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Zeitschrift Fur Rheumatologie Apr 2024As a result of digitalization in medicine wearable computing devices (wearables) are becoming increasingly more important. Wearables are small portable electronic... (Review)
Review
As a result of digitalization in medicine wearable computing devices (wearables) are becoming increasingly more important. Wearables are small portable electronic devices with which the user can record data relevant to health, such as number of steps, activity profile, electrocardiogram (ECG), heart and breathing frequency or oxygen saturation. Initial studies on the use of wearables in patients with rheumatological diseases show the opening up of new possibilities for prevention, disease monitoring and treatment. This study provides the current data situation and the implementation of wearables in the discipline of rheumatology. Additionally, future potential fields of application as well as challenges and limits of the implementation of wearables are illustrated.
Topics: Humans; Rheumatology; Telemedicine; Wearable Electronic Devices; Electrocardiography
PubMed: 37289217
DOI: 10.1007/s00393-023-01377-8 -
Theranostics 2023Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics. Upon exposure to endogenous/exogenous stimuli, the stimuli-activatable... (Review)
Review
Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics. Upon exposure to endogenous/exogenous stimuli, the stimuli-activatable nanomedicine could be self-assembled, disassembled, or functionally activated to improve its biosafety and diagnostic/therapeutic potency. A myriad of tumor-specific features, including a low pH, a high redox level, and overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, and radiation) have been considered for the design of stimuli-activatable nano-medicinal products. Recently, novel stimuli sources have been explored and elegant designs emerged for stimuli-activatable nanomedicine. In addition, multi-functional theranostic nanomedicine has been employed for imaging-guided or image-assisted antitumor therapy. In this review, we rationalize the development of theranostic nanomedicine for clinical pressing needs. Stimuli-activatable self-assembly, disassembly or functional activation approaches for developing theranostic nanomedicine to realize a better diagnostic/therapeutic efficacy are elaborated and state-of-the-art advances in their structural designs are detailed. A reflection, clinical status, and future perspectives in the stimuli-activatable nanomedicine are provided.
Topics: Humans; Nanomedicine; Precision Medicine; Neoplasms; Theranostic Nanomedicine; Oxidation-Reduction
PubMed: 37908735
DOI: 10.7150/thno.87854 -
Experimental Biology and Medicine... 2024
Topics: Medicine; Biology
PubMed: 38463388
DOI: 10.3389/ebm.2024.10069 -
Theoretical Medicine and Bioethics Oct 2023A movement asking to take race out of medicine is growing in the US. While we agree with the necessity to get rid of flawed assumptions about biological race that...
A movement asking to take race out of medicine is growing in the US. While we agree with the necessity to get rid of flawed assumptions about biological race that pervade automatic race correction in medical algorithms, we urge caution about insisting on a blanket eliminativism about race in medicine. If we look at racism as a fundamental cause, in the sense that this notion has been introduced in epidemiological studies by Bruce Link and Jo Phelan, we must conclude that race is indispensable to consider, investigate, and denounce the health effects of multilevel racism, and cannot be eliminated by addressing more specific risk factors in socially responsible epidemiology and clinical medicine. This does not mean that realism about human races is vindicated. While maintaining that there are no human races, we show how it is that a non-referring concept can nonetheless turn out indispensable for explaining real phenomena.
Topics: Humans; Racial Groups; Racism; Medicine; Clinical Medicine
PubMed: 37040059
DOI: 10.1007/s11017-023-09622-6 -
Canadian Journal of Psychiatry. Revue... Mar 2024
Review
Topics: Humans; Forensic Psychiatry; Canada; Psychiatry; Writing
PubMed: 37769295
DOI: 10.1177/07067437231200843 -
Journal of Cancer Research and Clinical... Aug 2023Artificial intelligence (AI) has been available in rudimentary forms for many decades. Early AI programs were successful in niche areas such as chess or handwriting... (Review)
Review
Artificial intelligence (AI) has been available in rudimentary forms for many decades. Early AI programs were successful in niche areas such as chess or handwriting recognition. However, AI methods had little practical impact on the practice of medicine until recently. Beginning around 2012, AI has emerged as an increasingly important tool in healthcare, and AI-based devices are now approved for clinical use. These devices are capable of processing image data, making diagnoses, and predicting biomarkers for solid tumors, among other applications. Despite this progress, the development of AI in medicine is still in its early stages, and there have been exponential technical advancements since 2022, with some AI programs now demonstrating human-level understanding of image and text data. In the past, technical advances have led to new medical applications with a delay of a few years. Therefore, now we might be at the beginning of a new era in which AI will become even more important in clinical practice. It is essential that this transformation is humane and evidence based, and physicians must take a leading role in ensuring this, particularly in hematology and oncology.
Topics: Humans; Artificial Intelligence; Medical Oncology; Neoplasms; Hematology
PubMed: 36920564
DOI: 10.1007/s00432-023-04666-6 -
Indian Journal of Dermatology,... 2023
Topics: Humans; Dermatology; Pathology, Clinical
PubMed: 37317736
DOI: 10.25259/IJDVL_114_2023 -
International Journal of Molecular... Sep 2023Base excision repair (BER) corrects forms of oxidative, deamination, alkylation, and abasic single-base damage that appear to have minimal effects on the helix. Since... (Review)
Review
Base excision repair (BER) corrects forms of oxidative, deamination, alkylation, and abasic single-base damage that appear to have minimal effects on the helix. Since its discovery in 1974, the field has grown in several facets: mechanisms, biology and physiology, understanding deficiencies and human disease, and using BER genes as potential inhibitory targets to develop therapeutics. Within its segregation of short nucleotide (SN-) and long patch (LP-), there are currently six known global mechanisms, with emerging work in transcription- and replication-associated BER. Knockouts (KOs) of BER genes in mouse models showed that single glycosylase knockout had minimal phenotypic impact, but the effects were clearly seen in double knockouts. However, KOs of downstream enzymes showed critical impact on the health and survival of mice. BER gene deficiency contributes to cancer, inflammation, aging, and neurodegenerative disorders. Medicinal targets are being developed for single or combinatorial therapies, but only PARP and APE1 have yet to reach the clinical stage.
Topics: Humans; Animals; Mice; Mice, Knockout; Medicine; Aging; DNA Repair; Biology
PubMed: 37762489
DOI: 10.3390/ijms241814186 -
Clinical and Translational Science May 2024
Topics: Humans; Translational Research, Biomedical; Evidence-Based Medicine
PubMed: 38752299
DOI: 10.1111/cts.13835 -
Cleveland Clinic Journal of Medicine Jan 2024The practice of outpatient medicine is demanding, encompasses a wide scope of practice, and leaves little time for internists to stay up to date with the current... (Review)
Review
The practice of outpatient medicine is demanding, encompasses a wide scope of practice, and leaves little time for internists to stay up to date with the current literature. This article reviews 5 studies published in 2022 and 2023 that have the potential to change the practice of outpatient medicine. Topics covered include chronic kidney disease, secondary cardiovascular disease, kidney stones, obesity, and lipid management.
Topics: Humans; Ambulatory Care; Internal Medicine; Physicians; Evidence-Based Medicine
PubMed: 38167397
DOI: 10.3949/ccjm.91a.23056