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Pathogens and Global Health Feb 2021Several studies have evaluated the association between killer-cell immunoglobulin-like receptors (KIR) genes and susceptibility risk to tuberculosis (TB) infection.... (Meta-Analysis)
Meta-Analysis
Several studies have evaluated the association between killer-cell immunoglobulin-like receptors (KIR) genes and susceptibility risk to tuberculosis (TB) infection. Nonetheless, their outcomes have not been conclusive and consistent. Here we implemented a systematic review and meta-analysis of KIR genes association to susceptibility risk of pulmonary TB (PTB) infection to attain a clear understanding of the involvement of these genes in susceptibility to PTB infection. A systematic search was conducted in the MEDLINE/PubMed and Scopus databases to find case-control studies published before November 2020. Pooled odds ratio (OR) and 95% confidence interval (95% CI) were calculated to determine the association between KIR genes and risk of PTB infection. After comprehensive searching and implementing the inclusion and exclusion criteria, 10 case-control studies were included in the meta-analysis. Four KIR genes were found to have significant positive association with PTB susceptibility risk of infection, including (OR = 1.454, 95% CI = 1.157-1.827; = 0.001), (OR = 1.481, 95% CI = 1.334-1.837; < 0.001), (OR = 1.782, 95% CI = 1.273-2.495; = 0.001) and (OR = 1.726, 95% CI = 1.277-2.333; < 0.001). However, the results showed that the remaining KIR genes () and two pseudogenes ( and ) did not have significant associations with risk of PTB infection. This meta-analysis provides reliable evidence that the KIR genes , and may be associated with an increased risk of PTB infection.
Topics: Genetic Predisposition to Disease; Genotype; Humans; Receptors, KIR; Tuberculosis, Pulmonary
PubMed: 33258733
DOI: 10.1080/20477724.2020.1848271 -
Critical Reviews in Eukaryotic Gene... 2021The junk DNA "pseudogenes," known as genomic fossils, are characterized by their ubiquitousness and abundance within the genomic structure. These genomics sets are...
The junk DNA "pseudogenes," known as genomic fossils, are characterized by their ubiquitousness and abundance within the genomic structure. These genomics sets are recognized by the potential activity of meta-regulating the parent genes; these are transcribed into interfering RNA, consequently acting on miRNA concentration, thereby shedding light on the crosstalk of the pseudogenes' miRNA, siRNA, lncRNA/tumor therapy co-relationship. Moreover, an upcoming visualization regarding pseudogenes is under investigation, which describes the potentiality of pseudogenes as a fundamental component of cancerous evolutionary processing tools. Accordingly, here is a systematic review covering pseudobirth, pseudosignatures, and functional properties of pseudogenes, concluding that these pseudogenes are hypothetically predictive tumor therapies.
Topics: Biological Evolution; Genetic Therapy; Genomics; Humans; Neoplasms; Pseudogenes; RNA Interference; RNA, Small Interfering
PubMed: 34591392
DOI: 10.1615/CritRevEukaryotGeneExpr.2021039540