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Sports (Basel, Switzerland) Dec 2023Fatigue has the potential to alter how impact forces are absorbed during running, heightening the risk of injury. Conflicting findings exist regarding alterations in... (Review)
Review
Fatigue has the potential to alter how impact forces are absorbed during running, heightening the risk of injury. Conflicting findings exist regarding alterations in both kinematics and plantar pressure. Thus, this systematic review and subsequent meta-analysis were conducted to investigate the impact of general and localized muscle fatigue on kinematics and plantar pressure distribution during running. Initial searches were executed on 30 November 2021 and updated on 29 April 2023, encompassing PubMed, The Cochrane Library, SPORTDiscus, and Web of Science without imposing any restrictions on publication dates or employing additional filters. Our PECOS criteria included cross-sectional studies on healthy adults during their treadmill running to mainly evaluate local muscle fatigue, plantar pressure distribution, biomechanics of running (kinematics, kinetics, and EMG results), and temporospatial parameters. The literature search identified 6626 records, with 4626 studies removed for titles and abstract screening. Two hundred and one articles were selected for full-text screening, and 20 studies were included in qualitative data synthesis. The pooled analysis showed a non-significant decrease in maximum pressure under the right forefoot's metatarsus, which was more than the left rearfoot after local muscle fatigue at a velocity of 15 km/h (-values = 0.48 and 0.62). The results were homogeneous and showed that local muscle fatigue did not significantly affect the right forefoot's stride frequency and length (-values = 0.75 and 0.38). Strength training for the foot muscles, mainly focusing on the dorsiflexors, is recommended to prevent running-related injuries. Utilizing a standardized knee and ankle joint muscle fatigue assessment protocol is advised. Future experiments should focus on various shoes for running and varying foot strike patterns for injury prevention.
PubMed: 38133108
DOI: 10.3390/sports11120241 -
Neurology and Therapy Dec 2023Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease characterized by progressive muscle weakness and atrophy. While chronic fatigue is a common...
INTRODUCTION
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease characterized by progressive muscle weakness and atrophy. While chronic fatigue is a common manifestation of SMA, the field lacks comprehensive data to assess the extent of its impact. Cure SMA, an SMA patient advocacy organization, conducted an online survey of its adults with SMA community members to measure the impact of fatigue.
METHODS
All survey respondents were asked to complete questions on demographics, use of SMA treatment, and quality of life, but respondents were randomized to receive three of the following fatigue instruments: the Modified Fatigue Impact Scale (MFIS), Multidimensional Fatigue Inventory (MFI), Fatigue Severity Scale (FSS), PedsQL™ Multidimensional Fatigue (PedsQL MF) Scale, and Spinal Muscular Atrophy Health Index (SMA-HI) fatigue modules. Scales were evaluated for reliability and overall fatigue scores were evaluated by multivariate regression models to determine which variables were related to the final scores of each instrument.
RESULTS
A total of 253 adults completed the online survey. When measured against the general population, statistically significant differences were found among adults with SMA for certain variables within each measurement instrument. However, there did not appear to be differences in fatigue levels among key subgroups within the SMA population.
CONCLUSIONS
This was the first use of more than two fatigue questionnaires simultaneously in SMA. The lack of a consistent relationship between SMA severity and fatigue levels was surprising. This may be related to the lack of specificity of the instruments for this population. An SMA-specific scale is needed to evaluate differences in fatigue impact across the SMA population.
PubMed: 37856000
DOI: 10.1007/s40120-023-00552-y -
Food Science & Nutrition Nov 2023Dietary creatine has been recently put forward as a possible intervention strategy to reduce post-COVID-19 fatigue syndrome yet no clinical study so far evaluated its...
Dietary creatine has been recently put forward as a possible intervention strategy to reduce post-COVID-19 fatigue syndrome yet no clinical study so far evaluated its efficacy and safety for this perplexing condition. In this parallel-group, randomized placebo-controlled double-blind trial, we analyzed the effects of 6-month creatine supplementation (4 g of creatine monohydrate per day) on various patient- and clinician-reported outcomes, and tissue creatine levels in 12 patients with post-COVID-19 fatigue syndrome. Creatine intake induced a significant increase in tissue creatine levels in vastus medialis muscle and right parietal white matter compared to the baseline values at both 3-month and 6-month follow-ups ( < .05). Two-way analysis of variance with repeated measures revealed a significant difference (treatment vs. time interaction) between interventions in tissue creatine levels ( < .05), with the creatine group was superior to placebo to augment creatine levels at vastus medialis muscle, left frontal white matter, and right parietal white matter. Creatine supplementation induced a significant reduction in general fatigue after 3 months of intake compared to baseline values ( = .04), and significantly improved scores for several post-COVID-19 fatigue syndrome-related symptoms (e.g., ageusia, breathing difficulties, body aches, headache, and difficulties concentrating) at 6-month follow-up ( < .05). Taking creatine for 6 months appears to improve tissue bioenergetics and attenuate clinical features of post-COVID-19 fatigue syndrome; additional studies are warranted to confirm our findings in various post-COVID-19 cohorts.
PubMed: 37970399
DOI: 10.1002/fsn3.3597 -
Orthopaedic Surgery Apr 2024Knee osteoarthritis (KOA) is widely recognized as a chronic joint disease characterized by degeneration of knee cartilage and subsequent bone hyperplasia. However, it is... (Review)
Review
Knee osteoarthritis (KOA) is widely recognized as a chronic joint disease characterized by degeneration of knee cartilage and subsequent bone hyperplasia. However, it is important to acknowledge the significant role of muscles in the development and progression of KOA. Muscle function (MF) and muscle quality (MQ) are key factors in understanding the involvement of muscles in KOA. Quantitative indices such as muscle mass, muscle strength, muscle cross-sectional area, muscle thickness, and muscle fatigue are crucial in assessing MF and MQ. Despite the growing interest in KOA, there is a scarcity of studies investigating the relationship between muscles and this condition. This review aims to examine the commonly used indices and measurement methods for assessing MF and MQ in clinical settings, while also exploring the association between muscles and KOA. Furthermore, this article highlights the importance of restoring MF and MQ to enhance symptom management and improve the quality of life for patients with KOA.
Topics: Humans; Osteoarthritis, Knee; Quality of Life; Knee Joint; Muscle, Skeletal; Lower Extremity
PubMed: 38438160
DOI: 10.1111/os.14022 -
European Journal of Sport Science Sep 2023This study aimed to determine the neuromuscular changes in muscle contractile properties and countermovement jump (CMJ) performance after a long distance (LD) triathlon,...
This study aimed to determine the neuromuscular changes in muscle contractile properties and countermovement jump (CMJ) performance after a long distance (LD) triathlon, inquiring to what extent it is influenced by gender and the evaluated muscle, and to explore for response differences. Four elite (2 females and 2 males) and 18 well-trained triathletes (3 females and 15 males) who competed in the 2019 LD Triathlon World Championship undergone, prior and post-race, a CMJ and a muscle contractile properties assessment in vastus lateralis (VL) and biceps femoris (BF) using tensiomyography. A mixed ANOVA was carried out to detect triathletes' neuromuscular changes after the competition. A large decrease in jump height and flight time was found in CMJ ( = 0.001, η= 0.767) with gender differences (η= 0.308). contraction (Tc), delay (Td) and sustain times (Ts) also showed a large decrease ( = 0.001, η= 0.174-0.413). However, maximum radial muscle belly displacement was not altered by the competition, but did greatly increase radial displacement velocity ( = 0.031; η= 0.212). No gender differences were found in contractile properties. Correlation analysis between race performance and the jumping and tensiomyography parameters only showed a moderate negative correlation with Tc of the BF in pre- and post-competition ( = -0.44; -0.43; = 0.05). In conclusion, triathletes after a LD World Championship suffer a sharp drop in jump performance and variations in VL's and BF's contractile properties, showing decreases in Tc, Td and Ts without gender differences. The regular use of these parameters can allow the monitoring of triathlete's neuromuscular fatigue and aid in the distribution of more efficient loads in their training cycles.Trainers and researchers in neuromuscular fatigue can have reference data of elite and well-trained triathletes after performing LD race.The magnitude of change in the CMJ and the contractile properties of BF and VL achieved in competition by these elite reference triathletes can guide to modulate triathletes training.The regular use of the parameters using these references can allow an exhaustive neuromuscular fatigue monitoring during the sessions or training cycles throughout the season.
Topics: Male; Female; Humans; Muscle Contraction; Muscle, Skeletal; Quadriceps Muscle; Hamstring Muscles
PubMed: 36221960
DOI: 10.1080/17461391.2022.2134053 -
Frontiers in Chemistry 2023Conjugate materials have a good application effect in muscle movement recovery. This article aims to provide more references for the practical application of conjugated...
Conjugate materials have a good application effect in muscle movement recovery. This article aims to provide more references for the practical application of conjugated materials in sports recovery. This paper takes the students of the local physical education college as the experimental object, and selects the students who have sports muscle fatigue or injury for the test. In this paper, they are randomly divided into two groups: the experimental group and the control group, with 19 students in each group. The experimental group used the conjugate material in this paper for muscle movement recovery, while the control group used the traditional method for muscle movement recovery. This paper tested the peak torque, total work done, maximum radial displacement, and contraction time of two groups of students after initial exercise and muscle recovery. The experimental results showed that after 80 h of muscle movement recovery, the peak torque values of isometric contraction (264.59) and concentric contraction (160.81) of students in the experimental group were higher than those of students in the control group (233.79) and concentric contraction (130.43), and the difference was statistically significant (p < 0.05); the isometric contraction time (30.02) and concentric contraction time (29.31) of the experimental group were also higher than those of the control group (27.31) and concentric contraction time (24.58), which was statistically significant (p < 0.05). This study shows that conjugated materials have a significant effect on promoting muscle recovery. They not only help to increase the peak torque of muscle isometric contraction and concentric contraction, but also increase the time of muscle contraction and improve muscle mass.
PubMed: 37577062
DOI: 10.3389/fchem.2023.1246926 -
Molecular Metabolism Dec 2023Estrogen related receptor α (ERRα) occupies a central node in the transcriptional control of energy metabolism, including in skeletal muscle, but whether modulation of...
OBJECTIVE
Estrogen related receptor α (ERRα) occupies a central node in the transcriptional control of energy metabolism, including in skeletal muscle, but whether modulation of its activity can directly contribute to extend endurance to exercise remains to be investigated. The goal of this study was to characterize the benefit of mice engineered to express a physiologically relevant activated form of ERRα on skeletal muscle exercise metabolism and performance.
METHODS
We recently shown that mutational inactivation of three regulated phosphosites in the amino terminal domain of the nuclear receptor ERRα impedes its degradation, leading to an accumulation of ERRα proteins and perturbation of metabolic homeostasis in ERRα mutant mice. Herein, we used a multi-omics approach in combination with physical endurance tests to ascertain the consequences of expressing the constitutively active phospho-deficient ERRα form on muscle exercise performance and energy metabolism.
RESULTS
Genetic heightening of ERRα activity enhanced exercise capacity, fatigue-resistance, and endurance. This phenotype resulted from extensive reprogramming of ERRα global DNA occupancy and transcriptome in muscle leading to an increase in oxidative fibers, mitochondrial biogenesis, fatty acid oxidation, and lactate homeostasis.
CONCLUSION
Our findings support the potential to enhance physical performance and exercise-induced health benefits by targeting molecular pathways regulating ERRα transcriptional activity.
Topics: Mice; Animals; Muscle, Skeletal; Receptors, Estrogen; Gene Expression Regulation; Running; ERRalpha Estrogen-Related Receptor
PubMed: 37802398
DOI: 10.1016/j.molmet.2023.101814 -
International Journal of Molecular... Oct 2023Spinal muscular atrophy (SMA) is a genetic disorder characterized by the loss of spinal motor neurons leading to muscle weakness and respiratory failure. Mitochondrial...
Spinal muscular atrophy (SMA) is a genetic disorder characterized by the loss of spinal motor neurons leading to muscle weakness and respiratory failure. Mitochondrial dysfunctions are found in the skeletal muscle of patients with SMA. For obvious ethical reasons, the diaphragm muscle is poorly studied, notwithstanding the very important role that respiratory involvement plays in SMA mortality. The main goal of this study was to investigate diaphragm functionality and the underlying molecular adaptations in SMNΔ7 mice, a mouse model that exhibits symptoms similar to that of patients with intermediate type II SMA. Functional, biochemical, and molecular analyses on isolated diaphragm were performed. The obtained results suggest the presence of an intrinsic energetic imbalance associated with mitochondrial dysfunction and a significant accumulation of reactive oxygen species (ROS). In turn, ROS accumulation can affect muscle fatigue, cause diaphragm wasting, and, in the long run, respiratory failure in SMNΔ7 mice. Exposure to the antioxidant molecule ergothioneine leads to the functional recovery of the diaphragm, confirming the presence of mitochondrial impairment and redox imbalance. These findings suggest the possibility of carrying out a dietary supplementation in SMNΔ7 mice to preserve their diaphragm function and increase their lifespan.
Topics: Humans; Mice; Animals; Diaphragm; Reactive Oxygen Species; Motor Neurons; Muscular Atrophy, Spinal; Muscle, Skeletal; Disease Models, Animal; Respiratory Insufficiency
PubMed: 37834400
DOI: 10.3390/ijms241914953 -
Journal of Neuroengineering and... Aug 2023Muscle strength and dexterity impairments are common among patients with multiple sclerosis (MS) producing limitations in activities of daily living related to the upper... (Randomized Controlled Trial)
Randomized Controlled Trial
BACKGROUND
Muscle strength and dexterity impairments are common among patients with multiple sclerosis (MS) producing limitations in activities of daily living related to the upper limb (UL). This study aimed to evaluate the effectiveness of serious games specifically developed for the MYO Armband® capture sensor in improving forearm and wrist mobility, UL muscle strength, dexterity, fatigue, functionality, quality of life, satisfaction, adverse effects and compliance.
METHODS
A double-blinded (allocation concealment was performed by a blinded investigator and by blinding for assessors) randomised controlled trial was conducted. The sample was randomised into two groups: an experimental group that received treatment based on UL serious games designed by the research team and controlled by the MYO Armband® gesture capture sensor, along with conventional rehabilitation and a control group that received the same conventional rehabilitation for the UL. Both groups received two 60-min sessions per week over an eight-week period. Wrist range of motion (goniometry), grip muscle strength (Jamar® dynamometer), coordination and gross UL dexterity (Box and Block Test), fatigue (Fatigue Severity Scale), functionality (ABILHAND), quality of life (Multiple Sclerosis Impact Scale-29), adverse effects (Simulator Sickness Questionnaire, SSQ), perceived workload (NASA-Task load index), satisfaction (Client Satisfaction Questionnaire-8 (CSQ-8), Satisfaction with Technology Scale, System Usability Scale (SUS) and QUEST 2.0) and compliance (attendance) were assessed in both groups pre-treatment, post-treatment and during a follow-up period of 2 weeks without receiving any treatment.
RESULTS
Significant differences were observed in the experimental group compared to the control group in the assessment of forearm supination (p = .004) and grip strength (p = .004). Adverse effects were minimal (SSQ: 7/100 points) and perceived workload was low (NASA-Task Load Index: 25/100 points) in the experimental group. The MYO Armband® technology proved to be useful for the participants (SUS: 80.66/100) and the satisfaction scales received high scores (QUEST 2.0: 59.4/70 points; Satisfaction with Technology: 84.36/100 points). There were significant differences between the groups in terms of attendance percentage (p = .029).
CONCLUSIONS
An experimental protocol using MYO Armband®-based serious games designed for UL rehabilitation showed improvements in active wrist range of motion and handgrip strength in patients with MS, with high satisfaction, minimal adverse effects and workload and excellent compliance.
TRIAL REGISTRATION NUMBER
This randomised controlled trial has been registered at ClinicalTrials.gov Identifier: NCT04171908.
Topics: Humans; Forearm; Activities of Daily Living; Hand Strength; Multiple Sclerosis; Quality of Life; Upper Extremity; Fatigue
PubMed: 37598176
DOI: 10.1186/s12984-023-01233-5 -
Orphanet Journal of Rare Diseases Jul 2023The European registry for individuals with GSD5 and other muscle glycogenosis (EUROMAC) was launched to register rare muscle glycogenosis in Europe, to facilitate...
BACKGROUND
The European registry for individuals with GSD5 and other muscle glycogenosis (EUROMAC) was launched to register rare muscle glycogenosis in Europe, to facilitate recruitment for research trials and to learn about the phenotypes and disseminate knowledge about the diseases. A network of twenty collaborating partners from eight European countries and the US contributed data on rare muscle glycogenosis in the EUROMAC registry.
METHODS
Following the initial report on demographics, neuromuscular features and comorbidity (2020), we here present the data on social participation, previous and current treatments (medication, supplements, diet and rehabilitation) and limitations. Furthermore, the following questionnaires were used: Fatigue severity scale (FSS), WHO Disability Assessment Scale (DAS 2.0), health related quality of life (SF36) and International Physical Activity Questionnaire (IPAQ).
RESULTS
Of 282 participants with confirmed diagnoses of muscle glycogenosis, 269 had GSD5. Of them 196 (73%) completed all questionnaires; for the others, the data were incomplete. The majority, 180 (67%) were currently working. Previous medical treatments included pain medication (23%) and rehabilitation treatment (60%). The carbohydrate-rich diet was reported to be beneficial for 68%, the low sucrose diet for 76% and the ketogenic diet for 88%. Almost all participants (93%) reported difficulties climbing stairs. The median FSS score was 5.22, indicating severe fatigue. The data from the WHODAS and IPAQ was not of sufficient quality to be interpreted.
CONCLUSIONS
The EUROMAC registry have provided insight into the functional and social status of participants with GSD5: most participants are socially active despite limitations in physical and daily life activities. Regular physical activity and different dietary approaches may alleviate fatigue and pain.
Topics: Humans; Glycogen Storage Disease Type V; Quality of Life; Social Participation; Functional Status; Glycogen Storage Disease; Fatigue
PubMed: 37488619
DOI: 10.1186/s13023-023-02825-z