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BMJ Open Gastroenterology Aug 2023Haemorrhoids are one of the most common gastrointestinal and anal diseases. In olive oil and honey propolis, flavonoids have beneficial effects on improving vascular... (Randomized Controlled Trial)
Randomized Controlled Trial
OBJECTIVE
Haemorrhoids are one of the most common gastrointestinal and anal diseases. In olive oil and honey propolis, flavonoids have beneficial effects on improving vascular function and decreasing vascular resistance. In this study, we aimed to produce a combination of these two substances in the form of lotions and assess their healing and side effects in comparison with routine treatment, anti-haemorrhoid ointment (containing hydrocortisone and lidocaine).
DESIGN
In this randomised clinical trial study, 86 patients with grade 2 or more haemorrhoid degrees, diagnosed by colonoscopy, were divided into two groups, the case (n=44) and control (n=42). The case group was treated with flavonoid lotion, and the control group was treated with anti-haemorrhoid ointment two times per day for 1 month. Patients were followed weekly with history and physical examination. The data of the two groups were collected before and after the intervention and statistically analysed.
RESULTS
Post-treatment reduction in haemorrhoid grade was significant in the case group (p=0.02). This ratio was insignificant in the control group (p=0.139). Flavonoid lotion (p<0.05) significantly reduced the signs and symptoms of haemorrhoids more than anti-haemorrhoid ointment.
CONCLUSION
According to the results, flavonoid lotion can be an excellent alternative to topical chemical drugs, such as anti-haemorrhoid ointment, in treating haemorrhoid disease. Besides its effectiveness and safety, it can be easily manufactured and widely available to patien.
Topics: Humans; Ointments; Colonoscopy; Flavonoids
PubMed: 37597875
DOI: 10.1136/bmjgast-2023-001158 -
HardwareX Sep 2023Lateral Flow Assays (LFA) have been one of the most widely adopted technologies in clinical diagnosis over recent years, especially during the COVID-19 pandemic, due to...
Lateral Flow Assays (LFA) have been one of the most widely adopted technologies in clinical diagnosis over recent years, especially during the COVID-19 pandemic, due to their feasibility, compactness, and rapid readout. However, the precise dispensing of antibodies-a key part of the fabrication process-requires costly line dispenser equipment, which poses a challenge to researchers with limited budgets. This study aims to resolve this key issue by introducing a Syringe-based Arduino-operated Low-cost Antibody Dispenser (SALAD). By utilizing a microneedle, stepper motor-driven syringe pump, and conveyor belt, SALAD can form micro-droplets to create an even band of antibodies. Our evaluation results showed comparable performance between SALAD and a commercialized model - Claremont ALFRD, with SALAD exceeding in affordability and feasibility. SALAD yielded an even signal, uniform bandwidth, and low background noise, yet optimization in the conveyor belt should be considered to enhance stability. With a low manufacturing cost ($200.61) compared to the commercialized models, our model is expected to provide an affordable approach for LFA researchers.
PubMed: 37497344
DOI: 10.1016/j.ohx.2023.e00455 -
Annals of Translational Medicine Aug 2023The primary function of an airway stent is to reestablish patency, impeding restenosis, supporting the tracheobronchial wall, or occluding fistulas. But stent-related... (Review)
Review
The primary function of an airway stent is to reestablish patency, impeding restenosis, supporting the tracheobronchial wall, or occluding fistulas. But stent-related complications are prevalent and can have devastating consequences. For this reason, stents are considered a last resort when there are no alternatives in treatment. Additionally, commercially available airway stents often poorly fit patients with complex airways, and they can cause various complications. At the end of the 20th century, three-dimensional (3D) printing technology was created. It has been transformative in healthcare and has been used in several applications. One of its first utilizations was the anatomical modeling of body structures that helps preoperative planning. In respiratory medicine, this technology has been essentially used in central airway diseases to produce 3D airway models and to create airway splints and prostheses. In the last decade, it has led to a transformation and allowed progress in personalized medicine, making patient-specific stents for individuals with complex airway problems. A patient-specific stent using 3D printing may minimize complications, improve quality of life, and reduce the need for repeated procedures. This review describes the recent advances in 3D printing technology, its use for developing airway prostheses to treat complex airway diseases, and the current evidence that supports its use.
PubMed: 37675337
DOI: 10.21037/atm-22-2878 -
Heliyon Sep 2023The osseous tissue can be classified as a nanocomposite that encompasses a complex interweaving of organic and inorganic matrices. This intricate amalgamation consists... (Review)
Review
The osseous tissue can be classified as a nanocomposite that encompasses a complex interweaving of organic and inorganic matrices. This intricate amalgamation consists of a collagen component and a mineral phase that are intricately arranged to form elaborate and perforated configurations. Hydroxyapatite, whether synthesized artificially or obtained from natural sources, has garnered considerable attention as a composite material in the field of bone tissue engineering due to its striking resemblance to bone in terms of structure and characteristics. Hydroxyapatite (HA) constitutes the predominant ceramic biomaterial for biomedical applications due to its ability to replicate the mineral composition of vertebrate bone. Nonetheless, it is noteworthy that the present biomimetic substance exhibits unfavorable mechanical characteristics, characterized by insufficient tensile and compressive strength, thus rendering it unsuitable for effective employment in the field of bone tissue engineering. Due to its beneficial attributes, hydroxyapatite (HA) is frequently employed in conjunction with various polymers and crosslinkers as composites to enhance mechanical properties and overall efficacy of implantable biomaterials engineered. The restoration of skeletal defects through the use of customized replacements is an effective way to replace damaged or lost bone structures. This method not only restores the bones' original functions but also reinstates their initial aesthetic appearance. The utilization of hydroxyapatite-polymer composites within 3D-printed grafts necessitates meticulous optimization of both mechanical and biological properties, in order to ensure their suitability for employment in medical devices. The utilization of 3D-printing technology represents an innovative approach in the manufacturing of HA-based scaffolds, which offers advantageous prospects for personalized bone regeneration. The expeditious prototyping method, with emphasis on the application of 3D printing, presents a viable approach in the development of bespoke prosthetic implants, grounded on healthcare data sets. 4D printing approach is an evolved form of 3D printing that utilizes programmable materials capable of altering the intended shape of printed structures, contingent upon single or dual stimulating factors. These factors include aspects such as pH level, temperature, humidity, crosslinking degree, and leaching factors.
PubMed: 37662765
DOI: 10.1016/j.heliyon.2023.e19363 -
Journal of Intelligence Jul 2023Play is an integrative process, and the skills acquired in it-overcoming impulses, behavior control, exploration and discovery, problem-solving, reasoning, drawing... (Review)
Review
Play is an integrative process, and the skills acquired in it-overcoming impulses, behavior control, exploration and discovery, problem-solving, reasoning, drawing conclusions, and attention to processes and outcomes are foundational cognitive structures that drive learning and motivation. Loose parts play is a prominent form of play that many scholars and educators explicitly endorse for cognitive development (e.g., divergent thinking, problem-solving). It is unique among play types because children can combine different play types and natural or manufactured materials in one occurrence. While educators and policymakers promote the benefits of loose parts play, no previous research has explored the direct relationship between preschool-age children's indoor loose parts play experiences and cognitive development. We address this gap by bringing together the relevant literature and synthesizing the empirical studies on common play types with loose parts, namely object and exploratory, symbolic and pretend, and constructive play. We also focus on studies that examine children's experiences through loose parts, highlighting the impact of different play types on learning through the reinforcement of cognitive skills, such as executive function, cognitive self-regulation, reasoning, and problem-solving. By examining the existing literature and synthesizing empirical evidence, we aim to deepen our understanding of the relationship between children's play with loose parts and its impact on cognitive development. Ultimately, pointing out the gaps in the literature that would add to the body of knowledge surrounding the benefits of play for cognitive development and inform educators, policymakers, and researchers about the significance of incorporating loose parts play into early childhood education.
PubMed: 37623534
DOI: 10.3390/jintelligence11080151 -
Scientific Reports Nov 2023The evaluation of deep-learning (DL) systems typically relies on the Area under the Receiver-Operating-Curve (AU-ROC) as a performance metric. However, AU-ROC, in its...
The evaluation of deep-learning (DL) systems typically relies on the Area under the Receiver-Operating-Curve (AU-ROC) as a performance metric. However, AU-ROC, in its holistic form, does not sufficiently consider performance within specific ranges of sensitivity and specificity, which are critical for the intended operational context of the system. Consequently, two systems with identical AU-ROC values can exhibit significantly divergent real-world performance. This issue is particularly pronounced in the context of anomaly detection tasks, a commonly employed application of DL systems across various research domains, including medical imaging, industrial automation, manufacturing, cyber security, fraud detection, and drug research, among others. The challenge arises from the heavy class imbalance in training datasets, with the abnormality class often incurring a considerably higher misclassification cost compared to the normal class. Traditional DL systems address this by adjusting the weighting of the cost function or optimizing for specific points along the ROC curve. While these approaches yield reasonable results in many cases, they do not actively seek to maximize performance for the desired operating point. In this study, we introduce a novel technique known as AUCReshaping, designed to reshape the ROC curve exclusively within the specified sensitivity and specificity range, by optimizing sensitivity at a predetermined specificity level. This reshaping is achieved through an adaptive and iterative boosting mechanism that allows the network to focus on pertinent samples during the learning process. We primarily investigated the impact of AUCReshaping in the context of abnormality detection tasks, specifically in Chest X-Ray (CXR) analysis, followed by breast mammogram and credit card fraud detection tasks. The results reveal a substantial improvement, ranging from 2 to 40%, in sensitivity at high-specificity levels for binary classification tasks.
Topics: Sensitivity and Specificity; ROC Curve; Radiography; Mammography; Algorithms
PubMed: 38036602
DOI: 10.1038/s41598-023-48482-x -
Nature Nov 2023Recreating complex structures and functions of natural organisms in a synthetic form is a long-standing goal for humanity. The aim is to create actuated systems with...
Recreating complex structures and functions of natural organisms in a synthetic form is a long-standing goal for humanity. The aim is to create actuated systems with high spatial resolutions and complex material arrangements that range from elastic to rigid. Traditional manufacturing processes struggle to fabricate such complex systems. It remains an open challenge to fabricate functional systems automatically and quickly with a wide range of elastic properties, resolutions, and integrated actuation and sensing channels. We propose an inkjet deposition process called vision-controlled jetting that can create complex systems and robots. Hereby, a scanning system captures the three-dimensional print geometry and enables a digital feedback loop, which eliminates the need for mechanical planarizers. This contactless process allows us to use continuously curing chemistries and, therefore, print a broader range of material families and elastic moduli. The advances in material properties are characterized by standardized tests comparing our printed materials to the state-of-the-art. We directly fabricated a wide range of complex high-resolution composite systems and robots: tendon-driven hands, pneumatically actuated walking manipulators, pumps that mimic a heart and metamaterial structures. Our approach provides an automated, scalable, high-throughput process to manufacture high-resolution, functional multimaterial systems.
Topics: Humans; Elastic Modulus; Robotics; Printing, Three-Dimensional; Feedback; Biomimetic Materials
PubMed: 37968527
DOI: 10.1038/s41586-023-06684-3 -
Research and Reports in Urology 2024Lower urinary tract dysfunction not only interferes with the health-related quality of life of patients but may also lead to acute kidney injury and infections. To... (Review)
Review
Lower urinary tract dysfunction not only interferes with the health-related quality of life of patients but may also lead to acute kidney injury and infections. To assess the bladder, urodynamic studies (UDS) have been implemented but the use of catheters leads to discomfort for the patient. Catheter-free long-term UDS would be useful and a potential solution could be ambulatory wireless devices that communicate via telemetry. Such sensors can detect pressure or volume. Numerous types of potential catheter-free sensors have been proposed for bladder monitoring. Despite substantial innovation in the manufacturing of implantable biomedical electronic systems, such sensors have remained at the laboratory stage due to a number of critical challenges. These challenges primarily concern hermeticity and biocompatibility, sensitivity and artifacts, drift, telemetry, and energy management. Having overcome these challenges, catheter-free ambulatory urodynamic monitoring could combine a synchronized intravesical pressure sensor with a volume analyzer but only the steps of cystometry and volume measurement are currently sufficiently reproducible to simulate UDS results. The measurement of volume by infrared optical sensors, in the form of abdominal patches, appears to be promising and studies are underway to market a telemetric ambulatory urodynamic monitoring system that includes an intravesical pressure sensor. There has been considerable progress in wearable and conformable electronics on many fronts, and continued collaboration between engineers and urologists could quickly overcome current challenges. In addition, to the diagnosis of UDS, such sensors could be useful in the development of a long-term closed-loop neuromodulation system. In this review, we explore the various types of catheter-free bladder sensors, inherent challenges and solutions to overcome these challenges, and the clinical potential of such long-term implantable sensors.
PubMed: 38192632
DOI: 10.2147/RRU.S387757 -
Annals of Translational Medicine Jun 2023Lumbar injuries are common among paratroopers during landing maneuvers. Although bracing is widely advocated to increase spine stability, the effect of lumbar bracing on...
BACKGROUND
Lumbar injuries are common among paratroopers during landing maneuvers. Although bracing is widely advocated to increase spine stability, the effect of lumbar bracing on parachuting has yet to be quantified and the Chinese parachutist does not have a uniform prophylactic brace. The aim is to compare the effects of a novel, self-designed and self-manufactured lumbosacral brace with two ordinary lumbar braces based on biomechanical assessment of the lumbar and lower extremity joints during parachute landing.
METHODS
The study cohort consisted of 30 elite male paratroopers. Each participant was instructed to jump off a platform at two different heights (60 and 120 cm, respectively) and land on the force plate in a half-squat posture. Participants at each height were tested under four different conditions (no brace, elastic brace, semi-rigid brace, and lumbosacral brace). The Vicon 3D motion capture system and force plate were used to record and calculate biomechanical data, such as vertical ground reaction forces (vGRFs), joint angles, moments, and energy absorption. After the experiment, every participant completed the study questionnaires.
RESULTS
The increase of the jumping height raised all the parameters significantly (P<0.01). The use of all three braces slightly decreased vGRF, and reduced the lumbar angle, moment, and angular velocity in the sagittal plane. The use of lumbosacral and semi-rigid braces restricted lumbar flexion more efficiently (P<0.05), and significantly increased the energy absorption of the hip joints (P<0.01) and hip flexion (P<0.01) at 120 cm. No significant effect of braces was found on the motion of knee and ankle joints. The subjective scores suggested that the lumbosacral brace was softer and more comfortable than the semi-rigid brace, and more effective than the elastic brace.
CONCLUSIONS
The lumbosacral brace markedly restricted the lumbar motion in the sagittal plane than the elastic brace and was more comfortable than the semi-rigid brace. Therefore, the innovative design, high efficiency, and comfortable landing of the lumbosacral brace represent a reliable option for parachute jumping and training.
PubMed: 37405007
DOI: 10.21037/atm-22-2793