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Molecular Biomedicine Dec 2023G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide array of physiological processes and responses, such as sensory perception (e.g.,... (Review)
Review
G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide array of physiological processes and responses, such as sensory perception (e.g., vision, taste, and smell), immune response, hormone regulation, and neurotransmission. Their diverse and essential roles in the body make them a significant focus for pharmaceutical research and drug development. Currently, approximately 35% of marketed drugs directly target GPCRs, underscoring their prominence as therapeutic targets. Recent advances in structural biology have substantially deepened our understanding of GPCR activation mechanisms and interactions with G-protein and arrestin signaling pathways. This review offers an in-depth exploration of both traditional and recent methods in GPCR structure analysis. It presents structure-based insights into ligand recognition and receptor activation mechanisms and delves deeper into the mechanisms of canonical and noncanonical signaling pathways downstream of GPCRs. Furthermore, it highlights recent advancements in GPCR-related drug discovery and development. Particular emphasis is placed on GPCR selective drugs, allosteric and biased signaling, polyphamarcology, and antibody drugs. Our goal is to provide researchers with a thorough and updated understanding of GPCR structure determination, signaling pathway investigation, and drug development. This foundation aims to propel forward-thinking therapeutic approaches that target GPCRs, drawing upon the latest insights into GPCR ligand selectivity, activation, and biased signaling mechanisms.
PubMed: 38047990
DOI: 10.1186/s43556-023-00156-w -
Lancet Regional Health. Americas Jan 2024This project aimed to synthesize the quantitative/qualitative evidence on the effectiveness of overweight/obesity prevention strategies implemented in Colombia and their... (Review)
Review
BACKGROUND
This project aimed to synthesize the quantitative/qualitative evidence on the effectiveness of overweight/obesity prevention strategies implemented in Colombia and their barriers and facilitators.
METHODS
A scoping review was conducted by searching PubMed, SciELO, Scopus, and the grey literature (2012–2023). In-depth interviews were also conducted among key stakeholders on their perception of these strategies’ effectiveness, barriers, and facilitators.
FINDINGS
26 records were included; four studies found positive changes in weight/body mass index, five found positive changes in physical activity, two found positive changes in food intake, and four found positive changes in healthy lifestyle knowledge, perception, attitudes, and habits. The main barrier reported was the obesogenic environment, and the facilitators were program flexibility and community engagement. Eighteen interviews were conducted (one interview per strategy); the main barriers reported were political, lack of evaluation access, economic situation, and lack of articulation; the main facilitators were incorporating the strategy into policies, articulation with stakeholders, and strong oversight.
INTERPRETATION
Moderate evidence indicates that these strategies positively impact outcomes related to overweight/obesity in Colombia, but more long-term studies are needed for overweight/obesity reduction. Lack of (1) evaluation and resources (barriers), (2) incorporation into policies (facilitators), and (3) strong stakeholder coordination (facilitators) was identified.
FUNDING
Global Health Consortium, Department of Global Health, FIU.
PubMed: 38250673
DOI: 10.1016/j.lana.2023.100656 -
Perception Sep 2023A novel geometrical optical illusion is reported in this article: the horizontal distances of the contextual structures distort the perceived vertical positions of...
A novel geometrical optical illusion is reported in this article: the horizontal distances of the contextual structures distort the perceived vertical positions of observed objects. Specifically, the illusion manifests in the form of connected boxes of varying widths but equal heights, each containing a circle at the center. Despite identical vertical positioning of the circles, they appear misaligned. The illusion diminishes when the boxes are removed. Potential underlying mechanisms are discussed.
Topics: Humans; Orientation; Optical Illusions
PubMed: 37427447
DOI: 10.1177/03010066231186557 -
ACS Nano Aug 2023Soft robotics is an exciting field of science and technology that enables robots to manipulate objects with human-like dexterity. Soft robots can handle delicate objects... (Review)
Review
Soft robotics is an exciting field of science and technology that enables robots to manipulate objects with human-like dexterity. Soft robots can handle delicate objects with care, access remote areas, and offer realistic feedback on their handling performance. However, increased dexterity and mechanical compliance of soft robots come with the need for accurate control of the position and shape of these robots. Therefore, soft robots must be equipped with sensors for better perception of their surroundings, location, force, temperature, shape, and other stimuli for effective usage. This review highlights recent progress in sensing feedback technologies for soft robotic applications. It begins with an introduction to actuation technologies and material selection in soft robotics, followed by an in-depth exploration of various types of sensors, their integration methods, and the benefits of multimodal sensing, signal processing, and control strategies. A short description of current market leaders in soft robotics is also included in the review to illustrate the growing demands of this technology. By examining the latest advancements in sensing feedback technologies for soft robots, this review aims to highlight the potential of soft robotics and inspire innovation in the field.
PubMed: 37530475
DOI: 10.1021/acsnano.3c04089 -
Sensors (Basel, Switzerland) Dec 2023With the rapid development of vision sensing, artificial intelligence, and robotics technology, one of the challenges we face is installing more advanced vision sensors... (Review)
Review
With the rapid development of vision sensing, artificial intelligence, and robotics technology, one of the challenges we face is installing more advanced vision sensors on welding robots to achieve intelligent welding manufacturing and obtain high-quality welding components. Depth perception is one of the bottlenecks in the development of welding sensors. This review provides an assessment of active and passive sensing methods for depth perception and classifies and elaborates on the depth perception mechanisms based on monocular vision, binocular vision, and multi-view vision. It explores the principles and means of using deep learning for depth perception in robotic welding processes. Further, the application of welding robot visual perception in different industrial scenarios is summarized. Finally, the problems and countermeasures of welding robot visual perception technology are analyzed, and developments for the future are proposed. This review has analyzed a total of 2662 articles and cited 152 as references. The potential future research topics are suggested to include deep learning for object detection and recognition, transfer deep learning for welding robot adaptation, developing multi-modal sensor fusion, integrating models and hardware, and performing a comprehensive requirement analysis and system evaluation in collaboration with welding experts to design a multi-modal sensor fusion architecture.
PubMed: 38139548
DOI: 10.3390/s23249700 -
Journal of Robotic Surgery Oct 2023Stereopsis may be an advantage of robotic surgery. Perceived robotic ergonomic advantages in visualisation include better exposure, three-dimensional vision, surgeon... (Review)
Review
Stereopsis may be an advantage of robotic surgery. Perceived robotic ergonomic advantages in visualisation include better exposure, three-dimensional vision, surgeon camera control, and line of sight screen location. Other ergonomic factors relating to visualisation include stereo-acuity, vergence-accommodation mismatch, visual-perception mismatch, visual-vestibular mismatch, visuospatial ability, visual fatigue, and visual feedback to compensate for lack of haptic feedback. Visual fatigue symptoms may be related to dry eye or accommodative/binocular vision stress. Digital eye strain can be measured by questionnaires and objective tests. Management options include treatment of dry eye, correction of refractive error, and management of accommodation and vergence anomalies. Experienced robotic surgeons can use visual cues like tissue deformation and surgical tool information as surrogates for haptic feedback.
Topics: Humans; Robotic Surgical Procedures; Asthenopia; Depth Perception; Accommodation, Ocular; Ergonomics
PubMed: 37204648
DOI: 10.1007/s11701-023-01618-7 -
Scientific Reports Jun 2023Knowing where objects are relative to us implies knowing where we are relative to the external world. Here, we investigated whether space perception can be influenced by...
Knowing where objects are relative to us implies knowing where we are relative to the external world. Here, we investigated whether space perception can be influenced by an experimentally induced change in perceived self-location. To dissociate real and apparent body positions, we used the full-body illusion. In this illusion, participants see a distant avatar being stroked in virtual reality while their own physical back is simultaneously stroked. After experiencing the discrepancy between the seen and the felt location of the stroking, participants report a forward drift in self-location toward the avatar. We wondered whether this illusion-induced forward drift in self-location would affect where we perceive objects in depth. We applied a psychometric measurement in which participants compared the position of a probe against a reference sphere in a two-alternative forced choice task. We found a significant improvement in task performance for the right visual field, indicated by lower just-noticeable differences, i.e., participants were better at judging the differences of the two spheres in depth. Our results suggest that the full-body illusion is able to facilitate depth perception at least unilaterally, implying that depth perception is influenced by perceived self-location.
Topics: Humans; Illusions; Differential Threshold; Emotions; Physical Examination; Stroke; Depth Perception
PubMed: 37386091
DOI: 10.1038/s41598-023-37715-8