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BMC Oral Health Jul 2022Several studies have demonstrated association between coffee consumption and periodontal diseases. However, no systematic review and meta-analysis was performed.... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Several studies have demonstrated association between coffee consumption and periodontal diseases. However, no systematic review and meta-analysis was performed. Therefore, we performed a systematic review and meta-analysis to evaluate the association between coffee intake and periodontitis.
METHODS
We defined PICO statement as "Do coffee drinkers have a higher association of periodontitis or tooth loss than non-coffee drinkers?". We searched for articles using the Embase and Medline databases. The odds ratio was used as an effect measure to evaluate the association between coffee and periodontitis We divided coffee intake doses into three groups: no intake (≤ 0.03 cups/day), low intake (0.03 < x < 1 cups/day), and high intake (≥ 1 cup/day). Cohort and cross-sectional studies were eligible for inclusion in this study. The Newcastle-Ottawa scale was used to qualitatively assess the risk of bias. The degree of heterogeneity between studies was quantified using I statistics.
RESULTS
Six articles were analysed, including two cohort studies and four cross-sectional studies. The pooled unadjusted odds ratios of periodontitis were 1.14 (0.93-1.39), 1.05 (0.73-1.52), 1.03 (0.91-1.16) and 1.10 (0.84-1.45) in the 4 meta-analyses (coffee drinker vs. non-coffee drinker, high intake vs. low intake, low intake vs. no intake, high intake vs. no intake), respectively.
CONCLUSION
This is the first meta-analysis to investigate the relationship between coffee consumption and periodontitis. There was no relationship between coffee consumption and periodontitis. Further studies are required to assess whether a relationship between coffee consumption and periodontitis exists or not. PROSPERO registration number: CRD42022301341.
Topics: Cohort Studies; Cross-Sectional Studies; Humans; Odds Ratio; Periodontitis; Risk Factors
PubMed: 35790921
DOI: 10.1186/s12903-022-02310-2 -
Scientific Reports Sep 2023To explore the efficacy and safety of fecal microbiota transplantation (FMT) as a treatment approach for ulcerative colitis (UC), a comprehensive systematic review and... (Meta-Analysis)
Meta-Analysis
To explore the efficacy and safety of fecal microbiota transplantation (FMT) as a treatment approach for ulcerative colitis (UC), a comprehensive systematic review and meta-analysis of randomized controlled trials was conducted. To collect and evaluate randomized controlled trials of high quality on FMT for UC, we searched a number of databases, including PubMed, Web of Science, Cochrane, Embase, and Medline, for studies published between the establishment of the databases and March 2023. We conducted a meta-analysis of the studies using Review Manager software (version 5.4.1) to determine the differences in rates of remission and adverse reactions between the FMT group and the control group, utilizing the risk ratio (RR) and 95% confidence interval (CI) to combine our findings. A total of 13 randomized controlled trials (RCTs) on the efficacy of FMT in patients with UC were included in the study, in which 580 patients participated, including 293 patients treated with FMT and 287 control subjects. Meta-analysis revealed that clinical remission was significantly better in the FMT group than in the control group [RR = 1.73; 95% CI = (1.41, 2.12); P < 0.00001]; endoscopic remission was significantly better in the FMT group than in the control group [RR = 1.74; 95% CI = (1.24, 2.44); P = 0.001]. Additionally, there were no significant differences in the incidence of adverse reactions between the two groups [RR = 1.00; 95% CI = (0.86, 1.15); P = 0.96]. Fecal microbiota transplantation has shown potential as a therapeutic intervention for inducing clinical remission in ulcerative colitis UC; nevertheless, the attainment of endoscopic remission and the maintenance of long-term remission continue to present challenges. Safety concerns persist throughout the treatment process, necessitating the implementation of measures to augment both safety and success rates.
Topics: Humans; Colitis, Ulcerative; Fecal Microbiota Transplantation; Databases, Factual; MEDLINE; Odds Ratio; Randomized Controlled Trials as Topic
PubMed: 37661203
DOI: 10.1038/s41598-023-41182-6 -
Nutrition Reviews Aug 2021Diet may be one of the modifiable environmental factors that could reduce depressive symptoms or abate the development of depression without side effects. However,... (Meta-Analysis)
Meta-Analysis
CONTEXT
Diet may be one of the modifiable environmental factors that could reduce depressive symptoms or abate the development of depression without side effects. However, previous reviews mainly focused on general adult populations.
OBJECTIVE
The aim of this systematic review and meta-analysis was to explore the association between healthy dietary patterns and depression risk in older adults.
DATA SOURCES
Eight databases were searched up to September 2019. The inclusion criteria were older adults aged ≥ 65 years, healthy dietary patterns, depression assessed by a physician or by validated screening tools, and quantitative study design.
DATA EXTRACTION
Data were extracted independently by 2 researchers, and the Preferred Reporting Items for Systematic Reviews and Meta-analyses guideline was followed.
DATA ANALYSIS
Meta-analysis was conducted by calculating the pooled odds ratio (OR) and 95% CIs. A total of 18 eligible studies were meta-analyzed. Results showed that a healthy dietary pattern is associated with a reduced risk of depression in older adults (OR, 0.85; 95%CI, 0.78-0.92; P < 0.001). There was high heterogeneity (I2 = 64.9%; P < 0.001) among the studies. Subgroup analyses indicated that sample size and depression screening tools were the main sources of study heterogeneity.
CONCLUSIONS
An inverse association between healthy dietary patterns and depression risk in older adults was found. However, the high heterogeneity among the studies should be considered.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO registration no. CRD 42020169195.
Topics: Aged; Depression; Diet; Humans; Odds Ratio; Risk Factors
PubMed: 33236111
DOI: 10.1093/nutrit/nuaa118 -
Journal of Endocrinological... Oct 2023The clinical and hormonal overlap between neoplastic (CS) and non-neoplastic (NNH/pCS) hypercortisolism is a challenge. Various dynamic tests have been proposed to allow... (Meta-Analysis)
Meta-Analysis Review
PURPOSE
The clinical and hormonal overlap between neoplastic (CS) and non-neoplastic (NNH/pCS) hypercortisolism is a challenge. Various dynamic tests have been proposed to allow an early discrimination between these conditions, but to date there is no agreement on which of them should be used.
AIM
To provide an overview of the available tests and to obtain a quantitative synthesis of their diagnostic performance in discriminating NNH/pCS from CS.
METHODS
The included articles, published between 1990 and 2022, applied one or more second line tests to differentiate NNH/pCS from CS patients. For the NNH/pCS group, we admitted the inclusion of patients presenting clinical features and/or biochemical findings suggestive of hypercortisolism despite apparent lack of a pCS-related condition.
RESULTS
The electronic search identified 339 articles. After references analysis and study selection, we identified 9 studies on combined dexamethasone-corticotropin releasing hormone (Dex-CRH) test, 4 on Desmopressin test and 3 on CRH test; no study on Dex-Desmopressin met the inclusion criteria. Dex-CRH test provided the highest sensitivity (97%, 95 CI% [88%; 99%]). CRH tests showed excellent specificity (99%, 95% CI [0%; 100%]), with low sensitivity. Although metaregression analysis based on diagnostic odds ratio failed to provide a gold standard, CRH test (64.77, 95% CI [0.15; 27,174.73]) seemed to lack in performance compared to the others (Dex-CRH 138.83, 95% CI [49.38; 390.32] and Desmopressin 110.44, 95% CI [32.13; 379.63]).
DISCUSSION
Both Dex-CRH and Desmopressin tests can be valid tools in helping discrimination between NNH/pCS and CS. Further studies are needed on this topic, possibly focusing on mild Cushing's Disease and well-characterized NNH/pCS patients.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022359774 , identifier CRD42022359774.
Topics: Humans; Diagnosis, Differential; Cushing Syndrome; Deamino Arginine Vasopressin; Hospitalization; Odds Ratio
PubMed: 37079177
DOI: 10.1007/s40618-023-02099-z -
Journal of Obstetrics and Gynaecology :... Dec 2023Previous studies evaluating the relationship between blood manganese (Mn) level and gestational diabetes mellitus (GDM) in pregnant women showed inconsistent results. A... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Previous studies evaluating the relationship between blood manganese (Mn) level and gestational diabetes mellitus (GDM) in pregnant women showed inconsistent results. A systematic review and meta-analysis was therefore performed to investigate the above association.
METHODS
Relevant observational studies were obtained by search of electronic databases including Medline, Embase, Cochrane Library and Web of Science from database inception to 10 March 2023. Two authors independently performed database search, literature identification and data extraction. A randomised-effects model was selected to pool the data by incorporating the influence of potential heterogeneity. Subgroup analysis was performed to evaluate the influence of study characteristics on the results of the meta-analysis.
RESULTS
Six datasets from five observational studies, involving 91,249 pregnant women were included in the meta-analysis. Among the participants, 3597 (3.9%) were diagnosed as GDM. Overall, pooled results showed that a high blood level of Mn was associated with a higher risk of GDM (compared between women with highest versus lowest category blood Mn, odds ratio: 1.31, 95% confidence interval: 1.19-1.44, < .001) with no significant heterogeneity ( for Cochrane -test = 0.93, = 0%). Subgroup analyses according to study design, mean maternal age, matrix or methods for measuring blood Mn, and the incidence of GDM also showed consistent results ( for subgroup difference all >.05).
CONCLUSIONS
Results of the meta-analysis suggest that a high blood Mn level may be a risk factor of GDM in pregnant women. Studies are needed to determine the underlying mechanisms, and to investigate if the relationship between blood Mn level and GDM is dose-dependent.
Topics: Pregnancy; Female; Humans; Diabetes, Gestational; Manganese; Risk Factors; Maternal Age; Odds Ratio
PubMed: 37921106
DOI: 10.1080/01443615.2023.2266646 -
Neuropsychiatrie : Klinik, Diagnostik,... Jun 2020In today's society, sleep disturbances and back pain are both common problems which threaten health. Although some studies have focused on the effects of sleep... (Meta-Analysis)
Meta-Analysis
BACKGROUND
In today's society, sleep disturbances and back pain are both common problems which threaten health. Although some studies have focused on the effects of sleep disturbances on back pain, no meta-analysis has been done. The purpose of this study is to systematically review and perform a meta-analysis on the effects of sleep disturbances on back pain.
METHODS
A literature search in PubMed, Scopus and EMBASE with keywords until June 2019 was performed. The eligible articles were evaluated qualitatively and the results were pooled using random effects. The publication bias and the degree of heterogeneity were examined.
RESULTS
In all, 21 studies were included in the meta-analysis. Sleep disturbances were associated with back pain (odds ratio 1.52; confidence interval [CI] 1.37-1.68; P < 0.001). In men, the odds ratio was 1.49 (CI 1.34-1.65; P < 0.001). In women, the odds ratio was 1.56 (CI 1.33-1.81; P < 0.001). Begg's test (P = 0.856) and Egger test (P = 0.188) did not show any publication bias. A funnel plot and trim-and-fill method showed publication bias, and heterogeneity was also high.
CONCLUSIONS
Sleep disturbance is associated with risk of back pain. Improving sleep can be a deterrent against back pain. Therefore, interventions to reduce sleep disturbances can help to improve health. On the other hand, the relationship between sleep disturbances and back pain can be two-sided, and back pain can also lead to sleep disturbances. Not only in view of the lifetime prevalence and the multifactorial impairments of those affected, but also in consideration of social and economic burdens, this issue will remain of considerable importance.
Topics: Back Pain; Female; Humans; Male; Odds Ratio; Prevalence; Sleep Wake Disorders
PubMed: 32166629
DOI: 10.1007/s40211-020-00339-9 -
Reviews on Environmental Health Dec 2022To investigate whether a possible association of mobile phone use with hearing impairment was conducted a systematic review and meta-analysis. (Meta-Analysis)
Meta-Analysis Review
OBJECTIVES
To investigate whether a possible association of mobile phone use with hearing impairment was conducted a systematic review and meta-analysis.
CONTENT
This is a systematic review and meta-analysis. A comprehensive literature search was carried out based on the Meta-analysis of Observational Studies in Epidemiology (MOOSE) methodology using PubMed, Scopus, Web of Science, OVID, and Cochrane. The Robins-I tool was used for quality assessment and risk of bias. Two investigators independently reviewed all articles. Pooled effect size was calculated and meta-analysis was performed to compute an overall effect size.
SUMMARY
Overall, five relevant studies (two cross-sectional and three cohort studies) with 92,978 participants were included in the analysis. The studies were stratified by design, there was no significant association between mobile phone use and hearing impairment in cross-sectional studies (OR=0.94, 95% CI=0.57-1.31) and cohort studies (OR=1.09, 95% CI=0.93-1.25). In addition, the effect estimates did not differ significantly between cross-sectional and cohort studies (Q=0.50, p=0.48). Overall, the pooled odds ratio (OR) of hearing impairment was 1.07 (95% CI: 0.94-1.20), which indicates no significant association between mobile phone use and hearing impairment.
OUTLOOK
Our findings indicate no association between mobile phone use and hearing impairment. However, these findings must be interpreted with caution.
Topics: Humans; Cell Phone; Cell Phone Use; Cross-Sectional Studies; Hearing Loss; Odds Ratio
PubMed: 34293837
DOI: 10.1515/reveh-2021-0062 -
Optometry and Vision Science : Official... Jan 2020Despite the increasing number of studies focused on the association between obstructive sleep apnea (OSA) and keratoconus (KC), to date, no comprehensive meta-analysis... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Despite the increasing number of studies focused on the association between obstructive sleep apnea (OSA) and keratoconus (KC), to date, no comprehensive meta-analysis or systematic review was published.
OBJECTIVE
The objective of this study was to evaluate the association between OSA and KC.
DATA SOURCES
Sources of data were PubMed, Scopus, and Web of Science databases.
STUDY ELIGIBILITY CRITERIA
The criteria for study eligibility were case-control studies and cohort studies reporting data on the association of OSA with KC with risk ratio, odds ratio, or hazard ratio with 95% confidence intervals or sufficient raw data for calculation.
STUDY APPRAISAL AND SYNTHESIS METHODS
Meta-analysis was conducted with a random-effects model using odds ratio with 95% confidence interval as the effect size. Heterogeneity was evaluated using the Q and I tests. Sensitivity analysis and assessment of publication bias were performed.
RESULTS
Five studies (four case-control studies and one cohort study) published between 2012 and 2016 and involving 33,844 subjects (16,922 patients with KC, 16,922 controls) were included in this meta-analysis. A significant association between OSA and KC has been shown (pooled odds ratio, 1.841; 95% confidence interval, 1.163 to 2.914; P = .009). A significant heterogeneity was observed (Q = 15.8, I = 74.6%). There was no evidence of significant publication bias (P = .07). The sensitivity analyses indicated the stability of results.
LIMITATIONS
Heterogeneity across the studies was observed. Data from four hospital-based case-control studies and one large population-based cohort study were combined. Most of the included studies ascertained OSA by the Berlin Questionnaire, which is a screening tool.
CONCLUSIONS
This meta-analysis provides significant evidence that OSA is associated with KC. Therefore, a proper screening for OSA is warned for KC patients for the prevention of various cardiovascular comorbidities. Further prospective studies are warranted to explore more in-depth the casual relationship between the two conditions.
Topics: Case-Control Studies; Cohort Studies; Humans; Keratoconus; Odds Ratio; Risk Factors; Sleep Apnea, Obstructive; Surveys and Questionnaires
PubMed: 31895272
DOI: 10.1097/OPX.0000000000001467 -
Wound Management & Prevention Sep 2021Smoking is a risk factor for many diseases. (Meta-Analysis)
Meta-Analysis
BACKGROUND
Smoking is a risk factor for many diseases.
PURPOSE
This study explored the relationship between current or past smoking and pressure injury (PI) risk through a systematic review and meta-analysis.
METHODS
The databases PubMed, Web of Science, and China National Knowledge Infrastructure were searched for the years between 2001 and 2020. Quality of evidence was estimated by the Newcastle-Ottawa Scale. The random effects model was applied to assess the odds ratios (OR) and 95% confidence intervals (CI); pooled adjusted OR and 95% CI, subgroup analysis, publication bias, sensitivity analyses, and meta-regression analysis were performed.
RESULTS
Fifteen (15) studies (12 retrospective and 3 prospective) comprising data on 11 304 patients were eligible for inclusion in the review. The meta-analysis demonstrated that smoking increased the risk of PI (OR = 1.498; 95% CI, 1.058-2.122), and the pooled adjusted OR (1.969) and 95% CI (1.406-2.757) confirmed this finding. Publication bias was not detected by funnel plot, Begg's test (P = .322), or Egger's test (P = .666). Subgroup analyses yielded the same observations in both retrospective (OR = 1.607; 95% CI, 1.043-2.475) and prospective (OR = 1.218; 95% CI, 0.735-2.017) studies. The results were consistent across sensitivity analyses (OR = 1.07; 95% CI, 1.043- 2.475). Relevant heterogeneity moderators were not identified by meta-regression analysis with PI incidence (P = .466), years of patient data included (P = .637), mean patient age (P = .650), and diabetes mellitus diagnosis (P = .509).
CONCLUSION
This study found that individuals who are current or formers smokers have an almost 1.5 times higher risk of PI development than do those who do not smoke.
Topics: Humans; Odds Ratio; Prospective Studies; Retrospective Studies; Risk Factors; Smoking; Pressure Ulcer
PubMed: 34473642
DOI: No ID Found -
Public Health Apr 2020Research has explored the relationship between job strain and adverse effects on physical and psychological health. Accordingly, the effects of job strain on mortality... (Meta-Analysis)
Meta-Analysis
OBJECTIVES
Research has explored the relationship between job strain and adverse effects on physical and psychological health. Accordingly, the effects of job strain on mortality risk were pooled based on longitudinal studies.
STUDY DESIGN
Systematic review and meta-analysis.
METHODS
Both researchers searched for published articles in scientific databases until May 2019. Then, the articles were screened based on the inclusion and exclusion criteria. The results were combined, and analyses of subgroups and reviewing the bias of the publication were performed as well.
RESULTS
Seventeen longitudinal studies included in the meta-analysis were from three continents: Europe, Asia, and America. The risk ratio (RR) of mortality based on job strain was equal to 1.20, with a confidence interval (CI) of 1.04-1.37 (P = 0.00.10). In men, the RR is 1.21, and the CI is 1.02-1.44 (P = 0.032), and in women, the RR is 0.97 and CI is 0.84-1.12 (P = 0.686). Evaluation of publication bias indicated nothing significant.
DISCUSSION
Based on the findings, it was found that job strain was a risk factor for mortality, and this finding was more appropriate for men. Hence, reducing job strain can be a deterrent against the dangers that threaten health.
Topics: Asia; Cohort Studies; Europe; Female; Humans; Male; Odds Ratio; Risk Factors; Stress, Psychological; United States; Workload
PubMed: 31927337
DOI: 10.1016/j.puhe.2019.10.030