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Brain Pathology (Zurich, Switzerland) Nov 2023
Topics: Child, Preschool; Humans; Male; Spinal Cord Neoplasms
PubMed: 37285582
DOI: 10.1111/bpa.13174 -
Indian Journal of Pathology &... 2024Juvenile xanthogranuloma is a benign self-limiting lesion commonly described in infants and young children. It most commonly involves the skin presenting as single or...
Juvenile xanthogranuloma is a benign self-limiting lesion commonly described in infants and young children. It most commonly involves the skin presenting as single or multiple yellowish-brown papules. Clinical scenario with the classic histomorphology showing histiocytic aggregates in the dermis with xanthomatous cytoplasm, toutan type giant cells, immunohistochemistry with positive CD68, CD163, factor XIIIa and negative CD1a and S-100 help in diagnosis. However, diagnosis becomes challenging with predominant systemic bone marrow involvement in post-B-lymphoblastic leukemia settings.
Topics: Infant; Child; Humans; Child, Preschool; Bone Marrow; Skin; Xanthogranuloma, Juvenile; Histiocytes; Xanthomatosis; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma
PubMed: 38358218
DOI: 10.4103/ijpm.ijpm_1253_21 -
Archivos Argentinos de Pediatria Oct 2023The infiltration of leukemia cells into the skin, known as leukemia cutis, is a rare presentation of this disease and accounts for a diagnostic challenge. The main...
The infiltration of leukemia cells into the skin, known as leukemia cutis, is a rare presentation of this disease and accounts for a diagnostic challenge. The main differential diagnoses include infections, other neoplastic diseases with skin involvement and histiocytic disorders, among others, as they entail different prognostic and therapeutic approaches. Here we describe two patients who were initially diagnosed with leukemia cutis, whose final diagnosis was of non-malignant diseases.
Topics: Humans; Leukemia; Skin Neoplasms; Skin; Diagnosis, Differential
PubMed: 36857109
DOI: 10.5546/aap.2022-02796.eng -
Haematologica May 2024
B-cell acute lymphoblastic leukemia and juvenile xanthogranuloma in a patient with thrombocytopenia and leukemia predisposition syndrome: novel clinical presentation and perspective.
Topics: Female; Humans; ETS Translocation Variant 6 Protein; Genetic Predisposition to Disease; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-ets; Repressor Proteins; Thrombocytopenia; Xanthogranuloma, Juvenile; Child; Adolescent
PubMed: 38031764
DOI: 10.3324/haematol.2023.284151