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Nature Communications Nov 2023Resorbable, implantable bioelectronic devices are emerging as powerful tools to reliably monitor critical physiological parameters in real time over extended periods....
Resorbable, implantable bioelectronic devices are emerging as powerful tools to reliably monitor critical physiological parameters in real time over extended periods. While degradable magnesium-based electronics have pioneered this effort, relatively short functional lifetimes have slowed clinical translation. Barrier films that are both flexible and resorbable over predictable timelines would enable tunability in device lifetime and expand the viability of these devices. Herein, we present a library of stereocontrolled succinate-based copolyesters which leverage copolymer composition and processing method to afford tunability over thermomechanical, crystalline, and barrier properties. One copolymer composition within this library has extended the functional lifetime of transient bioelectronic prototypes over existing systems by several weeks-representing a considerable step towards translational devices.
Topics: Polymers; Electronics
PubMed: 37949871
DOI: 10.1038/s41467-023-42775-5 -
Biosensors Jul 2023Spatial profiling technologies fill the gap left by the loss of spatial information in traditional single-cell sequencing, showing great application prospects. After... (Review)
Review
Spatial profiling technologies fill the gap left by the loss of spatial information in traditional single-cell sequencing, showing great application prospects. After just a few years of quick development, spatial profiling technologies have made great progress in resolution and simplicity. This review introduces the development of spatial omics sequencing based on microfluidic array chips and describes barcoding strategies using various microfluidic designs with simplicity and efficiency. At the same time, the pros and cons of each strategy are compared. Moreover, commercialized solutions for spatial profiling are also introduced. In the end, the future perspective of spatial omics sequencing and research directions are discussed.
Topics: Microfluidics
PubMed: 37504111
DOI: 10.3390/bios13070712 -
Progress in Biophysics and Molecular... 2023In 2021 I noted that in all information-based systems we understand, Cognition creates Code, which controls Chemical reactions. Known agents write software which... (Review)
Review
In 2021 I noted that in all information-based systems we understand, Cognition creates Code, which controls Chemical reactions. Known agents write software which controls hardware, and not the other way around. I proposed the same is true in all of biology. Though the textbook description of cause and effect in biology proposes the reverse, that Chemical reactions produce Code from which Cognition emerges, there are no examples in the literature demonstrating either step. A mathematical proof for the first step, cognition generating code, is based on Turing's halting problem. The second step, code controlling chemical reactions, is the role of the genetic code. Thus a central question in biology: What is the nature and source of cognition? In this paper I propose a relationship between biology and Quantum Mechanics (QM), hypothesizing that the same principle that enables an observer to collapse a wave function also grants biology its agency: the organism's ability to act on the world instead of merely being a passive recipient. Just as all living cells are cognitive (Shapiro 2021, 2007; McClintock 1984; Lyon 2015; Levin 2019; Pascal and Pross, 2022), I propose humans are quantum observers because we are made of cells and all cells are observers. This supports the century-old view that in QM, the observer does not merely record the event but plays a fundamental role in its outcome.The classical world is driven by laws, which are deductive; the quantum world is driven by choices, which are inductive. When the two are combined, they form the master feedback loop of perception and action for all biology. In this paper I apply basic definitions of induction, deduction and computation to known properties of QM to show that the organism altering itself (and its environment) is a whole shaping its parts. It is not merely parts comprising a whole. I propose that an observer collapsing the wave function is the physical mechanism for producing negentropy. The way forward in solving the information problem in biology is understanding the relationship between cognition and QM.
Topics: Humans; Cognition; Genetic Code; Software; Physics; Quantum Theory
PubMed: 37142170
DOI: 10.1016/j.pbiomolbio.2023.04.007 -
International Journal of Molecular... Mar 2024Thirty years ago, scientists' attention was focused on studying individual molecules, as well as their structure and function [...].
Thirty years ago, scientists' attention was focused on studying individual molecules, as well as their structure and function [...].
Topics: Russia; Biophysics
PubMed: 38612377
DOI: 10.3390/ijms25073565 -
Advanced Science (Weinheim,... Aug 2023Photoacoustic microscopy can image many biological molecules and nano-agents in vivo via low-scattering ultrasonic sensing. Insufficient sensitivity is a long-standing...
Photoacoustic microscopy can image many biological molecules and nano-agents in vivo via low-scattering ultrasonic sensing. Insufficient sensitivity is a long-standing obstacle for imaging low-absorbing chromophores with less photobleaching or toxicity, reduced perturbation to delicate organs, and more choices of low-power lasers. Here, the photoacoustic probe design is collaboratively optimized and a spectral-spatial filter is implemented. A multi-spectral super-low-dose photoacoustic microscopy (SLD-PAM) is presented that improves the sensitivity by ≈33 times. SLD-PAM can visualize microvessels and quantify oxygen saturation in vivo with ≈1% of the maximum permissible exposure, dramatically reducing potential phototoxicity or perturbation to normal tissue function, especially in imaging of delicate tissues, such as the eye and the brain. Capitalizing on the high sensitivity, direct imaging of deoxyhemoglobin concentration is achieved without spectral unmixing, avoiding wavelength-dependent errors and computational noises. With reduced laser power, SLD-PAM can reduce photobleaching by ≈85%. It is also demonstrated that SLD-PAM achieves similar molecular imaging quality using 80% fewer contrast agents. Therefore, SLD-PAM enables the use of a broader range of low-absorbing nano-agents, small molecules, and genetically encoded biomarkers, as well as more types of low-power light sources in wide spectra. It is believed that SLD-PAM offers a powerful tool for anatomical, functional, and molecular imaging.
Topics: Microscopy; Lasers; Ultrasonics; Light
PubMed: 37310419
DOI: 10.1002/advs.202302486 -
Nature Communications Nov 2023Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable...
Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable achievements, two major challenges hinder their practical application in medical settings. First, they necessitate sustainable energy solutions with biodegradable components via biosafe powering mechanisms. More importantly, reliability in their function is undermined by unpredictable device lifetimes due to the complex polymer degradation kinetics. Here, we propose an on-demand bioresorbable neurostimulator to address these issues, thus allowing for clinical operations to be manipulated using biosafe ultrasound sources. Our ultrasound-mediated transient mechanism enables (1) electrical stimulation through transcutaneous ultrasound-driven triboelectricity and (2) rapid device elimination using high-intensity ultrasound without adverse health effects. Furthermore, we perform neurophysiological analyses to show that our neurostimulator provides therapeutic benefits for both compression peripheral nerve injury and hereditary peripheral neuropathy. We anticipate that the on-demand bioresorbable neurostimulator will prove useful in the development of medical implants to treat peripheral neuropathy.
Topics: Humans; Absorbable Implants; Reproducibility of Results; Peripheral Nerve Injuries; Physics; Electric Stimulation
PubMed: 37951985
DOI: 10.1038/s41467-023-42791-5 -
International Journal of Molecular... Jul 2023Magneto-responsive textiles have emerged lately as an important carrier in various fields, including biomedical engineering. To date, most research has been performed on...
Magneto-responsive textiles have emerged lately as an important carrier in various fields, including biomedical engineering. To date, most research has been performed on single magnetic fibers and focused mainly on the physical characterization of magnetic textiles. Herein, from simple woven and non-woven textiles we engineered materials with magnetic properties that can become potential candidates for a smart magnetic platform for heating treatments. Experiments were performed on tissue-mimicking materials to test the textiles' heating efficiency in the site of interest. When the heat was induced with magneto-responsive textiles, the temperature increase in tissue-mimicking phantoms depended on several factors, such as the type of basic textile material, the concentration of magnetic nanoparticles deposited on the textile's surface, and the number of layers covering the phantom. The values of temperature elevation, achieved with the use of magnetic textiles, are sufficient for potential application in magnetic hyperthermia therapies and as heating patches or bandages.
Topics: Heating; Textiles; Hyperthermia, Induced; Hot Temperature; Magnetics
PubMed: 37511504
DOI: 10.3390/ijms241411744 -
Advanced Materials (Deerfield Beach,... Dec 2023Helical plants have the ability of tropisms to respond to natural stimuli, and biomimicry of such helical shapes into artificial muscles has been vastly popular....
Helical plants have the ability of tropisms to respond to natural stimuli, and biomimicry of such helical shapes into artificial muscles has been vastly popular. However, the shape-mimicked actuators only respond to artificially provided stimulus, they are not adaptive to variable natural conditions, thus being unsuitable for real-life applications where on-demand, autonomous operations are required. Novel artificial muscles made of hierarchically patterned helically wound yarns that are self-adaptive to environmental humidity and temperature changes are demonstrated here. Unlike shape-mimicked artificial muscles, a unique microstructural biomimicking approach is adopted, where the muscle yarns can effectively replicate the hydrotropism and thermotropism of helical plants to their microfibril level using plant-like microstructural memories. Large strokes, with rapid movement, are obtained when the individual microfilament of yarn is inlaid with hydrogel and further twisted into a coil-shaped hierarchical structure. The developed artificial muscle provides an average actuation speed of ≈5.2% s at expansion and ≈3.1% s at contraction cycles, being the fastest amongst previously demonstrated actuators of similar type. It is demonstrated that these muscle yarns can autonomously close a window in wet climates. The building block yarns are washable without any material degradation, making them suitable for smart, reusable textile and soft robotic devices.
Topics: Muscles; Textiles; Movement; Robotics; Humidity
PubMed: 36965152
DOI: 10.1002/adma.202212046 -
PloS One 2023We propose a model for the structure formation of jellyfish swimming based on active Brownian particles. We address the phenomena of counter-current swimming, avoidance...
We propose a model for the structure formation of jellyfish swimming based on active Brownian particles. We address the phenomena of counter-current swimming, avoidance of turbulent flow regions and foraging. We motivate corresponding mechanisms from observations of jellyfish swarming reported in the literature and incorporate them into the generic modelling framework. The model characteristics is tested in three paradigmatic flow environments.
Topics: Animals; Biomechanical Phenomena; Cnidaria; Scyphozoa; Physics; Swimming
PubMed: 37428796
DOI: 10.1371/journal.pone.0288378 -
Journal of Applied Clinical Medical... Oct 2023The American Association of Physicists in Medicine (AAPM) is a nonprofit professional society whose primary purposes are to advance the science, education, and...
The American Association of Physicists in Medicine (AAPM) is a nonprofit professional society whose primary purposes are to advance the science, education, and professional practice of medical physics. The AAPM has more than 8000 members and is the principal organization of medical physicists in the United States. The AAPM will periodically define new practice guidelines for medical physics practice to help advance the science of medical physics and to improve the quality of service to patients throughout the United States. Existing medical physics practice guidelines will be reviewed for the purpose of revision or renewal, as appropriate, on their fifth anniversary or sooner. Each medical physics practice guideline represents a policy statement by the AAPM, has undergone a thorough consensus process in which it has been subjected to extensive review, and requires the approval of the Professional Council. The medical physics practice guidelines recognize that the safe and effective use of diagnostic and therapeutic radiology requires specific training, skills, and techniques, as described in each document. Reproduction or modification of the published practice guidelines and technical standards by those entities not providing these services is not authorized. The following terms are used in the AAPM practice guidelines: Must and Must Not: Used to indicate that adherence to the recommendation is considered necessary to conform to this practice guideline. While must is the term to be used in the guidelines, if an entity that adopts the guideline has shall as the preferred term, the AAPM considers that must and shall have the same meaning. Should and Should Not: Used to indicate a prudent practice to which exceptions may occasionally be made in appropriate circumstances.
Topics: Humans; United States; Health Physics; Societies; Radiation Oncology; Peer Review
PubMed: 37708093
DOI: 10.1002/acm2.14151