airway changes.
MATERIALS AND METHODS
Barium sulfate was mixed with water to make a paste for the tongue's dorsum. A preoperative digital lateral cephalogram was obtained, and a postoperative evaluation was conducted six weeks after the procedure. In the cephalostat, the Frankfort horizontal and median planes were aligned parallel to the floor, and a radiograph was taken after the breathing cycle to standardize the hyoid bone location. Preoperative lateral cephalogram analysis using Burstone's hard tissue landmarks confirmed skeletal class II or III deformities. First, the narrowest part of the posterior pharyngeal airway was measured. Second, the narrowest portion between the soft palate and posterior pharyngeal wall parallel to the Frankfort horizontal plane was measured preoperatively, and the procedure was repeated six weeks postop.
RESULTS
Complexity characterizes the pharyngeal airway, which, along with the surrounding structures, facilitates the bodily functions of eating, talking, and breathing. The pharyngeal airway is located behind the nose, mouth, and larynx, and adjusting the jaws changes the size and structure of the pharyngeal airway and surrounding soft tissues, which may affect breathing. A statistically significant change is detected in the posterior palatal and posterior lingual airways after different orthognathic operations. After the mandible is moved forward, both the posterior palatal and posterior lingual airways enlarge. Furthermore, the soft palate exhibits slight decreases in length, thickness, and angle. Additionally, there is an anterosuperior displacement of the hyoid bone. Following maxillary superior impaction, mandibular autorotation is seen in a counterclockwise direction, which has the same result as that of mandibular advancement.
CONCLUSION
It is essential to consider these soft tissue changes when planning orthognathic procedures, as alterations in the pharyngeal airway may impact the patient's postoperative breathing and overall health. Patients with OSA or those at risk of developing it should be closely evaluated and managed appropriately during the surgical planning process.
PubMed: 37664273
DOI: 10.7759/cureus.42836 -
European Journal of Dentistry Jul 2023The permanent first mandibular molar (PFMM) is the first tooth to erupt, usually at the age of 6 years. It is the most effective oral masticatory unit due to its wide...
OBJECTIVES
The permanent first mandibular molar (PFMM) is the first tooth to erupt, usually at the age of 6 years. It is the most effective oral masticatory unit due to its wide occlusal surface and its role in favorable occlusion. This study describes the prevalence of PFMM loss and the reasons for extraction in a group of King Faisal Dental Complex Clinics (KFUDC) Saudi attendees. In addition, to report postextraction complications, consider the gender, age, and the time elapsed from the moment of the extraction.
MATERIALS AND METHODS
A cross-sectional study was performed in January to April 2020, focusing on the loss of PFMM among a group of Saudis attending KFUDC in Al Hofuf, Saudi Arabia. A total of 417 participants were recruited. The inclusion criteria were adults aged ≥ 18 years. The principal investigator performed all the necessary measures for calibration in the forms of training on clinical examination and interviews.
STATISTICAL ANALYSIS
Data were analyzed using the Statistical Package for the Social Science, version 25 (SPSS Inc., Illinois, United States).
RESULT
Four hundred seventeen attendees participated in the present study. Majority were males 73.9% (308), and 26.1% (109) females. A third, 30% (125), reported missing PFMM; the overwhelming majority reported the reason for extraction as caries 93.6% (117).On clinical examination, 80.8% (101) had complications; drifting of adjacent teeth was the most common complication, 57.6% (72), followed by supraeruption in 23.2% (29).More males than females reported missing PFMM (22.8 and 7.2%, respectively), and those ≥ 25 years reported more missing PFMM than younger (17.5 and 12.5%, ≤ 0.000). Those confirmed with systemic diseases reported more missing PFMM than their counterpart (23.3 and 6.7%, ≤ 0.01).Those with good oral hygiene reported less missing PFMM than their poor oral hygiene counterparts (27.8 and 34%). Those who had good knowledge about the complications of early extraction of PFMM stated less missing PFMM than their counterparts (15.6 and 14.4%, ≤ 0.01).
CONCLUSION
This study indicated that PFMM were the most common extracted tooth. Caries is the principal reason for tooth extraction among the studied population, followed by periodontal diseases. Emphasis on preventing dental caries is essential to maintain a socially and economically productive life and reduce the burden of oral disease.
PubMed: 36495864
DOI: 10.1055/s-0042-1757904 -
Korean Journal of Orthodontics Jun 2024Understanding the orofacial characteristics and growth patterns in children is essential for both orthodontics and research on children with orofacial abnormalities....
OBJECTIVE
Understanding the orofacial characteristics and growth patterns in children is essential for both orthodontics and research on children with orofacial abnormalities. However, a concise resource of normative data on the size and relative position of these structures in different populations is not available. Our objective was to aggregate normative data to assess the growth of the orofacial skeletal structures in children with a well-balanced face and normal occlusion.
METHODS
The MEDLINE, Embase, and Scopus databases were searched. Inclusion criteria included longitudinal and cross-sectional studies on cephalometric measurement of skeletal tissues and a study population ≤ 18 years with a well-balanced face and normal occlusion. Key study parameters were extracted, and knowledge was synthesized. A quality appraisal was performed using a 10-point scale.
RESULTS
The final selection comprised of 12 longitudinal and 33 cross-sectional studies, the quality of which ranged from good to excellent. Our results showed that from childhood to adulthood, the length of the cranial base increased significantly while the cranial base angle remained constant; both the maxilla and mandible moved forward and downward. The profile becomes straighter with age.
CONCLUSIONS
Growth patterns in children with a well-balanced face and normal occlusion follow accepted theories of growth.
PubMed: 38898629
DOI: 10.4041/kjod23.224 -
Journal of Ethnopharmacology Mar 2024Patients with ischemic stroke (IS) often continue to exhibit cerebral microcirculatory dysfunction even after receiving thrombolytic therapy. Enhancing the function of...
ETHNOPHARMACOLOGICAL RELEVANCE
Patients with ischemic stroke (IS) often continue to exhibit cerebral microcirculatory dysfunction even after receiving thrombolytic therapy. Enhancing the function of cerebral microvascular endothelia represents a pivotal advancement in the therapeutic strategy for ischemic microcirculatory disturbances. A traditional Chinese medicinal formulation named Shexiang Tongxin Dropping Pills (STDP), has been clinically employed to ameliorate microcirculatory abnormalities. Existing literature attests to the beneficial role of STDP on endothelial cells (ECs). Nevertheless, specific impacts and underlying mechanisms of STDP in rectifying IS-induced cerebral microvascular dysfunction warrant further exploration.
AIM OF THE STUDY
This investigation seeks to delineate the effects of STDP on cerebral microvascular endothelial damage induced by ischemic stroke and to elucidate the underlying mechanism involved.
MATERIALS AND METHODS
Middle cerebral artery occlusion and reperfusion (MCAO/R) technique was employed to established ischemic stroke model in mice. The therapeutic efficacy of STDP on cerebral microvascular function was assessed through laser speckle contrast imaging, behavioral assays, and histological evaluations. Biochemical markers in the brain tissue, including GSH, SOD, MDA, and ROS, were quantified using specific assay kits. In vitro study, oxygen-glucose deprivation and reperfusion (OGD/R) was performed in bEnd.3 cells. The cytoprotective potential of STDP was then evaluated by measuring cell viability, LDH activity, endothelial permeability, and oxidative stress parameters. Important targets in critical pathway were verified by immunoblotting and immunofluorescence both in mice brain slices and bEnd.3 cells.
RESULTS
STDP decrease brain infarct size, repaired microvascular cerebral blood flow and attenuated neurological deficiency in MCAO/R mice. Moreover, STDP abolished MCAO/R-induced oxidative stress which was reflected by rescuing GSH content, restoration of SOD activity and T-AOC, reduction of MDA and ROS. Ex vivo, STDP increased cerebral microvascular endothelial cells viability, abolished oxidative stress and decreased their permeability after ODG/R. Mechanistically, STDP significantly suppressed endothelial ROS-TXNIP mediated the activation of NLRP3 inflammasome in vivo and in vitro.
CONCLUSION
STDP improves ischemic stroke-induced cerebral microcirculatory deficits by regulating cerebral microvascular endothelial ROS/TXNIP/NLRP3 signaling pathway.
Topics: Humans; Mice; Animals; NLR Family, Pyrin Domain-Containing 3 Protein; Endothelial Cells; Ischemic Stroke; Reactive Oxygen Species; Microcirculation; Signal Transduction; Infarction, Middle Cerebral Artery; Superoxide Dismutase; Reperfusion Injury; Brain Ischemia; Carrier Proteins; Drugs, Chinese Herbal
PubMed: 38122909
DOI: 10.1016/j.jep.2023.117567 -
Journal of Dentistry Nov 2023As jaw-tracking systems integrate into digital prosthetic workflows, their accuracy remains underexplored. This study aimed to evaluate the in vitro accuracy of a novel...
OBJECTIVES
As jaw-tracking systems integrate into digital prosthetic workflows, their accuracy remains underexplored. This study aimed to evaluate the in vitro accuracy of a novel digital jaw-tracking system (Modjaw, Villeurbanne, France) by comparing its precision and trueness to that of an industrial scanner.
METHODS
Upper and lower typodont models were scanned with an industrial-grade optical scanner (ATOS Q, Carl Zeiss GOM Metrology GmbH, Germany) to produce master scans. The models were placed in a phantom head with artificial joints to replicate five different intermaxillary relationships (IMRs). The 1, 2, 3, 4, and 5 mm IMR distances were stabilized by five silicone bites. The silicone bites were repositioned after each measurement. ATOS scanned the whole artificial joint with the models three times in each IMR to assess the precision of the repositioning (i.e., bite precision). The master scans were uploaded to Modjaw. Modjaw recorded the five IMR positions three times each to assess the precision of the Modjaw. Precision was calculated by aligning the scans within the same group, whereas Modjaw trueness was evaluated by aligning ATOS and Modjaw scans. The mean absolute distance (MAD) between aligned surfaces was calculated. The effect of IMR on the MAD was evaluated using a linear mixed model.
RESULTS
The mean bite precision across the IMRs was 7.6 ± 0.53 µm. Modjaw precision over the IMRS was 9.7 ± 1.76 µm, and the trueness was 10.8 ± 1.40 µm. Increased IMRs up to 4 mm significantly increased the MAD from 6.5 to 8.5 µm for the bite precision, 4.8 to 15.7 µm Modjaw precision, and 7.1 to 14.9 µm for trueness.
CONCLUSIONS
Modjaw excelled in accuracy, comparable to industrial scanners and superior to traditional methods. IMR elevation marginally deteriorates the accuracy. Future studies should extend to varied movements beyond centric relations and encompass the influence of intraoral scanners.
Topics: Dental Impression Technique; Models, Dental; Computer-Aided Design; Imaging, Three-Dimensional; Silicones
PubMed: 37777084
DOI: 10.1016/j.jdent.2023.104730 -
European Archives of Paediatric... Aug 2023This study aims to evaluate whether there is a correlation between otitis and dental malocclusions.
PURPOSE
This study aims to evaluate whether there is a correlation between otitis and dental malocclusions.
METHODS
Electronic databases were searched for observational studies published until July 2021 without language or time restrictions.
PROSPERO
CRD42021270760. Observational studies on children with and without OM and/or malocclusion were included. After removing duplicates and excluding not-eligible articles, two reviewers screened relevant articles independently. Two reviewers independently extracted data and assessed data quality and validity through the Newcastle-Ottawa Scale (NOS) quality assessment tool for non-randomized studies.
RESULTS
Five studies met the selection inclusion criteria and were included in the studies for a total of 499 patients. Three studies investigated the relationship between malocclusion and otitis media, while the remaining two studies analyzed the inverse relationship and one of them considered eustachian tube dysfunction as a proxy of OM. An association between malocclusion and otitis media and vice versa emerged, although with relevant limitations.
CONCLUSION
There is some evidence that there is an association between otitis and malocclusion; however, it is not yet possible to establish a definitive correlation.
Topics: Humans; Child; Otitis Media; Malocclusion
PubMed: 37338742
DOI: 10.1007/s40368-023-00807-0 -
JACC. Asia Aug 2023The p.R4810K variant is associated with moyamoya disease in East Asian individuals and increases the risk of developing intracranial major artery stenosis/occlusion...
BACKGROUND
The p.R4810K variant is associated with moyamoya disease in East Asian individuals and increases the risk of developing intracranial major artery stenosis/occlusion (ICASO) that affects anterior circulation. Meanwhile, 0.5% to 2.5% of asymptomatic East Asian individuals also carry this variant. As such, additional factors are likely required to develop ICASO in variant carriers. Familial hypercholesterolemia (FH) is a common genetic disorder in Japan that has a significant associated risk of developing premature coronary atherosclerosis; however, the relationship between ICASO and FH remains unknown.
OBJECTIVES
This study aimed to determine if FH facilitates p.R4810K carriers to develop ICASO.
METHODS
We enrolled patients with FH who had undergone brain magnetic resonance angiography at our hospital from May 2005 to March 2020. The p.R4810K variant, and and mutations were genotyped. ICASO lesions in the brain magnetic resonance angiogram were analyzed.
RESULTS
Six p.R4810K variant carriers were identified among 167 patients with FH (, n = 104; , n = 22). Five of the carriers (83.3%) exhibited ICASO in the anterior circulation; a significant difference in ICASO frequency was observed between the variant carriers and noncarriers ( = 0.025). The median number of stenotic or occluded arteries in the anterior circulation was also significantly larger in the variant carriers (3 vs 1, = 0.01); however, did not differ between patients with FH with and mutations.
CONCLUSIONS
Patients with FH exhibit increased prevalence and severity of ICASO associated with p.R4810K. Gene mutations for FH may confer an increased risk of ICASO in p.R4810K carriers.
PubMed: 37614551
DOI: 10.1016/j.jacasi.2023.03.011 -
Journal of Orthodontic Science 2023To evaluate the lingual dental arch form types in class I canine and molar relationship based on scanning dental cast models using three-dimensional laser scan and to...
OBJECTIVES
To evaluate the lingual dental arch form types in class I canine and molar relationship based on scanning dental cast models using three-dimensional laser scan and to give a new lingual arch form pattern created on this classification to be used for clinical submission by studying three-dimensional virtual models of the normal occlusion samples.
MATERIALS AND METHODS
Maxillary and mandibular casts of 120 young adults (18-24 ± 1.84 years) have normal occlusion that was scanned using a 3Shape E1 laser scanner, and then, the data were analyzed using SPSS software; then, we used K-means cluster to classify the arch form into clusters depending on the measurement of 10 landmarks designated on the lingual surface of the teeth.
RESULTS
Many dental arch patterns have been established for both the mandible and the maxilla.
CONCLUSION
The minimum sizes were found in the females, and the biggest sizes were found in the male subjects, and three sets were well defined for each sex; three categories for each mandible and maxilla are as follows: narrow, mid, and broad. The lingual arch form can be classified into three groups based on posterior and anterior dimensions, so a template of the three arch forms has been exemplified.
PubMed: 38234645
DOI: 10.4103/jos.jos_119_22 -
Biomedicines Sep 2023There are two main methods used for dentin hypersensitivity (DH) treatment: dentinal tubule occlusion and blockage of nerve activity. Dentifrices are the most common...
There are two main methods used for dentin hypersensitivity (DH) treatment: dentinal tubule occlusion and blockage of nerve activity. Dentifrices are the most common vehicles for active ingredients used for DH treatment. The aim of this study was to evaluate the efficacy of three toothpastes on dentinal tubule occlusion, mineral acquisition, and dentin hardness. Forty human dentin disks were submerged in 40% citric acid for 30 s and then exposed to tooth brushing for 2 min twice a day for 14 days using three toothpastes: Dontodent Sensitive (group 1), Dr. Wolff's Biorepair (group 2), and Sensodyne Repair and Protect (group 3). In the control group (group 4), the samples were brushed with water. All of the samples were evaluated using scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), and Vickers dentin hardness determination. On SEM images, the degree of dentinal tubule occlusion was assessed using a five-grade scale. The mean score values in groups 1-4 were 3.60 ± 0.69, 2.20 ± 0.91, 2.30 ± 1.16, and 5.00 ± 0.00, significantly higher in study groups when compared to the control group (Kruskal Wallis test < 0.05). EDX evaluation showed significantly higher calcium and phosphorus concentrations in groups 1 and 3 when compared to control group d. The mean values of Vickers dentin hardness numbers in groups 1-4 were 243.03 ± 10.014, 327.38 ± 56.65, 260.29 ± 37.69, and 225.83 ± 29.93, respectively. No statistically significant results were obtained when comparing the hardness mean values in groups (Kruskal-Wallis statistical test, = 0.372 > 0.05). All three toothpastes tested demonstrated significant occlusion of dentinal tubules. Dontodent Sensitive and Sensodyne Repair and Protect toothpastes enhanced the calcium and phosphorus content of the dentin surface. None of the toothpastes increased dentin hardness as a result of mineral acquisition.
PubMed: 37760904
DOI: 10.3390/biomedicines11092464