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Reproductive Biology and Endocrinology... Sep 2021Sequential embryo transfer has been proposed as a way to improve embryo implantation in women for in vitro fertilization (IVF), but the effect on pregnancy outcomes...
BACKGROUND
Sequential embryo transfer has been proposed as a way to improve embryo implantation in women for in vitro fertilization (IVF), but the effect on pregnancy outcomes remains ambiguous. This systematic review was conducted to investigate the efficacy of sequential embryo transfer on IVF outcomes.
METHODS
A literature search was performed in the PubMed, Web of Science, Cochrane Library, ScienceDirect and Wanfang databases. Data were pooled using a random- or fixed-effects model according to study heterogeneity. The results are expressed as relative risks (RRs) with 95% confidence intervals (CIs). Heterogeneity was evaluated by the I statistic. The study protocol was registered prospectively on INPLASY, ID: INPLASY202180019.
RESULTS
Ten eligible studies with 2658 participants compared sequential embryo transfer and cleavage transfer, while four studies with 513 participants compared sequential embryo transfer and blastocyst transfer. The synthesis results showed that the clinical pregnancy rate was higher in the sequential embryo transfer group than in the cleavage embryo transfer group (RR 1.42, 95% CI 1.26-1.60, P< 0.01) for both women who did experience repeated implantation failure (RIF) (RR 1.58, 95% CI 1.17-2.13, P< 0.01) and did not experience RIF (Non-RIF) (RR 1.44, 95% CI 1.20-1.66, P< 0.01). However, sequential embryo transfer showed no significant benefit over blastocyst embryo transfer.
CONCLUSION
The current systematic review demonstrates that sequential cleavage and blastocyst embryo transfer improve the clinical pregnancy rate over conventional cleavage embryo transfer. For women with adequate embryos, sequential transfer could be attempted following careful consideration. More high-grade evidence from prospective randomized studies is warranted.
Topics: Blastocyst; Cleavage Stage, Ovum; Embryo Transfer; Embryo, Mammalian; Female; Fertilization in Vitro; Humans; Infertility; Pregnancy; Pregnancy Outcome; Pregnancy Rate; Treatment Outcome
PubMed: 34521412
DOI: 10.1186/s12958-021-00824-y -
Zygote (Cambridge, England) Aug 2023Fertilization failure (FF) and zygotic arrest after ICSI have a huge effect on both patients and clinicians, but both problems are usually unexpected and cannot be... (Review)
Review
Fertilization failure (FF) and zygotic arrest after ICSI have a huge effect on both patients and clinicians, but both problems are usually unexpected and cannot be properly diagnosed. Fortunately, in recent years, gene sequencing has allowed the identification of multiple genetic variants underlying failed ICSI outcomes, but the use of this approach is still far from routine in the fertility clinic. In this systematic review, the genetic variants associated with FF, abnormal fertilization and/or zygotic arrest after ICSI are compiled and analyzed. Forty-seven studies were included. Data from 141 patients carrying 121 genetic variants affecting 16 genes were recorded and analyzed. In total, 27 variants in (in 50 men) and 26 variants in (in 24 women) are two of the factors related to oocyte activation failure that could explain a high percentage of male-related and female-related FF. Additional variants identified were reported in , and (in men), and , , , , , , and (in women). Most of these variants are pathogenic or potentially pathogenic (89/121, 72.9%), as demonstrated by experimental and/or approaches. Most individuals carried bi-allelic variants (89/141, 63.1%), but pathogenic variants in heterozygosity have been identified for and . Clinical treatment options for affected individuals, such as chemical-assisted oocyte activation (AOA) or cRNA injection in the oocyte, are still experimental. In conclusion, a genetic study of known pathogenic variants may help in diagnosing recurrent FF and zygotic arrest and guide patient counselling and future research perspectives.
Topics: Male; Female; Animals; Sperm Injections, Intracytoplasmic; Zygote; Oocytes; Fertilization
PubMed: 37212058
DOI: 10.1017/S096719942300014X -
Journal of Midwifery & Women's Health Mar 2022Recently, there is a growing interest in cryopreservation for nonmedical reasons, widely known as planned oocyte cryopreservation. This review aims to summarize and... (Review)
Review
INTRODUCTION
Recently, there is a growing interest in cryopreservation for nonmedical reasons, widely known as planned oocyte cryopreservation. This review aims to summarize and understand the characteristics of women who undergo or consider planned oocyte cryopreservation, identify their initial sources of information, and describe the oocyte disposition. This information should assist health professionals with shared decision-making.
METHODS
A systematic review was performed and reported following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) recommendations. PubMed, Scopus, and Web of Science were searched from inception to January 2021 without any limitation on publication date. Studies were included if they were in English and examined the characteristics of users or potential users of planned oocyte cryopreservation, initial information sources, and the oocyte disposition. Extracted data were analyzed using thematic analysis. The methodological quality of the recruited studies was assessed with the QualSyst criteria.
RESULTS
Of 1074 initially retrieved records, 29 met the inclusion criteria, including 12 qualitative and 17 quantitative studies. Response rates of surveys ranged between 38% and 85%. Most of the users or potential users of planned oocyte cryopreservation were single, highly educated, and employed and had a mean age of 37 years. Media and friends were the most common sources of initial knowledge about planned oocyte cryopreservation, and health professionals were a less common source. The majority of planned oocyte cryopreservation users did not attempt pregnancy with their frozen oocytes, yet they did not regret having undergone the procedure. The results regarding the disposition intentions of unused frozen oocytes are inconsistent.
DISCUSSION
Most of the users or potential users of planned oocyte cryopreservation have specific demographic characteristics and do not ultimately use their cryopreserved oocytes. Unused oocytes can be discarded or donated to other women or to research. By understanding the main characteristics of potential users of planned oocyte cryopreservation, health professionals can provide proper counseling and support effective decision-making.
Topics: Counseling; Cryopreservation; Female; Fertility Preservation; Humans; Intention; Oocytes; Pregnancy
PubMed: 35156301
DOI: 10.1111/jmwh.13332 -
Reproductive Biomedicine Online Dec 2023The aim of this systematic review and meta-analysis was to quantify the effect of random start ovarian stimulation (RSOS) compared with conventional start ovarian... (Meta-Analysis)
Meta-Analysis Review
The aim of this systematic review and meta-analysis was to quantify the effect of random start ovarian stimulation (RSOS) compared with conventional start ovarian stimulation (CSOS) in cancer patients before gonadotoxic treatment. The final analytical cohort encompassed 688 RSOS and 1076 CSOS cycles of cancer patients before gonadotoxic treatment. Eleven studies were identified by database searches of MEDLINE, Cochrane Library and cited references. The primary outcomes of interest were the number of oocytes and mature oocytes collected, the number of embryos cryopreserved and the metaphase II (MII)-antral follicle count (AFC) ratio. The studies were rated from medium to high quality (from 6 to 9) according to the Newcastle-Ottawa Quality Assessment Scale. The two protocols resulted in similar numbers of oocytes collected, MII oocytes, embryos available for cryopreservation and comparable MII-AFC and fertilization rates. The duration of ovarian stimulation was longer (standardized mean difference [SMD] 0.35, 95% CI 0.09 to 0.61; P = 0.009) and gonadotrophin consumption was higher (SMD 0.23, 95% CI 0.06 to 0.40; P = 0.009) in RSOS compared with CSOS. This systematic review and meta-analysis show that the duration of stimulation is longer, and the total gonadotrophin consumption is higher in cancer patients undergoing RSOS compared with those undergoing CSOS, with no significant effect on mature oocyte yield.
Topics: Humans; Female; Fertility Preservation; Oocyte Retrieval; Cryopreservation; Neoplasms; Oocytes; Gonadotropins; Ovulation Induction; Retrospective Studies
PubMed: 37857156
DOI: 10.1016/j.rbmo.2023.103337 -
BJOG : An International Journal of... May 2021Advances in vitrification techniques have enabled planned oocyte cryopreservation ('Planned OC'). (Meta-Analysis)
Meta-Analysis
BACKGROUND
Advances in vitrification techniques have enabled planned oocyte cryopreservation ('Planned OC').
OBJECTIVES
To explore the cost-efficiency and utilisation of planned OC, as well as patients' perspectives on the process.
SEARCH STRATEGY
A systematic search in PubMed/MEDLINE, Embase, Cochrane Database and PsychINFO, for all relevant studies published between January 2007 and December 2019.
SELECTION CRITERIA
The protocol followed PRISMA guidelines in PECO format, and was registered with PROSPERO.
DATA COLLECTION AND ANALYSIS
Two independent reviewers evaluated all manuscripts for inclusion eligibility. Authors were contacted for missing data. Included studies were assessed for risk of bias and for heterogeneity. Weighted effects were measured and plotted.
MAIN RESULTS
The search yielded 12 545 records, of which 43 were included. Planned OC is cost-efficient at 35, assuming 60% utilisation; and at 37 assuming utilising donor sperm when necessary. At 38 it is cost-efficient to defer planned OC in favour of undergoing 2 IVF cycles. Currently, utilisation of banked-oocytes within 22-58 months, is up to 15%. Nine percent of warmed banked oocytes result in life births. Online resources and treating physicians are equally important sources of information regarding planned OC. Most patients think planned OC is ideal before age 35 and are not fully aware of what the process entails and tend to overestimate the success rates. The main barrier to wider endorsement of planned OC is being wary of potential health implications or of limited success.
CONCLUSION
Planned OC is an adequate method for preserving fertility. However, knowledge gaps result in under-utilisation leading to reduced cost-efficiency.
TWEETABLE ABSTRACT
Identifying facilitators and barriers for wider adoption of banking oocytes can enhance the cost-efficiency of this modality.
Topics: Cost-Benefit Analysis; Cryopreservation; Fertility Preservation; Humans; Oocytes; Procedures and Techniques Utilization; Vitrification
PubMed: 33021076
DOI: 10.1111/1471-0528.16555 -
Journal of Gynecology Obstetrics and... Jun 2021There are conflicting reports regarding circulating leptin and its relationship between pregnancy outcomes in infertile women undergoing in vitro fertilization (IVF) or... (Meta-Analysis)
Meta-Analysis
There are conflicting reports regarding circulating leptin and its relationship between pregnancy outcomes in infertile women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). We performed a systematic review and meta-analysis to assess the association between serum or follicular fluid (FF) leptin concentrations reported for infertile women and their IVF outcome. A systematic search was undertaken in available databases (PubMed, Scopus, Web of Science, The Cochrane Library and Embase) to find studies published up to Aug 2020 and the standardized mean difference with 95 % confidence interval was taken from 14 eligible studies. Both graphical (funnel plots) and test methods (Egger's regression test and the Begg) assessed the presence of publication bias. Subgroup analysis was used to investigate the source of heterogeneity. Pooled effect sizes based on the eligible papers indicated that of there is no statistically significant correlation between leptin levels in follicular fluid and serum on the day of ovum pick-up (OPU) and day of HCG (human chorionic gonadotrophin) administration in pregnant and non-pregnant women who underwent IVF/ICSI cycles. However, combination of leptin in serum and/or FF with other parameters may be a useful marker to predict IVF outcome.
Topics: Biomarkers; Female; Fertilization in Vitro; Follicular Fluid; Humans; Leptin; Pregnancy; Pregnancy Rate; Sperm Injections, Intracytoplasmic
PubMed: 33007525
DOI: 10.1016/j.jogoh.2020.101924 -
Reproductive Sciences (Thousand Oaks,... Nov 2022Oocyte vitrification is a widespread and well-established assisted reproduction technique that has enabled some patient groups to obtain clinical results equivalent to... (Review)
Review
Oocyte vitrification is a widespread and well-established assisted reproduction technique that has enabled some patient groups to obtain clinical results equivalent to those using fresh oocytes. However, as the number of babies born from vitrified oocytes has increased, so has the discussion regarding the method's safety for the offspring. Cryogenic oocyte damage caused by chemical, mechanical, and thermal stress has raised concern. In this systematic review, we asked the question of whether oocyte vitrification impacts offspring health. From 2007 to 2021, 13 studies were included in the analysis. All studies were observational and presented neonatal outcomes. A total of 4,159 babies were analyzed. Data from these studies were used to assess the following outcomes: multiple pregnancies, cesarean section, gestational age at delivery, the number of live births, birth weight, Apgar scores, congenital anomalies, and baby health. The most extended follow-ups evaluated children until 1, 2, and 6 years of age. According to the evidence appraised in this systematic review, vitrification seems to be a safe method for oocyte cryopreservation and child health, at least in the short term. Nevertheless, there is an urgent need for additional long-term data results from big databases and also for randomized controlled trials to improve the levels of evidence.
Topics: Pregnancy; Female; Humans; Vitrification; Embryo Transfer; Cesarean Section; Pregnancy Rate; Oocytes; Cryopreservation
PubMed: 35099778
DOI: 10.1007/s43032-022-00868-4 -
Transboundary and Emerging Diseases Sep 2022Poultry and poultry-derived products such as meat and eggs are among the main sources of non-typhoidal Salmonella (NTS) transmission to humans. Therefore, we performed a... (Meta-Analysis)
Meta-Analysis Review
Poultry and poultry-derived products such as meat and eggs are among the main sources of non-typhoidal Salmonella (NTS) transmission to humans. Therefore, we performed a systematic review and used random-effects meta-analyses to (1) estimate the prevalence of NTS in poultry samples from birds, products and subproducts and environmental samples, (2) examine the diversity and frequency of their serovars and (3) estimate the prevalence and profiles of anti-microbial resistance (AMR) in NTS isolates reported in studies from the Americas. We included 157 studies from 15 countries comprising 261,408 poultry samples and estimated an overall pooled prevalence of 17.9% (95% Confidence Interval: 10.8-26.3) in birds, 21.8% (17.7-26.1) in products and subproducts and 29.5% (24.2-35.1) in environmental samples. At the national level, the prevalence of NTS was heterogeneous across countries with the highest values in Mexico, the United States and Canada. In total, 131 serovars were identified from 13,388 isolates; Heidelberg, Kentucky, Enteritidis and Typhimurium were the most prevalent in the overall top 10 ranking (range 6.5%-20.8%). At the national level, Enteritidis and Typhimurium were identified in most of the countries, though with national differences in their ranks. The prevalence of AMR increased from 24.1% for 1 antibiotic to 36.2% for 2-3 antibiotics and 49.6% for ≥ 4 antibiotics. Kentucky, Heidelberg, Typhimurium and Enteritidis were the serovars with the highest prevalence of AMR. Besides, tetracycline, ampicillin, streptomycin, ceftiofur and amoxicillin-clavulanic acid were the most frequent antibiotics to which NTS showed resistance. In conclusion, NTS was distributed through the avian production chain with high and heterogeneous values of prevalence in poultry samples. Besides, there were distinctive patterns of serovars distribution across countries and an alarming prevalence of AMR among zoonotic serovars.
Topics: Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Animals; Anti-Bacterial Agents; Humans; Ovum; Poultry; Prevalence; Salmonella; Salmonella Infections, Animal; Serogroup; Streptomycin; Tetracycline; United States
PubMed: 34724337
DOI: 10.1111/tbed.14362 -
European Journal of Obstetrics,... Dec 2021Assisted Reproductive Technology by means of oocyte donation is a very successful method leading to psychosocial consequences in donors. The aim of the present study was... (Review)
Review
Assisted Reproductive Technology by means of oocyte donation is a very successful method leading to psychosocial consequences in donors. The aim of the present study was to conduct a systematic review of the existing literature on the psychosocial consequences of oocyte donation in the donors. The present study was conducted as a systematic review based on the PRISMA checklist. Searches were performed in PubMed, Web of Science, Scopus, and SID databases for the documents written between 2000 and 2020 regardless of the research methodology and the employed tools. English and Persian articles focusing on psychological and social issues of oocyte donation were reviewed. From 2,759 studies which were found, finally 14 related ones were selected. Psychosocial challenges of donors were obtained in three dimensions including short-term and long-term psychological reactions to treatment complications, emotional reactions to their function as an oocyte donor, and emotional reactions to the resulting offspring resulting and related social challenges. According to the existing studies, oocyte donation is a challenging process with short-term and long-term psychosocial consequences for donors. In order to prevent the feasible psychosocial hazards caused by the donation process, it is necessary to provide oocyte donors with psychosocial support, proper counseling, and awareness of the facts and possible issues ahead.
Topics: Counseling; Humans; Oocyte Donation; Oocytes; Reproductive Techniques, Assisted; Tissue Donors
PubMed: 34689024
DOI: 10.1016/j.ejogrb.2021.10.009 -
Poultry Science Mar 2022Globally, the production of Pekin ducks for meat and eggs is considerable, with an estimated >200 million ducks slaughtered yearly for their meat in the United States... (Review)
Review
Globally, the production of Pekin ducks for meat and eggs is considerable, with an estimated >200 million ducks slaughtered yearly for their meat in the United States and the European Union alone. However, despite the size of the Pekin duck industries, there is a lack of research-based guidance regarding the welfare of the ducks. The purpose of this systematic review is to examine and summarize available scientific literature related to the welfare of Pekin ducks raised on commercial farms for meat and eggs. Specifically, we aimed to identify topics where sufficient literature exists to support best-practice duck welfare recommendations, as well as further research needs. The literature search targeted original research papers and review articles published in English. Six pre-establish inclusion/exclusion criteria were applied, yielding 63 publications. We summarized their content based their main topic of focus. For all original studies, we additionally recorded the country where the study was executed, scale of the project (commercial or experimental barns), general information about the housing system and management (waterers, flooring, ventilation, group size, and space allowance), and the types of outcome variables collected. We begin with an overview of key publication trends. We then synthesize and discuss welfare outcomes related to key housing/management decisions: bathing water, flooring and litter, stocking density and space availability, ventilation/air quality, lighting, outdoor access, and for egg laying birds the availability of nest boxes. Throughout, we outline specific research gaps, as well as overarching research needs.
Topics: Animal Welfare; Animals; Ducks; Meat; Ovum
PubMed: 35042179
DOI: 10.1016/j.psj.2021.101614