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International Journal of Clinical... Nov 2023In recent years, breastfeeding has been largely promoted due to health benefits for the children and the mothers and social, economic, and environmental advantages.... (Review)
Review
BACKGROUND
In recent years, breastfeeding has been largely promoted due to health benefits for the children and the mothers and social, economic, and environmental advantages. World Health Organization (WHO) recommends breastfeeding for at least 2 years and to be continued for as long as this is desired by the mother-child dyad.Despite its advantages, including protection against caries in the 1st year of life, prevention of malocclusions, and development of more normal breathing patterns, there is a great controversy in the literature regarding breastfeeding involvement in elevated risk for early childhood caries (ECC).Breastfeeding and oral health are strongly related. Breastfeeding can influence oral health and development, but oral findings, such as tethered tissues and natal/neonatal teeth, may negatively affect lactation.
CONCLUSION
A healthy collaboration between the oral health care provider and the lactation specialist is important in order to identify those oral findings and prevent breastfeeding implications, but also in order to facilitate uneventful breastfeeding by emphasizing oral health care prevention strategies.
CLINICAL SIGNIFICANCE
Information on the advantages of certain lactation aspects and the potential risks for ECC is important for the pediatric dentist to be able to form an individualized treatment/prevention plan that will benefit and promote the oral and general health of young patients.
HOW TO CITE THIS ARTICLE
Papadopoulou P, Boka V, Arapostathis K. Integration of Breastfeeding Consultation and Practices in the Scope of Pediatric Dentistry: Collaboration with Lactation Specialists. Int J Clin Pediatr Dent 2023;16(S-3):S306-S310.
PubMed: 38268628
DOI: 10.5005/jp-journals-10005-2698 -
Journal of Indian Prosthodontic Society 2023The aim of this study was to evaluate the accuracy of models of partially edentulous arches obtained by three-dimensional (3D) printing.
AIM
The aim of this study was to evaluate the accuracy of models of partially edentulous arches obtained by three-dimensional (3D) printing.
SETTINGS AND DESIGN
This was an in vitro study.
MATERIALS AND METHODS
Fifteen partially edentulous models were evaluated, using two methods of measuring dimensions: virtual, using the Standard Tessellation Language files of the models and software (control group), and physical, through printing the models and digital caliper (test group). For both methods, measurements were made regarding the dimensions of the teeth (width and length - buccal/lingual or palatal/occlusal) and distances between the teeth.
STATISTICAL ANALYSIS USED
For the variable of linear measurements (width and length) and distances between teeth of the same hemiarch, the Wilcoxon test was used, while for the variable between opposite hemiarches, the paired t-test was used.
RESULTS
In the evaluation of the linear measurements, a significant difference was observed only when the width of the molar tooth was analyzed (P = 0.014). When the buccal length was measured, all teeth had linear measurements provided by the virtual method that was lower than the physical (P = 0.000), as well as the lingual/palatal length in incisors (P = 0.003) and molars (P = 0.009) and in total (P = 0.001). As for the analyses between teeth, no difference was identified between the measurements provided by the virtual method compared to the physical one.
CONCLUSIONS
The 3D printer used to print partially edentulous models provided linear distortions in the teeth but without changes in the distances between teeth of the same hemiarch and between teeth of opposite hemiarches.
Topics: Humans; Imaging, Three-Dimensional; Models, Dental; Mouth, Edentulous; Printing, Three-Dimensional; Incisor
PubMed: 37861612
DOI: 10.4103/jips.jips_130_23 -
The Keio Journal of Medicine Sep 2023Pachyonychia congenita (PC) is a rare, autosomal dominant inherited disorder of keratinization that is characterized by a triad of focal palmoplantar keratoderma,...
Pachyonychia congenita (PC) is a rare, autosomal dominant inherited disorder of keratinization that is characterized by a triad of focal palmoplantar keratoderma, plantar pain, and hypertrophic nail dystrophy. It can be debilitating, causing significantly impaired mobility. PC is diagnosed clinically alongside identification of a heterozygous pathogenic mutation in one of five keratin genes: KRT6A, KRT6B, KRT6C, KRT16, or KRT17. Each keratin gene mutation is associated with a distinct clinical phenotype, with variable age of onset and additional features, which has allowed classification by genotype. Additional features include pilosebaceous cysts, follicular hyperkeratosis, natal teeth, oral leukokeratosis, hidradenitis suppurativa, itching, and neurovascular structures. Although classed as rare, the prevalence of PC is likely to be underestimated. There is no cure or specific treatment for PC at present. Current treatments are limited to conservative measures to reduce plantar friction and trauma, mechanical debridement, topical treatments, and treatments for associated features or complications, most commonly infection. However, through active research in collaboration with PC Project, a patient-advocacy group, and the International PC Research Registry, a global registry of PC patients, there are now many new potential therapeutic options on the horizon. This review summarizes the clinical features associated with PC and highlights the current and future treatment of its manifestations.
PubMed: 37766547
DOI: 10.2302/kjm.2023-0012-IR -
International Journal of Clinical... 2023The eruption process is under strong genetic control, external environmental factors also significantly contribute to this process. Therefore the present study was...
BACKGROUND
The eruption process is under strong genetic control, external environmental factors also significantly contribute to this process. Therefore the present study was undertaken to identify the influence of birth characteristics and feeding practices on the eruption of the first primary tooth among healthy children in Pune, Maharashtra, India.
MATERIALS AND METHODS
The study was undertaken among 200 children aged 3-24 months. Children with any underlying conditions, those not accompanied by their mother and with neonatal teeth/natal teeth were excluded. The birth weight, gestational age, and type of delivery were obtained from medical records of the child. Data on feeding practices and the age of eruption of the first primary tooth was recorded after a structured interview of the mother followed by oral examination of the child. Gestational age was categorized into >37 weeks and <37 weeks, birth weight was divided into three groups-<1500, 1500-2500, and >2500 gm and four groups according to feeding practice during the first 6 months of life (exclusively breastfed, exclusively bottle fed, combination of breastfeeding and bottle feeding, and spoon-feeding).
RESULTS
The mean age of eruption in the study population was 9.17 months. A9.05 months in males and 9.44 in females. A statistically significant correlation was noted with gestational age, birth weight, and feeding practices. Infants with a gestational age of >37 weeks, higher birth weight and those who were exclusively breastfed for the first 6 months had an earlier eruption of first primary teeth.
CONCLUSION
External factors seem to influence the eruption of the primary tooth. More longitudinal studies with larger sample sizes and matching confounders are needed to clearly understand the factors affecting the primary tooth eruption.
HOW TO CITE THIS ARTICLE
Shetty SS, Mathur A, Gopalakrishnan D, Influence of Birth Characteristics and Feeding Practices on Eruption of Primary Teeth in Children: A Preliminary Cross-sectional Observational Study. Int J Clin Pediatr Dent 2023;16(5):724-727.
PubMed: 38162243
DOI: 10.5005/jp-journals-10005-2665 -
Life (Basel, Switzerland) Jan 2024(1) Background: Congenital erythropoietic porphyria (CEP), named Günther's disease, is a rare recessive type of porphyria, resulting from deficient uroporphyrinogen III...
(1) Background: Congenital erythropoietic porphyria (CEP), named Günther's disease, is a rare recessive type of porphyria, resulting from deficient uroporphyrinogen III synthase (UROS), the fourth enzyme of heme biosynthesis. The phenotype ranges from extremely severe perinatal onset, with life-threatening hemolytic anaemia, to mild or moderate cutaneous involvement in late-onset forms. This work reviewed the perinatal CEP cases recorded in France in order to analyse their various presentations and evolution. (2) Methods: Clinical and biological data were retrospectively collected through medical and published records. (3) Results: Twenty CEP cases, who presented with severe manifestations during perinatal period, were classified according to the main course of the disease: antenatal features, acute neonatal distress and postnatal diagnosis. Antenatal symptoms (seven patients) were mainly hydrops fetalis, hepatosplenomegaly, anemia, and malformations. Six of them died prematurely. Five babies showed acute neonatal distress, associated with severe anemia, thrombocytopenia, hepatosplenomegaly, liver dysfunction, and marked photosensitivity leading to diagnosis. The only two neonates who survived underwent hematopoietic stem cell transplantation (HSCT). Common features in post-natal diagnosis (eight patients) included hemolytic anemia, splenomegaly, skin sensitivity, and discoloured teeth and urine. All patients underwent HSCT, with success for six of them, but with fatal complications in two patients. The frequency of the missense variant named C73R is striking in antenatal and neonatal presentations, with 9/12 and 7/8 independent alleles, respectively. (4) Conclusions: The most recent cases in this series are remarkable, as they had a less fatal outcome than expected. Regular transfusions from the intrauterine period and early access to HSCT are the main objectives.
PubMed: 38255745
DOI: 10.3390/life14010130 -
Brazilian Journal of Veterinary Medicine 2023Oral and dental diseases are common in horses, as evidenced by the results of incidence studies of dental diseases carried out on abattoir specimens or sports horses....
Oral and dental diseases are common in horses, as evidenced by the results of incidence studies of dental diseases carried out on abattoir specimens or sports horses. Thus, periodic dental examinations in horses are essential to ensure the maintenance of dental health and proper use of ingested food. A retrospective study of the dental records of 416 Quarter Horses (256 males, 160 females), distributed in the western region of the Rio Grande do Norte, Brazil, was conducted. Horses were examined between July 2012 and August 2022. The variables collected were age, sex, type of diet, dental alterations identified, and history of colic in the last 365 days. The animals were divided into three groups according to age: group I (2 to 6 years old), group II (7to12 years old), and group III (13to 24 years old). Pairwise comparisons were performed using Tukey's correction. The most frequent dental alterations were excessive tip of the tooth enamel, limited/asymmetric lateral excussion, oral ulceration, eruption of the first premolar tooth, and rostral hook. Statistical differences (p<0.05) were observed between the age groups in the following alterations: excessive tip of the tooth enamel, limited/asymmetric lateral excussion, eruption of the first premolar tooth, rostral hook, palatitis, step, caudal hook, retention of deciduous cheek teeth, wave, tartarus, underbite, periodontal disease, and incisors of the dorsal curve. Dental disorders in horses are of major clinical importance.
PubMed: 37484205
DOI: 10.29374/2527-2179.bjvm000323 -
International Journal of Oral Science Mar 2024Human with bi-allelic WNT10A mutations and epithelial Wnt10a knockout mice present enlarged pulp chamber and apical displacement of the root furcation of multi-rooted...
Human with bi-allelic WNT10A mutations and epithelial Wnt10a knockout mice present enlarged pulp chamber and apical displacement of the root furcation of multi-rooted teeth, known as taurodontism; thus, indicating the critical role of Wnt10a in tooth root morphogenesis. However, the endogenous mechanism by which epithelial Wnt10a regulates Hertwig's epithelial root sheath (HERS) cellular behaviors and contributes to root furcation patterning remains unclear. In this study, we found that HERS in the presumptive root furcating region failed to elongate at an appropriate horizontal level in K14-Cre;Wnt10a mice from post-natal day 0.5 (PN0.5) to PN4.5. EdU assays and immunofluorescent staining of cyclin D1 revealed significantly decreased proliferation activity of inner enamel epithelial (IEE) cells of HERS in K14-Cre;Wnt10a mice at PN2.5 and PN3.5. Immunofluorescent staining of E-Cadherin and acetyl-α-Tubulin demonstrated that the IEE cells of HERS tended to divide perpendicularly to the horizontal plane, which impaired the horizontal extension of HERS in the presumptive root furcating region of K14-Cre;Wnt10a mice. RNA-seq and immunofluorescence showed that the expressions of Jag1 and Notch2 were downregulated in IEE cells of HERS in K14-Cre;Wnt10a mice. Furthermore, after activation of Notch signaling in K14-Cre;Wnt10a molars by Notch2 adenovirus and kidney capsule grafts, the root furcation defect was partially rescued. Taken together, our study demonstrates that an epithelial Wnt10a-Notch signaling axis is crucial for modulating HERS cell proper proliferation and horizontal-oriented division during tooth root furcation morphogenesis.
Topics: Humans; Female; Mice; Animals; Tooth Root; Tooth; Odontogenesis; Signal Transduction; Dental Enamel; Epithelial Cells; Nerve Tissue Proteins; Wnt Proteins
PubMed: 38480698
DOI: 10.1038/s41368-024-00288-x -
Scientific Reports Jan 2024This study investigated natal factors influencing developmental defects of enamel (DDE) in premature infants using a newly refined preterm developmental defects of...
This study investigated natal factors influencing developmental defects of enamel (DDE) in premature infants using a newly refined preterm developmental defects of enamel (PDDE) index. Dental examinations were conducted on a cohort of 118 preterm infants (average age 3.5 ± 1.4 years) to record PDDE scores, while reviewing their medical records to examine natal factors. According to the logistic regression analysis, factors related to DDE prevalence were advanced maternal age, gestational age < 28 weeks, birth weight < 1000 g, 1 min APGAR score < 7, and hospitalization period > 2 months, which were significantly higher by 2.91, 5.53, 7.63, 10.02, and 4.0 times, respectively. According to regression analysis with generalized linear models, the PDDE scores were approximately 7.65, 4.96, and 15.0 points higher in premature children diagnosed with bronchopulmonary dysplasia, intraventricular hemorrhage, and necrotizing enterocolitis, respectively. When endotracheal intubation was performed, the PDDE score was 5.06 points higher. The prevalence of PDDE was primarily observed bilaterally in the maxillary anterior teeth. Extremely preterm infants showed significantly delayed tooth eruption, suggesting that the influence of gestational age on dental development rates. Identifying the factors related to DDE in premature children can inform early dental interventions to support the oral health of high-risk children.
Topics: Child; Infant; Female; Humans; Infant, Newborn; Child, Preschool; Prospective Studies; Gestational Age; Premature Birth; Infant, Extremely Premature; Developmental Defects of Enamel
PubMed: 38267499
DOI: 10.1038/s41598-024-52525-2