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International Journal of Community... Oct 2023Premenstrual syndrome (PMS) is one of the causes of poor performance in women, with direct and indirect adverse effects on their marital, family, and social life. This... (Randomized Controlled Trial)
Randomized Controlled Trial
BACKGROUND
Premenstrual syndrome (PMS) is one of the causes of poor performance in women, with direct and indirect adverse effects on their marital, family, and social life. This study aimed to examine the effect of cognitive-behavioral counseling on resilience in adolescent girls with PMS.
METHODS
This randomized clinical trial was conducted from February to May 2018 on 15-17-year-old girl adolescents in Hamadan high schools. Using the block randomization method and the block size of 10, we randomly assigned 120 participants with moderate to severe PMS into intervention (N=60) and control groups (N=60). Participants in the intervention group received eight 60-minute cognitive-behavioral counseling sessions for 8 weeks, and the control group received no intervention. Data were gathered using demographic questionnaire, Premenstrual Symptoms Screening Tool, and the Connor-Davidson resilience scale. Statistical analysis was performed using SPSS version 16. The Chi-square, independent-samples t-test, and paired t-tests were used to analyze the data. P values <0.05 were considered significant.
RESULTS
The mean total resilience score and all its dimensions increased in the intervention group 3 months after the intervention (P<0.05). Mean scores of total resilience and all subscales except spiritual influences showed statistically significant differences between the intervention and control groups 3 months after the intervention (P<0.05).
CONCLUSION
Cognitive-behavioral counseling can improve resilience in female adolescents with moderate to severe PMS. It is recommended that school counselors can use cognitive-behavioral counseling to improve the resilience of girls with moderate to severe PMS. IRCT2015052615341N6.
Topics: Adolescent; Female; Humans; Premenstrual Syndrome; Counseling; Surveys and Questionnaires; Counselors; Cognition
PubMed: 37901183
DOI: 10.30476/IJCBNM.2023.99040.2276 -
Psychoneuroendocrinology May 2024Premenstrual dysphoric disorder (PMDD) is a mood disorder for which selective progesterone receptor modulator (SPRM) treatment has been demonstrated to be beneficial.... (Randomized Controlled Trial)
Randomized Controlled Trial
Premenstrual dysphoric disorder (PMDD) is a mood disorder for which selective progesterone receptor modulator (SPRM) treatment has been demonstrated to be beneficial. The neural signatures of this treatment have been so far identified as greater fronto-cingulate reactivity during aggressive response to provocation, but no changes in terms of gray matter structure. White matter has recently been found to differ between patients with PMDD and healthy controls. The present study thus sought to investigate the relationship between white matter volume and SPRM treatment in patients with PMDD. A pharmaco-neuroimaging study was conducted on patients with PMDD participating in a randomized controlled trial. Participants underwent magnetic resonance imaging before and after treatment randomization to ulipristal acetate (an SPRM), or placebo, for three months. The interaction effect of treatment by time on white matter volume (WMV) was assessed. Voxel based morphometry analyses were performed on both a whole brain exploratory level and on regions of interest. No treatment effect was observed on WMV in any region, including the anterior thalamic radiations, cingulum, forceps minor, fornix, inferior fronto-occipital fasciculus, superior cerebellar peduncle, superior longitudinal fasciculus, and uncinate fasciculus. This is the first finding to indicate that no white matter volume alterations follow three-month progesterone antagonism, suggesting that white matter volume does not participate in symptom relief upon SPRM treatment for PMDD.
Topics: Female; Humans; Premenstrual Dysphoric Disorder; White Matter; Receptors, Progesterone; Brain; Gray Matter
PubMed: 38295626
DOI: 10.1016/j.psyneuen.2024.106977 -
Quantitative Imaging in Medicine and... Mar 2024[This corrects the article DOI: 10.21037/qims-22-506.].
[This corrects the article DOI: 10.21037/qims-22-506.].
PubMed: 38545082
DOI: 10.21037/qims-2023-03 -
International Journal of Environmental... Nov 2023This study aims to clarify the association between the severity of dysmenorrhea and psychological distress among working women in central Tokyo and examine the effect...
This study aims to clarify the association between the severity of dysmenorrhea and psychological distress among working women in central Tokyo and examine the effect modification of job stressors. The participants in this cross-sectional study were 312 women who had undergone health check-ups in the "Marunouchi Hokenshitsu" project. The severity of dysmenorrhea was defined as the degree of daily life disturbance with menstrual pain, and the outcome variable was the K6 scores. To assess the association of psychological distress with the severity of dysmenorrhea, multiple regression analyses were performed. The results revealed that 18.3% of the 289 working women were in the moderate/severe group of dysmenorrhea. In multiple regression analysis, moderate/severe dysmenorrhea was significantly associated with higher levels of psychological distress, but the significance disappeared after adjusting for gynecology such as premenstrual syndrome (PMS) and workplace-related factors. The degree of job control was significantly associated with lower levels of psychological distress and may modify psychological distress caused by dysmenorrhea. Moderate/severe dysmenorrhea may be associated with higher levels of psychological distress in working women, and psychological symptoms of PMS) and the degree of job control were possible effect factors, and there may be effect modification by the degree of job control.
Topics: Humans; Female; Dysmenorrhea; Tokyo; Cross-Sectional Studies; Premenstrual Syndrome; Psychological Distress; Surveys and Questionnaires
PubMed: 37947577
DOI: 10.3390/ijerph20217021 -
Psychological Medicine Aug 2023The psychological risk factors of premenstrual dysphoric disorder (PMDD) are not fully understood, but initial evidence points to a potential role of unfavorable...
BACKGROUND
The psychological risk factors of premenstrual dysphoric disorder (PMDD) are not fully understood, but initial evidence points to a potential role of unfavorable cognitive emotion regulation (ER-) strategies. Given the symptom cyclicity of PMDD, ambulatory assessment is ideally suited to capture psychological and physiological processes across the menstrual cycle. Our study examines habitual ER-strategies in women with PMDD and their predictive value for the course of mood and basal cortisol across the cycle in affected women.
METHODS
Women with and without PMDD ( = 61 each) were compared regarding habitual mindfulness, reappraisal, and repetitive negative thinking (RNT). Momentary affect and cortisol output were assessed over two consecutive days per cycle phase (menstrual, follicular, ovulatory, late luteal).
RESULTS
Women with PMDD reported lower mindfulness, less use of reappraisal and stronger RNT than controls (s < 0.035). In women with PMDD, higher mindfulness and reappraisal and lower RNT predicted decreased negative and increased positive affect across the menstrual cycle (s < 0.027). However, women using more favorable ER-strategies displayed stronger mood cyclicity, resulting in stronger mood deterioration in the late luteal phase, thereby resembling women with more unfavorable ER-strategies toward the end of the cycle. Lower mindfulness predicted lower cortisol in the menstrual phase.
CONCLUSIONS
Protective ER-strategies seem to be generally linked to better momentary mood in women with PMDD, but do not appear to protect affected women from premenstrual mood deterioration. Habitual mindfulness, in turn, seems to buffer blunted cortisol activity in women with PMDD, especially in the menstrual phase.
Topics: Female; Humans; Premenstrual Dysphoric Disorder; Hydrocortisone; Premenstrual Syndrome; Emotional Regulation; Follicular Phase; Menstrual Cycle; Cognition
PubMed: 35979813
DOI: 10.1017/S0033291722002495 -
Annals of Medicine and Surgery (2012) May 2024Saffron, derived from Crocus sativus, is gaining research attention for potential therapeutic applications. Its diverse clinical applications extend to cardiovascular... (Review)
Review
Saffron, derived from Crocus sativus, is gaining research attention for potential therapeutic applications. Its diverse clinical applications extend to cardiovascular health, diabetes management, sleep quality, psychiatric illnesses, and rheumatoid arthritis. Saffron's positive effects on blood pressure, glucose levels, cognitive function, and inflammatory markers contribute to its versatility. Additionally, carotenoids like crocin and crocetin suggest anti-cancer potential. In terms of reproductive health, saffron's impact on male reproductive health shows conflicting findings on semen parameters. However, in female reproductive health, saffron appears promising for managing dysmenorrhoea, reducing menstrual pain, regulating hormonal fluctuations, and improving overall menstrual health. Safety considerations highlight the importance of adhering to specified dosages, as excessive intake may lead to toxicity. Yet, within the therapeutic range, saffron is considered safe, relieving symptoms without serious side effects, according to clinical research. Future trials in 2023 will explore saffron's potential in cancer therapy, diabetes management, mental health, stress response, cardiovascular health, postmenopausal women's well-being, and chronic obstructive pulmonary disease (COPD). This ongoing research underscores saffron's adaptability and promise as a natural treatment across various medical applications, emphasizing its efficacy. The current review, therefore, aims to provide up-to-date insights on saffron's role particularly in the realm of reproductive health, contributing to a growing body of evidence supporting its diverse therapeutic benefits.
PubMed: 38694315
DOI: 10.1097/MS9.0000000000002013 -
National Toxicology Program Technical... Dec 2023Black cohosh (Actaea racemose L.) is widely used as a botanical dietary supplement to alleviate female gynecological symptoms, such as premenstrual syndrome and changes...
Toxicology and carcinogenesis studies of black cohosh root extract (CASRN 84776-26-1) administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats and female B6C3F1/N mice.
Black cohosh (Actaea racemose L.) is widely used as a botanical dietary supplement to alleviate female gynecological symptoms, such as premenstrual syndrome and changes associated with menopause, and to stimulate labor. Despite its popularity, limited data are available on the long-term safety of black cohosh products. To address this knowledge gap, 2-year National Toxicology Program (NTP) carcinogenicity studies were conducted in Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. To emulate a potential human exposure scenario in which a woman might use black cohosh throughout pregnancy and lactation, perinatal exposure was included for the rat study. (Abstract Abridged).
PubMed: 38127057
DOI: 10.22427/NTP-TR-603 -
Nutrients Dec 2023Dysregulated food craving is a complex weight-related behavior. To identify novel targets for enhancing the efficacy of weight loss interventions, we examined whether...
Dysregulated food craving is a complex weight-related behavior. To identify novel targets for enhancing the efficacy of weight loss interventions, we examined whether food craving varies across the menstrual cycle according to the abdominal obesity type and premenstrual dysphoric disorder (PMDD) diagnosis, and, if so, whether it is related to affective symptomatology. Reproductive-age women were classified into one of the four study groups according to whether they have abdominal obesity (AO) or are abdominally lean (AL), and the presence of PMDD: (1) AO:PMDD+ (n = 13), (2) AL:PMDD+ (n = 14), (3) AO:PMDD- (n = 15), and (4) AL:PMDD- (n = 16). Self-report measures as well as urinary luteinizing hormone (LH) tests were provided by the participants across 2-3 menstrual cycles. The ratings of food cravings were similar across the menstrual cycle, except the last, late luteal subphase as the AO:PMDD+ participants had the highest food craving rating. Irritability and depression were correlated with food cravings, but not in a distinctive manner across the menstrual cycle by group. Our study found that women with abdominal obesity and PMDD display a temporal vulnerability to a food-related behavior. The possibility of shared neurobiology between the two conditions is discussed and should be examined in future studies.
Topics: Female; Humans; Premenstrual Dysphoric Disorder; Craving; Lutein; Luteal Phase; Obesity, Abdominal; Menstrual Cycle; Obesity
PubMed: 38068858
DOI: 10.3390/nu15235000 -
Women's Health (London, England) 2024Premenstrual dysphoric disorder is a depressive disorder affecting 5%-8% of people with menstrual cycles. Despite evidence that facial emotion detection is altered in...
BACKGROUND
Premenstrual dysphoric disorder is a depressive disorder affecting 5%-8% of people with menstrual cycles. Despite evidence that facial emotion detection is altered in depressive disorders, with enhanced detection of negative emotions (negativity bias), minimal research exists on premenstrual dysphoric disorder.
OBJECTIVES
The goal of this study was to investigate the effect of premenstrual dysphoric disorder symptoms and the premenstrual phase on accuracy and intensity at detection of facial emotions.
DESIGN
Cross-sectional quasi-experimental design.
METHOD
The Facial Emotion Detection Task was administered to 72 individuals assigned female at birth with no premenstrual dysphoric disorder ( = 30), and provisional PMDD ( = 42), based on a retrospective -based measure of premenstrual dysphoric disorder. Facial emotion detection was examined both irrespective of menstrual cycle phase, and as a function of premenstrual phase (yes, no). The task used neutral-to-emotional facial expression morphs (15 images/morph). Participants indicated the emotion detected for each image within the progressive intensity morph. For all six basic emotions (sad, angry, fearful, happy, disgust, and surprise), two scores were calculated: accuracy of responses and the intensity within the morph at which the correct emotion was first detected (image number).
RESULTS
Individuals reporting moderate/severe symptoms of premenstrual dysphoric disorder had more accurate and earlier detection of disgust, regardless of cycle phase. In addition, those with provisional premenstrual dysphoric disorder detected sad emotions earlier. A premenstrual dysphoric disorder group × cycle phase interaction also emerged: individuals reporting premenstrual dysphoric disorder symptoms were more accurate at detecting facial emotions during the premenstrual phase compared to the rest of the cycle, with a large effect size for sad emotions.
CONCLUSION
The findings suggest enhanced facial emotion processing in individuals reporting symptoms of premenstrual dysphoric disorder, particularly for sadness and disgust. However, replication is required with larger samples and prospective designs. This premenstrual dysphoric disorder premenstrual emotion detection advantage suggests an adaptive cognitive mechanism in premenstrual syndrome/premenstrual dysphoric disorder, and challenges stigma surrounding premenstrual experiences.
Topics: Humans; Female; Premenstrual Dysphoric Disorder; Cross-Sectional Studies; Emotions; Adult; Facial Expression; Menstrual Cycle; Young Adult; Premenstrual Syndrome
PubMed: 38877749
DOI: 10.1177/17455057241259176 -
Journal of Psychopathology and Clinical... Aug 2023Suicide is a leading cause of death among females of reproductive age. The menstrual cycle is a plausible yet understudied trigger for acute suicide risk....
Suicide is a leading cause of death among females of reproductive age. The menstrual cycle is a plausible yet understudied trigger for acute suicide risk. Cross-sectional studies have demonstrated a greater frequency of suicide attempts and deaths in the weeks before and after the onset of menses compared to other cycle phases. Here, using prospective daily ratings, we examine the relationship between the cycle and suicidal ideation (SI) and related symptoms known to show a cyclical change in some patients (depression, hopelessness, guilt, rejection sensitivity, interpersonal conflict, anxiety, mood swings, and anger/irritability). Thirty-eight naturally cycling outpatients recruited for past-month SI reported SI severity and other symptoms across an average of 40 days. Participants were excluded for hormone use, pregnancy, irregular cycles, serious medical illness, and body mass index > 29.9 or < 18. Intraclass correlations ranged from .29 to .46, highlighting that most symptom variance lies within-person. Cyclical worsening of symptoms was evaluated using phase contrasts in multilevel models. Most symptoms, including SI, were significantly worse in the perimenstrual phase than in all other phases. Additionally, anger/irritability was higher in the midluteal than in the midfollicular phase, and several symptoms of depression were higher in the midfollicular than in the periovulatory phase. Otherwise, symptoms did not significantly differ between the midluteal, midfollicular, and periovulatory phases. Cycle phase predictors accounted for 25% of the within-person variance in SI. Females with SI may be at risk for perimenstrual worsening of SI and related symptoms. These findings highlight the importance of assessing the cycle phase for improved prediction of suicide risk. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Topics: Humans; Female; Suicidal Ideation; Outpatients; Cross-Sectional Studies; Prospective Studies; Suicide, Attempted; Premenstrual Syndrome
PubMed: 37326562
DOI: 10.1037/abn0000838