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La Medicina Del Lavoro Dec 2023Quantification of asbestos fibers has been mainly performed in the lung but rarely in other organs. However, this may be relevant to understanding better translocation... (Review)
Review
BACKGROUND
Quantification of asbestos fibers has been mainly performed in the lung but rarely in other organs. However, this may be relevant to understanding better translocation pathways and the oncogenic effects of asbestos on the human body. Electron microscopy is the best technology available to assess the type of fiber, dimensions, and distribution of asbestos fibers in different tissues and as a biomarker of cumulative dose.
OBJECTIVES
This scoping review aims to summarize the findings of the studies in which asbestos fibers have been quantified by electron microscopy, occasionally associated with X-ray microanalysis, in normal and pathological tissue of ten abdominal organs.
METHODS
A scoping review has been performed by searching articles that quantified asbestos fibers in abdominal organs by electron microscopy (Scanning- SEM or Transmission- TEM).
RESULTS
The 12 selected studies included 204 cases, and 325 samples were analyzed. The colon and rectum, kidney, bladder, and abdominal lymph nodes were the organs with at least ten samples available with quantification of asbestos fibers. Asbestos fibers were detected in all the abdominal organs considered: the highest value (152,32 million fibers per gram of dry tissue) was found in the colon and was identified using STEM with EDS.
CONCLUSION
The studies included were heterogeneous in terms of exposure and cases, type of samples, as well as analytical techniques, therefore we cannot confirm a specific pattern of distribution in any organ, based on the low homogeneity of the exposure status. The colon is the organ in which the number of fibers is the highest, probably because of exposure arising from both internal distribution of inhaled fibers and ingestion. Additional studies of the number of asbestos fibers in abdominal organs should be made to achieve better representativity.
Topics: Humans; Asbestos; Lung
PubMed: 38060208
DOI: 10.23749/mdl.v114i6.14946 -
Journal of Occupational Medicine and... Dec 2023The research project GAIN (working healthy in inclusion companies) deals with the topics of health and work in inclusive companies. Due to a great need for research on...
BACKGROUND
The research project GAIN (working healthy in inclusion companies) deals with the topics of health and work in inclusive companies. Due to a great need for research on (occupational) health (e.g. physical and mental health status) and workplace design in companies employing people with disabilities, this project pursues the primary goal of generating information for the development and implementation of health-preserving measures within the framework of occupational health and safety, and risk assessment, for employees with and without impairments in inclusive companies.
METHODS
Within the framework of the project, the employees of three inclusive companies will be examined with the help of an interdisciplinary and triangulative approach. Using quantitative and qualitative methods, specific physical workloads and hazards will be investigated by means of baseline screening methods and measurement techniques, specifically among employees with physical disabilities and impairments. In the statistical analysis, descriptive methods will be used to record the current state, while inferential statistical methods will be used to evaluate health maintenance measures. Inferential statistics for continuous data with confidence intervals based on the statistical parametric mapping (SPM) method will also be performed. The significance level will be set at 5%. Qualitative methods will be used to analyse structures and working conditions within the companies, with particular attention to the specific construction of the relationship between work, health and disability.
CONCLUSIONS
The structures in inclusion companies must be specifically designed to support and promote the understanding of work and health in relation to the idea of one's own body, its positioning in space and its performance. These characteristics are to be identified in the course of the project and bundled into best-practice recommendations. Furthermore, it is the aim of the research project to derive recommendations for action at its conclusion and to present further advice for the promotion of health in inclusive companies.
PubMed: 38102673
DOI: 10.1186/s12995-023-00399-x -
Medycyna Pracy Dec 2023Central register of data on exposure to carcinogenic or mutagenic chemical substances, their mixtures, agents or technological processes (CRCR) conducted by Nofer...
[Occupational carcinogens and mutagens in Poland - occurrence and workers' exposure in the years 2018-2021 based on the data from Central register of carcinogenic or mutagenic agents].
BACKGROUND
Central register of data on exposure to carcinogenic or mutagenic chemical substances, their mixtures, agents or technological processes (CRCR) conducted by Nofer Institute of Occupational Medicine (NIOM) enables monitoring of such agents occurrence in working environment in Poland. The NIOM conducts CRCR based on the provisions of the Regulation of the Minister of Health of 24 July 2012 on chemical substances, their mixtures, agents or technological processes with carcinogenic or mutagenic effects in the work environment. The work summarizes the information reported to CRCR in 2018-2021.
MATERIAL AND METHODS
The data were extracted from CRCR, to which it was transferred by sanitary inspections. The data were extracted from CRCR. Data in this register is gathered based on employers' notifications to sanitary inspection. The study includes the number of reported agents (chemical substances and technological processes), the number of enterprises and the number of persons exposed to particular groups of agents (chemical substances, technological processes, ionizing radiation).
RESULTS
The number of substances notified to the CRCR increases, from 382 reported substances in 2018 to 444 in 2021. Significant increase in the number of enterprises reporting technological processes (from 981 in 2018 to 5422 in 2021) and the number of exposed persons results from the law amendments extending the list of carcinogenic or mutagenic processes.
CONCLUSIONS
The CRCR is a unique database on the occurrence and exposure to occupational carcinogens and mutagens, in which data from over 20 years has been collected. The increase in the number of reports to the register was mainly influenced by legislative changes regarding carcinogenic or mutagenic agents. Due to amount and complexity of data, they can be used for analysis in projects and programs aimed at raising awareness and reducing risk of occupational exposure to carcinogens and also during legislative works in Poland and in the EU. Med Pr Work Health Saf. 2023;74(5):399-407.
Topics: Humans; Carcinogens; Mutagens; Poland; Occupational Exposure
PubMed: 38104340
DOI: 10.13075/mp.5893.01459 -
Revue Medicale de Liege Jun 2024Occupational medicine is an essential branch of preventive medicine that aims to protect the health of workers in the workplace. Any work situation exposes the worker to...
Occupational medicine is an essential branch of preventive medicine that aims to protect the health of workers in the workplace. Any work situation exposes the worker to occupational hazards. The three levels of prevention applied in occupational medicine make it possible, together, to control risks. Primary prevention aims to prevent the occurrence of damage related to occupational risks, secondary prevention aims to early detect work-related health problems and in tertiary prevention, the objective is to limit the consequences of occupational risks or diseases already developed. It is not always possible to completely eliminate an occupational hazard. Regular medical examinations, at a frequency appropriate to the risks identified, meet this objective and therefore make it possible to detect work-related health problems or problems that could influence work. A proactive approach focused on prevention helps to reduce occupational risks, prevent work-related diseases, and to promote a healthy and safe work environment for all.
Topics: Humans; Occupational Medicine; Occupational Diseases; Accidents, Occupational; Occupational Health
PubMed: 38869113
DOI: No ID Found -
International Journal of Preventive... 2024Impact/impulse and continuous noise are two main causes of noise-induced hearing loss (NIHL) in workplaces. The aim of this study was to compare the effects of...
BACKGROUND
Impact/impulse and continuous noise are two main causes of noise-induced hearing loss (NIHL) in workplaces. The aim of this study was to compare the effects of impulse/impact noise and continuous noise on hearing status.
METHODS
In this study, 259 workers referred to the occupational medicine clinic of Shahid Rahnemoun hospital, Yazd, Iran, entered the study and were divided into two groups: with exposure to impact/impulse noise and with exposure to continuous noise. Hearing thresholds were measured and compared between the two groups by pure-tone audiometry (PTA). The frequency of hearing loss and audiometric notch according to the results of PTA was compared between the two groups. Data were analyzed by SPSS (ver. 16) using Student's -test, Chi-square test, and Mann-Whitney U test.
RESULTS
Hearing thresholds were significantly higher at all frequencies in the impact noise group. The hearing threshold at 6000 Hz was higher than other frequencies in both groups. The frequency of hearing loss at high frequencies was higher in the impact group. The frequency of audiometric notch was not significantly different between the two groups.
CONCLUSIONS
The results of this study showed that hearing loss after exposure to impact/impulse noise is probably more frequent and more severe than exposure to continuous noise, but the pattern of hearing loss is similar in both types of noise exposure.
PubMed: 38487700
DOI: 10.4103/ijpvm.ijpvm_368_21 -
Annals of Global Health 2023It is a prevalent misconception that healthcare professionals are specialists and thus can effectively manage their health. This is probably true, but given recent...
It is a prevalent misconception that healthcare professionals are specialists and thus can effectively manage their health. This is probably true, but given recent pandemics and the rise in violence in medical settings, one is compelled to question whether their health and safety are sufficient for a robust healthcare system. This is important because protecting and promoting the health, safety, and well-being of health workers will improve the quality of patient care and increase the resilience of health services in the face of outbreaks and public health emergencies. We thus strive to answer this question and suggest potential remedies to this growing public health issue.
Topics: Humans; Disease Outbreaks; Government Programs; Health Personnel; Health Workforce; Medical Assistance
PubMed: 37692379
DOI: 10.5334/aogh.4167 -
Clinical and Experimental Pediatrics May 2024Exposure of an individual to occupational and environmental risk factors for a certain disease affects them and their family. Children are highly vulnerable in this...
Exposure of an individual to occupational and environmental risk factors for a certain disease affects them and their family. Children are highly vulnerable in this setting because they are family-dependent. This review discusses diseases that occur in children according to the occupational and behavioral characteristics of their parents. Toxic agents in the home environment can affect children's health. Maternal exposure to substances during pregnancy may directly affect fetal outcomes. The Industrial Accident Compensation Insurance Act in Korea was amended in 2023 to compensate for children's adverse health effects due to their parents' occupational risks. The long working hours and smoking behaviors of parents and toxic materials in the home environment are highlighted. To control for the diverse factors affecting children's health in medical research, this review introduces directed acyclic graphs. Pediatric, occupational, and environmental medicine must collaborate to prevent childhood diseases related to environmental factors.
PubMed: 37605537
DOI: 10.3345/cep.2023.00115 -
Neoplasia (New York, N.Y.) Oct 2023Voltage-dependent anion-selective channel protein 1 (VDAC1) is the most abundant protein in the mitochondrial outer membrane and plays a crucial role in the control of...
Voltage-dependent anion-selective channel protein 1 (VDAC1) is the most abundant protein in the mitochondrial outer membrane and plays a crucial role in the control of hepatocellular carcinoma (HCC) progress. Our previous research found that cytosolic molecular chaperone heat shock protein 90 (Hsp90) interacted with VDAC1, but the effect of the C-terminal and N-terminal domains of Hsp90 on the formation of VDAC1 oligomers is unclear. In this study, we focused on the effect of the C-terminal domain of Hsp90 on VDAC1 oligomerization, ubiquitination, and VDAC1 channel activity. We found that Hsp90 C-terminal domain inhibitor Novobiocin promoted VDAC1 oligomerization, release of cytochrome c, and activated mitochondrial apoptosis pathway. Atomic coarse particle modeling simulation revealed C-terminal domain of Hsp90α stabilized VDAC1 monomers. The purified VDAC1 was reconstituted into a planar lipid bilayer, and electrophysiology experiments of patch clamp showed that the Hsp90 C-terminal inhibitor Novobiocin increased VDAC1 channel conductance via promoting VDAC1 oligomerization. The mitochondrial ubiquitination proteomics results showed that VDAC1 K274 mono-ubiquitination was significantly decreased upon Novobiocin treatment. Site-directed mutation of VDAC1 (K274R) weakened Hsp90α-VDAC1 interaction and increased VDAC1 oligomerization. Taken together, our results reveal that Hsp90 C-terminal domain inhibition promotes VDAC1 oligomerization and VDAC1 channel conductance by decreasing VDAC1 K274 mono- ubiquitination, which provides a new perspective for mitochondria-targeted therapy of HCC.
Topics: Humans; Carcinoma, Hepatocellular; Apoptosis; Novobiocin; Liver Neoplasms; Ubiquitination; Voltage-Dependent Anion Channel 1
PubMed: 37717471
DOI: 10.1016/j.neo.2023.100935 -
Medycyna Pracy Dec 2023The unexpected outbreak of the COVID-19 pandemic has led huge impact on health and safety of employees. Although now the epidemiological situation has improved, but it...
BACKGROUND
The unexpected outbreak of the COVID-19 pandemic has led huge impact on health and safety of employees. Although now the epidemiological situation has improved, but it remains a challenge, especially in light of the emergence of new threats. The aim of the work is to present an epidemiological analysis of data on COVID-19 as an occupational disease in Poland.
MATERIAL AND METHODS
The analysis covered all cases of occupational diseases sent by state sanitary inspectors to the Central Register of Occupational Diseases. The years 2020-2022 and such available data as: age, gender, activities and territorial differentiation were analyzed. The data were presented as absolute numbers and incidence rates per 100 000 employed persons and for healthcare workers also per 100 000 persons authorized to practice.
RESULTS
In the period 2020-2022 in Poland 7030 diseases recognized as occupational diseases were recorded, of which almost half were infectious diseases (47%). Among infectious diseases, dominated COVID-19 in number of 2059 cases. In this period 98.6% of all cases of COVID-19 were concentrated in the health care and social activities. According to workplaces, most diseases were caused by working in hospitals - 1825 cases (88.6% of all COVID-19 cases in the healthcare workers). Most cases concerned nurses - 1355 cases (65,8%) and doctors - 212 cases (10,3%). The incidence of COVID-19 in the group of physicians per 10 000 persons entitled to practice ranged from 2.6 in 2020 to 68.3 in 2022, while among nurses and midwives the rates were 7.9 and 194.9, respectively.
CONCLUSIONS
The COVID-19 pandemic changed the picture of occupational diseases in Poland. Therefore, it is very important to understand the key contributions of people working in environments where workers are at increased risk of contracting COVID-19 due to the nature of their work, and to promote the recognition of COVID-19 as an occupational disease. Med Pr Work Health Saf. 2023;74(6):479-86.
Topics: Humans; SARS-CoV-2; Poland; Pandemics; COVID-19; Occupational Diseases; Communicable Diseases
PubMed: 38160421
DOI: 10.13075/mp.5893.01437 -
Resuscitation Dec 2023
PubMed: 37898472
DOI: 10.1016/j.resuscitation.2023.110023