-
Frontiers in Microbiology 2024The associations between gut microbiota and cardiovascular disease have been reported in previous studies. However, the relationship between gut microbiota and...
BACKGROUND
The associations between gut microbiota and cardiovascular disease have been reported in previous studies. However, the relationship between gut microbiota and endocarditis remains unclear.
METHODS
A bidirectional Mendelian randomization (MR) study was performed to detect the association between gut microbiota and endocarditis. Inverse variance weighted (IVW) method was considered the main result. Simultaneously, heterogeneity and pleiotropy tests were conducted.
RESULTS
Our study suggests that family Victivallaceae ( = 0.020), genus group ( = 0.047), genus Escherichia Shigella ( = 0.024), genus Peptococcus ( = 0.028) and genus Sellimonas ( = 0.005) play protective roles in endocarditis. Two microbial taxa, including genus Blautia ( = 0.006) and genus Ruminococcus2 ( = 0.024) increase the risk of endocarditis. At the same time, endocarditis has a negative effect on genus group ( = 0.048). Besides, no heterogeneity or pleiotropy was found in this study.
CONCLUSION
Our study emphasized the certain role of specific gut microbiota in patients with endocarditis and clarified the negative effect of endocarditis on gut microbiota.
PubMed: 38298894
DOI: 10.3389/fmicb.2024.1320095 -
Scientific Reports Apr 2024The oral cavity harbors complex communities comprising bacteria, archaea, fungi, protozoa, and viruses. The oral microbiota is establish at birth and develops further...
The oral cavity harbors complex communities comprising bacteria, archaea, fungi, protozoa, and viruses. The oral microbiota is establish at birth and develops further during childhood, with early life factors such as birth mode, feeding practices, and oral hygiene, reported to influence this development and the susceptibility to caries. We here analyzed the oral bacterial composition in saliva of 260 Swedish children at two, three and five years of age using 16S rRNA gene profiling to examine its relation to environmental factors and caries development at five years of age. We were able to assign the salivary bacterial community in each child at each time point to one of seven distinct clusters. We observed an individual dynamic in the development of the oral microbiota related to early life factors, such as being first born, born by C-section, maternal perinatal antibiotics use, with a distinct transition between three and five years of age. Different bacterial signatures depending on age were related to increased caries risk, while Peptococcus consistently linked to reduced risk of caries development.
Topics: Infant, Newborn; Humans; Child, Preschool; RNA, Ribosomal, 16S; Dental Caries Susceptibility; Sweden; Mouth; Saliva; Bacteria; Dental Caries
PubMed: 38605085
DOI: 10.1038/s41598-024-59126-z