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Journal of Affective Disorders Jun 2024Agentive steadfastness was identified as a potential trait marker with which to anticipate prognostically that a patient will persevere steadfastly and take congruent... (Review)
Review
BACKGROUND
Agentive steadfastness was identified as a potential trait marker with which to anticipate prognostically that a patient will persevere steadfastly and take congruent action in facing the demands of living. Taken as an enduring expression of personality, this study investigated agentive steadfastness among adult social media respondents (n = 511) in relation to temperament and character as captured in Cloninger's psychobiological model of personality.
METHODS
Participants recruited though snowball sampling on social media platforms, applied the 27-item Agentive Steadfastness Index (ASI) and the 240-item Temperament and Character Inventory (TCI-R-240).
RESULTS
Agentive steadfastness was statistically predicted by the Self-directedness (β = 0.634), Self-transcendence (β = 0.119), Harm Avoidance (β = -0.142) and the Reward Dependence (β = 0.071) scales, accounting for 63.3 % of the variance in one stepwise regression model. In another stepwise model for the TCI-R-240 subscales, the Purposeful (β = 0.359), Anticipatory Worry (β = -0.353), and the Responsibility (β = 0.259) subscales accounted for respectively 56.8 %, 11.2 % and 2.8 % of the variance in ASI scores.
LIMITATIONS
Results are limited to adult social media respondents who were willing to participate.
CONCLUSIONS
Agentive steadfastness may serve as a trait marker of well-being and the good prognostic associations that have been established for high self-directedness, low harm avoidance, as well as resilience, and character strengths. It may be assessed clinically to anticipate prognostically the extent to which a patient will persevere steadfastly and take congruent action in facing the demands of living and adversity.
PubMed: 38844170
DOI: 10.1016/j.jad.2024.06.017 -
Scientific Reports Jul 2023This study aimed to explore the mediating and moderating effects of resilience and perseverance on pilots' self-efficacy and capability of handling special situations....
This study aimed to explore the mediating and moderating effects of resilience and perseverance on pilots' self-efficacy and capability of handling special situations. Using cluster sampling, 251 pilots' self-efficacy, special flight situation handling capability, resilience and perseverance were assessed using standardized scales. Pilots with high self-efficacy can improve their resilience to enhance their capability to handle special situations. An analysis was performed that included perseverance in the mediation model, and results showed that the influence of self-efficacy on special situation handling through resilience was moderated by perseverance. The relations between self-efficacy and special flight situation handling capability present a moderated mediation model. A pilot's capability of handling special situations, ensuring flight safety and combat capability may be enhanced by improving their self-efficacy, resilience, and perseverance.
Topics: Male; Humans; Pilots; Military Personnel; Self Efficacy
PubMed: 37402846
DOI: 10.1038/s41598-023-38009-9 -
Social Psychological and Personality... Jul 2023It is unknown how co-rumination, or perseverating on problems or feelings another person, unfolds in the daily lives of romantic couples. Using a variance decomposition...
It is unknown how co-rumination, or perseverating on problems or feelings another person, unfolds in the daily lives of romantic couples. Using a variance decomposition procedure on data from a 14-day dyadic diary, we assessed how much variance in co-rumination was attributable to temporally stable and varying factors, as well as whether co-rumination is better measured as a couple-level or individual-level process. Within-person, within-couple fluctuations in co-rumination contributed most (~33%) to the total variance and summary scores based on these fluctuations were reliable. Stable between-couple differences accounted for ~14% of the total variance and could also be reliably assessed. However, within-couple agreement in co-rumination was low, such that the reliability at the level of within-couple change was inadequate. Research is needed to understand these divergent perceptions of co-rumination and potential downstream consequences. We conclude by considering how these results inform theory and can be applied to similar dyadic constructs.
PubMed: 38333597
DOI: 10.1177/19485506221116989 -
Adicciones Mar 2024The objective of this study is to validate The Gambler's Beliefs Questionnaire, a measure of gamblers' cognitive distortions. The psychometric properties of the scale...
The objective of this study is to validate The Gambler's Beliefs Questionnaire, a measure of gamblers' cognitive distortions. The psychometric properties of the scale were analyzed with a Spanish sample of 515 participants aged from 16 and 24 years. Three scales related to pathological gambling (SOGS-RA and MAGS) and to social desirability were administered. A cross-sectional validation was performed, obtaining a scale with 21 items distributed in two independent factors (Luck/perseverance and Illusion of control). The internal consistency (α = .93) and test-retest reliability (r = .69) are adequate. GBQ scale scores correlate significantly with other measures of pathological gambling (SOGS: r = .35; MAGS: r = .40, both p ≤ .001). Higher levels of cognitive distortions are associated with a higher likelihood of being classified as a problem or at-risk gambler. GBQ scores are influenced by social desirability, although the effect sizes are small (r below .20). The GBQ is a useful instrument in the diagnosis and evaluation of the treatment of Spanish youths and adolescents with gambling problems.
Topics: Adolescent; Humans; Gambling; Reproducibility of Results; Cross-Sectional Studies; Surveys and Questionnaires; Research Design
PubMed: 36200228
DOI: 10.20882/adicciones.1719 -
Research Square Aug 2023Identification of children with sepsis-associated multiple organ dysfunction syndrome (MODS) at risk for poor outcomes remains a challenge. Data-driven phenotyping...
OBJECTIVE
Identification of children with sepsis-associated multiple organ dysfunction syndrome (MODS) at risk for poor outcomes remains a challenge. Data-driven phenotyping approaches that leverage electronic health record (EHR) data hold promise given the widespread availability of EHRs. We sought to externally validate the data-driven 'persistent hypoxemia, encephalopathy, and shock' (PHES) phenotype and determine its association with inflammatory and endothelial biomarkers, as well as biomarker-based pediatric risk-strata.
DESIGN
We trained and validated a random forest classifier using organ dysfunction subscores in the EHR dataset used to derive the PHES phenotype. We used the classifier to assign phenotype membership in a test set consisting of prospectively enrolled pediatric septic shock patients. We compared biomarker profiles of those with and without the PHES phenotype and determined the association with established biomarker-based mortality and MODS risk-strata.
SETTING
25 pediatric intensive care units (PICU) across the U.S.
PATIENTS
EHR data from 15,246 critically ill patients sepsis-associated MODS and 1,270 pediatric septic shock patients in the test cohort of whom 615 had biomarker data.
INTERVENTIONS
None.
MEASUREMENTS AND MAIN RESULTS
The area under the receiver operator characteristic curve (AUROC) of the new classifier to predict PHES phenotype membership was 0.91(95%CI, 0.90-0.92) in the EHR validation set. In the test set, patients with the PHES phenotype were independently associated with both increased odds of complicated course (adjusted odds ratio [aOR] of 4.1, 95%CI: 3.2-5.4) and 28-day mortality (aOR of 4.8, 95%CI: 3.11-7.25) after controlling for age, severity of illness, and immuno-compromised status. Patients belonging to the PHES phenotype were characterized by greater degree of systemic inflammation and endothelial activation, and overlapped with high risk-strata based on PERSEVERE biomarkers predictive of death and persistent MODS.
CONCLUSIONS
The PHES trajectory-based phenotype is reproducible, independently associated with poor clinical outcomes, and overlap with higher risk-strata based on validated biomarker approaches.
PubMed: 37577648
DOI: 10.21203/rs.3.rs-3216613/v1 -
Rheumatology (Oxford, England) Apr 2024Patients with RA were at increased risk for COVID-19-associated hospitalization and death during the first year of the pandemic in Greece. We aimed to examine their...
OBJECTIVES
Patients with RA were at increased risk for COVID-19-associated hospitalization and death during the first year of the pandemic in Greece. We aimed to examine their outcomes after the SARS-Cov-2 Omicron, a more contagious but with milder clinical impacts variant, prevailed.
METHODS
A retrospective, nationwide study was conducted between 1 January 2022 and 30 June 2022 in all RA patients under treatment and matched (1:5) on age, sex and region of domicile random general population comparators. Confirmed SARS-CoV-2 infections, hospitalizations and deaths, anti-rheumatic medications, prior COVID-19, vaccinations and anti-viral medications were recorded.
RESULTS
Among 34 182 RA patients, infections (n = 5569, 16.29%), hospitalizations (n = 489, 1.43%) and deaths (n = 106, 0.31%) were more frequent than among comparators. Incidence rates per 1000 person/years of infection [IRR (95% CI):1.19 (1.16, 1.23)], hospitalization [IRR (95% CI):2.0 (1.82, 2.24)], and death [IRR (95% CI):1.81 (1.44, 2.27)] were increased in RA despite better vaccination coverage (89% vs 84%) and more frequent use of anti-viral medications (2.37% vs 1.08). Logistic regression analysis after correcting for age, sex, vaccinations, prior COVID-19, and anti-viral medications in SARS-CoV-2 infected RA patients and comparators revealed increased risk of hospitalization (OR: 2.02, 95% CI: 1.79, 2.27) and death [OR: 1.73, (95% CI: 1.36, 2.20)] in RA. Among infected RA patients, rituximab treatment conferred increased risks for hospitalization [OR: 6.12, (95% CI: 2.89, 12.92)] and death [OR: 12.06 (95% CI: 3.90, 37.31)], while JAK inhibitors increased only hospitalization risk [OR: 2.18 (95% CI: 1.56, 3.06)].
CONCLUSION
RA remains a risk factor for hospitalization and death in an era of a relatively low COVID-19 fatality rate, pointing to the need of perseverance in vaccination programs and wider use of anti-viral medications.
Topics: Humans; COVID-19; Cohort Studies; SARS-CoV-2; Retrospective Studies; Greece; Arthritis, Rheumatoid; Antiviral Agents; Hospitalization
PubMed: 37467059
DOI: 10.1093/rheumatology/kead354 -
Journal of Applied Gerontology : the... Jul 2023Social prescribing is a non-clinical approach to addressing social, environmental, and economic factors affecting how people feel physical and/or emotionally. It...
Social prescribing is a non-clinical approach to addressing social, environmental, and economic factors affecting how people feel physical and/or emotionally. It involves connecting people to "community assets" (e.g., local groups, organizations, and charities) that can contribute to positive well-being. We sought to explain in what ways, for whom, and why the cultural sector can support social prescribing with older people. We conducted semi-structured interviews with 28 older people (aged 60+) and 25 cultural sector staff. The following nine concepts, developed from interview data, progressed the understanding of tailoring cultural offers, which came from our previous realist review- Through tailoring, we propose that older people might experience one or more of the following benefits from engaging with a cultural offer as part of social prescribing-being immersed, psychological holding, connecting, and transforming through self-growth.
Topics: Aged; Humans; Social Inclusion; Health Status
PubMed: 36724235
DOI: 10.1177/07334648231154043 -
Frontiers in Psychology 2023The concept of Grit refers to a person's ability to maintain perseverance and passion in the pursuit of long-term objectives. However, research on the applicability of...
BACKGROUND
The concept of Grit refers to a person's ability to maintain perseverance and passion in the pursuit of long-term objectives. However, research on the applicability of the Grit-Original scale (Grit-O) in the Latin American context is limited.
OBJECTIVE
This instrumental design study aimed to analyze the structure of this scale and its factorial invariance in relation to gender, as well as to examine its convergent validity with job satisfaction and happiness.
METHODS
A sample of 364 Peruvian workers that were selected through non-probabilistic convenience sampling in 2021.
RESULTS
The results of the confirmatory factor analysis showed that the two-dimensional structure of 12 items presented adequate goodness-of-fit indices. Additionally, the instrument is invariant between men and women. Likewise, the convergent relationship between the Grit scale, job satisfaction, and happiness variables was confirmed, which supports the validity of the instrument in the study context.
CONCLUSION
The findings of the study confirm that the GRIT-O is a measure with adequate psychometric properties in the Peruvian context.
PubMed: 37637915
DOI: 10.3389/fpsyg.2023.1234594 -
International Journal of Molecular... Jan 2024The mechanistic influences of dopamine (DA) signaling and impact on motor function are nearly always interpreted from changes in nigrostriatal neuron terminals in... (Review)
Review
The mechanistic influences of dopamine (DA) signaling and impact on motor function are nearly always interpreted from changes in nigrostriatal neuron terminals in striatum. This is a standard practice in studies of human Parkinson's disease (PD) and aging and related animal models of PD and aging-related parkinsonism. However, despite dozens of studies indicating an ambiguous relationship between changes in striatal DA signaling and motor phenotype, this perseverating focus on striatum continues. Although DA release in substantia nigra (SN) was first reported almost 50 years ago, assessment of nigral DA signaling changes in relation to motor function is rarely considered. Whereas DA signaling has been well-characterized in striatum at all five steps of neurotransmission (biosynthesis and turnover, storage, release, reuptake, and post-synaptic binding) in the nigrostriatal pathway, the depth of such interrogations in the SN, outside of cell counts, is sparse. However, there is sufficient evidence that these steps in DA neurotransmission in the SN are operational and regulated autonomously from striatum and are present in human PD and aging and related animal models. To complete our understanding of how nigrostriatal DA signaling affects motor function, it is past time to include interrogation of nigral DA signaling. This brief review highlights evidence that changes in nigral DA signaling at each step in DA neurotransmission are autonomous from those in striatum and changes in the SN alone can influence locomotor function. Accordingly, for full characterization of how nigrostriatal DA signaling affects locomotor activity, interrogation of DA signaling in SN is essential.
Topics: Animals; Humans; Dopamine; Signal Transduction; Synaptic Transmission; Corpus Striatum; Substantia Nigra; Parkinson Disease
PubMed: 38256204
DOI: 10.3390/ijms25021131 -
Frontiers in Behavioral Neuroscience 2023Impulsivity is a known risk factor for the development of substance use disorders and other psychiatric conditions that is influenced by both genetics and environment....
INTRODUCTION
Impulsivity is a known risk factor for the development of substance use disorders and other psychiatric conditions that is influenced by both genetics and environment. Although research has linked parental mental health to children's impulsivity, potential mediators of this relationship remain understudied. The current investigation leverages the large national Adolescent Brain Cognitive Development (ABCD) Study to assess the mediating role of family conflict - an important social context for youth development - in the relationship between parental mental health and youth impulsivity.
METHODS
Data were from the first three annual waves of the ABCD study (Baseline = 11,876 children, = 9.9 years; 48% female; 52% White). Parental mental health conditions were self-reported internalizing, externalizing, and total problems. Youth completed the family conflict scale, and Urgency, Planning (lack of), Perseverance (lack of), Sensation Seeking, and Positive Urgency (UPPS-P) scale to measure impulsivity. To determine if within-family change in conflict from baseline to year 1 explained changes in the strength of relations between baseline parental mental health and year 2 youth impulsivity, longitudinal causal mediation analyses were conducted, controlling for demographic factors (i.e., age, sex, race, household income, parental education, marital status), as well as baseline levels of family conflict and outcomes. Separate mediation models were run for each mental health condition and each UPPS-P subscale.
RESULTS
Above and beyond bivariate relations, longitudinal mediation models, which included covariates, showed family conflict significantly (s < 0.001) mediated relations between all three parental mental health conditions and all but one (i.e., sensation seeking) UPPS-P subscales. The proportion mediated through family conflict for internalizing problems and total problems on facets of impulsivity (except sensation seeking) ranged from 9% (for lack of perseverance) to 17% (for lack of planning). Proportion mediated via family conflict for externalizing problems on youth's impulsivity (except sensation seeking) was slightly higher, ranging between 13% (lack of perseverance) to 21% (lack of planning).
DISCUSSION
Family conflict may be an important intergenerational factor linking parental mental health and youth's impulsivity. Addressing parental mental health and family conflict may help curb increased impulsivity in youth, and in turn reduce adolescent substance use disorders.
PubMed: 37942273
DOI: 10.3389/fnbeh.2023.1213894