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Scientific Reports Sep 2023Shape, size, composition, and function of the bones in the human body vary on the macro, micro and nanoscale. This can influence changes caused by taphonomy and...
Shape, size, composition, and function of the bones in the human body vary on the macro, micro and nanoscale. This can influence changes caused by taphonomy and post-mortem preservation, including DNA. Highly mineralised compact bone is less susceptible to taphonomic factors than porous trabecular bone. Some studies imply that DNA can be better preserved in trabecular bone, due to remnants of the soft tissue or bacteria better digesting organic matter while not digesting DNA. The aim of this study was to understand the differences between compact (diaphyses) and trabecular (epiphyses) bone on a molecular level and thus the reasons for the better preservation of the DNA in the trabecular bone. The powder obtained from epiphyses and diaphyses of metacarpals and metatarsals was analysed using ATR-FTIR spectroscopy and compared. Samples with poorest DNA preservation originated from diaphyses, predominantly of metatarsals. They were characterised by higher concentrations of phosphates and crystallinity, while lower collagen quality in comparison to samples with the best DNA preservation. Epiphyses presented higher concentrations of better-preserved collagen while diaphyses had higher concentrations of carbonates and phosphates and higher crystallinity. Due to better-preserved collagen in the epiphyses, the soft tissue remnants hypothesis seems more likely than the bacteria hypothesis.
Topics: Humans; Metatarsal Bones; Metacarpal Bones; Cancellous Bone; Spectroscopy, Fourier Transform Infrared; DNA; Phosphates; Ataxia Telangiectasia Mutated Proteins
PubMed: 37726341
DOI: 10.1038/s41598-023-41259-2 -
Orthopaedic Surgery Nov 2023To design appropriate orthosis for hallux valgus, a difficult foot condition that affects a quarter of the body's bones, we need to clarify the numerical biomechanical...
OBJECTIVE
To design appropriate orthosis for hallux valgus, a difficult foot condition that affects a quarter of the body's bones, we need to clarify the numerical biomechanical features, which have not been established in previous biomechanical studies. Therefore, we constructed a finite element model of the bunion foot to investigate the orthopaedic force compensation mechanism.
METHODS
A patient with moderate hallux valgus was recruited. CT imaging data in DICOM format were extracted for three-dimensional foot model reconstruction. In conjunction with the need for rapid design of bunion orthosis, a metatarsal force application sizing method based on an orthogonal test design was investigated. The orthogonal test design was used to obtain the hallux valgus angle (HVA) and the inter metatarsal angle (IMA) data for different force combinations. Based on the extreme difference analysis and analysis of variance of the test results, the influence of different force combinations on the bunion angle was quickly determined.
RESULTS
The results showed that the stress concentration occurred mainly in the first metatarsal bone. The distribution trend was in the medial and lateral middle of the bone and gradually decreased to the dorsal base of the bone body. The greatest stress occurs in the cartilage between the phalanges and metatarsals. In 25 groups of simulation experiments, HVA was reduced from 27.7° to 13°, and IMA was reduced from 12.5° to 7.3°.
CONCLUSION
Applying detailed orthopaedic force collocation to the first metatarsal column can effectively restore the mechanics and kinematics of hallux valgus, and provide a reference for the treatment of bunion valgus and the design of orthopaedic devices.
Topics: Humans; Hallux Valgus; Finite Element Analysis; Osteotomy; Bunion; Orthotic Devices; Treatment Outcome
PubMed: 37667965
DOI: 10.1111/os.13862 -
Acta Orthopaedica Jul 20233-dimensional midfoot motion is hard to evaluate in clinical practice. We present a new computed tomography (CT)-based radiostereometric analysis (CT-RSA) technique to...
BACKGROUND AND PURPOSE
3-dimensional midfoot motion is hard to evaluate in clinical practice. We present a new computed tomography (CT)-based radiostereometric analysis (CT-RSA) technique to examine in vivo midfoot kinematics during single-leg stance and compare it with marker-based radiostereometry (RSA).
PATIENTS AND METHODS
8 patients were examined with bilateral non- and full-weight-bearing CT images of the midfoot. 1st tarsometatarsal motion was analyzed using a surface-registration technique (CT-RSA). As all patients had unilateral tantalum markers in the 1st cuneiform (C1) and 1st metatarsal (M1), comparison of precision with markerbased RSA was performed. CT-RSA precision was evaluated with surface registration of both C1-M1 bone and C1-M1 tantalum markers, while RSA precision was determined with C1-M1 markers only. Additionally, to remove motion bias, we evaluated intrasegmental CT-RSA precision by comparing proximal with distal part of M1.
RESULTS
Under physical load, the primary movement for the 1st tarsometatarsal joint was M1 dorsiflexion (mean 1.4°), adduction (mean 1.4°), and dorsal translation (mean 1.1 mm). CT-RSA precision, using surface bone or markers, was in the range of 0.3-0.7 mm for translation and 0.6-1.6° for rotation. In comparison, RSA precision was in the range of 0.4-0.9 mm for translation and 1.0-1.7° for rotation. Finally, intrasegmental CT-RSA precision was in the range of 0.1-0.2 mm for translation and 0.4-0.5° for rotation.
CONCLUSION
CT-RSA is a valid and precise, non-invasive method to measure midfoot kinematics when compared with conventional RSA.
Topics: Humans; Radiostereometric Analysis; Biomechanical Phenomena; Tantalum; Tomography, X-Ray Computed; Bone and Bones
PubMed: 37493528
DOI: 10.2340/17453674.2023.16905 -
Frontiers in Endocrinology 2023Although the pathology and bacterial status of the "normal" bone stump after operation of diabetic foot osteomyelitis (DFO) are of great significance for the prognosis...
BACKGROUND
Although the pathology and bacterial status of the "normal" bone stump after operation of diabetic foot osteomyelitis (DFO) are of great significance for the prognosis of foot wounds, there are only a few studies on this topic; hence, it is clinically relevant and urgent to study this topic.
METHODS
The data of 57 inpatients with DFO from June 2021 to April 2022 were collected, all of whom had DFO in the forefoot and underwent conservative surgery. After the surgical removal of necrotic bone, bone biopsies were taken from the necrotic phalangeal bone and the reserved "normal" metatarsal stump. They were cultured, after which antibiotic susceptibility test and pathological screening were carried out. According to clinical judgment, inpatients' wounds were divided into metatarsal affected group and metatarsal unaffected group. We then compared and analyzed the pathological and bacterial characteristics of preserved "normal" bone stump and its effect on wound healing and prognosis.
RESULTS
The poor concordance rate between deep soft tissue culture and infected phalange culture was only 19.3%. The deep soft tissue (72.6%), infected phalange (70.7%), and metatarsal stump (71.4%) were mainly infected with gram-negative Bacillus. The proportion of increased significantly in bone tissue. had the highest drug resistance (88%, 22/25). There was no significant difference in several clinical characteristics and wound healing regardless of whether their metatarsal stumps were affected. Most reserved "normal" metatarsal stumps (84.2%, 48/57) were positive by pathological diagnosis and bacterial culture testing; only 15.7% (9/57) samples were truly sterile. Only 8.3% (4/48) of the former patients healed within 6 months; whereas, all the latter (9/9) patients healed within 6 months. However, the majority (89.6%, 43/48) could heal. There was no difference in operations, skin grafting, negative pressure wound therapy, and mortality between the two groups.
CONCLUSION
The most reserved "normal" metatarsal stumps have been invaded by bacteria. However, the majority stumps can be preserved, and the wound will eventually be healed according to the pathological and bacterial culture results.
Topics: Humans; Diabetic Foot; Metatarsal Bones; Osteomyelitis; Foot; Wound Healing; Diabetes Mellitus
PubMed: 37600693
DOI: 10.3389/fendo.2023.1165305 -
Journal of Orthopaedic Surgery and... Sep 2023This study analyzed the advantages and disadvantages of different procedures for stage IIA progressive collapsing foot deformity (PCFD) through three-dimensional finite...
BACKGROUND
This study analyzed the advantages and disadvantages of different procedures for stage IIA progressive collapsing foot deformity (PCFD) through three-dimensional finite element models.
METHODS
A previous validated stage IIA PCFD FEA model was established consisting of 16 bones, 56 ligaments, 5 muscles and soft tissues. The ligament properties of the spring, deltoid, short plantar and long plantar ligaments, and plantar fascia were attenuated according to a previous publication. Medial column fusion (MCF), medializing calcaneal osteotomy (MCO), lateral column lengthening (LCL), and subtalar joint arthroereisis (SJA) operations were simulated in this model. The indexes of plantar stress distribution, maximum von Mises of the medial and lateral columns, strain of the medial ligaments and plantar fascia that supported the medial longitudinal arch, arch height, talo-first metatarsal angle, calcaneus pitch angle, and talonavicular coverage angle were all compared before and after simulated single-foot weight loading.
RESULTS
The maximum plantar stress of PCFD decreased with MCO and SJA but increased with MCF and LCL. MCF and LCL failed to significantly reduce the stress on the medial column fragments, thereby increasing their stress. Both MCO and SJA relieved medial plantar stress. MCF had no significant effect on stress relief of the medial ligament. MCO, LCL, and SJA were all shown to reduce the pressure on the medial plantar ligament, with LCL having the most obvious effect. All four procedures corrected the arch deformity; however, MCF was not as effective as the other methods. SJA is the best method for restoring arch height and correcting arch deformities. For stage IIA PCFD, isolated MCF failed to reduce pressure on the medial column; however, isolated MCO significantly reduced the pressure on the medial plantar and ligamentous soft tissues while restoring the foot's arch and correcting the hindfoot valgus.
CONCLUSION
SJA with type II sinus tarsi implant effectively transferred pressure from the medial plantar tract to the lateral side and restored the arch. Isolated LCL was not found suitable for stage IIA PCFD.
Topics: Humans; Finite Element Analysis; Foot Deformities; Foot; Ligaments, Articular
PubMed: 37741994
DOI: 10.1186/s13018-023-04216-3 -
Arthroscopy Techniques Sep 2023First metatarsophalangeal arthrodesis has been used to treat end-stage arthritis of the great toe (e.g., gout, post-traumatic, infection), severe hallux valgus...
First metatarsophalangeal arthrodesis has been used to treat end-stage arthritis of the great toe (e.g., gout, post-traumatic, infection), severe hallux valgus deformity, hallux valgus caused by neuromuscular disorders, rheumatoid forefoot deformity, primary hallux varus, and rigid plantarflexion deformities, as well as a salvage procedure for failed previous operation of the great toe. As with any arthrodesis procedure, proper positioning of the hallux in first metatarsophalangeal arthrodesis is of utmost importance for good clinical outcome. The chief problem tends to be sagittal alignment. In case of the significant dorsiflexion malunion of the fusion site with excessive plantar pressure of the first metatarsophalangeal joint and abutment of the hallux to the shoebox, corrective osteotomy is indicated. If there is isolated excessive plantar pressure of the first metatarsophalangeal joint without hallux problem, arthroscopic sesamoidectomy and bone shaving of the plantar side of the first metatarsal head is another surgical option. The purpose of this technical note is to describe the details of arthroscopic sesamoidectomy and bone shaving of the plantar side of the first metatarsal head.
PubMed: 37780654
DOI: 10.1016/j.eats.2023.05.002 -
Cureus Apr 2024Hallux valgus (HV) is a relatively frequent disease caused by a complicated structural malformation of the primary ray. The bunion or middle projection generated by the... (Review)
Review
Hallux valgus (HV) is a relatively frequent disease caused by a complicated structural malformation of the primary ray. The bunion or middle projection generated by the hallux's lateral displacement and pronation is merely one element of the three-dimensional abnormality. HV may trigger severe discomfort and affect joint kinematics. The specific kinematic cause is still unknown. Female age, gender, restrictive footwear, and heritage are risk indicators. HV frequently coexists along metatarsal adducts, equines contracture, hammertoe imperfection, and pes planus. HV is a frequent foot ailment with multiple, complicated, unknown etiology and course. HV has a preference for females. It is an ongoing condition for which there is no known treatment to reduce or prevent improvement. Fibrodysplasia ossificans progressiva (FOP) is distinguished by hereditary symmetrical HV deformities or symptoms that begin heterotopic calcification that is either idiopathic or caused by trauma, such as subcutaneous immunizations. Localized heterotopic calcification may be preceded by aggravating, recurring soft-tissue enlargements (flare-ups). Heterotopic calcification may happen anywhere; however, it most commonly impacts locations near the axial bone structure during the early/mild phases until advancing to the appendicular skeleton. As an effect of calcification affecting the flexibility of the joints, it might cause limitations in motion. The initial line of therapy focuses on non-surgical methods including night splinting, orthotics, and larger shoes. The next suggested line of action is surgical intervention if conservative therapy fails. Patients have good postoperative tolerance, and bone union often happens six to seven weeks after surgery. Stretching exercises help to restore function by extending shortened soft tissue and restoring range of motion (ROM). The goal of joint mobilization, a form of manual treatment method, is to extend the ligament, the soft tissue surrounding the limited joint, and the restricting joint capsule by applying modest amplitude passive movement to the joint components.
PubMed: 38779237
DOI: 10.7759/cureus.58750 -
Cureus Jan 2024Purpose Cuboid bone and its fibromuscular supports maintain the lateral longitudinal arch in weight transmission during different gait cycle phases. Morphometry of the...
Purpose Cuboid bone and its fibromuscular supports maintain the lateral longitudinal arch in weight transmission during different gait cycle phases. Morphometry of the cuboid bone is essential for designing a cuboid prosthesis for foot reconstruction and establishing an individual's biological profile. The present study aims to assess the morphology and morphometry of the cuboid bone. Materials and methods The study used 103 cuboid bones (right 50, left 53) of unknown sex. Different shapes of cuboid articular facets were observed, and the morphometric parameters such as length, breadth, and height of cuboid, and the dimensions of articular facets in cuboid (calcaneal facet, fourth and fifth metatarsal facets, ecto-cuneiform facet, navicular facet, and facet for os peroneum) were analyzed. Results The mean length, breadth, and height of the cuboid bone were 33.69 ± 2.61 mm, 25.43 ± 2.87 mm, and 23.03 ± 2.43 mm, respectively. The mean transverse and vertical diameters were 23.22 ± 2.4 mm and 15.97 ± 1.85 mm, respectively. Facet for os peroneum was observed in 74.76% and for navicular bone in 26.2%. The mean transverse and vertical diameters were 7.16 ± 2.08 and 6.78 ± 1.78 mm, respectively. The depth of the peroneal groove was 4.30 ± 1.11 mm. Conclusion The morphometric data from the present study could assist in preoperative planning and designing of prostheses for foot reconstruction, and in establishing the biological profile of an individual, which can help the anthropologists in identifying the unknown remains.
PubMed: 38313952
DOI: 10.7759/cureus.51622 -
Orthopaedic Surgery Dec 2023Rotational Scarf osteotomy has its unique advantages in treating hallux valgus, but it also has certain drawbacks. The biomechanical differences between rotational Scarf...
OBJECTIVE
Rotational Scarf osteotomy has its unique advantages in treating hallux valgus, but it also has certain drawbacks. The biomechanical differences between rotational Scarf and translational Scarf osteotomy are not clear evaluates the correction ability and biomechanical difference of two surgical methods for hallux valgus by finite element analysis.
METHODS
The computerized tomography data of a hallux valgus patient were selected to establish a finite element model. The standard Scarf osteotomy was simulated based on the model, and the rotation and translation were performed, respectively. The size of the intermetatarsal angle, contact area, distal metatarsal articular angle and the absolute length of the first metatarsal was compared between the two groups. We completed the cartilage, ligament and other tissues on the bone model to establish a full foot model. We analyzed the troughing, plantar aponeurosis tension, plantar soft tissue, and ground stress and also observed the stability of the fracture site by a three-point bending test.
RESULTS
Both surgical methods may effectively correct the intermetatarsal angle. After rotational osteotomy, the contact area increased, and the length of the first metatarsal bone initially increased and then decreased compared to that in the translational group. Furthermore, rotational Scarf significantly increased the distal metatarsal articular angle. Mechanical analysis showed that the cancellous bone in the contact part of the fracture site in the translation group had greater stress, which was the reason for the occurrence of the troughing. Stress distribution of plantar aponeurosis, plantar soft tissue, and the ground showed no significant difference. The three-point bending test showed that the separation of the broken ends of the rotational Scarf osteotomy model (0.133 mm) was slightly smaller than the translational group (0.147 mm).
CONCLUSION
Both surgical methods can successfully correct intermetatarsal angle (IMA). Compared to traditional translational Scarf osteotomy, rotational Scarf osteotomy is more conducive to postoperative stability and healing, but it also has certain drawbacks. In clinical practice, individualized surgical methods still need to be selected for different types of patients with hallux valgus.
Topics: Humans; Hallux Valgus; Finite Element Analysis; Metatarsal Bones; Osteotomy; Metatarsophalangeal Joint; Treatment Outcome
PubMed: 37731316
DOI: 10.1111/os.13903 -
Bioengineering (Basel, Switzerland) Nov 2023The foot, as the foundation of the human body, bears the vast majority of the body's weight. Obese children bear more weight than healthy children in the process of...
The foot, as the foundation of the human body, bears the vast majority of the body's weight. Obese children bear more weight than healthy children in the process of walking and running. This study compared three footwear midsole structures (solid, lattice, and chiral) based on plantar pressure distribution and bone stress in obese and healthy children through numerical simulation. The preparation for the study included obtaining a thin-slice CT scan of a healthy 9-year-old boy's right foot, and this study distinguished between a healthy and an obese child by applying external loadings of 25 kg and 50 kg in the finite element models. The simulation results showed that the plantar pressure was mainly concentrated in the forefoot and heel due to the distribution of gravity (first metatarsal, fourth metatarsal, and heel bone, corresponding to plantar regions M1, M4, and HM and HL) on the foot in normal standing. Compared with the lattice and solid EVA structures, in both healthy and obese children, the percentage reduction in plantar pressure due to the chiral structure in the areas M1, M4, HM, and HL was the largest with values of 38.69%, 34.25%, 64.24%, and 54.03% for an obese child and 33.99%, 28.25%, 56.08%, and 56.96% for a healthy child. On the other hand, higher pressures (15.19 kPa for an obese child and 5.42 kPa for a healthy child) were observed in the MF area when using the chiral structure than when using the other two structures, which means that this structure can transfer an amount of pressure from the heel to the arch, resulting in a release in the pressure at the heel region and providing support at the arch. In addition, the study found that the chiral structure was not highly sensitive to the external application of body weight. This indicates that the chiral structure is more stable than the other two structures and is minimally affected by changes in external conditions. The findings in this research lay the groundwork for clinical prevention and intervention in foot disorders in obese children and provide new research ideas for shoe midsole manufacturers.
PubMed: 38002430
DOI: 10.3390/bioengineering10111306