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Proceedings of the National Academy of... Jan 2024Plastics are now omnipresent in our daily lives. The existence of microplastics (1 µm to 5 mm in length) and possibly even nanoplastics (<1 μm) has recently raised...
Plastics are now omnipresent in our daily lives. The existence of microplastics (1 µm to 5 mm in length) and possibly even nanoplastics (<1 μm) has recently raised health concerns. In particular, nanoplastics are believed to be more toxic since their smaller size renders them much more amenable, compared to microplastics, to enter the human body. However, detecting nanoplastics imposes tremendous analytical challenges on both the nano-level sensitivity and the plastic-identifying specificity, leading to a knowledge gap in this mysterious nanoworld surrounding us. To address these challenges, we developed a hyperspectral stimulated Raman scattering (SRS) imaging platform with an automated plastic identification algorithm that allows micro-nano plastic analysis at the single-particle level with high chemical specificity and throughput. We first validated the sensitivity enhancement of the narrow band of SRS to enable high-speed single nanoplastic detection below 100 nm. We then devised a data-driven spectral matching algorithm to address spectral identification challenges imposed by sensitive narrow-band hyperspectral imaging and achieve robust determination of common plastic polymers. With the established technique, we studied the micro-nano plastics from bottled water as a model system. We successfully detected and identified nanoplastics from major plastic types. Micro-nano plastics concentrations were estimated to be about 2.4 ± 1.3 × 10 particles per liter of bottled water, about 90% of which are nanoplastics. This is orders of magnitude more than the microplastic abundance reported previously in bottled water. High-throughput single-particle counting revealed extraordinary particle heterogeneity and nonorthogonality between plastic composition and morphologies; the resulting multidimensional profiling sheds light on the science of nanoplastics.
Topics: Humans; Microscopy; Microplastics; Plastics; Drinking Water; Algorithms
PubMed: 38190543
DOI: 10.1073/pnas.2300582121 -
Journal of the National Cancer Institute Dec 2023Colorectal cancer is the third most common malignancy worldwide and is strongly linked to lifestyle and environmental risk factors. Although several drinking-water...
BACKGROUND
Colorectal cancer is the third most common malignancy worldwide and is strongly linked to lifestyle and environmental risk factors. Although several drinking-water disinfection by-products are confirmed rodent carcinogens, the evidence in humans for carcinogenicity associated with these by-products, including colorectal cancer, is still inconclusive.
METHODS
We assessed the association of long-term exposure to trihalomethanes (THMs), the most prevalent disinfection by-products in chlorinated drinking water, with incidence of colorectal cancer in 58 672 men and women in 2 population-based cohorts. Exposure was assessed by combining long-term information of residential history with drinking water-monitoring data. Participants were categorized according to no exposure, low exposure (<15 µg/L), and high exposure (≥15 µg/L). Incident cases of colorectal cancer were ascertained by use of the Swedish National Cancer Register.
RESULTS
During an average follow-up of 16.8 years (988 144 person-years), 1913 cases of colorectal cancer were ascertained (1176 cases in men and 746 in women, respectively). High THM concentrations in drinking water (≥15 µg/L) were associated with increased risk of colorectal cancer in men (hazard ratio = 1.26, 95% confidence interval = 1.05-1.51) compared with no exposure. When subsites were assessed, the association was statistically significant for proximal colon cancer (hazard ratio = 1.59, 95% confidence interval = 1.11 to 2.27) but not for distal colon cancer or rectal cancer. In women, we observed overall no association of THMs with colorectal cancer.
CONCLUSION
These results add further evidence that disinfection by-products in drinking water may be a possible risk factor for proximal colon cancer in men. This observation was made at THM concentrations lower than those in most previous studies.
Topics: Male; Humans; Female; Drinking Water; Disinfection; Cohort Studies; Environmental Exposure; Water Purification; Colonic Neoplasms; Trihalomethanes
PubMed: 37551954
DOI: 10.1093/jnci/djad145 -
Environmental Research Nov 2023Water fluoridation is considered a safe and effective public health strategy to improve oral health. This review aimed to systematically summarize the available evidence... (Review)
Review
Water fluoridation is considered a safe and effective public health strategy to improve oral health. This review aimed to systematically summarize the available evidence of water fluoridation in Australia, focusing on the history, health impacts, cost effectiveness, challenges, and limitations. A systematic search was conducted on the Ovid Medline, Web of Science, Scopus, ProQuest Central, Cinahl, and Informit databases to identify literature on water fluoridation in Australia. A grey literature search and backward snowballing were used to capture additional literature. Primary studies, reviews, letters, and opinion papers were included in the quantitative analysis and summarized based on the year of publication and geographical location. The data were extracted from primary studies and summarized under three subheadings: history, community health impacts and the limitations and challenges. Water fluoridation in Australia was first implemented in 1953 in Tasmania. Most states and territories in Australia embraced water fluoridation by 1977 and currently, 89% of the Australian population has access to fluoridated drinking water. Studies report that water fluoridation has reduced dental caries by 26-44% in children, teenagers, and adults, benefiting everyone regardless of age, income, or access to dental care. It has been recognized as a cost-effective intervention to prevent dental caries, especially in rural and low-income areas. Water fluoridation as a public health measure has faced challenges, including political and public opposition, implementation and maintenance costs, access and equity, communication and education, and ethical concerns. Variations in research activities on water fluoridation across Australian states and territories over the last seven decades can be due to several factors, including the time of implementation, funding, and support. Ongoing monitoring and research to review and update optimal fluoride levels in drinking water in Australia is warranted to ensure sustainable benefits on oral health while preventing any adverse impacts.
PubMed: 37598841
DOI: 10.1016/j.envres.2023.116915 -
Toxics Jul 2023The stability of drinking water distribution systems and the management of disinfection by-products are critical to ensuring public health safety. In this paper, the... (Review)
Review
The stability of drinking water distribution systems and the management of disinfection by-products are critical to ensuring public health safety. In this paper, the interrelationships between corrosion products in the network, microbes, and drinking water quality are elucidated. This review also discusses the mechanisms through which corrosive by-products from the piping network influence the decay of disinfectants and the formation of harmful disinfection by-products. Factors such as copper corrosion by-products, CuO, CuO, and Cu play a significant role in accelerating disinfectant decay and catalyzing the production of by-products. Biofilms on pipe walls react with residual chlorine, leading to the formation of disinfection by-products (DBPs) that also amplify health risks. Finally, this paper finally highlights the potential of peroxymonosulfate (PMS), an industrial oxidant, as a disinfectant that can reduce DBP formation, while acknowledging the risks associated with its corrosive nature. Overall, the impact of the corrosive by-products of pipe scale and microbial communities on water quality in pipe networks is discussed, and recommendations for removing DBPs are presented.
PubMed: 37505570
DOI: 10.3390/toxics11070606 -
BMC Public Health Sep 2023Periodontitis has become an increasingly important public health issue, coupled with a high economic burden for prevention and treatment. Exposure to essential trace...
BACKGROUND
Periodontitis has become an increasingly important public health issue, coupled with a high economic burden for prevention and treatment. Exposure to essential trace heavy metals has been associated with various diseases; however, the relationships between essential trace heavy metals and periodontitis remain inconclusive.
OBJECTIVES
To investigate the association between essential trace heavy metals in tap water and periodontitis in a nationally representative sample in China.
METHODS
We conducted a nationwide study including 1348 participants from the Fourth National Oral Health Survey in the 2015-2016 period. The trace heavy metals concentration was measured in the local pipeline terminal tap water. Periodontitis was diagnosed according to the classification scheme proposed at the 2018 world workshop on the classification of periodontal and peri-implant diseases and conditions. We used weighted multivariable logistic regression to estimate the association between essential trace heavy metals and the risk of periodontitis. We additionally used spline analysis to explore the possible nonlinear dose-response associations.
RESULTS
Periodontitis patients were exposed to higher concentrations of essential trace heavy metals. In adjusted models, for 1 SD increase in the concentration of iron, manganese, and copper in tap water, the risk of periodontitis increased by 30% (OR: 1.30, 95%CI: 1.12-1.50), 20% (OR: 1.20, 95%CI: 1.03-1.41), and 20% (OR: 1.20, 95%CI: 1.04-1.39), respectively. Stratified analyses demonstrated that the associations between essential trace heavy metals and periodontitis were higher in females, elders, and rural residents. Spline analysis revealed nonlinear exposure-response relationships between periodontitis and exposure to iron, manganese, and copper in tap water.
CONCLUSIONS
Exposures to essential trace heavy metals in drinking water were associated with greater odds of periodontitis. Given the growing burden of periodontitis, our study sheds light on tailored public health policies for improving drinking water standards to alleviate periodontitis impairment.
Topics: Female; Humans; Aged; Drinking Water; Copper; Manganese; Metals, Heavy; Iron; China; Periodontitis; Health Surveys
PubMed: 37667326
DOI: 10.1186/s12889-023-16391-3 -
Food & Nutrition Research 2023Water, being an essential nutrient, is crucial for all life. Adequate maintenance of body water compartments is required for optimal fluid balance, which is a... (Review)
Review
Water, being an essential nutrient, is crucial for all life. Adequate maintenance of body water compartments is required for optimal fluid balance, which is a prerequisite for cellular homeostasis and blood pressure regulation. Water balance is the result of dietary intake of both fluids and foods as well as metabolically produced water, excretion from the kidneys and losses from other sources (e.g. sweat and feces). The water content in food items varies considerably and ranges from about 5% in nuts to 90% in many fruits and vegetables. Intake of drinking water and beverages also provides varying amounts of water. In everyday life assessment of water balance (i.e. hydration status) is challenging as clinical observations are inaccurate. There is no data regarding drinking water intake in the Nordic or Baltic countries.
PubMed: 38084150
DOI: 10.29219/fnr.v67.9975 -
Water Research Mar 2024Rodents represent the single largest group within mammals and host a diverse array of zoonotic pathogens. Urbanisation impacts wild mammals, including rodents, leading... (Review)
Review
Rodents represent the single largest group within mammals and host a diverse array of zoonotic pathogens. Urbanisation impacts wild mammals, including rodents, leading to habitat loss but also providing new resources. Urban-adapted (synanthropic) rodents, such as the brown rat (R. norvegicus), black rat (R. rattus), and house mouse (Mus musculus), have long successfully adapted to living close to humans and are known carriers of zoonotic pathogens. Two important enteric, zoonotic protozoan parasites, carried by rodents, include Cryptosporidium and Giardia. Their environmental stages (oocysts/cysts), released in faeces, can contaminate surface and wastewaters, are resistant to common drinking water disinfectants and can cause water-borne related gastritis outbreaks. At least 48 species of Cryptosporidium have been described, with C. hominis and C. parvum responsible for the majority of human infections, while Giardia duodenalis assemblages A and B are the main human-infectious assemblages. Molecular characterisation is crucial to assess the public health risk linked to rodent-related water contamination due to morphological overlap between species. This review explores the global molecular diversity of these parasites in rodents, with a focus on evaluating the zoonotic risk from contamination of water and wasterwater with Cryptosporidium and Giardia oocysts/cysts from synanthropic rodents. Analysis indicates that while zoonotic Cryptosporidium and Giardia are prevalent in farmed and pet rodents, host-specific Cryptosporidium and Giardia species dominate in urban adapted rodents, and therefore the risks posed by these rodents in the transmission of zoonotic Cryptosporidium and Giardia are relatively low. Many knowledge gaps remain however, and therefore understanding the intricate dynamics of these parasites in rodent populations is essential for managing their impact on human health and water quality. This knowledge can inform strategies to reduce disease transmission and ensure safe drinking water in urban and peri‑urban areas.
Topics: Mice; Humans; Animals; Rats; Cryptosporidium; Cryptosporidiosis; Water Quality; Drinking Water; Rodentia; Giardiasis; Giardia; Feces; Oocysts; Cysts
PubMed: 38290188
DOI: 10.1016/j.watres.2024.121165 -
Cells Oct 2023Arsenic (As) is a metalloid naturally present in the environment, in food, water, soil, and air; however, its chronic exposure, even with low doses, represents a public... (Review)
Review
Arsenic (As) is a metalloid naturally present in the environment, in food, water, soil, and air; however, its chronic exposure, even with low doses, represents a public health concern. For a long time, As was used as a pigment, pesticide, wood preservative, and for medical applications; its industrial use has recently decreased or has been discontinued due to its toxicity. Due to its versatile applications and distribution, there is a wide spectrum of human As exposure sources, mainly contaminated drinking water. The fact that As is present in drinking water implies chronic human exposure to this metalloid; it has become a worldwide health problem, since over 200 million people live where As levels exceed safe ranges. Many health problems have been associated with As chronic exposure including cancer, cardiovascular diseases, gastrointestinal disturbances, and brain dysfunctions. Because As can cross the blood-brain barrier (BBB), the brain represents a target organ where this metalloid can exert its long-term toxic effects. Many mechanisms of As neurotoxicity have been described: oxidative stress, inflammation, DNA damage, and mitochondrial dysfunction; all of them can converge, thus leading to impaired cellular functions, cell death, and in consequence, long-term detrimental effects. Here, we provide a current overview of As toxicity and integrated the global mechanisms involved in cognitive and behavioral impairment induced by As exposure show experimental strategies against its neurotoxicity.
Topics: Humans; Arsenic; Drinking Water; Arsenic Poisoning; Brain; Neurotoxicity Syndromes; Cognition
PubMed: 37947615
DOI: 10.3390/cells12212537 -
Cureus Oct 2023The aim was to determine whether urine pH changed or not with different pH values of drinking water. With the results obtained from animal studies, comments can be made...
AIM
The aim was to determine whether urine pH changed or not with different pH values of drinking water. With the results obtained from animal studies, comments can be made about the effect of water with different pH levels that people drink on kidney stones.
METHOD
A total of 24 Wistar Albino rats were divided into three groups containing eight rats each: the first group was given water with pH 5.5, the second group was given water with pH 7 and the third group was given water with pH 8.2 in the same environment and conditions during 13 days. All rats consumed water in line with their natural feeding habits. All rats had urine pH measurements performed and recorded every day at the same time. The groups were later compared in terms of daily pH values.
RESULTS
When daily urine pH values were compared, there were statistically significant differences between pH measurements on the first, fourth and seventh day (p=0.02, p=0.017 and p=0.007, respectively). When first-day values are compared with post-hoc analyses, the urine pH in Group 2 was identified to be lower compared to Group 1 and Group 3 (p<0.001). When the fourth-day values were assessed, the urine pH of Group 2 was observed to be higher than Group 1 and Group 3 (p<0.001). On the seventh day, Group 3 had higher urine pH compared to the other groups (p<0.001).
CONCLUSION
The variation in drinking water pH does not directly change urine pH; however, it causes a change in the urine pH on different days.
PubMed: 38022142
DOI: 10.7759/cureus.47437 -
Journal of Exposure Science &... Nov 2023Exposure assessment of inorganic arsenic is challenging due to the existence of multiple species, complexity of arsenic metabolism, and variety of exposure sources.... (Review)
Review
Exposure assessment of inorganic arsenic is challenging due to the existence of multiple species, complexity of arsenic metabolism, and variety of exposure sources. Exposure assessment of arsenic during pregnancy is further complicated by the physiological changes that occur to support fetal growth. Given the well-established toxicity of inorganic arsenic at high concentrations, continued research into the potential health effects of low-level exposure on maternal and fetal health is necessary. Our objectives were to review the value of and challenges inherent in measuring inorganic arsenic species in pregnancy and highlight related research priorities. We discussed how the physiological changes of pregnancy influence arsenic metabolism and necessitate the need for pregnancy-specific data. We reviewed the biomonitoring challenges according to common and novel biological matrices and discussed how each matrix differs according to half-life, bioavailability, availability of laboratory methods, and interpretation within pregnancy. Exposure assessment in both established and novel matrices that accounts for the physiological changes of pregnancy and complexity of speciation is a research priority. Standardization of laboratory method for novel matrices will help address these data gaps. Research is particularly lacking in contemporary populations of pregnant women without naturally elevated arsenic drinking water concentrations (i.e. <10 µg/l).
Topics: Pregnancy; Humans; Female; Arsenic; Biological Monitoring; Arsenicals; Drinking Water; Fetus
PubMed: 35948664
DOI: 10.1038/s41370-022-00457-2