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Endocrinology, Diabetes & Metabolism... Oct 2023We report a 61-year-old male patient without personal history of thyroid carcinoma or radiation exposure. In 2011, he presented with a cervical mass whose biopsy...
SUMMARY
We report a 61-year-old male patient without personal history of thyroid carcinoma or radiation exposure. In 2011, he presented with a cervical mass whose biopsy diagnosed a papillary thyroid carcinoma (PTC) in a lymph node metastasis (LNM). Total thyroidectomy with lymphadenectomy of central and ipsilateral compartment was performed. Histopathology identified a 2 mm follicular variant of PTC and LNM in 25/25 lymph nodes. The patient was treated with 150 mCi of radioactive iodine (RAI), followed by levothyroxine suppressive therapy. In 2016, a retrotracheal mass was diagnosed, suggesting local recurrence; patient was submitted to surgical excision and RAI therapy (120 mCi). Due to seizures, in 2019, a brain CT was performed that diagnosed brain metastases. The patient underwent debulking of the main lesion. Histopathology analysis confirmed a metastatic lesion with variated morphology: classical PTC and follicular pattern and hobnail and tall cell features. Molecular analysis revealed BRAFV600E in LNM at presentation and BRAFV600E and TERT promoter (TERTp) mutations in the recurrent LNM and brain metastasis. Based upon this experience we review the reported cases of subcentimetric PTC with brain metastases and discuss the molecular progression of the present case.
LEARNING POINTS
Papillary microcarcinoma (PMCs) usually have very good prognosis with low impact on patient survival. PMCs presenting in elderly patients with LNM at diagnosis may carry a guarded outcome. Brain metastasis although rare indicate aggressive phenotypic features. Patient risk stratification of PMCs based on histopathological analysis and genetic testing may have a significant impact on prognosis providing therapeutic markers, that may predict disease progression and overall outcome.
PubMed: 38108305
DOI: 10.1530/EDM-23-0025 -
Multimedia Manual of Cardiothoracic... Jul 2023Uniportal video-assisted thoracic surgery has grown in popularity in recent years, becoming the treatment of choice for minimally invasive resections of mediastinal...
Uniportal video-assisted thoracic surgery has grown in popularity in recent years, becoming the treatment of choice for minimally invasive resections of mediastinal lesions. The many advantages of video-assisted thoracic surgery, including decreasing postoperative pain, morbidity and length of hospitalization, have increased its utilization for optimal patient care. In our case, this approach was used on a 55-year-old female patient who presented with a retrotracheal mass protruding through the thoracic inlet. The resection was performed through the chest via a uniportal video-assisted thoracic surgery technique with an unremarkable operative and postoperative course.
Topics: Female; Humans; Middle Aged; Parathyroid Glands; Thoracic Surgery, Video-Assisted; Pain, Postoperative; Mediastinum; Postoperative Period
PubMed: 37435871
DOI: 10.1510/mmcts.2023.013