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Scientific Reports Jul 2023We probe the gravitational properties of two neighboring planets, Earth and Venus. To justify a comparison between gravity models of the two planets, spherical harmonic...
We probe the gravitational properties of two neighboring planets, Earth and Venus. To justify a comparison between gravity models of the two planets, spherical harmonic series were considered up to a degree and order of 100. The topography and gravity aspects, including [Formula: see text] (vertical derivative of the vertical component of the gravity field), strike alignment (SA), comb factor (CF), and I invariant derived from the Marussi tensor, were calculated for the two planets at specifically selected zones that provided sufficient resolution. From Γ we discovered that the N-NW edge of Lakshmi Planum does not show any subduction-like features. Its Γ signature resembles passive continental margins on Earth, like those surrounding the Indian Peninsula. Moreover, according to SA and CF, the Pacific and Philippine-North American Contact Zone on Earth indicates significantly higher level of deformation due to convergent motion of the plates, whereas the deformation level on Venus is significantly smaller and local, when considering an equatorial rifting zone (ERZ) of Venus (between Atla-Beta Regios) as diverging boundaries. The strain mode on the East African Rift system is smaller in comparison with ERZ as its Venusian analog. The topography-I analysis suggests a complicated nature of the topographic rise on Beta Regio. We show that specific regions in this volcanic rise are in incipient stages of upward motion, with denser mantle material approaching the surface and thinning the crust, whereas some risen districts show molten and less dense underlying crustal materials. Other elevated districts appear to be due to mantle plumes and local volcanic activities with large density of underlying material.
PubMed: 37507435
DOI: 10.1038/s41598-023-39100-x -
Science Advances Dec 2023Knowledge of high-pressure melting curves of silicate minerals is critical for modeling the thermal-chemical evolution of rocky planets. However, the melting temperature...
Knowledge of high-pressure melting curves of silicate minerals is critical for modeling the thermal-chemical evolution of rocky planets. However, the melting temperature of davemaoite, the third most abundant mineral in Earth's lower mantle, is still controversial. Here, we investigate the melting curves of two minerals, MgSiO bridgmanite and CaSiO davemaoite, under their stability field in the mantle by performing first-principles molecular dynamics simulations based on the density functional theory. The melting curve of bridgmanite is in excellent agreement with previous studies, confirming a general consensus on its melting temperature. However, we predict a much higher melting curve of davemaoite than almost all previous estimates. Melting temperature of davemaoite at the pressure of core-mantle boundary (~136 gigapascals) is about 7700(150) K, which is approximately 2000 K higher than that of bridgmanite. The ultrarefractory nature of davemaoite is critical to reconsider many models in the deep planetary interior, for instance, solidification of early magma ocean and geodynamical behavior of mantle rocks.
PubMed: 38055828
DOI: 10.1126/sciadv.adj2660 -
Proceedings of the National Academy of... Dec 2023Sediments in southern Laos and eastern Thailand confirm that the Australasian tektite strewn field came from an extraterrestrial impact crater on the Bolaven Plateau of...
Sediments in southern Laos and eastern Thailand confirm that the Australasian tektite strewn field came from an extraterrestrial impact crater on the Bolaven Plateau of southern Laos. The principal evidence is the Bolaven diamicton, a pebbly to bouldery breccia that is thickest and coarsest on the plateau. Tektites, the melted target material strewn widely by the forces of the impact 789.0 ± 1.8 ka ago, lie either within the uppermost part of the diamicton or atop it. On the flanks of the plateau, the basal diamicton often contains clasts from preimpact lavas and gravels and sometimes mantles broken Mesozoic bedrock. Locally, its upper portions contain unweathered boulders of basalt or sandstone. Its sharp upper contact with a thick sandy silt implies that the two beds formed in rapid succession. These characteristics of the Bolaven diamicton show that it resulted primarily from the excavation, comminution, and launch of sandstone and weathered basaltic lavas from a crater on the Bolaven Plateau, and entrained other materials while in transit.
PubMed: 38048466
DOI: 10.1073/pnas.2310351120 -
Blood Advances Apr 2024Cytopenias represent the most common side effect of CAR T-cell therapy (CAR-T) and can predispose for severe infectious complications. Current grading systems, such as... (Observational Study)
Observational Study
Cytopenias represent the most common side effect of CAR T-cell therapy (CAR-T) and can predispose for severe infectious complications. Current grading systems, such as the Common Terminology Criteria for Adverse Events (CTCAE), neither reflect the unique quality of post-CAR-T neutrophil recovery, nor do they reflect the inherent risk of infections due to protracted neutropenia. For this reason, a novel EHA/EBMT consensus grading was recently developed for Immune Effector Cell-Associated HematoToxicity (ICAHT). In this multicenter, observational study, we applied the grading system to a large real-world cohort of 549 patients treated with BCMA- or CD19-directed CAR-T for refractory B-cell malignancies (112 multiple myeloma [MM], 334 large B-cell lymphoma [LBCL], 103 mantle cell lymphoma [MCL]) and examined the clinical sequelae of severe (≥3°) ICAHT. The ICAHT grading was strongly associated with the cumulative duration of severe neutropenia (r = 0.92, P < .0001), the presence of multilineage cytopenias, and the use of platelet and red blood cell transfusions. We noted an increased rate of severe ICAHT in patients with MCL vs those with LBCL and MM (28% vs 23% vs 15%). Severe ICAHT was associated with a higher rate of severe infections (49% vs 13%, P < .0001), increased nonrelapse mortality (14% vs 4%, P < .0001), and inferior survival outcomes (1-year progression-free survival: 35% vs 51%, 1-year overall survival: 52% vs 73%, both P < .0001). Importantly, the ICAHT grading demonstrated superior capacity to predict severe infections compared with the CTCAE grading (c-index 0.73 vs 0.55, P < .0001 vs nonsignificant). Taken together, these data highlight the clinical relevance of the novel grading system and support the reporting of ICAHT severity in clinical trials evaluating CAR-T therapies.
Topics: Humans; Adult; Incidence; Receptors, Chimeric Antigen; Cytopenia; Neutropenia; Adaptor Proteins, Signal Transducing; Lymphoma, Mantle-Cell; Multiple Myeloma
PubMed: 38181508
DOI: 10.1182/bloodadvances.2023011767 -
Nature Aug 2023Kimberlites are volatile-rich, occasionally diamond-bearing magmas that have erupted explosively at Earth's surface in the geologic past. These enigmatic magmas,...
Kimberlites are volatile-rich, occasionally diamond-bearing magmas that have erupted explosively at Earth's surface in the geologic past. These enigmatic magmas, originating from depths exceeding 150 km in Earth's mantle, occur in stable cratons and in pulses broadly synchronous with supercontinent cyclicity. Whether their mobilization is driven by mantle plumes or by mechanical weakening of cratonic lithosphere remains unclear. Here we show that most kimberlites spanning the past billion years erupted about 30 million years (Myr) after continental breakup, suggesting an association with rifting processes. Our dynamical and analytical models show that physically steep lithosphere-asthenosphere boundaries (LABs) formed during rifting generate convective instabilities in the asthenosphere that slowly migrate many hundreds to thousands of kilometres inboard of rift zones. These instabilities endure many tens of millions of years after continental breakup and destabilize the basal tens of kilometres of the cratonic lithosphere, or keel. Displaced keel is replaced by a hot, upwelling mixture of asthenosphere and recycled volatile-rich keel in the return flow, causing decompressional partial melting. Our calculations show that this process can generate small-volume, low-degree, volatile-rich melts, closely matching the characteristics expected of kimberlites. Together, these results provide a quantitative and mechanistic link between kimberlite episodicity and supercontinent cycles through progressive disruption of cratonic keels.
PubMed: 37495695
DOI: 10.1038/s41586-023-06193-3 -
Journal of Clinical Oncology : Official... Jun 2024Female Hodgkin lymphoma (HL) survivors treated with chest radiotherapy (RT) at a young age have a strongly increased risk of breast cancer (BC). Studies in childhood...
PURPOSE
Female Hodgkin lymphoma (HL) survivors treated with chest radiotherapy (RT) at a young age have a strongly increased risk of breast cancer (BC). Studies in childhood cancer survivors have shown that doxorubicin exposure may also increase BC risk. Although doxorubicin is the cornerstone of HL chemotherapy, the association between doxorubicin and BC risk has not been examined in HL survivors treated at adult ages.
METHODS
We assessed BC risk in a cohort of 1,964 female 5-year HL survivors, treated at age 15-50 years in 20 Dutch hospitals between 1975 and 2008. We calculated standardized incidence ratios, absolute excess risks, and cumulative incidences. Doxorubicin exposure was analyzed using multivariable Cox regression analyses.
RESULTS
After a median follow-up of 21.6 years (IQR, 15.8-27.1 years), 252 women had developed invasive BC or ductal carcinoma in situ. The 30-year cumulative incidence was 20.8% (95% CI, 18.2 to 23.4). Survivors treated with a cumulative doxorubicin dose of >200 mg/m had a 1.5-fold increased BC risk (95% CI, 1.08 to 2.1), compared with survivors not treated with doxorubicin. BC risk increased 1.18-fold (95% CI, 1.05 to 1.32) per additional 100 mg/m doxorubicin ( = .004). The risk increase associated with doxorubicin (yes no) was not modified by age at first treatment (hazard ratio [HR], 1.5 [95% CI, 0.9 to 2.6]; HR, 1.3 [95% CI, 0.9 to 1.9) or chest RT (HR, 1.9 [95% CI, 1.06 to 3.3]; HR, 1.2 [95% CI, 0.8 to 1.8]).
CONCLUSION
This study shows that treatment with doxorubicin is associated with increased BC risk in both adolescent and adult HL survivors. Our results have implications for BC surveillance guidelines for HL survivors and treatment strategies for patients with newly diagnosed HL.
Topics: Humans; Hodgkin Disease; Female; Doxorubicin; Adolescent; Adult; Breast Neoplasms; Cancer Survivors; Middle Aged; Young Adult; Antibiotics, Antineoplastic; Incidence; Netherlands; Risk Factors
PubMed: 38359378
DOI: 10.1200/JCO.23.01386 -
Scientific Reports Nov 2023We modeled gravity data to explore Mercury's internal structure and show the presence of crustal heterogeneities in density. We first evaluated the lithospheric flexure...
We modeled gravity data to explore Mercury's internal structure and show the presence of crustal heterogeneities in density. We first evaluated the lithospheric flexure occurring in the spherical harmonic degree range 5-80, according to the flexural isostatic response curve. We thus estimated a mean elastic lithosphere thickness of about 30 [Formula: see text] 10 km and modeled the crust-mantle interface, which varies from 19 to 42 km depth, according to a flexural compensation model. The isostatic gravity anomalies were then obtained as the residual field with respect to the contributions from topography and lithospheric flexure. Isostatic anomalies are mainly related to density variations in the crust: gravity highs mostly correspond to large-impact basins suggesting intra-crustal magmatic intrusions as the main origin of these anomalies. Isostatic gravity lows prevail, instead, above intercrater plains and may represent the signature of a heavily fractured crust.
PubMed: 37963890
DOI: 10.1038/s41598-023-46081-4 -
Data in Brief Dec 2023Crop phenology data offer crucial information for crop yield estimation, agricultural management, and assessment of agroecosystems. Such information becomes more...
Crop phenology data offer crucial information for crop yield estimation, agricultural management, and assessment of agroecosystems. Such information becomes more important in the context of increasing year-to-year climatic variability. The dataset provides in-situ crop phenology data (first leaves emergence and harvest date) of major European crops (wheat, corn, sunflower, rapeseed) from seventeen field study sites in Bulgaria and two in France. Additional information such as the sowing date, area of each site, coordinates, method and equipment used for phenophase data estimation, and photos of the France sites are also provided. The georeferenced ground-truth dataset provides a solid base for a better understanding of crop growth and can be used to validate the retrieval of phenological stages from remote sensing data.
PubMed: 37822888
DOI: 10.1016/j.dib.2023.109623 -
Scientific Reports Oct 2023Rift margins provide insights into the processes governing the rupture of the continental lithosphere and the subsequence formation of sedimentary basins. The...
Rift margins provide insights into the processes governing the rupture of the continental lithosphere and the subsequence formation of sedimentary basins. The Proterozoic basement underlying Somaliland has been affected by multiple rifting; however, the crustal structure of these rifted basins remains unknown. This study utilized teleseismic receiver function analysis, Bayesian inversion, common conversion point imaging and 2D forward gravity modelling to examine the crust and upper mantle of Somaliland. The results indicate 36.8-38.2 km of crust in southern Somaliland, while the central and northern regions feature thinned crust (~ 21 km) with 5-6 km thick sediments. The joint analysis of radial and transverse components of receiver functions and shear wave splitting revealed fast axis directions trending to 50-56° in the upper mantle, indicating that azimuthal anisotropy is oriented in the regional Africa-Arabia plate motion. Such orientation may have resulted from lattice preferred orientation of olivine from the asthenospheric flow. Additionally, the fast polarization of the crust in central Somaliland is oriented at - 15°, indicating fossil deformation in the thinned crust related to the NW-SE trending Late Jurassic rift event. Further, the fast polarization for stations near the Gulf of Aden is oriented at 75-80°, suggesting crustal deformation associated with the Oligocene rift event. The crustal anisotropy at southern Somaliland revealed fast polarization oriented at - 85°, indicating a preserved far-field response of the WNW-ESE trending Late Cretaceous rift event. Overall, the study provides for the first-time insight into the rift-related extensional strain fabric in the crust and upper mantle anisotropy induced by asthenospheric flow in Somaliland.
PubMed: 37838770
DOI: 10.1038/s41598-023-44358-2 -
Journal of Applied Clinical Medical... Mar 2024A well-known limitation of multi-leaf collimators is that they cannot easily form island blocks. This can be important in mantle region therapy. Cerrobend photon blocks,...
PURPOSE
A well-known limitation of multi-leaf collimators is that they cannot easily form island blocks. This can be important in mantle region therapy. Cerrobend photon blocks, currently used for supplementary shielding, are labor-intensive and error-prone. To address this, an innovative, non-toxic, automatically manufactured photon block using 3D-printing technology is proposed, offering a patient-specific and accurate alternative.
METHODS AND MATERIALS
The study investigates the development of patient-specific photon shielding blocks using 3D-printing for three different patient cases. A 3D-printed photon block shell filled with tungsten ball bearings (BBs) was designed to have similar dosimetric properties to Cerrobend standards. The generation of the blocks was automated using the Eclipse Scripting API and Python. Quality assurance was performed by comparing the expected and actual weight of the tungsten BBs used for shielding. Dosimetric and field geometry comparisons were conducted between 3D-printed and Cerrobend blocks, utilizing ionization chambers, imaging, and field geometry analysis.
RESULTS
The quality assurance assessment revealed a -1.3% average difference in the mass of tungsten ball bearings for different patients. Relative dose output measurements for three patient-specific blocks in the blocked region agreed within 2% of each other. Against the Treatment Planning System (TPS), both 3D-printed and Cerrobend blocks agreed within 2%. For each patient, 6 MV image profiles taken through the 3D-printed and Cerrobend blocks agreed within 1% outside high gradient regions. Jaccard distance analysis of the MV images against the TPS planned images, found Cerrobend blocks to have 15.7% dissimilarity to the TPS, while that of the 3D-printed blocks was 6.7%.
CONCLUSIONS
This study validates a novel, efficient 3D-printing method for photon block creation in clinical settings. Despite potential limitations, the benefits include reduced manual labor, automated processes, and greater precision. It holds potential for widespread adoption in radiation therapy, furthering non-toxic radiation shielding.
Topics: Humans; Tungsten; Photons; Radiometry; Printing, Three-Dimensional; Radiation Protection; Radiotherapy Planning, Computer-Assisted; Radiotherapy Dosage
PubMed: 38213084
DOI: 10.1002/acm2.14225