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Sports Medicine (Auckland, N.Z.) Mar 2021Technology has long been used to track player movements in team sports, with initial tracking via manual coding of video footage. Since then, wearable microtechnology in...
BACKGROUND
Technology has long been used to track player movements in team sports, with initial tracking via manual coding of video footage. Since then, wearable microtechnology in the form of global and local positioning systems has provided a less labour-intensive way of monitoring movements. As such, there has been a proliferation in research pertaining to these devices.
OBJECTIVE
A systematic review of studies that investigate the validity and/or reliability of wearable microtechnology to quantify movement and specific actions common to intermittent team sports.
METHODS
A systematic search of CINAHL, MEDLINE, and SPORTDiscus was performed; studies included must have been (1) original research investigations; (2) full-text articles written in English; (3) published in a peer-reviewed academic journal; and (4) assessed the validity and/or reliability of wearable microtechnology to quantify movements or specific actions common to intermittent team sports.
RESULTS
A total of 384 studies were retrieved and 187 were duplicates. The titles and abstracts of 197 studies were screened and the full texts of 88 manuscripts were assessed. A total of 62 studies met the inclusion criteria. Additional 10 studies, identified via reference list assessment, were included. Therefore, a total of 72 studies were included in this review.
CONCLUSION
There are many studies investigating the validity and reliability of wearable microtechnology to track movement and detect sport-specific actions. It is evident that for the majority of metrics, validity and reliability are multi-factorial, in that it is dependent upon a wide variety of factors including wearable technology brand and model, sampling rate, type of movement performed (e.g., straight line, change of direction) and intensity of movement (e.g., walk, sprint). Practitioners should be mindful of the accuracy and repeatability of the devices they are using when making decisions on player training loads.
Topics: Humans; Microtechnology; Reproducibility of Results; Sports; Team Sports; Wearable Electronic Devices
PubMed: 33368031
DOI: 10.1007/s40279-020-01399-1 -
Sports Medicine - Open Jan 2022Collisions in rugby union and sevens have a high injury incidence and burden, and are also associated with player and team performance. Understanding the frequency and...
BACKGROUND
Collisions in rugby union and sevens have a high injury incidence and burden, and are also associated with player and team performance. Understanding the frequency and intensity of these collisions is therefore important for coaches and practitioners to adequately prepare players for competition. The aim of this review is to synthesise the current literature to provide a summary of the collision frequencies and intensities for rugby union and rugby sevens based on video-based analysis and microtechnology.
METHODS
A systematic search using key words was done on four different databases from 1 January 1990 to 1 September 2021 (PubMed, Scopus, SPORTDiscus and Web of Science).
RESULTS
Seventy-three studies were included in the final review, with fifty-eight studies focusing on rugby union, while fifteen studies explored rugby sevens. Of the included studies, four focused on training-three in rugby union and one in sevens, two focused on both training and match-play in rugby union and one in rugby sevens, while the remaining sixty-six studies explored collisions from match-play. The studies included, provincial, national, international, professional, experienced, novice and collegiate players. Most of the studies used video-based analysis (n = 37) to quantify collisions. In rugby union, on average a total of 22.0 (19.0-25.0) scrums, 116.2 (62.7-169.7) rucks, and 156.1 (121.2-191.0) tackles occur per match. In sevens, on average 1.8 (1.7-2.0) scrums, 4.8 (0-11.8) rucks and 14.1 (0-32.8) tackles occur per match.
CONCLUSIONS
This review showed more studies quantified collisions in matches compared to training. To ensure athletes are adequately prepared for match collision loads, training should be prescribed to meet the match demands. Per minute, rugby sevens players perform more tackles and ball carries into contact than rugby union players and forwards experienced more impacts and tackles than backs. Forwards also perform more very heavy impacts and severe impacts than backs in rugby union. To improve the relationship between matches and training, integrating both video-based analysis and microtechnology is recommended. The frequency and intensity of collisions in training and matches may lead to adaptations for a "collision-fit" player and lend itself to general training principles such as periodisation for optimum collision adaptation. Trial Registration PROSPERO registration number: CRD42020191112.
PubMed: 35050440
DOI: 10.1186/s40798-021-00398-4 -
Electrophoresis Jul 2022Accurate manipulation of fluids in microfluidic devices is an important factor affecting their functions. Since the emergence of microfluidic technology to transport... (Review)
Review
Accurate manipulation of fluids in microfluidic devices is an important factor affecting their functions. Since the emergence of microfluidic technology to transport fluids in microchannels, the electric field has been utilized as an effective dynamic pumping mechanism. This review attempts to provide a fundamental insight of the various electric-driven flows in microchannels and their working mechanisms as micropumps for microfluidic devices. Different electrokinetic mechanisms implemented in electrohydrodynamic-, electroosmosis-, electrothermal, and dielectrophoresis-based micropumps are discussed. A detailed description of different mechanisms is presented to provide a comprehensive overview on the key parameters used in electric micropumps. Furthermore, electrode configurations and their shapes in different micropumps are explored and categorized to provide conclusive information for the selection of efficient, simple, and affordable strategies to transport fluids in microfluidic devices. In this paper, recent theoretical, numerical and experimental investigations are covered to provide a better insight both on the operational mechanisms and strategies for lab-on-chip applications.
Topics: Electricity; Electrodes; Electroosmosis; Microfluidic Analytical Techniques; Microfluidics
PubMed: 35452525
DOI: 10.1002/elps.202100317 -
Biosensors & Bioelectronics Apr 2022It has been reported that more than 90% of cancer patients are died from cancer metastasis. Circulating tumor cells (CTCs) could detach from solid tumors to form new... (Review)
Review
It has been reported that more than 90% of cancer patients are died from cancer metastasis. Circulating tumor cells (CTCs) could detach from solid tumors to form new lesions via blood transport and play an important role in cancer metastasis and progression. As part of the liquid biopsy, the investigation and analysis toward CTCs are of great importance for prognosis assessment and tumor precision medical treatment. Unfortunately, the enrichment of circulating tumor cells has been a huge challenge due to the fact that CTCs are very rare and vulnerable. Thus, a number of effective strategies have been developed for the enrichment of CTCs. This paper discusses the advantages and disadvantages of label-free and label-based methods commonly used in the isolation of CTCs. In particular, we systematically review the most recent advances in the combination of microfluidic chips and biosensing for the enrichment of circulating tumor cells. Finally, we put forward the current barriers that need to be overcome and developmental trends in the CTCs research.
Topics: Biosensing Techniques; Cell Separation; Humans; Liquid Biopsy; Microfluidic Analytical Techniques; Microfluidics; Neoplastic Cells, Circulating
PubMed: 35078145
DOI: 10.1016/j.bios.2022.114025 -
Advanced Drug Delivery Reviews 2020Microneedles (MNs) have been used to deliver drugs for over two decades. These platforms have been proven to increase transdermal drug delivery efficiency dramatically...
Microneedles (MNs) have been used to deliver drugs for over two decades. These platforms have been proven to increase transdermal drug delivery efficiency dramatically by penetrating restrictive tissue barriers in a minimally invasive manner. While much of the early development of MNs focused on transdermal drug delivery, this technology can be applied to a variety of other non-transdermal biomedical applications. Several variations, such as multi-layer or hollow MNs, have been developed to cater to the needs of specific applications. The heterogeneity in the design of MNs has demanded similar variety in their fabrication methods; the most common methods include micromolding and drawing lithography. Numerous materials have been explored for MN fabrication which range from biocompatible ceramics and metals to natural and synthetic biodegradable polymers. Recent advances in MN engineering have diversified MNs to include unique shapes, materials, and mechanical properties that can be tailored for organ-specific applications. In this review, we discuss the design and creation of modern MNs that aim to surpass the biological barriers of non-transdermal drug delivery in ocular, vascular, oral, and mucosal tissue.
Topics: Administration, Topical; Biological Transport; Drug Delivery Systems; Equipment Design; Humans; Microinjections; Microtechnology; Polymers; Prostheses and Implants
PubMed: 31837356
DOI: 10.1016/j.addr.2019.11.010 -
Sports Medicine - Open Jan 2020Collisions (i.e. tackles, ball carries, and collisions) in the rugby league have the potential to increase injury risk, delay recovery, and influence individual and team... (Review)
Review
BACKGROUND
Collisions (i.e. tackles, ball carries, and collisions) in the rugby league have the potential to increase injury risk, delay recovery, and influence individual and team performance. Understanding the collision demands of the rugby league may enable practitioners to optimise player health, recovery, and performance.
OBJECTIVE
The aim of this review was to (1) characterise the dose of collisions experienced within senior male rugby league match-play and training, (2) systematically and critically evaluate the methods used to describe the relative and absolute frequency and intensity of collisions, and (3) provide recommendations on collision monitoring.
METHODS
A systematic search of electronic databases (PubMed, SPORTDiscus, Scopus, and Web of Science) using keywords was undertaken. A meta-analysis provided a pooled mean of collision frequency or intensity metrics on comparable data sets from at least two studies.
RESULTS
Forty-three articles addressing the absolute (n) or relative collision frequency (n min) or intensity of senior male rugby league collisions were included. Meta-analysis of video-based studies identified that forwards completed approximately twice the number of tackles per game than backs (n = 24.6 vs 12.8), whilst ball carry frequency remained similar between backs and forwards (n = 11.4 vs 11.2). Variable findings were observed at the subgroup level with a limited number of studies suggesting wide-running forwards, outside backs, and hit-up forwards complete similar ball carries whilst tackling frequency differed. For microtechnology, at the team level, players complete an average of 32.7 collisions per match. Limited data suggested hit-up and wide-running forwards complete the most collisions per match, when compared to adjustables and outside backs. Relative to playing time, forwards (n min = 0.44) complete a far greater frequency of collision than backs (n min = 0.16), with data suggesting hit-up forwards undertake more than adjustables, and outside backs. Studies investigating g force intensity zones utilised five unique intensity schemes with zones ranging from 2-3 g to 13-16 g. Given the disparity between device setups and zone classification systems between studies, further analyses were inappropriate. It is recommended that practitioners independently validate microtechnology against video to establish criterion validity.
CONCLUSIONS
Video- and microtechnology-based methods have been utilised to quantify collisions in the rugby league with differential collision profiles observed between forward and back positional groups, and their distinct subgroups. The ball carry demands of forwards and backs were similar, whilst tackle demands were greater for forwards than backs. Microtechnology has been used inconsistently to quantify collision frequency and intensity. Despite widespread popularity, a number of the microtechnology devices have yet to be appropriately validated. Limitations exist in using microtechnology to quantify collision intensity, including the lack of consistency and limited validation. Future directions include application of machine learning approaches to differentiate types of collisions in microtechnology datasets.
PubMed: 31970529
DOI: 10.1186/s40798-019-0233-9 -
Sports Medicine - Open Feb 2021Global positioning systems (GPS) imbedded with accelerometer systems (AS) are used in rugby union (RU) to collect information on absolute and relative distances,...
BACKGROUND
Global positioning systems (GPS) imbedded with accelerometer systems (AS) are used in rugby union (RU) to collect information on absolute and relative distances, distances in different speed zones, high-speed running (HSR) distances, repeated high-intensity efforts (RHIE) and collisions and impacts. This information can be used to monitor match play which can then be used to plan training sessions. The objective of this review was to conduct a systematic review of studies which have reported the use of GPS and AS.
METHODS
A systematic review of the use of GPS and AS in both age-grade and senior rugby was conducted. The authors systematically searched electronic databases from January 2010 until March 2020. Keywords included rugby union, GPS, global position* and microtechnology.
RESULTS
A total of 51 studies met the eligibility criteria and were included in this review. There was a total of 34 studies utilising GPS and AS in senior RU players (mean ± SD; age 26.2 ± 1.9 years; height 185.7 ± 2.6 cm; mass 101.3 ± 4.2 kg) and 17 studies in age-grade RU players (mean ± SD; age 17.6 ± 1.5 years; height 182.1 ± 3.3 cm; mass 87.1 ± 8.6 kg). The results of this review highlighted that there are differences between backs and forwards and within these positions in these groups during both match play and training sessions. The backs covered greater total absolute, relative and HSR distance compared to forwards. Forwards are involved in more collisions and impacts than backs. When investigating the most intense periods of match play, studies in this review highlighted that the demands during these periods outweigh the average demands of the game. It was proposed that a rolling average over different time epochs is the best way to assess this and ensure that the most intense periods of play are assessed and monitored.
CONCLUSIONS
The information highlighted in this review can be used to help coaches assess performances in match play, allow them to plan appropriate training sessions and monitor training load.
PubMed: 33616786
DOI: 10.1186/s40798-021-00305-x -
Diagnostics (Basel, Switzerland) Jun 2022Human Papilloma Virus (HPV) represents the most prevalent genital infection in young women of reproductive age. (Review)
Review
BACKGROUND
Human Papilloma Virus (HPV) represents the most prevalent genital infection in young women of reproductive age.
OBJECTIVE
This systematic review aims to estimate the effect of HPV infection during pregnancy and assess the correlation between HPV and adverse pregnancy outcomes.
MATERIALS AND METHODS
The search strategy has been developed based on the PICOS framework: Population (pregnant women infected with HPV), Intervention (HPV infection confirmed by molecular tests), Comparator (pregnant women without HPV infection), Outcomes (adverse pregnancy outcomes) and Study design (observational studies). We searched PubMed, Web of Science, and Scopus databases on 8 January 2022 by using the following keywords: "HPV", "prematurity", "preterm birth", "miscarriage", "premature rupture of membranes", "adverse pregnancy outcome", "low birth weight", "fetal growth restriction", "pregnancy-induced hypertensive disorders", "preeclampsia". Selection criteria were HPV infection confirmed within maximum 2 years before pregnancy with a molecular test and adverse pregnancy outcomes. (Results: Although numerous studies are conducted on this topic, data are still controversial regarding identifying maternal HPV infection as a risk factor for adverse pregnancy outcomes. More prospective large cohort studies are needed to prove a causative relationship.
PubMed: 35741280
DOI: 10.3390/diagnostics12061471 -
Electrophoresis Apr 2022Tumor microenvironment is a multicomponent system consisting of tumor cells, noncancer cells, extracellular matrix, and signaling molecules, which hosts tumor cells with... (Review)
Review
Tumor microenvironment is a multicomponent system consisting of tumor cells, noncancer cells, extracellular matrix, and signaling molecules, which hosts tumor cells with integrated biophysical and biochemical elements. Because of its critical involvement in tumor genesis, invasion, metastasis, and resistance, the tumor microenvironment is emerging as a hot topic of tumor biology and a prospective therapeutic target. Unfortunately, the complex of microenvironment modeling in vitro is technically challenging and does not effectively generalize the local tumor tissue milieu. Recently, significant advances in microfluidic technologies have provided us with an approach to imitate physiological systems that can be utilized to mimic the characterization of tumor responses with pathophysiological relevance in vitro. In this review, we highlight the recent progress and innovations in microfluidic technology that facilitates the tumor microenvironment study. We also discuss the progress and future perspective of microfluidic bionic approaches with high efficiency for the study of tumor microenvironment and the challenges encountered in cancer research, drug discovery, and personalized therapy.
Topics: Biomimetics; Humans; Lab-On-A-Chip Devices; Microfluidics; Neoplasms; Tumor Microenvironment
PubMed: 35179796
DOI: 10.1002/elps.202100360 -
Research in Sports Medicine (Print) 2020The aim of this article was to systematically review the methods adopted to collect and interpret external training load (ETL) using microtechnology incorporating global...
The aim of this article was to systematically review the methods adopted to collect and interpret external training load (ETL) using microtechnology incorporating global positioning system (GPS). The main deficiencies identified concerned the non-collection of match ETL, and the non-consideration of potential confounders (e.g. playing position, fitness level, starting status or session content). Also, complementary training (individual/reconditioning) and pre-match warm-up were rarely quantified. To provide a full picture of the training demands, ETL was commonly complemented by internal training load monitoring with the rating of perceived exertion predominantly adopted instead of heart rate recordings. Continuous data collection and interpretation of ETL data in professional football vary widely between observational studies, possibly reflecting the actual procedures adopted in practical settings. Evidence about continuous ETL monitoring in female players, and female as well as male goalkeepers is lacking.
Topics: Athletic Performance; Geographic Information Systems; Humans; Microtechnology; Soccer
PubMed: 31755307
DOI: 10.1080/15438627.2019.1686703