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Brain and Cognition Dec 2023Hyperlexia, a strong orientation towards written materials, along with a discrepancy between the precocious acquisition of decoding skills and weaker comprehension...
BACKGROUND
Hyperlexia, a strong orientation towards written materials, along with a discrepancy between the precocious acquisition of decoding skills and weaker comprehension abilities, characterizes up to 20% of autistic children. Sometimes perceived as an obstacle to oral language acquisition, hyperlexia may alternatively be the first step in a non-social pathway of language acquisition in autism.
METHOD
We describe two monozygotic twin brothers, both autistic and hyperlexic, from the ages of 4 to 8 years old. Following an in-depth diagnostic assessment, we investigated cross-sectionally and longitudinally their verbal and non-verbal cognitive abilities, language, reading and writing skills, interests, and strengths.
RESULTS
The twins' features, including their high non-verbal level of intelligence, their special interests, and their skills in various domains, were highly similar. Their language consisted exclusively of letters and numbers until their fourth year. After that, their vocabulary broadened until they developed full sentences, and their perception-related interests expanded and merged over time to serve the development of other skills.
CONCLUSION
Our results show that hyperlexic skills can be harnessed to favor oral language development. Given the strong concordance between the twins' cognitive and behavioral phenotypes, we discuss the environmental and genetic influence that could explain their abilities.
Topics: Child; Child, Preschool; Humans; Male; Autistic Disorder; Language Development; Longitudinal Studies; Reading; Twins, Monozygotic
PubMed: 37839243
DOI: 10.1016/j.bandc.2023.106099 -
BMC Oral Health Oct 2023The extraction of impacted mandibular third molars might cause large bone defects in the distal area of second molars. A new strategy was innovatively employed here... (Randomized Controlled Trial)
Randomized Controlled Trial
A novel concentrated growth factor (CGF) and bio-oss based strategy for second molar protection after impacted mandibular third molar extraction: a randomized controlled clinical study.
BACKGROUND
The extraction of impacted mandibular third molars might cause large bone defects in the distal area of second molars. A new strategy was innovatively employed here combining autologous bone, Bio-Oss, concentrated growth factors (CGF) gel and CGF membrane for bone repair, and the present study aimed at exploring safety as well as short- and long-term efficacy of this new protocol clinically.
MATERIALS AND METHODS
A total of 66 participants were enrolled in this randomized single-blind clinical trial, and randomly allocated to control group (only blood clots), test A group (autogenous bone, Bio-Oss with barrier membrane) and test B group (autogenous bone, Bio-Oss, CGF gel with CGF membrane). The postoperative outcomes including PoSSe scale, periodontal probing depth (PD), degree of gingival recession and computed tomography measurements were assessed at 3rd, 6th, 12th month. A p-value < 0.05 was considered statistically significant.
RESULTS
In PoSSe scale, no significant difference was observed except a significant alleviation of early-stage pain perception in test B group (p < 0.05). Also, test B group exhibited better effect on periodontal healing and gingival recession reduction after 6 months (p < 0.05). Both two test groups showed more new bone formation than the control group (p < 0.05). It is noteworthy that the bone repair of test B group was significantly better than that of test A at 3rd and 6th month (p < 0.05), yet no difference was observed at 12th month (p > 0.05).
CONCLUSION
Both two test groups could achieve stable long-term efficacy on bone defect repair. The use of CGF gel and CGF membrane could accelerate early-stage bone repair, alleviate short-term pain after surgery, reduce long-term probing depth and relieve economic cost for patients. This new bone repair protocol is worthy of promoting by clinicians.
TRIAL REGISTRATION
This study was registered with the identification number ChiCTR2300068466 on 20/02/2023 at Chinese Clinical Trial Registry. Also, it was ethically approved from the institutional ethics committee at the Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (No:2023-010-01), and has been conducted in accordance to the guidelines of the declaration of Helsinki. Written informed consent was obtained from all participants in the study.
Topics: Humans; Molar, Third; Gingival Recession; Single-Blind Method; Tooth Extraction; China; Molar; Tooth, Impacted; Mandible; Intercellular Signaling Peptides and Proteins
PubMed: 37828455
DOI: 10.1186/s12903-023-03411-2 -
Journal of Vision Apr 2024The perceived slant of a stereoscopic surface is altered by the presence of a surrounding surface, a phenomenon termed stereo slant contrast. Previous studies have shown...
The perceived slant of a stereoscopic surface is altered by the presence of a surrounding surface, a phenomenon termed stereo slant contrast. Previous studies have shown that a slanted surround causes a fronto-parallel surface to appear slanted in the opposite direction, an instance of "bidirectional" contrast. A few studies have examined slant contrast using slanted as opposed to fronto-parallel test surfaces, and these also have shown slant contrast. Here, we use a matching method to examine slant contrast over a wide range of combinations of surround and test slants, one aim being to determine whether stereo slant contrast transfers across opposite directions of test and surround slant. We also examine the effect of the test on the perceived slant of the surround. Test slant contrast was found to be bidirectional in virtually all test-surround combinations and transferred across opposite test and surround slants, with little or no decline in magnitude as the test-surround slant difference approached the limit. There was a weak bidirectional effect of the test slant on the perceived slant of the surround. We consider how our results might be explained by four mechanisms: (a) normalization of stereo slant to vertical; (b) divisive normalization of stereo slant channels in a manner analogous to the tilt illusion; (c) interactions between center and surround disparity-gradient detectors; and (d) uncertainty in slant estimation. We conclude that the third of these (interactions between center and surround disparity-gradient detectors) is the most likely cause of stereo slant contrast.
Topics: Humans; Depth Perception; Contrast Sensitivity; Photic Stimulation; Vision, Binocular
PubMed: 38683571
DOI: 10.1167/jov.24.4.24 -
ELife Sep 2023Crowding occurs when the presence of nearby features causes highly visible objects to become unrecognizable. Although crowding has implications for many everyday tasks...
Crowding occurs when the presence of nearby features causes highly visible objects to become unrecognizable. Although crowding has implications for many everyday tasks and the tremendous amounts of research reflect its importance, surprisingly little is known about how depth affects crowding. Most available studies show that stereoscopic disparity reduces crowding, indicating that crowding may be relatively unimportant in three-dimensional environments. However, most previous studies tested only small stereoscopic differences in depth in which disparity, defocus blur, and accommodation are inconsistent with the real world. Using a novel multi-depth plane display, this study investigated how large (0.54-2.25 diopters), real differences in target-flanker depth, representative of those experienced between many objects in the real world, affect crowding. Our findings show that large differences in target-flanker depth increased crowding in the majority of observers, contrary to previous work showing reduced crowding in the presence of small depth differences. Furthermore, when the target was at fixation depth, crowding was generally more pronounced when the flankers were behind the target as opposed to in front of it. However, when the flankers were at fixation depth, crowding was generally more pronounced when the target was behind the flankers. These findings suggest that crowding from clutter outside the limits of binocular fusion can still have a significant impact on object recognition and visual perception in the peripheral field.
Topics: Histological Techniques; Visual Perception
PubMed: 37665324
DOI: 10.7554/eLife.85143 -
Sensors (Basel, Switzerland) Aug 2023Tactile sensing plays a pivotal role in achieving precise physical manipulation tasks and extracting vital physical features. This comprehensive review paper presents an... (Review)
Review
Tactile sensing plays a pivotal role in achieving precise physical manipulation tasks and extracting vital physical features. This comprehensive review paper presents an in-depth overview of the growing research on tactile-sensing technologies, encompassing state-of-the-art techniques, future prospects, and current limitations. The paper focuses on tactile hardware, algorithmic complexities, and the distinct features offered by each sensor. This paper has a special emphasis on agri-food manipulation and relevant tactile-sensing technologies. It highlights key areas in agri-food manipulation, including robotic harvesting, food item manipulation, and feature evaluation, such as fruit ripeness assessment, along with the emerging field of kitchen robotics. Through this interdisciplinary exploration, we aim to inspire researchers, engineers, and practitioners to harness the power of tactile-sensing technology for transformative advancements in agri-food robotics. By providing a comprehensive understanding of the current landscape and future prospects, this review paper serves as a valuable resource for driving progress in the field of tactile sensing and its application in agri-food systems.
Topics: Touch; Touch Perception; Technology; Engineering; Fruit
PubMed: 37687818
DOI: 10.3390/s23177362 -
Biomimetics (Basel, Switzerland) Sep 2023Depth estimation is an ill-posed problem; objects of different shapes or dimensions, even if at different distances, may project to the same image on the retina. Our...
Depth estimation is an ill-posed problem; objects of different shapes or dimensions, even if at different distances, may project to the same image on the retina. Our brain uses several cues for depth estimation, including monocular cues such as motion parallax and binocular cues such as diplopia. However, it remains unclear how the computations required for depth estimation are implemented in biologically plausible ways. State-of-the-art approaches to depth estimation based on deep neural networks implicitly describe the brain as a hierarchical feature detector. Instead, in this paper we propose an alternative approach that casts depth estimation as a problem of active inference. We show that depth can be inferred by inverting a hierarchical generative model that simultaneously predicts the eyes' projections from a 2D belief over an object. Model inversion consists of a series of biologically plausible homogeneous transformations based on Predictive Coding principles. Under the plausible assumption of a nonuniform fovea resolution, depth estimation favors an active vision strategy that fixates the object with the eyes, rendering the depth belief more accurate. This strategy is not realized by first fixating on a target and then estimating the depth; instead, it combines the two processes through action-perception cycles, with a similar mechanism of the saccades during object recognition. The proposed approach requires only local (top-down and bottom-up) message passing, which can be implemented in biologically plausible neural circuits.
PubMed: 37754196
DOI: 10.3390/biomimetics8050445 -
International Journal of Women's Health 2023Gender-based perceptions about maternal health care during pregnancy draw attention to the existence of gender inequity in maternal health care. This study aimed to...
PURPOSE
Gender-based perceptions about maternal health care during pregnancy draw attention to the existence of gender inequity in maternal health care. This study aimed to understand the gender-based perception of gender roles and norms, gender relations, social support, and psychosocial variation in maternal health care during pregnancy.
METHODS
A qualitative study was conducted in three rural districts of Jimma, Ethiopia. Participants were purposefully chosen from the community groups, including male and female health development armies, religious leaders, health extension workers, midwifery nurses, and primary health care unit directors. The data was gathered through in-depth interviews and focus group discussions. The actual data was collected by men and women qualitative study experts. Atlas ti Ver 9 was used for the analysis. The data was initially coded then changed to a sub-category and at last converted to a category.
RESULTS
Four categories emerged: Gender-based roles and norms, psychosocial variation, social support, and gender relations. The informants described men's and women's independent and shared roles improve maternal health care service usage during pregnancy. Once the women became pregnant, men undertook a variety of demanding duties to enhance maternity service consumption. Gender relations and shared decision-making were essential in facilitating maternal healthcare utilization during pregnancy and beyond.
CONCLUSION
This study revealed that maternal health care should not be limited to women alone. Men's and women's prior maternal health experiences, in addition to their knowledge and beliefs, have significantly impacted the utilization of maternal healthcare services during pregnancy. Policymakers and academics should consider men's essential contribution to maternal health care during pregnancy. However, in order to increase their intention to use maternal health care services, it is necessary to clearly identify the interests of women in which men should be involved.
PubMed: 37849848
DOI: 10.2147/IJWH.S418653 -
Scientific Reports Jul 2023Pulse-coupled neural networks perform well in many fields such as information retrieval, depth estimation and object detection. Based on pulse coupled neural network...
Pulse-coupled neural networks perform well in many fields such as information retrieval, depth estimation and object detection. Based on pulse coupled neural network (PCNN) theory, this paper constructs a visual perception model framework and builds a real image reproduction platform. The model firstly analyzes the structure and generalization ability of neural network multi-class classifier, uses the minimax criterion of feature space as the splitting criterion of visual perception decision node, which solves the generalization problem of neural network learning algorithm. In the simulation process, the initial threshold is optimized by the two-dimensional maximum inter-class variance method, and in order to improve the real-time performance of the algorithm, the fast recurrence formula of neural network is derived and given. The PCNN image segmentation method based on genetic algorithm is analyzed. The genetic algorithm improves the loop termination condition and the adaptive setting of model parameters of PCNN image segmentation algorithm, but the PCNN image segmentation algorithm still has the problem of complexity. In order to solve this problem, this paper proposed an IGA-PCNN image segmentation method combining the improved algorithm and PCNN model. Firstly, it used the improved immune genetic algorithm to adaptively obtain the optimal threshold, and then replaced the dynamic threshold in PCNN model with the optimal threshold, and finally used the pulse coupling characteristics of PCNN model to complete the image segmentation. From the coupling characteristics of PCNN, junction close space of image and gray level characteristics, it determined the local gray mean square error of image connection strength coefficient. The feature extraction and object segmentation properties of PCNN come from the spike frequency of neurons, and the number of neurons in PCNN is equal to the number of pixels in the input image. In addition, the spatial and gray value differences of pixels should be considered comprehensively to determine their connection matrix. Digital experiments show that the multi-scale multi-task pulse coupled neural network model can shorten the total training time by 17 h, improve the comprehensive accuracy of the task test data set by 1.04%, and shorten the detection time of each image by 4.8 s compared with the series network model of multiple single tasks. Compared with the traditional PCNN algorithm, it has the advantages of fast visual perception and clear target contour segmentation, and effectively improves the anti-interference performance of the model.
PubMed: 37507535
DOI: 10.1038/s41598-023-39376-z -
Scientific Reports Mar 2024Depth perception is crucial in human vision, allowing us to move and interact with our 3-D surroundings. We used a stereoscopic transparent stimulus comprising parallel...
Depth perception is crucial in human vision, allowing us to move and interact with our 3-D surroundings. We used a stereoscopic transparent stimulus comprising parallel overlapping transparent stereoscopic surfaces (POTS) to understand depth perception better. The study focused on exploring the effect of a surrounding frame on the perceived depth of a POTS configuration. The research was based on a proposed idea that explains an "off-frame" effect: a frame at a different depth from a 2-D photograph depicting a 3-D scene increases its apparent depth qualitatively. The idea assumes that processing the disparity between a frame and a photo reduces the reliability of the photograph's flatness cues and increases depth magnitude in depth cue integration. We examined whether the idea can be applied to a 3-D POTS with the flatness cue as the constant accommodation. Through three experiments, the study showed that frames impact the perceived depth magnitude of a POTS configuration. More specifically, the depth magnitude increases as the frame's disparity concerning the monitor plane increases and decreases as the frame's size increases. We discussed the results in the context of depth cue combination.
PubMed: 38509233
DOI: 10.1038/s41598-024-57283-9 -
The Journal of Neuroscience : the... Dec 2023During binocular rivalry, conflicting images are presented one to each eye and perception alternates stochastically between them. Despite stable percepts between...
During binocular rivalry, conflicting images are presented one to each eye and perception alternates stochastically between them. Despite stable percepts between alternations, modeling suggests that neural signals representing the two images change gradually, and that the duration of stable percepts are determined by the time required for these signals to reach a threshold that triggers an alternation. However, direct physiological evidence for such signals has been lacking. Here, we identify a neural signal in the human visual cortex that shows these predicted properties. We measured steady-state visual evoked potentials (SSVEPs) in 84 human participants (62 females, 22 males) who were presented with orthogonal gratings, one to each eye, flickering at different frequencies. Participants indicated their percept while EEG data were collected. The time courses of the SSVEP amplitudes at the two frequencies were then compared across different percept durations, within participants. For all durations, the amplitude of signals corresponding to the suppressed stimulus increased and the amplitude corresponding to the dominant stimulus decreased throughout the percept. Critically, longer percepts were characterized by more gradual increases in the suppressed signal and more gradual decreases of the dominant signal. Changes in signals were similar and rapid at the end of all percepts, presumably reflecting perceptual transitions. These features of the SSVEP time courses are well predicted by a model in which perceptual transitions are produced by the accumulation of noisy signals. Identification of this signal underlying binocular rivalry should allow strong tests of neural models of rivalry, bistable perception, and neural suppression. During binocular rivalry, two conflicting images are presented to the two eyes and perception alternates between them, with switches occurring at seemingly random times. Rivalry is an important and longstanding model system in neuroscience, used for understanding neural suppression, intrinsic neural dynamics, and even the neural correlates of consciousness. All models of rivalry propose that it depends on gradually changing neural activity that on reaching some threshold triggers the perceptual switches. This manuscript reports the first physiological measurement of neural signals with that set of properties in human participants. The signals, measured with EEG in human observers, closely match the predictions of recent models of rivalry, and should pave the way for much future work.
Topics: Male; Female; Humans; Visual Perception; Vision, Binocular; Evoked Potentials, Visual; Photic Stimulation; Visual Cortex; Vision Disparity
PubMed: 37907256
DOI: 10.1523/JNEUROSCI.1325-23.2023